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公开(公告)号：US20090126724A1
公开(公告)日：2009-05-21
申请号：US11813758
申请日：2006-01-12
CPC分类号： F16K15/148 , A61M15/00 , A61M16/08 , A61M16/0833 , A61M16/20 , A61M16/208
摘要： A one-way valve (10) is disclosed which comprises a body portion (12) defining a passage through which fluid is able to pass during use, a support member (22) disposed in the passage, a seat member (28) disposed in the passage and provided with at least one aperture (32), a shaft (24) extending between the support member (22) and the seat member (28) and a membrane (26) disposed on the shaft (24) such that the membrane (26) is rotatable relative to the shaft (24). The seat member (28) cooperates with the membrane (26) such that a first predetermined pressure differential across the membrane (26) causes the membrane to cover the at least one aperture (32) and thereby prevent fluid flow past the seat member (28), and such that a second predetermined pressure differential of opposite polarity to the first predetermined pressure differential causes the membrane (26) to not cover the at least one aperture (32) and thereby permit fluid flow past the seat member (28).
摘要翻译： 公开了一种单向阀（10），其包括主体部分（12），其限定使用期间流体能够通过的通道，设置在通道中的支撑构件（22），设置在所述通道中的座椅构件（28） 通道并且设置有至少一个孔（32），在支撑构件（22）和座构件（28）之间延伸的轴（24）和设置在轴（24）上的膜（26），使得膜 （26）可相对于所述轴（24）旋转。 座构件（28）与隔膜（26）协作，使跨过隔膜（26）的第一预定压力差导致膜覆盖至少一个孔（32），从而防止流体流过座椅构件（28） ），并且使得与第一预定压差相反的极性的第二预定压力差导致膜（26）不覆盖至少一个孔（32），从而允许流体流过座构件（28）。
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公开(公告)号：US20120065134A1
公开(公告)日：2012-03-15
申请号：US13003726
申请日：2009-07-13
CPC分类号： C07K14/195 , A61K38/00 , C07K7/08
摘要： The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signalling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-CD40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.
摘要翻译： 本发明提供组合物，其包含不衍生自CD40L的天然结合配偶体如CD40或来自天然CD40-CD40L界面的CD40L依赖性信号传导肽基抑制剂。 更具体地，本发明的肽基抑制剂衍生自不表达CD40-CD40L共刺激途径的天然来源。 本发明还提供具有增强的CD40L结合亲和力的肽基抑制剂的合成衍生物和类似物或相对于其母体分子增强的抑制活性。
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公开(公告)号：US09880151B2
公开(公告)日：2018-01-30
申请号：US14112512
申请日：2012-05-23
CPC分类号： G01N33/5014 , C07K14/4723 , C07K2319/00 , C07K2319/74 , C12N2503/02 , C40B60/12
摘要： The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs.
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4.发明申请公开(公告)号：US20140141452A1
公开(公告)日：2014-05-22
申请号：US14112512
申请日：2012-05-23
IPC分类号： G01N33/50
CPC分类号： G01N33/5014 , C07K14/4723 , C07K2319/00 , C07K2319/74 , C12N2503/02 , C40B60/12
摘要： The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs.
摘要翻译： 本发明提供了确定或鉴定或分离具有细胞类型选择性和/或至少能够通过动物受试者的血液脑屏障的细胞穿透肽（CPP）或其类似物或衍生物的方法。 本发明还提供CPP及其类似物及其衍生物，例如序列表SEQ ID NO：1-27所列的那些，以及包含一种或多种CPP的组合物，包括其中CPP或其类似物或衍生物的缀合物 与货物分子有关。 本发明还提供了将货物分子跨细胞膜运送到细胞内的特定位置，以及用于治疗，预防和/或诊断本发明的CPP或类似物或衍生物所连接的货物分子可治疗的疾病的方法。 本发明还提供用于鉴定或分离CPP的定制肽文库。
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5.发明授权Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith 有权用于治疗急性呼吸窘迫综合征（ARDS）的组合物和用途以及与其相关的临床疾病公开(公告)号：US08822409B2
公开(公告)日：2014-09-02
申请号：US12665263
申请日：2008-06-20
CPC分类号： A61K38/08 , A61K38/10 , A61K38/16 , G01N33/5088 , G01N2800/125
摘要： Polypeptides are identified through an assay based on inhibiting AP-I signalling activity and others to treat acute respiratory distress syndrome (ARDS) and clinical disorders associated with the development of ARDS.
摘要翻译： 通过基于抑制AP-1信号传导活性和其他治疗急性呼吸窘迫综合征（ARDS）和与ARDS发展相关的临床疾病的测定来鉴定多肽。
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6.发明申请COMPOSITIONS AND USES THEREOF FOR THE TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) AND CLINICAL DISORDERS ASSOCIATED WITH THEREWITH 有权治疗与急性呼吸道综合征（ARDS）和临床症状相关的急性呼吸综合征（ARDS）及临床症状的组合物及其用途公开(公告)号：US20110053831A1
公开(公告)日：2011-03-03
申请号：US12665263
申请日：2008-06-20
CPC分类号： A61K38/08 , A61K38/10 , A61K38/16 , G01N33/5088 , G01N2800/125
摘要： Polypeptides are identified through an assay based on inhibiting AP-I signalling activity and others to treat acute respiratory distress syndrome (ARDS) and clinical disorders associated with the development of ARDS.
