公开(公告)号：US10428200B2

公开(公告)日：2019-10-01

申请号：US15490412

申请日：2017-04-18

申请人： BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA ,  NORTHWESTERN UNIVERSITY

发明人： Ton That Hai ,  John-Bruce Devault Green ,  Timothy Michael Fulghum ,  Phillip Byron Messersmith ,  Tadas Stanislovas Sileika

IPC分类号： C08K5/13 ,  A61L31/16 ,  A61L31/04 ,  A61L31/06 ,  A61K31/05 ,  A61K31/08 ,  A61K31/11 ,  A61K31/132 ,  A61K31/194 ,  A61K31/722 ,  A61K47/02 ,  G01N33/543 ,  G01N33/551 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61K47/58 ,  A61K47/59

摘要： The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

公开(公告)号：USRE47452E1

公开(公告)日：2019-06-25

申请号：US15446651

申请日：2017-03-01

申请人： Baxter International Inc. ,  Baxter Healthcare SA

发明人： Tuan Bui ,  Ton That Hai ,  Mark Nordhaus ,  Paul Sanders ,  Cong Jiang ,  David Lamb ,  Ozlem Yardimci ,  Kent L. Lurvey ,  Vadim V. Krongauz

IPC分类号： A61M39/04 ,  A61L31/14 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  C07D213/30 ,  C08J9/36 ,  A61M39/16

摘要： A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.

公开(公告)号：US20170218174A1

公开(公告)日：2017-08-03

申请号：US15490412

申请日：2017-04-18

申请人： Baxter International Inc. ,  Baxter Healthcare SA ,  Northwestern University

发明人： Ton That Hai ,  John-Bruce Devault Green ,  Timothy Michael Fulghum ,  Phillip Byron Messersmith ,  Tadas Stanislovas Sileika

IPC分类号： C08K5/13 ,  A61L31/16 ,  A61L31/04 ,  A61L31/06

摘要： The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

公开(公告)号：US20170173226A1

公开(公告)日：2017-06-22

申请号：US15449752

申请日：2017-03-03

申请人： BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA ,  NORTHWESTERN UNIVERSITY

发明人： Ton That Hai ,  John-Bruce Devault Green ,  Timothy Michael Fulghum ,  Phillip Byron Messersmith ,  Tadas Stanislovas Sileika

IPC分类号： A61L33/00 ,  A61L29/06 ,  A61L29/16 ,  A61L29/08 ,  A61L33/06 ,  A61L33/04

CPC分类号： A61L33/0017 ,  A61L27/54 ,  A61L29/06 ,  A61L29/085 ,  A61L29/16 ,  A61L31/048 ,  A61L31/06 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/0094 ,  A61L33/04 ,  A61L33/068 ,  A61L33/08 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02

摘要： The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

公开(公告)号：US09655917B2

公开(公告)日：2017-05-23

申请号：US14298693

申请日：2014-06-06

申请人： BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA ,  NORTHWESTERN UNIVERSITY

发明人： Ton That Hai ,  John-Bruce Devault Green ,  Timothy Michael Fulghum ,  Phillip Byron Messersmith ,  Tadas Stanislovas Sileika

IPC分类号： A61K31/722 ,  A61K31/194 ,  A61K31/132 ,  A61K31/11 ,  A61K31/08 ,  A61K31/05 ,  A61K47/02 ,  A61K47/48 ,  G01N33/543 ,  G01N33/551 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16

CPC分类号： C08K5/13 ,  A61K31/05 ,  A61K31/08 ,  A61K31/11 ,  A61K31/132 ,  A61K31/194 ,  A61K31/722 ,  A61K47/02 ,  A61K47/58 ,  A61K47/59 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/042 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/404 ,  G01N33/54353 ,  G01N33/551

摘要： The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

公开(公告)号：US20140128445A1

公开(公告)日：2014-05-08

申请号：US14153641

申请日：2014-01-13

申请人： Baxter Healthcare SA ,  Baxter International Inc.

发明人： Guohan Yang ,  Ton That Hai ,  Bennett Melnick ,  Paul Sanders ,  Cong Jiang ,  Catherine Quinn ,  Jie Li ,  Arounaguiry Ambroise ,  Larry R. Brown

IPC分类号： A61K47/48 ,  A61K31/405

CPC分类号： A61K47/48215 ,  A61K31/405 ,  A61K47/60

摘要： The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.

