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公开(公告)号：US06605617B2
公开(公告)日：2003-08-12
申请号：US09951265
申请日：2001-09-11
Applicant: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Elisa Jazan
Inventor： Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Elisa Jazan
IPC: C07D47104
CPC classification number: C07D409/04 , A61K31/19 , A61K31/4709 , A61K31/4745 , A61K31/513 , C07D401/04 , C07D401/14 , C07D405/04 , C07D413/04 , C07D417/04 , C07D453/02 , C07D471/04 , A61K2300/00
Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
Abstract translation: 提供具有式I和II的有机化合物，其中变量具有本文所述的值。药物制剂包括有机化合物或其药学上可接受的盐和药学上可接受的载体，并且可以通过将有机化合物或其药学上可接受的盐 有机化合物与载体和水。 治疗患者的方法包括向有需要的患者施用本发明的药物制剂。
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公开(公告)号：US20090281100A1
公开(公告)日：2009-11-12
申请号：US12317493
申请日：2008-12-23
Applicant: Paul A. Barsanti , Dirksen Bussiere , Stephen D. Harrison , Carla C. Heise , Johanna M. Jansen , Elisa Jazan , Timothy D. Machajewski , Christopher McBride , William R. McCrea, JR. , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Joel B. Silver , Allan S. Wagman , Marion Wiesmann , Kelly Wayman
Inventor： Paul A. Barsanti , Dirksen Bussiere , Stephen D. Harrison , Carla C. Heise , Johanna M. Jansen , Elisa Jazan , Timothy D. Machajewski , Christopher McBride , William R. McCrea, JR. , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Joel B. Silver , Allan S. Wagman , Marion Wiesmann , Kelly Wayman
IPC: A61K31/5377 , A61K31/497 , A61K31/4709
CPC classification number: C07D401/04 , A61K31/4375 , A61K31/4709 , A61K31/496 , A61K31/52 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/04
Abstract: Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.
Abstract translation: 提供了抑制各种酶和治疗各种病症的方法，其包括向受试者施用结构I或IB的化合物，其药学上可接受的盐，其互变异构体或互变异构体的药学上可接受的盐。 具有结构I和IB的化合物具有以下结构并具有本文所述的变量。 这些化合物可用于制备用于抑制各种酶的药物，并用于治疗由这些酶介导的病症。
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公开(公告)号：US07470709B2
公开(公告)日：2008-12-30
申请号：US10644055
申请日：2003-08-19
Applicant: Paul A. Barsanti , Dirksen Bussiere , Stephen D. Harrison , Carla C. Heise , Johanna M. Jansen , Elisa Jazan , Timothy D. Machajewski , Christopher McBride , William R. McCrea, Jr. , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Joel B. Silver , Allan S. Wagman , Marion Wiesmann , Kelly Wayman
Inventor： Paul A. Barsanti , Dirksen Bussiere , Stephen D. Harrison , Carla C. Heise , Johanna M. Jansen , Elisa Jazan , Timothy D. Machajewski , Christopher McBride , William R. McCrea, Jr. , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Joel B. Silver , Allan S. Wagman , Marion Wiesmann , Kelly Wayman
IPC: A61K31/47
CPC classification number: C07D401/04 , A61K31/4375 , A61K31/4709 , A61K31/496 , A61K31/52 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/04
Abstract: Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.
Abstract translation: 提供了抑制各种酶和治疗各种病症的方法，其包括向受试者施用结构I或IB的化合物，其药学上可接受的盐，其互变异构体或互变异构体的药学上可接受的盐。 具有结构I和IB的化合物具有以下结构并具有本文所述的变量。 这些化合物可用于制备用于抑制各种酶的药物，并用于治疗由这些酶介导的病症。
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Patent Agency Ranking
公开(公告)号：US06774237B2
公开(公告)日：2004-08-10
申请号：US10284017
申请日：2002-10-30
Applicant: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Elisa Jazan
Inventor： Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Elisa Jazan
IPC: C07D21516
CPC classification number: C07D409/04 , A61K31/19 , A61K31/4709 , A61K31/4745 , A61K31/513 , C07D401/04 , C07D401/14 , C07D405/04 , C07D413/04 , C07D417/04 , C07D453/02 , C07D471/04 , A61K2300/00
Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
Abstract translation: 提供具有式I和II的有机化合物，其中变量具有本文所述的值。药物制剂包括有机化合物或其药学上可接受的盐和药学上可接受的载体，并且可以通过将有机化合物或其药学上可接受的盐 有机化合物与载体和水。 治疗患者的方法包括向有需要的患者施用本发明的药物制剂。
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公开(公告)号：US20100184754A1
公开(公告)日：2010-07-22
申请号：US12651612
申请日：2010-01-04
Applicant: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, JR. , Christopher McBride , Elisa Jazan
Inventor： Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, JR. , Christopher McBride , Elisa Jazan
IPC: A61K31/541 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61P35/04
CPC classification number: C07D471/04 , A61K31/19 , A61K31/439 , A61K31/47 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/513 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D453/02 , A61K2300/00
Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
Abstract translation: 提供具有式I和II的有机化合物，其中变量具有本文所述的值。 药物制剂包括有机化合物或其药学上可接受的盐和药学上可接受的载体，并且可以通过将有机化合物的有机化合物或药学上可接受的盐与载体和水混合来制备。 治疗患者的方法包括向有需要的患者施用本发明的药物制剂。
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公开(公告)号：US07064215B2
公开(公告)日：2006-06-20
申请号：US10187967
申请日：2002-07-02
Applicant: Paul A. Renhowe , Cynthia M. Shafer , Christopher McBride , Joel Benjamin Silver , Sabina Pecchi , Timothy D. Machajewski , William R. McCrea, Jr. , Daniel J. Poon , Teresa Thomas
Inventor： Paul A. Renhowe , Cynthia M. Shafer , Christopher McBride , Joel Benjamin Silver , Sabina Pecchi , Timothy D. Machajewski , William R. McCrea, Jr. , Daniel J. Poon , Teresa Thomas
IPC: C07D271/02 , C07D285/14
CPC classification number: C07D403/04
Abstract: Organic compounds having the structure I are provided where the variables have the values described herein. Pharmaceutical formulations and medicaments include the organic compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compound or a pharmaceutically acceptable salt of the organic compound with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation or medicament according to the invention to a patient in need thereof.
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公开(公告)号：US06800760B2
公开(公告)日：2004-10-05
申请号：US10613411
申请日：2003-07-03
Applicant: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Elisa Jazan
Inventor： Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Elisa Jazan
IPC: C07D21516
CPC classification number: C07D409/04 , A61K31/19 , A61K31/4709 , A61K31/4745 , A61K31/513 , C07D401/04 , C07D401/14 , C07D405/04 , C07D413/04 , C07D417/04 , C07D453/02 , C07D471/04 , A61K2300/00
Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
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公开(公告)号：US06762194B2
公开(公告)日：2004-07-13
申请号：US10387355
申请日：2003-03-12
Applicant: Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Eliza Jazan
Inventor： Paul A. Renhowe , Sabina Pecchi , Timothy D. Machajewski , Cynthia M. Shafer , Clarke Taylor , William R. McCrea, Jr. , Christopher McBride , Eliza Jazan
IPC: A61K3147
CPC classification number: C07D409/04 , A61K31/19 , A61K31/4709 , A61K31/4745 , A61K31/513 , C07D401/04 , C07D401/14 , C07D405/04 , C07D413/04 , C07D417/04 , C07D453/02 , C07D471/04 , A61K2300/00
Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
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