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公开(公告)号：US11597787B2
公开(公告)日：2023-03-07
申请号：US17073666
申请日：2020-10-19
发明人： Takeshi Sekiguchi , Kengo Kanazaki
IPC分类号： C08F220/30 , C08F220/32 , C08J3/05
摘要： Provided is a particle suitable for a specimen test, which has high sensitization efficiency in a reaction with an antibody, shows high detection sensitivity as a latex reagent, hardly agglutinates during its storage, and hardly causes nonspecific adsorption even when not post-coated. The particle is a particle including a copolymer containing a monomer unit derived from a styrene-based monomer and a monomer unit derived from a glycidyl group-containing monomer, the particle being represented by the following general formula (1): in the general formula (1), L1 represents a copolymer moiety containing the monomer unit derived from the styrene-based monomer and the monomer unit derived from the glycidyl group-containing monomer, “n” represents from 4 to 11, and R1 and R2 each represent a hydrogen atom, an alkyl group, or a halogen.
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公开(公告)号：US20210122863A1
公开(公告)日：2021-04-29
申请号：US17073666
申请日：2020-10-19
发明人： Takeshi Sekiguchi , Kengo Kanazaki
IPC分类号： C08F220/32 , C08J3/05
摘要： Provided is a particle suitable for a specimen test, which has high sensitization efficiency in a reaction with an antibody, shows high detection sensitivity as a latex reagent, hardly agglutinates during its storage, and hardly causes nonspecific adsorption even when not post-coated. The particle is a particle including a copolymer containing a monomer unit derived from a styrene-based monomer and a monomer unit derived from a glycidyl group-containing monomer, the particle being represented by the following general formula (1): in the general formula (1), L1 represents a copolymer moiety containing the monomer unit derived from the styrene-based monomer and the monomer unit derived from the glycidyl group-containing monomer, “n” represents from 4 to 11, and R1 and R2 each represent a hydrogen atom, an alkyl group, or a halogen.
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公开(公告)号：US20220163535A1
公开(公告)日：2022-05-26
申请号：US17667823
申请日：2022-02-09
发明人： Ryo Natori , Sakae Suda , Fumio Yamauchi , Kengo Kanazaki , Takeshi Sekiguchi , Yutaka Tani , Kazumichi Nakahama , Minako Nakasu
IPC分类号： G01N33/68 , G01N33/543 , G01N33/53 , C08F220/32 , C08J7/14
摘要： The particle is a particle including, in a surface layer thereof, a copolymer having a repeating unit A having a side chain A having, at a terminal thereof, a carboxy group to be bonded to a ligand and a repeating unit B having a side chain B having a hydroxy group at a terminal thereof, wherein when the particle is dispersed in ion-exchanged water, the surface layer of the particle is hydrated to form a swollen layer, wherein the density of the carboxy groups to be incorporated into the swollen layer satisfies a value of from 0.04 group/nm3 to 0.15 group/nm3, and wherein the ratio of a particle diameter in water to be measured when the particle is dispersed in ion-exchanged water to a dry particle diameter to be measured when the particle is dried satisfies a value of from 1.10 to 1.40.
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公开(公告)号：US12111311B2
公开(公告)日：2024-10-08
申请号：US16986662
申请日：2020-08-06
发明人： Sakae Suda , Masao Suzuki , Kazumichi Nakahama , Keiichiro Tsubaki , Kengo Kanazaki , Ryo Natori , Fumio Yamauchi
IPC分类号： G01N33/543 , C08F20/26 , C08F212/08 , C08F220/32 , C08F220/34 , C08F220/38 , C08L33/06 , G01N33/547
CPC分类号： G01N33/54353 , C08F212/08 , C08F220/346 , C08F220/382 , G01N33/54313 , G01N33/547 , C08F20/26 , C08F220/325 , C08L33/068
摘要： The present disclosure provides a particle showing a small non-specific adsorption, having a reactive functional group for chemically bonding a ligand thereto, and being suitable for an agglutination method; a particle for the agglutination method having a ligand chemically bonded to the particle; a reagent, a kit and a method for detecting a target substance, each for in vitro diagnosis, each of which contains the particle. The particle includes a polymer having a unit having a linker A in a side chain, wherein when both terminals of the linker A are represented by X1 and X2, the linker A has a reactive functional group for chemically bonding a ligand thereto in one of X1 and X2; one of X1 and X2 includes an ester structure; and a sum of bonds between atoms linearly connecting X1 and X2 is 18 to 24 and the X1 and X2 contain CH2 or CH.
