公开(公告)号：US20200157605A1

公开(公告)日：2020-05-21

申请号：US16752467

申请日：2020-01-24

Applicant: CANON KABUSHIKI KAISHA

Inventor： Tsutomu Honma ,  Atsushi Takahashi ,  Masato Minami ,  Tetsuya Yano ,  Yuki Sato

IPC: C12Q1/686 ,  G01N21/64 ,  G06T7/62 ,  G06F17/18

Abstract: To analyze the concentration of an analyte in a sample, the number of molecules or particles or concentration of the analyte is determined using a table associating at least one piece of information about a plurality of reaction fields generated by splitting a liquid containing the sample, the at least one piece of information being selected from the group consisting of information about the number of positive reaction fields and information about the number of negative reaction fields, with the number of molecules or particles or concentration of the analyte in the sample or in at least some of the plurality of reaction fields.

公开(公告)号：US20170333575A1

公开(公告)日：2017-11-23

申请号：US15513035

申请日：2015-10-09

Applicant: CANON KABUSHIKI KAISHA

Inventor： Teruyuki Kondo ,  Yasuhiro Aoyama ,  Hisatsugu Yamada ,  Yoshinori Hasegawa ,  Shinsuke Sando ,  Yu Kimura ,  Natsuki Matsumoto ,  Fumio Yamauchi ,  Tetsuya Yano ,  Masato Minami ,  Atsushi Takahashi ,  Kengo Kanazaki ,  Satoshi Ogawa

IPC: A61K49/22 ,  A61K49/00

CPC classification number: A61K49/221 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0054

Abstract: To provide a polymer having a high ratio of the amount thereof present in a tumor to the amount thereof present in blood (hereinafter, sometimes abbreviated as a tumor/blood ratio).The polymer has phosphorylcholine (derivative) as a side chain and has a dye (near-infrared dye) having absorption in the near-infrared wavelength region bound to the polymer.

公开(公告)号：US09352053B2

公开(公告)日：2016-05-31

申请号：US13926666

申请日：2013-06-25

Applicant: CANON KABUSHIKI KAISHA

Inventor： Yasuhiko Tabata ,  Sachiko Yamauchi ,  Mayuko Kishi ,  Masato Minami ,  Mika Yamagata ,  Satoshi Yuasa ,  Tetsuya Yano

IPC: A61K49/00

CPC classification number: A61K49/00 ,  A61K49/0021 ,  A61K49/0093

Abstract: An iron oxide particle constituting a Resovist (trademark) absorbs a small quantity of light in a near infrared region and emits a weak photoacoustic signal. According to a particle having a catechol-like compound and iron atoms, the particle having a ratio of the number of moles of the catechol-like compound to the number of moles of the iron atoms of 270/10,000 or more, light absorption in the near infrared region increases and a strong photoacoustic signal can be transmitted.

Abstract translation: 构成Resovist（商标）的氧化铁颗粒在近红外区域吸收少量的光并发出弱的光声信号。 根据具有儿茶酚样化合物和铁原子的粒子，具有儿茶酚状化合物的摩尔数与铁原子摩尔数的比例为270 / 10,000以上的粒子， 近红外区域增加，并且可以传输强的光声信号。

公开(公告)号：US08980543B2

公开(公告)日：2015-03-17

申请号：US13906885

申请日：2013-05-31

Applicant: Canon Kabushiki Kaisha

Inventor： Fumio Yamauchi ,  Kimihiro Yoshimura ,  Katsuaki Kuge ,  Tetsuya Yano ,  Masahiro Shirakawa ,  Yasuhiro Aoyama ,  Shinsuke Sando

IPC: C12Q1/00

CPC classification number: C12Q1/54 ,  C12Q1/32 ,  C12Q1/34 ,  G01N24/088 ,  G01R33/281 ,  G01R33/4633 ,  G01R33/465 ,  G01R33/483 ,  G01R33/5601 ,  Y02P20/582

Abstract: An object of the present invention is to provide a substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity. Alternatively, imaging of the enzyme activity is performed by a multi-dimensional nuclear resonance imaging method.

Abstract translation: 本发明的目的是提供一种能够高精度地检测酶活性的底物探针和通过使用该基底探针的多核磁共振法检测酶活性的方法。 通过使用用于通过多维核磁共振法测定酶活性的底物探针进行多维核磁共振，其特征在于含有被活性酶选择性识别的酶识别位点作为 至少一个结构单元和至少三个具有核自旋和不同共振频率的核磁共振活性核连接的基团，其特异性地存在于酶识别中，从而检测底物探针和酶的存在 活动。 或者，通过多维核共振成像方法进行酶活性的成像。

公开(公告)号：US20130243694A1

公开(公告)日：2013-09-19

申请号：US13772958

申请日：2013-02-21

Applicant: CANON KABUSHIKI KAISHA

Inventor： Shinzaburo Ito ,  Kengo Kanazaki ,  Tatsuki Fukui ,  Fumiko Tomatsu ,  Masato Minami ,  Tetsuya Yano ,  Hiroyuki Aoki

IPC: A61K49/22

CPC classification number: A61K49/222 ,  A61K9/1647 ,  A61K49/0036 ,  A61K49/0093

Abstract: A particle includes a copolymer of lactic acid and glycolic acid, and at least one compound selected from silicon naphthalocyanine and derivatives of silicon naphthalocyanine, in which the particle has a particle size of 10 nm or more and less than 1000 nm.

