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17 条记录 (耗时 0.024 秒)

    Process for the preparation of carboxylic anhydrides from olefinic hydrocarbons
    1.
    发明授权
    Process for the preparation of carboxylic anhydrides from olefinic hydrocarbons 失效
    从烯烃制备羧酸酐的方法

    公开(公告)号：US3989751A

    公开(公告)日：1976-11-02

    申请号：US531946

    申请日：1974-12-12

    申请人： Denis Forster ,  Arnold Hershman

    发明人： Denis Forster ,  Arnold Hershman

    IPC分类号： C07C51/14 ,  C07C51/54 ,  C07C51/56

    CPC分类号： C07C51/54 ,  C07C51/14 ,  C07C51/56

    摘要： The present invention relates to an improved process for the preparation of organic carboxylic acid anhydrides, specifically by the reaction of ethylenically unsaturated compounds having 2 to 30 carbon atoms with carbon monoxide and carboxylic acids or substances which yield carboxylic acids under reaction conditions at a temperature of 50.degree. C to 300.degree. C and a partial pressure of carbon monoxide of from 1 to 200 atm. in the presence of a catalyst composition essentially comprised of1. a cobalt or nickel compound, and2. an iodide component subject to the conditions that the atomic ratio of iodide to cobalt or nickel is from 1:1 to 300:1,3. a catalyst preserver or regenerator component selected from the group consisting of hydrogen or a compound capable of giving rise to hydrogen under the reaction conditions. The process is particularly suited to the production of propionic anhydride.

    摘要翻译： 本发明涉及一种制备有机羧酸酐的改进方法，特别是通过具有2-30个碳原子的烯属不饱和化合物与一氧化碳和羧酸或在反应条件下在温度为 50℃至300℃，一氧化碳分压为1至200atm。 在催化剂组合物的存在下，基本上由以下组成的催化剂组合物1.钴或镍化合物和2.根据碘化物对钴或镍的原子比从1：1至300的条件的一种碘化物组分：

    Use of infrared spectroscopy for on-line process control and endpoint detection
    3.
    发明授权
    Use of infrared spectroscopy for on-line process control and endpoint detection 失效
    使用红外光谱仪进行在线过程控制和端点检测

    公开(公告)号：US06818450B2

    公开(公告)日：2004-11-16

    申请号：US10150030

    申请日：2002-05-17

    申请人： David R. Eaton ,  Walter Gavlick ,  Gary Klopf ,  Arnold Hershman ,  Denis Forster

    发明人： David R. Eaton ,  Walter Gavlick ,  Gary Klopf ,  Arnold Hershman ,  Denis Forster

    IPC分类号： C12P3300

    CPC分类号： G01N21/75 ,  C07F9/3813 ,  G01N21/3577 ,  G01N2021/3595 ,  Y10T436/117497 ,  Y10T436/163333 ,  Y10T436/200833 ,  Y10T436/201666 ,  Y10T436/202499

    摘要： The present invention is directed to an analytical method for measuring the concentration of an N-(phosphonomethyl)iminodiacetic acid (“NPMIDA”) substrate, an N-(phosphonomethyl)glycine product, formaldehyde, formic acid, N-methyl-N-(phosphonomethyl)glycine (“NMG”), N-methyl-aminomethylphosphonic acid (MAMPA) or aminomethylphosphonic acid (“AMPA”)) in an aqueous mixture thereof, using infrared spectroscopy. The present invention is also directed to a process for oxidizing an N-(phosphonomethyl)iminodiacetic acid substrate to form a N-(phosphonomethyl)glycine product, and as part of the process, measuring the concentration of at least one reactant, product or byproduct of the oxidation reaction using the analytical method of the present invention and controlling the oxidation process in response to the measurement taken.

