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11 条记录 (耗时 0.035 秒)

    Ph-selective delivery system using crosslinked polymeric resins as vehicles
    1.
    发明授权
    Ph-selective delivery system using crosslinked polymeric resins as vehicles 失效
    使用交联聚合物树脂作为载体的选择性递送系统

    公开(公告)号：US06471955B1

    公开(公告)日：2002-10-29

    申请号：US09050042

    申请日：1998-03-30

    申请人： Samuel J. Tremont ,  Denis Forster ,  Ricky L. Fenton ,  Yinong Ma

    发明人： Samuel J. Tremont ,  Denis Forster ,  Ricky L. Fenton ,  Yinong Ma

    IPC分类号： A61K3175

    CPC分类号： A61K31/5575 ,  A61K47/58 ,  A61K47/6927 ,  Y10S514/926 ,  Y10S514/927

    摘要： This invention provides a method of preparing a polymeric delivery system for active ingredients having enhanced site specific release performance characteristics. The delivery system is formed either by attaching the active ingredient to a linker through an acid-sensitive covalent bond, then forming a covalent bond between the linker and a portion of the subunits of a crosslinked polystyrene polymer, or by attaching a linker to a portion of the subunits of a crosslinked polystyrene polymer, then attaching the active ingredient to the polymer-linker combination through an acid-sensitive covalent bond. The invention also provides a delivery system comprising an active ingredient covalently bonded through an acid-sensitive covalent bond to a linker, which is in turn covalently bonded to a portion of subunits of a crosslinked polystyrene polymer. The invention further provides a method for treatment or prevention of gastric ulcers using a delivery system capable of delivering prostaglandin or prostacyclin drugs, especially misoprostol.

    摘要翻译： 本发明提供了制备具有增强的位点特异性释放性能特征的活性成分的聚合物递送系统的方法。 递送系统通过将活性成分通过酸敏感共价键连接到接头上，然后在接头与交联聚苯乙烯聚合物的一部分亚单位之间形成共价键，或通过将接头连接到部分 的交联聚苯乙烯聚合物的亚基，然后通过酸敏感共价键将活性成分连接到聚合物 - 连接体组合。 本发明还提供了一种递送系统，其包含通过酸敏感共价键共价结合至接头的活性成分，其接触共价键合到交联聚苯乙烯聚合物的一部分亚单位。 本发明还提供了使用能够递送前列腺素或前列环素药物，特别是米索前列醇的递送系统来治疗或预防胃溃疡的方法。

    Process for producing phosphorous acid
    6.
    发明授权
    Process for producing phosphorous acid 有权
    亚磷酸生产方法

    公开(公告)号：US06194604B1

    公开(公告)日：2001-02-27

    申请号：US09274629

    申请日：1999-03-23

    申请人： Yinong Ma ,  Jerald D. Heise

    发明人： Yinong Ma ,  Jerald D. Heise

    IPC分类号： C07F938

    CPC分类号： C01B25/163

    摘要： A process for the manufacture of phosphorous acid by selective hydrolysis of phosphite esters. A hydrolysis feed mixture comprising phosphite esters and phosphate esters is contacted with liquid water or steam to selectively hydrolyze the phosphite esters to phosphorous acid. The feed mixture may be prepared by oxidation of elemental phosphorous in the presence of an alcohol. In the oxidation and/or a subsequent esterification step, P(III) and P(V) oxyacids produced in the oxidation reaction are esterified, preferably quantitatively. The ester mixture may be washed to remove unesterified phosphoric and hypophosphorous acid, after which the selective hydrolysis is carried out.

    摘要翻译： 通过选择性水解亚磷酸酯制备亚磷酸的方法。 将包含亚磷酸酯和磷酸酯的水解进料混合物与液态水或蒸汽接触以选择性地将亚磷酸酯水解成亚磷酸。 进料混合物可以通过在醇存在下氧化元素磷来制备。 在氧化和/或随后的酯化步骤中，在氧化反应中产生的P（III）和P（V）含氧酸优选定量地酯化。 可以洗涤酯混合物以除去未酯化的磷酸和次磷酸，然后进行选择性水解。

    POLYMER INTERLAYERS COMPRISING EPOXIDIZED VEGETABLE OIL
    8.
    发明申请
    POLYMER INTERLAYERS COMPRISING EPOXIDIZED VEGETABLE OIL 审中-公开
    包含环氧化蔬菜油的聚合物中间层

    公开(公告)号：US20130074931A1

    公开(公告)日：2013-03-28

    申请号：US13240834

    申请日：2011-09-22

    申请人： Wenjie Chen ,  Yinong Ma

    发明人： Wenjie Chen ,  Yinong Ma

    IPC分类号： B32B27/42 ,  H01L31/0203 ,  C08K5/1515 ,  B32B27/06

    CPC分类号： C08K5/1515 ,  B32B17/10605 ,  B32B17/10761 ,  C08K5/103 ,  C08K5/11 ,  C08L29/14 ,  H01L31/0481 ,  Y02E10/50 ,  Y10T428/31844

    摘要： An interlayer comprised of a thermoplastic resin, varying amounts of an epoxidized vegetable oil, and, optionally, a conventional plasticizer. The use of a thermoplastic resin, an epoxidized vegetable (plant) oil, and, optionally, a conventional plasticizer creates synergy allowing the flow of the interlayer to be increased without sacrificing other characteristics typically associated with an increased flow (e.g., increased blocking and creep, exudation, surface roughness formation, decreased mechanical strength, and decreased manufacturing capability). In this regard, the epoxidized vegetable oil acts as a flow improvement agent, resulting in a high-flow interlayer. As a result, a thinner interlayer can be utilized in forming multiple layer panels because the resulting thinner interlayer has improved flow properties.

    摘要翻译： 由热塑性树脂，不同量的环氧化植物油和任选的常规增塑剂组成的中间层。 使用热塑性树脂，环氧化植物油（植物）油和任选的常规增塑剂产生协同作用，允许中间层的流动增加而不牺牲通常与增加的流动相关的其它特征（例如，增加的阻塞和蠕变 ，渗出，表面粗糙度形成，机械强度降低，制造能力下降）。 在这方面，环氧化植物油用作流动改进剂，导致高流动中间层。 结果，由于所形成的较薄的夹层具有改善的流动性，所以可以将较薄的中间层用于形成多层板。