Abstract translation: 颗粒包括乳酸和乙醇酸的共聚物，以及至少一种选自硅萘酞菁和硅萘酞菁衍生物的化合物，其中颗粒的粒径为10nm以上且小于1000nm。

公开(公告)号：US20130095038A1

公开(公告)日：2013-04-18

申请号：US13651727

申请日：2012-10-15

Applicant: CANON KABUSHIKI KAISHA

Inventor： Mayuko Kishi ,  Fumiko Tomatsu ,  Tatsuki Fukui ,  Tetsuya Yano ,  Kouichi Kato ,  Mika Yamagata ,  Satoshi Yuasa

IPC: A61K49/00

CPC classification number: A61K49/0034 ,  A61K49/0093

Abstract: Provided are particles where a hydrophilic coloring agent having an anionic functional group, such as ICG, hardly leaks from the particles. The particles include a coloring agent having an anionic functional group, such as ICG, ions of a polyvalent metal, such as iron ions (Fe2+ or Fe3+), zinc ions, and a polyol compound.

Abstract translation: 提供具有阴离子官能团的亲水着色剂如ICG的颗粒几乎不会从颗粒中泄漏出来。 颗粒包括具有阴离子官能团的着色剂，如ICG，多价金属离子如铁离子（Fe2 +或Fe3 +），锌离子和多元醇化合物。

公开(公告)号：US20200150135A1

公开(公告)日：2020-05-14

申请号：US16733112

申请日：2020-01-02

Applicant: CANON KABUSHIKI KAISHA

Inventor： Tsutomu Honma ,  Atsushi Takahashi ,  Masato Minami ,  Tetsuya Yano

IPC: G01N35/00 ,  G01N21/64

Abstract: To analyze the concentration of an analyte in a sample, the size distribution of a plurality of reaction fields generated by splitting a liquid containing the sample is divided into a plurality of classes. A class used for concentration determination is set based on the number or proportion of the positive reaction fields or the number or proportion of the negative reaction fields in each class. The concentration of the analyte is determined based on data for the set class.

公开(公告)号：US20150374856A1

公开(公告)日：2015-12-31

申请号：US14767362

申请日：2014-02-21

Applicant: CANON KABUSHIKI KAISHA

Inventor： Koji Miki ,  Tatsuhiro Inoue ,  Yasuhito Kobayashi ,  Katsuya Nakano ,  Kouichi Ohe ,  Fumio Yamauchi ,  Tetsuya Yano ,  Masato Minami

IPC: A61K49/22 ,  C08B37/08

CPC classification number: A61K49/221 ,  A61K47/50 ,  A61K47/51 ,  A61K47/55 ,  A61K47/56 ,  A61K47/61 ,  C08B37/0072

Abstract: Provided is a compound having a high ICG content that has high accumulation property in a tumor and has a large intensity of a photoacoustic signal emitted from the tumor even when a time period elapses after administration. Specifically, provided is a hyaluronic acid derivative to which polyethylene glycol and an ICG derivative are conjugated.

Abstract translation: 提供具有ICG含量高的化合物，其在肿瘤中具有高的积聚性，并且即使在给药后经过时间段，也具有从肿瘤发射的光声信号的强度较大。 具体地，提供了聚乙二醇和ICG衍生物共轭的透明质酸衍生物。

公开(公告)号：US20150071861A1

公开(公告)日：2015-03-12

申请号：US14395193

申请日：2013-05-22

Applicant: CANON KABUSHIKI KAISHA

Inventor： Teruyuki Kondo ,  Yasuhiro Aoyama ,  Hisatsugu Yamada ,  Yoshinori Hasegawa ,  Hidehito Tochio ,  Yu Kimura ,  Masahiro Shirakawa ,  Fuminori Sugihara ,  Tetsuya Matsuda ,  Shinsuke Sando ,  Masato Minami ,  Fumio Yamauchi ,  Tetsuya Yano ,  Hidetoshi Tsuzuki

IPC: A61K49/12 ,  C08F30/02

CPC classification number: A61K49/126 ,  A61K49/12 ,  C08F30/02

Abstract: As a substance used as a contrast agent for a method of nuclear magnetic resonance analysis or a method of magnetic resonance imaging, a substance with high selectivity and high sensitivity was demanded. According to the present invention, when a polymer having, in a side chain thereof, a sequence of a 1H—13C—15N, 1H—15N—13C or 1H—13C—13C bond, that is, a structure labeled with stable isotopes of 13C and 15N, is used, the abundance of such a sequence in one molecule can be increased, and hence, high selectivity and higher sensitivity can be attained when used as a contrast agent.

Abstract translation: 作为用于核磁共振分析方法的造影剂的物质或磁共振成像方法，需要具有高选择性和高灵敏度的物质。 根据本发明，当其侧链具有1H-13C-15N，1H-15N-13C或1H-13C-13C键的序列的聚合物，即，用稳定同位素标记的结构 13C和15N时，可以增加一个分子中的这种序列的丰度，因此当用作造影剂时可以获得高选择性和更高的灵敏度。

公开(公告)号：US20240026424A1

公开(公告)日：2024-01-25

申请号：US18478721

申请日：2023-09-29

Applicant: CANON KABUSHIKI KAISHA

Inventor： TAKUSHI ICHINOO ,  SATOSHI OGAWA ,  MASATO MINAMI ,  Tetsuya Yano

IPC: C12Q1/6818 ,  C12Q1/6806 ,  C12N9/22 ,  C12N15/11 ,  G01N21/64

CPC classification number: C12Q1/6818 ,  C12Q1/6806 ,  C12N9/22 ,  C12N15/11 ,  G01N21/6428 ,  C12N2310/20 ,  C12N2320/10 ,  G01N2021/6439

Abstract: A reagent contains complex particles, each including a particle and a complex bound to the particle, and an aqueous liquid in which the complex particles are dispersed. The complex includes a Cas protein and a guide RNA bound to the Cas protein.