    摘要翻译： 本发明涉及一种用于测量N-（膦酰基甲基）亚氨基二乙酸（“NPMIDA”）底物，N-（膦酰基甲基）甘氨酸产物，甲醛，甲酸，N-甲基-N-（ 膦酰基甲基）甘氨酸（“NMG”），N-甲基 - 氨基甲基膦酸（MAMPA）或氨基甲基膦酸（“AMPA”））在其水性混合物中。 本发明还涉及一种氧化N-（膦酰基甲基）亚氨基二乙酸底物以形成N-（膦酰基甲基）甘氨酸产物的方法，作为该方法的一部分，测量至少一种反应物，产物或副产物的浓度 的氧化反应使用本发明的分析方法，并且响应于测量而控制氧化过程。

    Detergent range aldehyde and alcohol mixtures and derivatives, and process therefor
    6.
    发明授权
    Detergent range aldehyde and alcohol mixtures and derivatives, and process therefor 失效
    洗涤剂范围醛和醇的混合物和衍生物，及其工艺

    公开(公告)号：US4598162A

    公开(公告)日：1986-07-01

    申请号：US549524

    申请日：1983-11-04

    申请人： Denis Forster ,  George F. Schaefer ,  George E. Barker

    发明人： Denis Forster ,  George F. Schaefer ,  George E. Barker

    IPC分类号： C07C29/141 ,  C07C31/125 ,  C07C45/50 ,  C07C45/62 ,  C07C45/66 ,  C07C45/72 ,  C07C45/74 ,  C07C47/21

    CPC分类号： C07C45/72 ,  C07C29/141 ,  C07C31/125 ,  C07C45/50 ,  C07C45/62 ,  C07C45/66 ,  C07C45/74

    摘要： Novel, liquid mixtures of isomeric aldehydes and alcohols are described in the C.sub.11 -C.sub.16 carbon range, the compounds being characterized by a main carbon branched at the position and moderate additional branching in most isomers; the aldehyde mixtures are prepared by an economic route from olefins involving oxo and aldol reaction with the reaction conducted in such a way as to give a high percentage of aldolable product, and preferably with a base catalyzed aldol reaction conducted under conditions to make high conversions attainable. The aldehyde mixtures can be hydrogenated to alcohols and converted to novel ethoxylates or sulfate compositions suitable for use as biodegradable detergents; or hydrogenated and oxidized to novel carboxylic acid compositions also suitable for detergent use.

    摘要翻译： 在C11-C16碳范围内描述了异构醛和醇的新型液体混合物，该化合物的特征在于在大多数异构体的位置处分支的主要碳和中等额外的支化; 醛混合物通过从烯烃的经济途径制备，所述烯烃涉及氧代和醛醇反应，所述反应以如下方式进行，以便产生高百分数的可醛化产物，并且优选在使得可获得高转化率的条件下进行碱催化的醛醇反应 。 醛混合物可以被氢化成醇并转化成适合用作可生物降解的洗涤剂的新型乙氧基化物或硫酸盐组合物; 或氢化和氧化成也适用于洗涤剂用途的新型羧酸组合物。

    Particles comprising amphiphilic copolymers
    7.
    发明授权
    Particles comprising amphiphilic copolymers 失效
    包含两亲共聚物的颗粒

    公开(公告)号：US06491903B1

    公开(公告)日：2002-12-10

    申请号：US08884012

    申请日：1997-06-27

    申请人： Denis Forster ,  Gary S. Jacob ,  James M. Warner

    发明人： Denis Forster ,  Gary S. Jacob ,  James M. Warner

    IPC分类号： A61K3174

    CPC分类号： A61K9/5138 ,  A61K9/1075 ,  C08J3/246 ,  Y10T428/2998

    摘要： Provided are methods of inhibiting bile acid uptake from the gastrointestinal system and reducing blood serum cholesterol by administering to a mammal, such as a human, an effective amount of particles comprising amphiphilic copolymers, having a crosslinked shell domain and an interior core domain.

