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公开(公告)号：US20220163535A1
公开(公告)日：2022-05-26
申请号：US17667823
申请日：2022-02-09
发明人： Ryo Natori , Sakae Suda , Fumio Yamauchi , Kengo Kanazaki , Takeshi Sekiguchi , Yutaka Tani , Kazumichi Nakahama , Minako Nakasu
IPC分类号： G01N33/68 , G01N33/543 , G01N33/53 , C08F220/32 , C08J7/14
摘要： The particle is a particle including, in a surface layer thereof, a copolymer having a repeating unit A having a side chain A having, at a terminal thereof, a carboxy group to be bonded to a ligand and a repeating unit B having a side chain B having a hydroxy group at a terminal thereof, wherein when the particle is dispersed in ion-exchanged water, the surface layer of the particle is hydrated to form a swollen layer, wherein the density of the carboxy groups to be incorporated into the swollen layer satisfies a value of from 0.04 group/nm3 to 0.15 group/nm3, and wherein the ratio of a particle diameter in water to be measured when the particle is dispersed in ion-exchanged water to a dry particle diameter to be measured when the particle is dried satisfies a value of from 1.10 to 1.40.
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公开(公告)号：US20210055292A1
公开(公告)日：2021-02-25
申请号：US16986662
申请日：2020-08-06
发明人： Sakae Suda , Masao Suzuki , Kazumichi Nakahama , Keiichiro Tsubaki , Kengo Kanazaki , Ryo Natori , Fumio Yamauchi
IPC分类号： G01N33/543 , C08F212/08 , C08F220/34 , C08F220/38 , G01N33/547
摘要： The present disclosure provides a particle showing a small non-specific adsorption, having a reactive functional group for chemically bonding a ligand thereto, and being suitable for an agglutination method; a particle for the agglutination method having a ligand chemically bonded to the particle; a reagent, a kit and a method for detecting a target substance, each for in vitro diagnosis, each of which contains the particle. The particle includes a polymer having a unit having a linker A in a side chain, wherein when both terminals of the linker A are represented by X1 and X2, the linker A has a reactive functional group for chemically bonding a ligand thereto in one of X1 and X2; one of X1 and X2 includes an ester structure; and a sum of bonds between atoms linearly connecting X1 and X2 is 18 to 24 and the X1 and X2 contain CH2 or CH.
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公开(公告)号：US12111311B2
公开(公告)日：2024-10-08
申请号：US16986662
申请日：2020-08-06
发明人： Sakae Suda , Masao Suzuki , Kazumichi Nakahama , Keiichiro Tsubaki , Kengo Kanazaki , Ryo Natori , Fumio Yamauchi
IPC分类号： G01N33/543 , C08F20/26 , C08F212/08 , C08F220/32 , C08F220/34 , C08F220/38 , C08L33/06 , G01N33/547
CPC分类号： G01N33/54353 , C08F212/08 , C08F220/346 , C08F220/382 , G01N33/54313 , G01N33/547 , C08F20/26 , C08F220/325 , C08L33/068
摘要： The present disclosure provides a particle showing a small non-specific adsorption, having a reactive functional group for chemically bonding a ligand thereto, and being suitable for an agglutination method; a particle for the agglutination method having a ligand chemically bonded to the particle; a reagent, a kit and a method for detecting a target substance, each for in vitro diagnosis, each of which contains the particle. The particle includes a polymer having a unit having a linker A in a side chain, wherein when both terminals of the linker A are represented by X1 and X2, the linker A has a reactive functional group for chemically bonding a ligand thereto in one of X1 and X2; one of X1 and X2 includes an ester structure; and a sum of bonds between atoms linearly connecting X1 and X2 is 18 to 24 and the X1 and X2 contain CH2 or CH.
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公开(公告)号：US20220276232A1
公开(公告)日：2022-09-01
申请号：US17671927
申请日：2022-02-15
发明人： Fumio Yamauchi , Kengo Kanazaki , Ryo Natori , Shoichi Kita
IPC分类号： G01N33/546 , C08G73/02 , G01N33/543
摘要： Provided are a latex agglutination reagent containing polyoxazoline that is preferable for use in a latex agglutination reaction and has a high sensitization action of sensitivity while a non-specific reaction can be suppressed, and a method for measuring a target substance in a specimen by a latex agglutination method. A latex agglutination reagent used in a method for measuring a target substance in a specimen by a latex agglutination method using an insoluble carrier that carries an antibody or an antigen contains polyoxazoline having a repeating unit represented by the following General Formula (in Formula (1), R represents a hydrogen atom or a methyl group, an ethyl group, or a propyl group, and n is an integer of 100 or greater).
