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公开(公告)号：US20140091012A1
公开(公告)日：2014-04-03
申请号：US14041712
申请日：2013-09-30
IPC分类号： B03C7/02
CPC分类号： B03C7/02 , B01L3/502753 , B01L2200/0652 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2400/086 , B03C5/005 , B03C5/026 , B03C2201/26
摘要： A microfluidic device for size-based particle separation and methods for its use, where the microfluidic device comprises: (a) an inlet reservoir, where the inlet reservoir is configured for communication with an inlet electrode, (b) an insulator constriction coupled to the inlet reservoir via a microchannel, where the insulator constriction comprises an insulating material, and (c) a plurality of outlet channels each defining a first end and a second end, where the first end of each of the plurality of outlet channels is coupled to the insulator constriction, where the second end of each of the plurality of outlet channels is coupled to one of a plurality of outlet reservoirs, and where the plurality of outlet reservoirs are configured for communication with one or more outlet electrodes.
摘要翻译： 一种用于基于尺寸的颗粒分离的微流体装置及其使用方法，其中所述微流体装置包括：（a）入口储存器，其中所述入口储存器被配置为与入口电极连通，（b）绝缘体收缩部， 入口储存器，其中所述绝缘体收缩部包括绝缘材料，以及（c）多个出口通道，每个出口通道限定第一端和第二端，其中所述多个出口通道中的每一个的第一端连接到所述入口储存器， 绝缘体收缩，其中多个出口通道中的每一个的第二端联接到多个出口储存器中的一个，并且其中多个出口储存器被配置为与一个或多个出口电极连通。
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公开(公告)号：US09192944B2
公开(公告)日：2015-11-24
申请号：US14041712
申请日：2013-09-30
CPC分类号： B03C7/02 , B01L3/502753 , B01L2200/0652 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2400/086 , B03C5/005 , B03C5/026 , B03C2201/26
摘要： A microfluidic device for size-based particle separation and methods for its use, where the microfluidic device comprises: (a) an inlet reservoir, where the inlet reservoir is configured for communication with an inlet electrode, (b) an insulator constriction coupled to the inlet reservoir via a microchannel, where the insulator constriction comprises an insulating material, and (c) a plurality of outlet channels each defining a first end and a second end, where the first end of each of the plurality of outlet channels is coupled to the insulator constriction, where the second end of each of the plurality of outlet channels is coupled to one of a plurality of outlet reservoirs, and where the plurality of outlet reservoirs are configured for communication with one or more outlet electrodes.
摘要翻译： 一种用于基于尺寸的颗粒分离的微流体装置及其使用方法，其中所述微流体装置包括：（a）入口储存器，其中所述入口储存器被配置为与入口电极连通，（b）绝缘体收缩部， 入口储存器，其中所述绝缘体收缩部包括绝缘材料，以及（c）多个出口通道，每个出口通道限定第一端和第二端，其中所述多个出口通道中的每一个的第一端连接到所述入口储存器， 绝缘体收缩，其中多个出口通道中的每一个的第二端联接到多个出口储存器中的一个，并且其中多个出口储存器被配置为与一个或多个出口电极连通。
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公开(公告)号：US10722889B2
公开(公告)日：2020-07-28
申请号：US16237158
申请日：2018-12-31
申请人： Alexandra Ros , Bahige G. Abdallah
发明人： Alexandra Ros , Bahige G. Abdallah
摘要： A microfluidic apparatus, systems and methods for microfluidic crystallization based on gradient mixing. In one embodiment, the apparatus includes (a) a first layer, (b) a plurality of first channels and a plurality of vacuum chambers both arranged in the first layer, where the plurality of vacuum chambers are each coupled to at least one of the first channels, (c) a membrane having first and second surfaces, where the first surface of the membrane is coupled to the first layer, (d) a second layer coupled to the second surface of the membrane, (e) a plurality of wells and a plurality of second channels both arranged in the second layer, where the wells are each coupled to at least one of the plurality of second channels and (f) a plurality of barrier walls each disposed in the plurality of second channels and arranged opposite to one of the plurality of vacuum chambers.
