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24 条记录 (耗时 0.037 秒)

    Compositions and methods of diagnosis and treatment using casein kinase I
    4.
    发明授权
    Compositions and methods of diagnosis and treatment using casein kinase I 失效
    使用酪蛋白激酶I的组合物和诊断和治疗方法

    公开(公告)号：US06512102B1

    公开(公告)日：2003-01-28

    申请号：US09472112

    申请日：1999-12-23

    申请人： Licen Xu ,  Stephen D. Harrison ,  Lewis T. Williams

    发明人： Licen Xu ,  Stephen D. Harrison ,  Lewis T. Williams

    IPC分类号： C07H2104

    CPC分类号： C12N15/1137 ,  A61K31/00 ,  A61K38/45 ,  A61K48/00

    摘要： The invention is generally directed to compositions and methods for affecting signal transduction using the casein kinase I (CKI) gene or gene product. The invention is more specifically directed to affecting the Wnt signal pathway using the CKI gene or gene product. The invention is particularly directed to using the CKI gene or gene product to treat and diagnose cancer, particularly breast and colon cancer. CKI&egr; is the preferred species. The field of the invention is compositions and methods for modulating signal transduction using the (CKI) gene or gene products and variants thereof. The invention is more specifically directed to modulating the Wnt signal pathway using the CKI gene or gene product. The invention is particularly directed to using the CKI gene or gene product to treat and diagnose disorders mediated by the Wnt signal pathway, especially hyperproliferative disorders, particularly breast and colon cancer.

    摘要翻译： 本发明一般涉及使用酪蛋白激酶I（CKI）基因或基因产物影响信号转导的组合物和方法。 本发明更具体地涉及使用CKI基因或基因产物影响Wnt信号通路。 本发明特别涉及使用CKI基因或基因产物来治疗和诊断癌症，特别是乳腺癌和结肠癌。 CKIepsi是首选品种。 本发明的领域是使用（CKI）基因或其基因产物及其变体调节信号转导的组合物和方法。 本发明更具体地涉及使用CKI基因或基因产物调节Wnt信号通路。 本发明特别涉及使用CKI基因或基因产物来治疗和诊断由Wnt信号通路介导的疾病，特别是过度增殖性疾病，特别是乳腺癌和结肠癌。

    Identification and use of selective inhibitors of glycogen synthase kinase 3
    5.
    发明授权
    Identification and use of selective inhibitors of glycogen synthase kinase 3 失效
    糖原合成酶激酶3选择性抑制剂的鉴定与应用

    公开(公告)号：US6057117A

    公开(公告)日：2000-05-02

    申请号：US267971

    申请日：1999-03-12

    申请人： Stephen D. Harrison ,  David B. Ring

    发明人： Stephen D. Harrison ,  David B. Ring

    IPC分类号： G01N33/573 ,  G01N33/53

    CPC分类号： G01N33/573

    摘要： The invention provides for use of selective inhibitors of GSK3 for treatment of diseases that are mediated by GSK3 activity, including non-insulin dependent diabetes mellitus (NIDDM) and Alzheimer's disease. Also described are methods of identifying inhibitors of GSK3 activity. The selective GSK3 inhibitor can be a peptide, peptoid, small organic molecule, or polynucleotide.

    摘要翻译： 本发明提供GSK3的选择性抑制剂用于治疗由GSK3活性介导的疾病，包括非胰岛素依赖性糖尿病（NIDDM）和阿尔茨海默氏病。 还描述了鉴定GSK3活性抑制剂的方法。 选择性GSK3抑制剂可以是肽，拟肽，小有机分子或多核苷酸。

    Method and apparatus for permitting radio unit roaming between trunked RF transmission sites over a wide area that encompasses plural multisite networks
    6.
    发明授权
    Method and apparatus for permitting radio unit roaming between trunked RF transmission sites over a wide area that encompasses plural multisite networks 失效
    允许无线电单元漫游在包含多个多站点网络的广泛区域的中继RF传输站点之间的方法和装置

    公开(公告)号：US5475683A

    公开(公告)日：1995-12-12

    申请号：US178548

    申请日：1994-01-07

    申请人： Stephen D. Harrison ,  Charles P. Brame

    发明人： Stephen D. Harrison ,  Charles P. Brame

    IPC分类号： H04W84/08 ,  H04J3/14

    CPC分类号： H04W84/08

    摘要： Digitally trunked radio transceivers are permitted to roam over an extended coverage area including two or more digitally trunked radio frequency communication networks. Each network includes at least one digital repeater site having a corresponding site coverage area and serving digitally trunked radio transceivers disposed within or near the site coverage area. Each network also includes a local multisite switch for routing communications between the digital repeater sites within the networks. Site adjacency information is established for each site and communicated between the networks. Each digitally trunked transceiver maintains a site adjacency list for its currently selected site and modifies that list when the transceiver roams into a new site coverage area and selects a new repeater site.

    摘要翻译： 数字集群无线电收发机被允许漫游在包括两个或多个数字集群的射频通信网络的扩展覆盖区域内。 每个网络包括至少一个具有对应的站点覆盖区域的数字中继站站点，以及设置在站点覆盖区域内或附近的数字集群无线电收发器。 每个网络还包括用于在网络内的数字中继站之间路由通信的本地多站点交换机。 为每个站点建立站点邻接信息，并在网络之间进行通信。 每个数字集群收发器为其当前选定的站点维护一个站点邻接列表，并且当收发器漫游到新的站点覆盖区域并选择一个新的中继站点时修改该列表。

    Inhibitors of glycogen synthase 3 kinase
    7.
    发明授权
    Inhibitors of glycogen synthase 3 kinase 失效
    糖原合成酶3激酶抑制剂

    公开(公告)号：US07053097B1

    公开(公告)日：2006-05-30

    申请号：US09707548

    申请日：2000-11-06

    申请人： Peter Schultz ,  David B. Ring ,  Stephen D. Harrison ,  Andrew M. Bray

    发明人： Peter Schultz ,  David B. Ring ,  Stephen D. Harrison ,  Andrew M. Bray

    IPC分类号： C07D473/16 ,  A61K31/52 ,  A61P25/28

    CPC分类号： C07D473/16

    摘要： Compounds of formula 1: wherein R1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0–3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R2 is hydroxy, amino, or lower alkoxy; R3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amino-acyl; R4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.

    摘要翻译： 式1的化合物：其中R 1是被0-3个选自低级烷基，卤素，羟基，低级烷氧基，氨基，低级的取代基取代的烷基，环烷基，芳基，芳烷基，杂芳基或杂芳烷基 烷基 - 氨基和硝基; R 2是羟基，氨基或低级烷氧基; R 3是H，低级烷基，低级酰基，低级烷氧基 - 酰基或氨基 - 酰基; R 4是H或低级烷基; 及其药学上可接受的盐和酯; 是GSK3的有效抑制剂。