Eg5 co-crystals
    1.
    发明授权
    Eg5 co-crystals 失效
    Eg5共晶体

    公开(公告)号:US07662581B1

    公开(公告)日:2010-02-16

    申请号:US11018091

    申请日:2004-12-20

    摘要: This invention provides methods of identifying an Eg5 binding ligand. The ligand is identified by using the atomic coordinates of an Eg5 crystal to generate a three dimensional structure. The three dimensional structure is used in molecular modeling techniques and docking experiments to identify ligands that bind to the binding pocket of Eg5. A novel binding pocket is identified. The invention also provides a crystallized Eg5 and ligand complex.

    摘要翻译: 本发明提供鉴定Eg5结合配体的方法。 通过使用Eg5晶体的原子坐标来鉴定配体以产生三维结构。 三维结构用于分子建模技术和对接实验以鉴定结合Eg5的结合口袋的配体。 识别出新的装订口袋。 本发明还提供了结晶的Eg5和配体络合物。

    Characterization of the GSK-3beta protein and methods of use thereof
    2.
    发明申请
    Characterization of the GSK-3beta protein and methods of use thereof 审中-公开
    GSK-3β蛋白的表征及其使用方法

    公开(公告)号:US20080004433A1

    公开(公告)日:2008-01-03

    申请号:US11879719

    申请日:2007-07-18

    IPC分类号: C07K14/00 C07K1/00 G06G7/48

    摘要: The invention provides the three-dimensional structure of a construct of glycogen synthase kinase 3 (GSK3); crystals of a construct of glycogen synthase kinase 3-β (GSK3-β) containing the protein's catalytic kinase domain; a method for crystallizing the protein construct to provide a GSK3 crystal sufficient for structure determination; and a method for using the GSK3 construct's three-dimensional structure for the identification of possible therapeutic compounds in the treatment of various disease conditions mediated by GSK3 activity.

    摘要翻译: 本发明提供了糖原合酶激酶3(GSK3)构建体的三维结构; 含有蛋白质催化激酶结构域的糖原合成酶激酶3-β(GSK3-β)构建体的晶体; 使蛋白质构建体结晶以提供足以进行结构测定的GSK3晶体的方法; 以及使用GSK3构建体的三维结构来鉴定可能的治疗化合物以治疗由GSK3活性介导的各种疾病状况的方法。

    Method for crystallizing human GSK3 and novel crystal structure thereof
    3.
    发明申请
    Method for crystallizing human GSK3 and novel crystal structure thereof 审中-公开
    人GSK3结晶方法及其新型晶体结构

    公开(公告)号:US20070020745A1

    公开(公告)日:2007-01-25

    申请号:US10366546

    申请日:2003-02-11

    摘要: The invention provides the three-dimensional structure of a construct of human glycogen synthase kinase 3 (GSK3); crystals of a construct of human glycogen synthase kinase 3-β (GSK3-β) containing the protein's catalytic kinase domain; a method for crystallizing the protein construct to provide a GSK3 crystal sufficient for structure determination; and a method for using the GSK3 construct's three-dimensional structure for the identification of possible therapeutic compounds in the treatment of various disease conditions mediated by GSK3 activity.′

    摘要翻译: 本发明提供人糖原合酶激酶3(GSK3)构建体的三维结构; 含有蛋白质催化激酶结构域的人类糖原合酶激酶3-β(GSK3-β)构建体的晶体; 使蛋白质构建体结晶以提供足以进行结构测定的GSK3晶体的方法; 以及使用GSK3构建体的三维结构来鉴定可能的治疗化合物以治疗由GSK3活性介导的各种疾病状况的方法。

    Method for cyrstallizing human GSK3 and novel crystal structure thereof
    6.
    发明申请
    Method for cyrstallizing human GSK3 and novel crystal structure thereof 审中-公开
    人GSK3凝胶化方法及其新型晶体结构

    公开(公告)号:US20070264699A1

    公开(公告)日:2007-11-15

    申请号:US11824457

    申请日:2007-06-29

    IPC分类号: C12N9/12 C07K1/107 C07K14/00

    摘要: The invention provides the three-dimensional structure of a construct of human glycogen synthase kinase 3 (GSK3); crystals of a construct of human glycogen synthase kinase 3-β (GSK3-β) containing the protein's catalytic kinase domain; a method for crystallizing the protein construct to provide a GSK3 crystal sufficient for structure determination; and a method for using the GSK3 construct's three-dimensional structure for the identification of possible therapeutic compounds in the treatment of various disease conditions mediated by GSK3 activity.

    摘要翻译: 本发明提供人糖原合酶激酶3(GSK3)构建体的三维结构; 含有蛋白质催化激酶结构域的人类糖原合酶激酶3-β(GSK3-β)构建体的晶体; 使蛋白质构建体结晶以提供足以进行结构测定的GSK3晶体的方法; 以及使用GSK3构建体的三维结构来鉴定可能的治疗化合物以治疗由GSK3活性介导的各种疾病状况的方法。