摘要翻译： 本发明涉及聚合物衍生物，其可以与含氨基的药物缀合以改善其体内特性。 随后可以释放聚合物衍生物以产生其天然形式的药物。 描述了制备和使用这些聚合物衍生物和药物偶联物的方法。

公开(公告)号：US20140364391A1

公开(公告)日：2014-12-11

申请号：US14298693

申请日：2014-06-06

申请人： BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA ,  NORTHWESTERN UNIVERSITY

发明人： Ton That Hai ,  John-Bruce Devault Green ,  Timothy Michael Fulghum ,  Phillip Byron Messersmith ,  Tadas Stanislovas Sileika

IPC分类号： A61K31/722 ,  A61K31/132 ,  A61K47/02 ,  A61K31/08 ,  A61K31/05 ,  A61K47/48 ,  A61K31/194 ,  A61K31/11

CPC分类号： C08K5/13 ,  A61K31/05 ,  A61K31/08 ,  A61K31/11 ,  A61K31/132 ,  A61K31/194 ,  A61K31/722 ,  A61K47/02 ,  A61K47/58 ,  A61K47/59 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/042 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/404 ,  G01N33/54353 ,  G01N33/551

摘要： The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

摘要翻译： 本发明提供将活性剂固定在基材表面上的方法，包括以下步骤：提供基材，使基材与包含三羟基苯基的化合物的溶液接触，从而形成经三羟基苯基处理的底物，并使三羟基苯基 - 用活性剂处理底物，从而将活性剂固定在基材上。 还提供了将活性剂固定在基材上的方法，包括提供底物的步骤，将包含三羟基苯基的化合物的溶液与活性剂的溶液组合，从而形成活性剂 - 三羟基苯基共轭物 并使底物与活性剂 - 三羟基苯基偶联物的溶液接触，从而将活性剂固定在基材上。 本发明还提供具有固定在其表面上的活性剂的衬底和医疗装置或器件组件。

公开(公告)号：US20140287016A1

公开(公告)日：2014-09-25

申请号：US14212325

申请日：2014-03-14

申请人： BAXTER INTERNATIONAL INC. ,  NORTHWESTERN UNIVERSITY ,  BAXTER HEALTHCARE SA

发明人： Ton That Hai ,  John-Bruce Devault Green ,  Timothy Michael Fulghum ,  Phillip Byron Messersmith ,  Tadas Stanislovas Sileika

IPC分类号： A61L33/08 ,  A61L31/06 ,  A61L31/04 ,  A61L33/00 ,  A61L31/16

CPC分类号： A61L33/0017 ,  A61L27/54 ,  A61L29/06 ,  A61L29/085 ,  A61L29/16 ,  A61L31/048 ,  A61L31/06 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/0094 ,  A61L33/04 ,  A61L33/068 ,  A61L33/08 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02

摘要： The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

摘要翻译： 本发明提供了将活性剂固定在基材表面上的方法，包括以下步骤：在底物上沉积底漆，从而形成底漆底物，使底漆与包含三羟基苯基的化合物溶液接触，从而形成 三羟基苯基处理的底漆，并使三羟基苯基处理的底漆与活性剂的溶液接触，从而将活性剂固定在基材上。 还提供了将活性剂固定在基材上的方法，包括提供底物的步骤，将包含三羟基苯基的化合物的溶液与活性剂的溶液组合，从而形成活性剂 - 三羟基苯基共轭物 并且将底漆底物与活性剂 - 三羟基苯基偶联物的溶液接触，从而将活性剂固定在基材上。 本发明还提供具有固定在其表面上的活性剂的衬底和医疗装置或器件组件。

公开(公告)号：US09895468B2

公开(公告)日：2018-02-20

申请号：US15449752

申请日：2017-03-03

申请人： BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA ,  NORTHWESTERN UNIVERSITY

发明人： Ton That Hai ,  John-Bruce Devault Green ,  Timothy Michael Fulghum ,  Phillip Byron Messersmith ,  Tadas Stanislovas Sileika

IPC分类号： A61L29/16 ,  A61L29/08 ,  A61L33/06 ,  A61L33/04 ,  A61L33/00 ,  A61L29/06

CPC分类号： A61L33/0017 ,  A61L27/54 ,  A61L29/06 ,  A61L29/085 ,  A61L29/16 ,  A61L31/048 ,  A61L31/06 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/0094 ,  A61L33/04 ,  A61L33/068 ,  A61L33/08 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02

摘要： The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

公开(公告)号：US09642949B2

公开(公告)日：2017-05-09

申请号：US14212325

申请日：2014-03-14

申请人： BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA ,  NORTHWESTERN UNIVERSITY

发明人： Ton That Hai ,  John-Bruce Devault Green ,  Timothy Michael Fulghum ,  Phillip Byron Messersmith ,  Tadas Stanislovas Sileika

IPC分类号： A61L33/08 ,  A61L31/06 ,  A61L31/04 ,  A61L33/00 ,  A61L31/16 ,  A61L27/54 ,  A61L29/16

CPC分类号： A61L33/0017 ,  A61L27/54 ,  A61L29/06 ,  A61L29/085 ,  A61L29/16 ,  A61L31/048 ,  A61L31/06 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/0094 ,  A61L33/04 ,  A61L33/068 ,  A61L33/08 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02

摘要： The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.