公开(公告)号：US20140154297A1

公开(公告)日：2014-06-05

申请号：US13663669

申请日：2012-10-30

申请人： Baxter International Inc. ,  Baxter Healthcare S.A.

发明人： Vadim V. Krongauz ,  Michael Tung-Kiung Ling ,  Dustin C. Cawthon

IPC分类号： A61K33/20 ,  A61K33/18

CPC分类号： A61K33/20 ,  A01N33/12 ,  A01N59/12 ,  A61K33/18 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/202 ,  A61L2300/208 ,  A61L2300/404 ,  C09D5/14 ,  A01N25/10 ,  A01N25/34 ,  A01N59/00

摘要： Substrates having antimicrobial films or coatings adhered to a surface of the substrate and methods for replenishing the antimicrobial activity of films or coatings adhered to substrate surfaces are disclosed. The antimicrobial films and coatings comprise a strongly basic anion-exchange resin and an anion bound to the strongly basic anion-exchange resin, the anion being free of transition metals. The methods involve exposing a film or coating to an anion having antimicrobial activity, the anion being free of transition metals, and the film or coating comprising a strongly basic anion-exchange resin, thereby obtaining an antimicrobial film or coating comprising the anion bound to the strongly basic anion-exchange resin.

摘要翻译： 公开了具有附着到基底表面上的抗微生物膜或涂层的底物以及补充附着于基底表面的膜或涂层的抗微生物活性的方法。 抗微生物膜和涂层包含强碱性阴离子交换树脂和与强碱性阴离子交换树脂结合的阴离子，阴离子不含过渡金属。 所述方法包括将膜或涂层暴露于具有抗微生物活性的阴离子，所述阴离子不含过渡金属，所述膜或涂层包含强碱性阴离子交换树脂，从而获得包含结合到阴离子交换树脂上的阴离子的抗微生物膜或涂层 强碱性阴离子交换树脂。

公开(公告)号：US20130224866A1

公开(公告)日：2013-08-29

申请号：US13865624

申请日：2013-04-18

申请人： Baxter International Inc. ,  Baxter Healthcare S.A.

发明人： Kent L. Lurvey ,  Shmuel Sternberg ,  Vadim V. Krongauz ,  Rosa H. Yeh ,  Robin G. Pauley ,  Dustin C. Cawthon ,  Ton That Hai ,  Lecon L. Woo ,  Ashok K. Khanna ,  Birendra K. Lal ,  Michael Tung-Kiung Ling ,  William S. Hoerle ,  Craig L. Sandford ,  Mark A. Nordhaus ,  Alexander Savitski ,  Nicklaus J. Kirichkow ,  Kenneth Glen Suh ,  Sivaramakrishnan Krishnamoorthy ,  Hsinjin E. Yang ,  Robert A. Clarke

IPC分类号： G01N21/78

CPC分类号： G01N21/78 ,  A61M39/02 ,  A61M39/045 ,  A61M39/16 ,  A61M39/26 ,  A61M2039/1033 ,  A61M2039/1072 ,  A61M2205/583 ,  A61M2205/584 ,  G01N31/22

摘要： A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent. The indicator includes a substrate and a microporous layer disposed on the substrate. The microporous layer is made from a polymer material having an index of refraction from about 1.25 to about 1.6 and is configured to change from a substantially opaque state to a substantially transparent state upon exposure to an antiseptic solution. The microporous layer resumes the substantially opaque state after a period of time.

摘要翻译： 公开了一种医疗装置，例如血管通路装置，用于提供对医用流体流路的通路，用于将医用流体引入或取出流路。 访问装置包括用于当访问装置已经暴露于防腐剂时提供视觉指示的指示器。 指示剂包括基材和设置在基材上的微孔层。 微孔层由具有大约1.25至大约1.6的折射率的聚合物材料制成，并且被配置为在暴露于防腐溶液时从基本上不透明的状态改变到基本上透明的状态。 微孔层在一段时间后恢复基本上不透明的状态。

公开(公告)号：US09574060B2

公开(公告)日：2017-02-21

申请号：US14802528

申请日：2015-07-17

申请人： Baxter International Inc. ,  Baxter Healthcare S.A.

