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公开(公告)号：US20140128445A1
公开(公告)日：2014-05-08
申请号：US14153641
申请日：2014-01-13
发明人： Guohan Yang , Ton That Hai , Bennett Melnick , Paul Sanders , Cong Jiang , Catherine Quinn , Jie Li , Arounaguiry Ambroise , Larry R. Brown
IPC分类号： A61K47/48 , A61K31/405
CPC分类号： A61K47/48215 , A61K31/405 , A61K47/60
摘要： The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
摘要翻译： 本发明涉及聚合物衍生物，其可以与含氨基的药物缀合以改善其体内特性。 随后可以释放聚合物衍生物以产生其天然形式的药物。 描述了制备和使用这些聚合物衍生物和药物偶联物的方法。
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公开(公告)号：USRE47452E1
公开(公告)日：2019-06-25
申请号：US15446651
申请日：2017-03-01
发明人： Tuan Bui , Ton That Hai , Mark Nordhaus , Paul Sanders , Cong Jiang , David Lamb , Ozlem Yardimci , Kent L. Lurvey , Vadim V. Krongauz
IPC分类号： A61M39/04 , A61L31/14 , A61L27/34 , A61L27/50 , A61L27/54 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/16 , C07D213/30 , C08J9/36 , A61M39/16
摘要： A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.
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公开(公告)号：US20180303531A1
公开(公告)日：2018-10-25
申请号：US15956370
申请日：2018-04-18
发明人： Paul Sanders , Timothy Fulghum
IPC分类号： A61B17/88
CPC分类号： A61B17/8819 , A61B17/8816 , A61B17/8822 , A61B2017/2923 , A61L2400/04
摘要： A single-handed applicator system includes an applicator, including a body and a bore defined by the body. The bore has a first end and a second end. The applicator includes a trigger, coupled to the body. The applicator includes a gear system, disposed within the body. The gear system engages with both a portion of a removable stylus and the trigger to actuate the trigger and rotate a gear along at least the portion of the removable stylus. The applicator system includes a delivery tube, configured to engage with the applicator at the first end of the bore. The applicator includes the removable stylus, configured to be received by the applicator at the second end of the bore. The removable stylus is configured to extend through both the bore and at least a portion of the delivery tube.
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公开(公告)号：US08962549B2
公开(公告)日：2015-02-24
申请号：US14153641
申请日：2014-01-13
发明人： Guohan Yang , Ton That Hai , Bennett Melnick , Paul Sanders , Cong Jiang , Catherine Quinn , Jie Li , Arounaguiry Ambroise , Larry R. Brown
IPC分类号： A61K47/48 , A61K31/405
CPC分类号： A61K47/48215 , A61K31/405 , A61K47/60
摘要： The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
摘要翻译： 本发明涉及聚合物衍生物，其可以与含氨基的药物缀合以改善其体内特性。 随后可以释放聚合物衍生物以产生其天然形式的药物。 描述了制备和使用这些聚合物衍生物和药物偶联物的方法。
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公开(公告)号：US20230355835A1
公开(公告)日：2023-11-09
申请号：US18199694
申请日：2023-05-19
发明人： John Barry , Paul Sanders , Rahul Singh , Krishnakumarsinh H. Parmar , Ben Ko , Stephanie Klunk
CPC分类号： A61L26/0038 , A61L26/008 , A61M35/003 , A61L26/009 , A61L26/0033 , A61L26/0023 , A61B17/00491 , A61L26/0042 , A61L26/0047 , A61L2400/04 , A61B2017/00942 , A61B2017/00898 , A61M5/2033
摘要： Polymeric compositions, methods, and delivery devices for inhibiting bleeding are disclosed. The method includes applying a dried material topically to a wound site, where the material may include a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood and where the material may not include an active agent such as thrombin. A spring-loaded delivery device as described herein may be used to apply the dried material.
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公开(公告)号：US20130202550A1
公开(公告)日：2013-08-08
申请号：US13754727
申请日：2013-01-30
发明人： Michael Dockal , Fritz Scheiflinger , Sabine Knappe , Susanne Till , Ton Hai , Paul Sanders
IPC分类号： A61K31/795
CPC分类号： A61K31/795 , A61K31/37 , A61K31/7024 , A61K31/727 , A61K38/37 , A61K38/4846 , A61K2300/00
摘要： The present invention provides pharmaceutical formulations including a non-anticoagulant, non-saccharide polymer that with at least one sulfate or sulfonate moiety. The pharmaceutical formulations of the invention are of use to improve blood clotting in a subject. Also provided are useful analytical methods utilizing these polymers to query the dynamics of blood clotting in vitro.