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公开(公告)号：US20210055286A1
公开(公告)日：2021-02-25
申请号：US16986649
申请日：2020-08-06
发明人： Masao Suzuki , Kazumichi Nakahama , Sakae Suda , Keiichiro Tsubaki , Kengo Kanazaki , Ryo Natori , Fumio Yamauchi
IPC分类号： G01N33/545 , G01N33/53 , C08F220/32
摘要： The present invention provides a particle that shows a small non-specific adsorption, has a reactive functional group for chemically bonding a ligand thereto, and is suitable for an agglutination method. The particle includes a polymer having a unit having a side chain A and a unit having a side chain B, wherein the side chain A has a carboxyl group at a terminal thereof, and has an ester bond and an amide bond in a molecular structure thereof; the side chain B has an alkyl group at a terminal thereof; and a zeta potential at the time when the particles are dispersed in water is minus 40 mV or higher and minus 5 mV or lower.
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公开(公告)号：US11925918B2
公开(公告)日：2024-03-12
申请号：US16831548
申请日：2020-03-26
IPC分类号： B01J20/10 , B01D15/14 , B01J20/08 , B01J20/24 , B01J20/28 , B01J20/283 , B01J20/286 , B01J20/30 , B09B3/10 , B09B101/30 , C01B33/18 , C02F1/28 , C02F101/20 , C02F103/08 , C22B11/00 , G21F9/12
CPC分类号： B01J20/103 , B01D15/14 , B01J20/08 , B01J20/24 , B01J20/28007 , B01J20/28016 , B01J20/2803 , B01J20/28052 , B01J20/283 , B01J20/286 , B01J20/3028 , B01J20/3085 , B09B3/10 , C01B33/18 , C02F1/281 , C02F1/286 , C02F1/288 , C22B11/042 , B01J2220/52 , B01J2220/58 , B09B2101/30 , C01P2004/50 , C01P2004/61 , C01P2004/64 , C02F2101/20 , C02F2103/08 , G21F9/12
摘要： A silica aggregate includes primary silica particles aggregated, the primary silica particles having an average particle size of 1 nm or more and less than 10 nm, the primary silica particles being crosslinked to each other by a bond containing a siloxane bond.
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公开(公告)号：US20200230573A1
公开(公告)日：2020-07-23
申请号：US16831548
申请日：2020-03-26
IPC分类号： B01J20/10 , C01B33/18 , B01J20/08 , B01J20/24 , B01J20/28 , B01J20/283 , B01J20/286 , B01J20/30 , C02F1/28 , B01D15/14 , B09B3/00 , C22B3/00
摘要： A silica aggregate includes primary silica particles aggregated, the primary silica particles having an average particle size of 1 nm or more and less than 10 nm, the primary silica particles being crosslinked to each other by a bond containing a siloxane bond.
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8.发明申请公开(公告)号：US20200222877A1
公开(公告)日：2020-07-16
申请号：US16830084
申请日：2020-03-25
摘要： A DNA complex includes a carrier and DNA immobilized on the carrier. 80% or more by mass of the DNA is single-stranded DNA, the DNA has an average molecular weight of 500,000 or less, and the DNA content is more than 15% by mass and 50% or less by mass of the DNA complex. The carrier contains an inorganic material. The DNA complex has an average particle size of 10 μm or more.
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公开(公告)号：US09750827B2
公开(公告)日：2017-09-05
申请号：US14767362
申请日：2014-02-21
发明人： Koji Miki , Tatsuhiro Inoue , Yasuhito Kobayashi , Katsuya Nakano , Kouichi Ohe , Fumio Yamauchi , Tetsuya Yano , Masato Minami
CPC分类号： A61K49/221 , A61K47/50 , A61K47/51 , A61K47/55 , A61K47/56 , A61K47/61 , C08B37/0072
摘要： Provided is a compound having a high ICG content that has high accumulation property in a tumor and has a large intensity of a photoacoustic signal emitted from the tumor even when a time period elapses after administration. Specifically, provided is a hyaluronic acid derivative to which polyethylene glycol and an ICG derivative are conjugated.
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10.发明授权公开(公告)号：US09592307B2
公开(公告)日：2017-03-14
申请号：US14413400
申请日：2013-07-17
发明人： Fumio Yamauchi , Satoshi Ogawa , Kengo Kanazaki , Daisuke Sasaguri , Atsushi Takahashi , Masato Minami , Tatsuki Fukui
IPC分类号： A61K49/00 , C07D209/12 , A61K49/22 , C07D209/14 , C07D209/60 , C07D403/14 , C07K7/06 , C07K16/40
CPC分类号： A61K49/221 , C07D209/12 , C07D209/14 , C07D209/60 , C07D403/14 , C07K7/06 , C07K16/40 , C07K2317/622
摘要： The present invention provides a compound which exhibits a high degree of accumulation into a tumor even when some extent of time has passed after performing administration and which facilitates an increase in the intensity of photoacoustic signal produced by the tumor.A compound produced by bonding of a polyethylene glycol and a specific cyanine based compound.
摘要翻译： 通过聚乙二醇与特定花青类化合物的结合制得的化合物。
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