发明人： Tuan Bui ,  Ton That Hai ,  Mark Nordhaus ,  Paul Sanders ,  Cong Jiang ,  David Lamb ,  Ozlem Yardimci ,  Kent L. Lurvey ,  Vadim V. Krongauz

IPC分类号： C08J9/36 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  C07D213/30 ,  A61M39/04 ,  A61M39/16

CPC分类号： C08J9/36 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L29/085 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/442 ,  A61L2400/18 ,  A61L2420/02 ,  A61M39/045 ,  A61M39/16 ,  C07D213/30 ,  C08J2207/10 ,  C08J2309/06 ,  C08J2345/00 ,  C08J2367/00 ,  C08J2369/00 ,  C08J2375/04 ,  C08J2377/00

摘要： A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.

摘要翻译： 公开和描述了将染料和抗微生物剂固定在用于医疗装置的聚合物盖或壳体上的方法。 表面可以是导管，连接器，药物瓶尖，袋尖，假体装置，内窥镜，输液泵的表面，键盘，触摸屏或手柄的表面。 这些表面也可以是与输注药物或透析治疗相关联的一种或多种，​​例如腹膜透析或血液透析，其中重要的是透析液的工作表面是无菌的。 这些表面包括用于腹膜透析套件的连接器或用于血液透析套件，袋尖，透析导管等。 还公开了一种用于确定表面是否已被灭菌的方法，以及用于如此指示的染料。

公开(公告)号：USRE47452E1

公开(公告)日：2019-06-25

申请号：US15446651

申请日：2017-03-01

申请人： Baxter International Inc. ,  Baxter Healthcare SA

发明人： Tuan Bui ,  Ton That Hai ,  Mark Nordhaus ,  Paul Sanders ,  Cong Jiang ,  David Lamb ,  Ozlem Yardimci ,  Kent L. Lurvey ,  Vadim V. Krongauz

IPC分类号： A61M39/04 ,  A61L31/14 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  C07D213/30 ,  C08J9/36 ,  A61M39/16

摘要： A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.

公开(公告)号：US20230157801A1

公开(公告)日：2023-05-25

申请号：US17988352

申请日：2022-11-16

申请人： BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA

发明人： Kevin Michael Lewis ,  Mark Alan Nordhaus ,  John-Bruce D. Green ,  Vadim V. Krongauz

IPC分类号： A61F2/00

CPC分类号： A61F2/0063 ,  A61F2002/0068 ,  A61F2210/0004

摘要： Disclosed herein are surgical mesh materials and methods of production and use thereof.

公开(公告)号：US20140162045A1

公开(公告)日：2014-06-12

申请号：US14102831

申请日：2013-12-11

申请人： BAXTER HEALTHCARE SA ,  BAXTER INTERNATIONAL INC.

发明人： Anthony Bourassa ,  Vadim V. Krongauz ,  Yann-Per Lee ,  Michael Tung-Kiung Ling ,  Richard J. Mennenoh ,  Zehra Sibel Sevinc

IPC分类号： C08L91/06 ,  C08L23/06 ,  C08K5/1515 ,  C08L27/06 ,  C08K5/12 ,  C08K5/098

CPC分类号： C08L91/06 ,  A61L2/081 ,  A61L2202/24 ,  C08J3/28 ,  C08J5/18 ,  C08J2327/06 ,  C08K3/22 ,  C08K5/0016 ,  C08K5/098 ,  C08K5/12 ,  C08K5/1515 ,  C08K2003/2227 ,  C08K2003/2289 ,  C08L23/06 ,  C08L27/06

摘要： Disclosed are PVC compositions with enhanced color resistance to electromagnetic irradiation & shelf life color stability; gamma-irradiated PVC articles; methods of making the gamma-irradiated PVC articles; and compositions including PVC resins for making the gamma-irradiated PVC articles.

摘要翻译： 公开了具有对电磁辐射的耐色性和保质期颜色稳定性的PVC组合物; γ-照射PVC制品; 制造γ-照射PVC制品的方法; 以及包括用于制造γ-照射的PVC制品的PVC树脂的组合物。