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4.发明申请公开(公告)号：US20190134631A1
公开(公告)日：2019-05-09
申请号：US16237158
申请日：2018-12-31
申请人： Alexandra Ros , Bahige G. Abdallah
发明人： Alexandra Ros , Bahige G. Abdallah
CPC分类号： B01L3/502761 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/0652 , B01L2300/0654 , B01L2300/0816 , B01L2300/0848 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/0896 , B01L2300/123 , B01L2300/16 , B01L2400/0424 , B01L2400/0487 , B01L2400/049 , B01L2400/0655 , G01N1/38
摘要： A microfluidic apparatus, systems and methods for microfluidic crystallization based on gradient mixing. In one embodiment, the apparatus includes (a) a first layer, (b) a plurality of first channels and a plurality of vacuum chambers both arranged in the first layer, where the plurality of vacuum chambers are each coupled to at least one of the first channels, (c) a membrane having first and second surfaces, where the first surface of the membrane is coupled to the first layer, (d) a second layer coupled to the second surface of the membrane, (e) a plurality of wells and a plurality of second channels both arranged in the second layer, where the wells are each coupled to at least one of the plurality of second channels and (f) a plurality of barrier walls each disposed in the plurality of second channels and arranged opposite to one of the plurality of vacuum chambers.
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公开(公告)号：US10166542B2
公开(公告)日：2019-01-01
申请号：US15510126
申请日：2015-09-17
申请人： Alexandra Ros , Bahige G. Abdallah
发明人： Alexandra Ros , Bahige G. Abdallah
摘要： A microfluidic apparatus, systems and methods for microfluidic crystallization based on gradient mixing. In one embodiment, the apparatus includes (a) a first layer, (b) a plurality of first channels and a plurality of vacuum chambers both arranged in the first layer, where the plurality of vacuum chambers are each coupled to at least one of the first channels, (c) a membrane having first and second surfaces, where the first surface of the membrane is coupled to the first layer, (d) a second layer coupled to the second surface of the membrane, (e) a plurality of wells and a plurality of second channels both arranged in the second layer, where the wells are each coupled to at least one of the plurality of second channels and (f) a plurality of barrier walls each disposed in the plurality of second channels and arranged opposite to one of the plurality of vacuum chambers.
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公开(公告)号：US20240216914A1
公开(公告)日：2024-07-04
申请号：US18603030
申请日：2024-03-12
申请人： Alexandra Ros , Daihyun Kim , Jinghui Luo
发明人： Alexandra Ros , Daihyun Kim , Jinghui Luo
CPC分类号： B01L3/502715 , B01L3/502753 , B01L3/502761 , B03C5/005 , B03C5/026 , B03C5/028 , B01L3/50273 , B01L2200/0647 , B01L2200/0652 , B01L2300/0816 , B01L2400/0406 , B01L2400/0415 , B01L2400/0424 , B01L2400/086 , B03C2201/26 , G01N2001/4038 , G01N2015/0038
摘要： Sub-micrometer bioparticles are separated by size in a microfluidic channel utilizing a ratchet migration mechanism. A structure within the microfluidic channel includes an array of micro-posts arranged in laterally shifted rows. Reservoirs are disposed at each end of the microfluidic channel. A biased AC potential is applied across the channel via electrodes immersed into fluid in each of the reservoirs to induce a non-uniform electric field through the microfluidic channel. The applied potential comprises a first waveform with a first frequency that induces electro-kinetic flow of sub-micrometer bioparticles in the microfluidic channel, and an intermittent superimposed second waveform with a higher frequency. The second waveform selectively induces a dielectrophoretic trapping force to selectively impart ratchet migration based on particle size for separating the sub-micrometer bioparticles by size in the microfluidic channel.
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公开(公告)号：US11944967B2
公开(公告)日：2024-04-02
申请号：US17524976
申请日：2021-11-12
申请人： Alexandra Ros , Daihyun Kim , Jinghui Luo
发明人： Alexandra Ros , Daihyun Kim , Jinghui Luo
CPC分类号： B01L3/502715 , B01L3/502753 , B01L3/502761 , B03C5/005 , B03C5/026 , B03C5/028 , B01L3/50273 , B01L2200/0647 , B01L2200/0652 , B01L2300/0816 , B01L2400/0406 , B01L2400/0415 , B01L2400/0424 , B01L2400/086 , B03C2201/26 , G01N2001/4038 , G01N2015/0038
摘要： Sub-micrometer bioparticles are separated by size in a microfluidic channel utilizing a ratchet migration mechanism. A structure within the microfluidic channel includes an array of micro-posts arranged in laterally shifted rows. Reservoirs are disposed at each end of the microfluidic channel. A biased AC potential is applied across the channel via electrodes immersed into fluid in each of the reservoirs to induce a non-uniform electric field through the microfluidic channel. The applied potential comprises a first waveform with a first frequency that induces electro-kinetic flow of sub-micrometer bioparticles in the microfluidic channel, and an intermittent superimposed second waveform with a higher frequency. The second waveform selectively induces a dielectrophoretic trapping force to selectively impart ratchet migration based on particle size for separating the sub-micrometer bioparticles by size in the microfluidic channel.
