Invention Application
- Patent Title: Benzimidazole quinolinones and uses thereof
- Patent Title (中): 苯并咪唑喹啉酮及其用途
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Application No.: US10839793Application Date: 2004-05-05
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Publication No.: US20050203101A1Publication Date: 2005-09-15
- Inventor: Paul Barsanti , Dirksen Bussiere , Stephen Harrison , Carla Heise , Johanna Jansen , Elisa Jazan , Timothy Machajewski , Christopher McBride , William McCrea , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith Pfister , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Joel Silver , Allan Wagman , Marion Wiesmann , Kelly Wayman
- Applicant: Paul Barsanti , Dirksen Bussiere , Stephen Harrison , Carla Heise , Johanna Jansen , Elisa Jazan , Timothy Machajewski , Christopher McBride , William McCrea , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith Pfister , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Joel Silver , Allan Wagman , Marion Wiesmann , Kelly Wayman
- Assignee: Chiron Corporation
- Current Assignee: Chiron Corporation
- Main IPC: A61K31/4375
- IPC: A61K31/4375 ; A61K31/4709 ; A61K31/496 ; A61K31/52 ; A61P35/00 ; C07D401/04 ; C07D401/14 ; C07D405/14 ; C07D409/14 ; C07D413/14 ; C07D453/02 ; C07D453/06 ; C07D471/04 ; C07D43/14
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Abstract:
Methods of treating cancer include contacting a cancer cell with 4-amino-5-fluoro-3-(5-piperazin-1-yl-1H-benzimidazol-2-yl)quinolin-2(1H)-one, 4-amino-5-fluoro-3-[5-(4-methyl-4-oxidopiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one, tautomers thereof, pharmaceutically acceptable salts thereof, pharmaceutically acceptable salts of the tautomers thereof, or a mixture thereof.
Information query
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