摘要翻译： 本发明提供药物制剂，其包含与至少一种硫酸盐或磺酸盐部分的非抗凝血剂，非糖类聚合物。 本发明的药物制剂可用于改善受试者的血液凝固。 还提供了使用这些聚合物来查询体外血液凝固动力学的有用的分析方法。
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公开(公告)号：US11679177B2
公开(公告)日：2023-06-20
申请号：US16041238
申请日：2018-07-20
发明人： John Barry , Paul Sanders , Rahul Singh , Krishnakumarsinh H. Parmar , Ben Ko , Stephanie Klunk
CPC分类号： A61L26/0038 , A61B17/00491 , A61L26/008 , A61L26/009 , A61L26/0023 , A61L26/0033 , A61L26/0042 , A61L26/0047 , A61M35/003 , A61B2017/00495 , A61B2017/00893 , A61B2017/00898 , A61B2017/00942 , A61L2400/04 , A61M5/2033 , A61M2005/3142
摘要： Polymeric compositions, methods, and delivery devices for inhibiting bleeding are disclosed. The method includes applying a dried material topically to a wound site, where the material may include a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood and where the material may not include an active agent such as thrombin. A spring-loaded delivery device as described herein may be used to apply the dried material.
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公开(公告)号：US09511053B2
公开(公告)日：2016-12-06
申请号：US14984589
申请日：2015-12-30
发明人： Sujatha Karoor , Ton That Hai , Cong Jiang , Paul Sanders , Cliff Holmes
IPC分类号： A61K31/06 , A61K31/4164 , A61K31/353 , A61K31/4178 , A61K31/4439 , A61K31/714 , A61K45/06
CPC分类号： A61K31/4164 , A61K31/353 , A61K31/4178 , A61K31/4439 , A61K31/714 , A61K45/06
摘要： Therapeutic compositions capable of removing excess nitric oxide are provided. The therapeutic compositions include nitronyl nitroxide monoradicals, B12 derivatives, flavonoid derivatives, the like and combinations thereof. The therapeutic compositions can be utilized in a number of suitable applications, such as to prevent or treat intradialytic hypotension during dialysis.
摘要翻译： 提供能够除去过量一氧化氮的治疗组合物。 治疗组合物包括硝基氮氧化物单价，B12衍生物，类黄酮衍生物等及其组合。 治疗组合物可以用于许多合适的应用中，例如在透析期间预防或治疗体内低血压。
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公开(公告)号：US09574060B2
公开(公告)日：2017-02-21
申请号：US14802528
申请日：2015-07-17
发明人： Tuan Bui , Ton That Hai , Mark Nordhaus , Paul Sanders , Cong Jiang , David Lamb , Ozlem Yardimci , Kent L. Lurvey , Vadim V. Krongauz
IPC分类号： C08J9/36 , A61L27/34 , A61L27/50 , A61L27/54 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , C07D213/30 , A61M39/04 , A61M39/16
CPC分类号： C08J9/36 , A61L27/34 , A61L27/50 , A61L27/54 , A61L29/085 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/404 , A61L2300/442 , A61L2400/18 , A61L2420/02 , A61M39/045 , A61M39/16 , C07D213/30 , C08J2207/10 , C08J2309/06 , C08J2345/00 , C08J2367/00 , C08J2369/00 , C08J2375/04 , C08J2377/00
摘要： A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.
摘要翻译： 公开和描述了将染料和抗微生物剂固定在用于医疗装置的聚合物盖或壳体上的方法。 表面可以是导管，连接器，药物瓶尖，袋尖，假体装置，内窥镜，输液泵的表面，键盘，触摸屏或手柄的表面。 这些表面也可以是与输注药物或透析治疗相关联的一种或多种，例如腹膜透析或血液透析，其中重要的是透析液的工作表面是无菌的。 这些表面包括用于腹膜透析套件的连接器或用于血液透析套件，袋尖，透析导管等。 还公开了一种用于确定表面是否已被灭菌的方法，以及用于如此指示的染料。
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公开(公告)号：US20160106713A1
公开(公告)日：2016-04-21
申请号：US14984589
申请日：2015-12-30
发明人： Sujatha Karoor , Ton That Hai , Cong Jiang , Paul Sanders , Cliff Holmes
IPC分类号： A61K31/4164 , A61K45/06 , A61K31/714 , A61K31/4439 , A61K31/4178
CPC分类号： A61K31/4164 , A61K31/353 , A61K31/4178 , A61K31/4439 , A61K31/714 , A61K45/06
摘要： Therapeutic compositions capable of removing excess nitric oxide are provided. The therapeutic compositions include nitronyl nitroxide monoradicals, B12 derivatives, flavonoid derivatives, the like and combinations thereof. The therapeutic compositions can be utilized in a number of suitable applications, such as to prevent or treat intradialytic hypotension during dialysis.
摘要翻译： 提供能够除去过量一氧化氮的治疗组合物。 治疗组合物包括硝基氮氧化物单价，B12衍生物，类黄酮衍生物等及其组合。 治疗组合物可以用于许多合适的应用中，例如在透析期间预防或治疗体内低血压。
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