    摘要翻译： 提供了通过向哺乳动物（例如人）施用有效量的包含具有交联壳结构域和内部核心结构域的两亲性共聚物的有效量的颗粒来抑制来自胃肠系统的胆汁酸摄取并降低血清胆固醇的方法。

    Ph-selective delivery system using crosslinked polymeric resins as vehicles
    8.
    发明授权
    Ph-selective delivery system using crosslinked polymeric resins as vehicles 失效
    使用交联聚合物树脂作为载体的选择性递送系统

    公开(公告)号：US06471955B1

    公开(公告)日：2002-10-29

    申请号：US09050042

    申请日：1998-03-30

    申请人： Samuel J. Tremont ,  Denis Forster ,  Ricky L. Fenton ,  Yinong Ma

    发明人： Samuel J. Tremont ,  Denis Forster ,  Ricky L. Fenton ,  Yinong Ma

    IPC分类号： A61K3175

    CPC分类号： A61K31/5575 ,  A61K47/58 ,  A61K47/6927 ,  Y10S514/926 ,  Y10S514/927

    摘要： This invention provides a method of preparing a polymeric delivery system for active ingredients having enhanced site specific release performance characteristics. The delivery system is formed either by attaching the active ingredient to a linker through an acid-sensitive covalent bond, then forming a covalent bond between the linker and a portion of the subunits of a crosslinked polystyrene polymer, or by attaching a linker to a portion of the subunits of a crosslinked polystyrene polymer, then attaching the active ingredient to the polymer-linker combination through an acid-sensitive covalent bond. The invention also provides a delivery system comprising an active ingredient covalently bonded through an acid-sensitive covalent bond to a linker, which is in turn covalently bonded to a portion of subunits of a crosslinked polystyrene polymer. The invention further provides a method for treatment or prevention of gastric ulcers using a delivery system capable of delivering prostaglandin or prostacyclin drugs, especially misoprostol.

    摘要翻译： 本发明提供了制备具有增强的位点特异性释放性能特征的活性成分的聚合物递送系统的方法。 递送系统通过将活性成分通过酸敏感共价键连接到接头上，然后在接头与交联聚苯乙烯聚合物的一部分亚单位之间形成共价键，或通过将接头连接到部分 的交联聚苯乙烯聚合物的亚基，然后通过酸敏感共价键将活性成分连接到聚合物 - 连接体组合。 本发明还提供了一种递送系统，其包含通过酸敏感共价键共价结合至接头的活性成分，其接触共价键合到交联聚苯乙烯聚合物的一部分亚单位。 本发明还提供了使用能够递送前列腺素或前列环素药物，特别是米索前列醇的递送系统来治疗或预防胃溃疡的方法。

    Preparation of pentyl nonanols
    9.
    发明授权
    Preparation of pentyl nonanols 失效
    戊基壬醇的制备

    公开(公告)号：US4518809A

    公开(公告)日：1985-05-21

    申请号：US499967

    申请日：1983-06-01

    申请人： Denis Forster ,  George F. Schaefer

    发明人： Denis Forster ,  George F. Schaefer

    IPC分类号： C07C29/141 ,  C07C31/125 ,  C07C45/50 ,  C07C45/62 ,  C07C45/66 ,  C07C45/72 ,  C07C45/74

    CPC分类号： C07C45/72 ,  C07C29/141 ,  C07C31/125 ,  C07C45/50 ,  C07C45/62 ,  C07C45/66 ,  C07C45/74

    摘要： A novel, liquid mixture of C.sub.14 isomeric alcohols is described which is suitable for use in forming effective and biodegradable detergents, the alcohols being characterized by a 5-carbon branch at the 2-position and moderate additional branching in most isomers; the alcohols are prepared by a novel economic route from propylene dimer, involving oxo, aldol and hydrogenation reactions with the oxo reaction conducted in such a way as to give a high percentage of aldolable product and preferably with a base-catalyzed aldol reaction conducted under particular conditions to make high conversions attainable.

    摘要翻译： 描述了C14异构醇的新型液体混合物，其适用于形成有效和可生物降解的洗涤剂，醇的特征在于2-位上的5-碳支链和大多数异构体中的中等额外支化; 醇通过丙烯二聚体的新型经济途径制备，涉及氧代，醛醇和氢化反应，其中羰基反应以这样一种方式进行，以提供高比例的可醛化产物，优选在特定条件下进行碱催化的醛醇反应 达到高转化率的条件。