公开(公告)号：US20140128445A1

公开(公告)日：2014-05-08

申请号：US14153641

申请日：2014-01-13

Applicant: Baxter Healthcare SA ,  Baxter International Inc.

Inventor： Guohan Yang ,  Ton That Hai ,  Bennett Melnick ,  Paul Sanders ,  Cong Jiang ,  Catherine Quinn ,  Jie Li ,  Arounaguiry Ambroise ,  Larry R. Brown

IPC: A61K47/48 ,  A61K31/405

CPC classification number: A61K47/48215 ,  A61K31/405 ,  A61K47/60

Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.

Abstract translation: 本发明涉及聚合物衍生物，其可以与含氨基的药物缀合以改善其体内特性。 随后可以释放聚合物衍生物以产生其天然形式的药物。 描述了制备和使用这些聚合物衍生物和药物偶联物的方法。

公开(公告)号：US08962549B2

公开(公告)日：2015-02-24

申请号：US14153641

申请日：2014-01-13

Applicant: Baxter International Inc. ,  Baxter Healthcare SA

Inventor： Guohan Yang ,  Ton That Hai ,  Bennett Melnick ,  Paul Sanders ,  Cong Jiang ,  Catherine Quinn ,  Jie Li ,  Arounaguiry Ambroise ,  Larry R. Brown

IPC: A61K47/48 ,  A61K31/405

CPC classification number: A61K47/48215 ,  A61K31/405 ,  A61K47/60

Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.

Abstract translation: 本发明涉及聚合物衍生物，其可以与含氨基的药物缀合以改善其体内特性。 随后可以释放聚合物衍生物以产生其天然形式的药物。 描述了制备和使用这些聚合物衍生物和药物偶联物的方法。