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公开(公告)号：US20220276232A1
公开(公告)日：2022-09-01
申请号：US17671927
申请日：2022-02-15
发明人： Fumio Yamauchi , Kengo Kanazaki , Ryo Natori , Shoichi Kita
IPC分类号： G01N33/546 , C08G73/02 , G01N33/543
摘要： Provided are a latex agglutination reagent containing polyoxazoline that is preferable for use in a latex agglutination reaction and has a high sensitization action of sensitivity while a non-specific reaction can be suppressed, and a method for measuring a target substance in a specimen by a latex agglutination method. A latex agglutination reagent used in a method for measuring a target substance in a specimen by a latex agglutination method using an insoluble carrier that carries an antibody or an antigen contains polyoxazoline having a repeating unit represented by the following General Formula (in Formula (1), R represents a hydrogen atom or a methyl group, an ethyl group, or a propyl group, and n is an integer of 100 or greater).
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公开(公告)号：US20210055286A1
公开(公告)日：2021-02-25
申请号：US16986649
申请日：2020-08-06
发明人： Masao Suzuki , Kazumichi Nakahama , Sakae Suda , Keiichiro Tsubaki , Kengo Kanazaki , Ryo Natori , Fumio Yamauchi
IPC分类号： G01N33/545 , G01N33/53 , C08F220/32
摘要： The present invention provides a particle that shows a small non-specific adsorption, has a reactive functional group for chemically bonding a ligand thereto, and is suitable for an agglutination method. The particle includes a polymer having a unit having a side chain A and a unit having a side chain B, wherein the side chain A has a carboxyl group at a terminal thereof, and has an ester bond and an amide bond in a molecular structure thereof; the side chain B has an alkyl group at a terminal thereof; and a zeta potential at the time when the particles are dispersed in water is minus 40 mV or higher and minus 5 mV or lower.
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公开(公告)号：US20210055292A1
公开(公告)日：2021-02-25
申请号：US16986662
申请日：2020-08-06
发明人： Sakae Suda , Masao Suzuki , Kazumichi Nakahama , Keiichiro Tsubaki , Kengo Kanazaki , Ryo Natori , Fumio Yamauchi
IPC分类号： G01N33/543 , C08F212/08 , C08F220/34 , C08F220/38 , G01N33/547
摘要： The present disclosure provides a particle showing a small non-specific adsorption, having a reactive functional group for chemically bonding a ligand thereto, and being suitable for an agglutination method; a particle for the agglutination method having a ligand chemically bonded to the particle; a reagent, a kit and a method for detecting a target substance, each for in vitro diagnosis, each of which contains the particle. The particle includes a polymer having a unit having a linker A in a side chain, wherein when both terminals of the linker A are represented by X1 and X2, the linker A has a reactive functional group for chemically bonding a ligand thereto in one of X1 and X2; one of X1 and X2 includes an ester structure; and a sum of bonds between atoms linearly connecting X1 and X2 is 18 to 24 and the X1 and X2 contain CH2 or CH.
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公开(公告)号：US11633715B2
公开(公告)日：2023-04-25
申请号：US16830084
申请日：2020-03-25
IPC分类号： B01J20/24 , B01J20/10 , B01J20/28 , C12N15/11 , C02F1/28 , B01D15/10 , B09B3/00 , C22B3/20 , B09B3/10 , C02F101/20 , C02F103/08 , B09B101/30
摘要： A DNA complex includes a carrier and DNA immobilized on the carrier. 80% or more by mass of the DNA is single-stranded DNA, the DNA has an average molecular weight of 500,000 or less, and the DNA content is more than 15% by mass and 50% or less by mass of the DNA complex. The carrier contains an inorganic material. The DNA complex has an average particle size of 10 μm or more.
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公开(公告)号：US11027026B2
公开(公告)日：2021-06-08
申请号：US15511898
申请日：2015-10-16
发明人： Hideo Saji , Kohei Sano , Akira Makino , Kengo Kanazaki , Fumio Yamauchi , Satoshi Ogawa
IPC分类号： A61K9/00 , A61K49/00 , C08G73/02 , G01N33/574
摘要： To provide a polymer having a high tumor/blood ratio. The present invention provides a polymer represented by the following formula (P1): wherein in the formula (P1), R0 represents any of a residue or a functional group derived from a cationic polymerization initiator; L represents a linker and L may not be present; n represents an integer of 1 or more; D represents a dye backbone of a dye having absorption in the near-infrared region.
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10.发明申请公开(公告)号：US20210096081A1
公开(公告)日：2021-04-01
申请号：US17109565
申请日：2020-12-02
摘要： A polymer dye includes at least one repeating unit represented by the following structural formula 1 and at least one selected from the group consisting of repeating units represented by the following structural formulas 2 and 3. Hydrogen peroxide present in or generated through enzymatic reaction in a biological sample can be detected by using the polymer dye.
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