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公开(公告)号：US20230243765A1
公开(公告)日：2023-08-03
申请号：US18295761
申请日：2023-04-04
申请人： Alexandra Ros , Daihyun Kim , Diandra Doppler , Jorvani Cruz Villarreal , Richard Kirian , Reza Nazari , Sahir Gandhi
发明人： Alexandra Ros , Daihyun Kim , Diandra Doppler , Jorvani Cruz Villarreal , Richard Kirian , Reza Nazari , Sahir Gandhi
IPC分类号： G01N23/20025 , G01N23/201 , B01L3/02 , G01N35/10 , B01L3/00
CPC分类号： G01N23/20025 , G01N23/201 , B01L3/0241 , G01N35/1016 , B01L3/502715 , G01N2223/30 , G01N2223/604 , G01N2223/612 , G01N2223/637 , G01N2223/1016 , G01N2223/203 , G01N2223/054 , G01N2035/1034 , B01L2300/0645
摘要： A single-piece hybrid droplet generator and nozzle component for serial crystallography. The single-piece hybrid droplet generator component including an internally-formed droplet-generation channel, an internally-formed sample channel, a nozzle, and a pair of electrode chambers. The droplet-generation channel extends from a first fluid inlet opening to the nozzle. The sample channel extends from a second fluid inlet opening to the droplet-generation channel and joins the droplet-generation channel at a junction. The nozzle is configured to eject a stream of segmented aqueous droplets in a carrier fluid from the droplet-generation channel through a nozzle opening of the single-piece component. The pair of electrode chambers are positioned adjacent to the droplet-generation channel near the junction between the droplet-generation channel and the sample channel. The timing of sample droplets in the stream of fluid ejected through the nozzle is controlled by applying a triggering signal to electrodes positioned in the electrode chambers of the single-piece component.
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公开(公告)号：US11649173B2
公开(公告)日：2023-05-16
申请号：US17237836
申请日：2021-04-22
申请人： Ana Egatz-Gomez , Alexandra Ros
发明人： Ana Egatz-Gomez , Alexandra Ros
IPC分类号： C01F17/36 , B01J19/12 , B01J19/00 , C09K11/02 , C01F17/265 , C09K11/77 , B82Y30/00 , B82Y40/00
CPC分类号： C01F17/36 , B01J19/0013 , B01J19/126 , C01F17/265 , C09K11/025 , C09K11/7773 , B01J2219/00033 , B01J2219/00141 , B01J2219/00162 , B01J2219/00166 , B82Y30/00 , B82Y40/00 , C01P2004/38 , C01P2004/64 , C01P2006/60
摘要： Synthesizing upconverting nanoparticles includes heating a precursor solution comprising one or more rare earth salts, an alkali metal salt or alkaline earth salt, and a solvent comprising a plasticizer in a microwave reactor to yield a product mixture, and cooling the product mixture to yield the upconverting nanoparticles. Core-shell upconverting nanoparticles are synthesized by combining the upconverting nanoparticles with a precursor solution comprising one or more rare earth salts, an alkali metal salt or alkaline earth salt, and a solvent comprising a plasticizer to yield a nanoparticle mixture, heating the nanoparticle mixture in a microwave reactor to yield a product mixture, and cooling the product mixture to yield the core-shell upconverting nanoparticles.
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公开(公告)号：US20220112079A1
公开(公告)日：2022-04-14
申请号：US17497675
申请日：2021-10-08
申请人： Alexandra Ros , John Spence , Diandra Doppler , Garrett Nelson , Richard Kirian , Reza Nazari , Ana Egatz-Gomez , Mukul Sonker , Mohammad Rabbani
发明人： Alexandra Ros , John Spence , Diandra Doppler , Garrett Nelson , Richard Kirian , Reza Nazari , Ana Egatz-Gomez , Mukul Sonker , Mohammad Rabbani
摘要： A microfluidic device for use in a serial crystallography apparatus includes a nozzle having an inlet, an outlet, and a first snap engagement feature. The microfluidic device further includes a fiber holder having an outlet and a second snap engagement feature. The first snap engagement feature is configured to engage the second snap engagement feature to removably couple the nozzle to the fiber holder. The outlet of the fiber holder is aligned with the inlet of the nozzle when the first snap engagement feature is coupled to the second snap engagement feature.
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