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公开(公告)号：US20210188809A1
公开(公告)日：2021-06-24
申请号：US16071200
申请日：2017-01-18
Applicant: BIOGEN MA INC.
Inventor： Timothy Chan , Kevin Guckian , Tracy Jenkins , Jermaine Thomas , Jeffrey Vessels , Gnanasambandam Kumaravel , Robert Meissner , Joseph P. Lyssikatos , Brian Lucas , Irina Leaf , Jeremy Duffield , Nathan Genung
IPC: C07D401/14 , A61K45/06
Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production. Formula (I) The compounds are IRAK-4 inhibitors useful for treating an inflammatory disease, an autoimmune disease, cancer, a cardiovascular disease, a disease of the central nervous system, a disease of the skin, an ophthalmic disease and condition, and a bone disease.
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公开(公告)号：US10577367B2
公开(公告)日：2020-03-03
申请号：US16271497
申请日：2019-02-08
Applicant: BIOGEN MA INC.
Inventor： Timothy Chan , Kevin Guckian , Tracy Jenkins , Jermaine Thomas , Jeffery Vessels , Gnanasambandam Kumaravel , Robert Meissner , Joseph Lyssikatos , Brian Lucas , Irina Leaf , Jeremy Duffield
IPC: C07D401/14 , C07D487/04 , A61K31/416 , A61K31/437 , A61K31/44 , A61P13/12 , A61P19/02 , C07D471/04 , C07D405/14 , C07D413/14 , C07B59/00 , C07D401/12 , C07D417/14
Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号：US10081646B2
公开(公告)日：2018-09-25
申请号：US15621665
申请日：2017-06-13
Applicant: BIOGEN MA INC.
Inventor： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC: C07D239/80 , C07F9/6512 , C07F9/60 , C07C217/58 , C07C229/36 , C07C233/47 , C07D215/20 , C07D263/24
CPC classification number: C07D215/20 , C07C217/58 , C07C217/74 , C07C229/36 , C07C233/47 , C07C2602/10 , C07D215/06 , C07D215/14 , C07D215/227 , C07D233/32 , C07D239/74 , C07D239/80 , C07D263/24 , C07D277/64 , C07D401/04 , C07F7/0836 , C07F9/091 , C07F9/60 , C07F9/6512 , C07F9/65744
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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公开(公告)号：US10034869B2
公开(公告)日：2018-07-31
申请号：US15644352
申请日：2017-07-07
Applicant: BIOGEN MA INC.
Inventor： Jermaine Thomas , Sha Mi , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel
IPC: A61K31/445 , A61K38/21 , C07D211/62 , C07D401/06 , C07D405/12 , C07D215/20 , A61K31/225 , A61K39/395 , A61K31/517 , A61K31/695 , A61K31/55 , C07K16/28 , A61K31/498 , A61K31/4709 , C07D211/34 , C07D211/60 , A61K31/4545
Abstract: The present invention provides compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and their use in modulating the activity of S1P receptors. Also provided is a pharmaceutical composition comprising the compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient or carrier.
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公开(公告)号：US09944666B2
公开(公告)日：2018-04-17
申请号：US15368454
申请日：2016-12-02
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Zhili Xin , Lei Zhang
IPC: C07D401/04 , C07D215/38 , C07D217/12 , A61K31/47 , C07F7/08 , A61K45/06 , C07C229/50 , A61K31/196 , C07D215/12 , A61K31/4545 , A61K31/506 , C07D295/096 , A61K31/495 , C07D213/74 , A61K31/496 , A61K31/551 , C07D239/42 , C07D241/20 , A61K31/497 , C07D211/14 , A61K31/451 , C07D205/04 , A61K31/397 , C07D401/06 , A61K31/4709 , C07D491/107 , C07D209/52 , A61K31/403 , C07D451/02 , A61K31/439 , A61K31/695 , C07C233/60 , C07D451/14
CPC classification number: C07F7/081 , A61K31/195 , A61K31/196 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/439 , A61K31/451 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K45/06 , C07C211/38 , C07C217/58 , C07C229/46 , C07C229/50 , C07C233/60 , C07C233/61 , C07C235/66 , C07C2102/10 , C07C2102/42 , C07C2102/44 , C07C2102/50 , C07C2103/62 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2602/50 , C07C2603/62 , C07C2603/74 , C07D205/04 , C07D209/52 , C07D211/14 , C07D213/74 , C07D215/12 , C07D215/20 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D295/096 , C07D401/04 , C07D401/06 , C07D451/02 , C07D451/14 , C07D471/08 , C07D491/107 , C07F7/0805 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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Patent Agency Ranking
公开(公告)号：US09827258B2
公开(公告)日：2017-11-28
申请号：US15397421
申请日：2017-01-03
Applicant: BIOGEN MA INC.
Inventor： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: A61K31/695 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C309/14 , C07C311/51 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D217/24 , C07D257/04 , C07D305/08 , C07D403/06 , C07D417/06 , C07F9/38 , C07F9/40 , A61K31/085 , A61K31/11 , A61K31/18 , A61K31/197 , A61K31/216 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C255/54 , C07D215/227 , C07D217/04 , C07D239/74 , C07D277/64 , C07D401/06 , C07F7/08 , A61K31/137 , A61K31/165 , A61K31/185 , A61K31/198 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/401
CPC classification number: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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公开(公告)号：US20170158687A1
公开(公告)日：2017-06-08
申请号：US15296601
申请日：2016-10-18
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: C07D451/02 , C07D401/06 , A61K45/06 , A61K31/4725 , C07D217/22 , A61K31/472
CPC classification number: C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
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公开(公告)号：US20160129023A1
公开(公告)日：2016-05-12
申请号：US14874600
申请日：2015-10-05
Applicant: Biogen MA Inc.
Inventor： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: A61K31/695 , A61K31/11 , A61K31/18 , A61K31/216 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/683 , A61K31/662 , A61K31/47 , A61K31/277 , A61K31/41 , A61K31/4709 , A61K31/472 , A61K31/337 , A61K31/517 , A61K31/428 , A61K31/404 , A61K45/06 , A61K31/085
CPC classification number: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
Abstract translation: 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是肌氨酸 - 甙类似物，磷酸化后，可以作为S1P受体的激动剂。
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公开(公告)号：US11572356B2
公开(公告)日：2023-02-07
申请号：US17004411
申请日：2020-08-27
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07D417/14 , C07D495/04 , C07D409/14 , C07D401/14 , C07D513/04 , C07D413/14 , A61K31/506 , C07D239/30 , C07F5/02 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号：US10577374B2
公开(公告)日：2020-03-03
申请号：US15698171
申请日：2017-09-07
Applicant: Sunesis Pharmaceuticals, Inc. , Biogen MA Inc.
Inventor： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: C07D277/82 , C07D487/14 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04 , A61K31/519
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
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