摘要翻译： 通过基于抑制AP-1信号传导活性和其他治疗急性呼吸窘迫综合征（ARDS）和与ARDS发展相关的临床疾病的测定来鉴定多肽。
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7.发明授权公开(公告)号：US06994982B1
公开(公告)日：2006-02-07
申请号：US09568229
申请日：2000-05-05
IPC分类号： G01N33/569
CPC分类号： C12N15/1086 , C07K7/06 , C07K7/08 , C07K14/001 , C12N15/10 , C12N15/1027 , C12N15/1034 , C12N15/1058 , C40B30/04 , C40B40/08 , C40B40/10 , C40B50/06 , G01N33/569 , G01N33/574 , G01N33/6845 , Y02A50/57 , Y02A50/58
摘要： The present invention provides a method for identifying a modulator or mediator of a biological activity, which activity includes antigenicity and or immunogenicity, said method comprising the step of: (i) producing a gene fragment expression library derived from defined nucleotide sequence fragments; and (ii) assaying the expression library for at least an amino acid sequence derived from step (i) for a biological activity wherein that activity is different from any activity the amino acid sequence may have in its native environment.
摘要翻译： 本发明提供了鉴定生物活性的调节剂或介体的方法，该活性包括抗原性和/或免疫原性，所述方法包括步骤
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公开(公告)号：US08802634B2
公开(公告)日：2014-08-12
申请号：US13003726
申请日：2009-07-13
IPC分类号： A61K38/16 , A61K38/10 , A61K38/00 , A61K39/385
CPC分类号： C07K14/195 , A61K38/00 , C07K7/08
摘要： The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signalling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-CD40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.
摘要翻译： 本发明提供组合物，其包含不衍生自CD40L的天然结合配偶体如CD40或来自天然CD40-CD40L界面的CD40L依赖性信号传导肽基抑制剂。 更具体地，本发明的肽基抑制剂衍生自不表达CD40-CD40L共刺激途径的天然来源。 本发明还提供具有增强的CD40L结合亲和力的肽基抑制剂的合成衍生物和类似物或相对于其母体分子增强的抑制活性。
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公开(公告)号：US08575070B2
公开(公告)日：2013-11-05
申请号：US11672419
申请日：2007-02-07
申请人： Paul Michael Watt , Roland Dunbrack
发明人： Paul Michael Watt , Roland Dunbrack
CPC分类号： C07K1/047 , C07K1/00 , C07K7/08 , C07K14/001 , C12N15/1037 , C12N15/1072 , C12N15/1089 , C12Q1/18 , C40B30/02 , C40B40/10 , G01N33/6824 , G01N33/6845 , G01N2500/10 , G06F19/18 , G06F19/22
摘要： The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer-readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.
摘要翻译： 本发明提供用于生产用于药物筛选应用的肽结构库的方法，其能够独立于衍生自其的蛋白质中的人造支架或侧翼序列折叠或假定其天然构象。 图书馆可以是高度多样化的，因为它们代表了自然界中存在的蛋白质结构的所有组成部分。 这些库也可以是非冗余的或归一化的，使得存在于源数据集中和/或本质上的特定结构的偏移被删除。 在特别优选的实施方案中，本发明提供了通过该方法制备的30,000个独立折叠结构。 本发明还提供计算机可读介质和包含与肽库相关的结构数据的系统，以及显示和筛选文库的方法。
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公开(公告)号：US20100029552A1
公开(公告)日：2010-02-04
申请号：US11660713
申请日：2005-08-22
申请人： Paul Michael Watt , Mark Fear
发明人： Paul Michael Watt , Mark Fear
IPC分类号： A61K38/16 , C07K14/00 , C07K5/06 , C07K7/06 , C07K7/08 , A61K38/05 , A61K38/08 , A61K38/10 , A61K31/7088 , A61P9/04
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/00 , Y02A50/401 , Y02A50/473
摘要： The present invention provides a method for the screening of nucleic acid fragment expression libraries and selecting encoded peptides based upon their ability to modulate the activity of a target protein or nucleic acid and assume conserved conformations compatible with albeit not reiterative of the target protein or nucleic acid. The present invention also provides methods for the diagnosis and treatment of ischemia. The present invention also provides c-Jun dimerization inhibitory peptides and analogues thereof that are useful for treatment of ischemia.
摘要翻译： 本发明提供了一种筛选核酸片段表达文库的方法，并根据其调节靶蛋白或核酸的活性的能力选择编码的肽，并假定与目标蛋白或核酸不相关的保守构象 。 本发明还提供了用于诊断和治疗缺血的方法。 本发明还提供了可用于治疗缺血的c-Jun二聚抑制肽及其类似物。
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