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    Methods, systems and apparatus for microfluidic crystallization based on gradient mixing
    1.
    发明授权
    Methods, systems and apparatus for microfluidic crystallization based on gradient mixing 有权

    公开(公告)号：US10722889B2

    公开(公告)日：2020-07-28

    申请号：US16237158

    申请日：2018-12-31

    申请人： Alexandra Ros ,  Bahige G. Abdallah

    发明人： Alexandra Ros ,  Bahige G. Abdallah

    IPC分类号： C30B7/08 ,  B01L3/00 ,  G01N1/38

    摘要： A microfluidic apparatus, systems and methods for microfluidic crystallization based on gradient mixing. In one embodiment, the apparatus includes (a) a first layer, (b) a plurality of first channels and a plurality of vacuum chambers both arranged in the first layer, where the plurality of vacuum chambers are each coupled to at least one of the first channels, (c) a membrane having first and second surfaces, where the first surface of the membrane is coupled to the first layer, (d) a second layer coupled to the second surface of the membrane, (e) a plurality of wells and a plurality of second channels both arranged in the second layer, where the wells are each coupled to at least one of the plurality of second channels and (f) a plurality of barrier walls each disposed in the plurality of second channels and arranged opposite to one of the plurality of vacuum chambers.

    Methods, Systems and Apparatus for Size-Based Particle Separation
    3.
    发明申请
    Methods, Systems and Apparatus for Size-Based Particle Separation 有权
    用于大小粒子分离的方法，系统和装置

    公开(公告)号：US20140091012A1

    公开(公告)日：2014-04-03

    申请号：US14041712

    申请日：2013-09-30

    申请人： Alexandra Ros ,  Bahige G. Abdallah ,  Tzu-Chiao Chao

    发明人： Alexandra Ros ,  Bahige G. Abdallah ,  Tzu-Chiao Chao

    IPC分类号： B03C7/02

    CPC分类号： B03C7/02 ,  B01L3/502753 ,  B01L2200/0652 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2400/086 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26

    摘要： A microfluidic device for size-based particle separation and methods for its use, where the microfluidic device comprises: (a) an inlet reservoir, where the inlet reservoir is configured for communication with an inlet electrode, (b) an insulator constriction coupled to the inlet reservoir via a microchannel, where the insulator constriction comprises an insulating material, and (c) a plurality of outlet channels each defining a first end and a second end, where the first end of each of the plurality of outlet channels is coupled to the insulator constriction, where the second end of each of the plurality of outlet channels is coupled to one of a plurality of outlet reservoirs, and where the plurality of outlet reservoirs are configured for communication with one or more outlet electrodes.

    摘要翻译： 一种用于基于尺寸的颗粒分离的微流体装置及其使用方法，其中所述微流体装置包括：（a）入口储存器，其中所述入口储存器被配置为与入口电极连通，（b）绝缘体收缩部， 入口储存器，其中所述绝缘体收缩部包括绝缘材料，以及（c）多个出口通道，每个出口通道限定第一端和第二端，其中所述多个出口通道中的每一个的第一端连接到所述入口储存器， 绝缘体收缩，其中多个出口通道中的每一个的第二端联接到多个出口储存器中的一个，并且其中多个出口储存器被配置为与一个或多个出口电极连通。

    Methods, systems and apparatus for microfluidic crystallization based on gradient mixing
    4.
    发明授权
    Methods, systems and apparatus for microfluidic crystallization based on gradient mixing 有权

    公开(公告)号：US10166542B2

    公开(公告)日：2019-01-01

    申请号：US15510126

    申请日：2015-09-17

    申请人： Alexandra Ros ,  Bahige G. Abdallah

    发明人： Alexandra Ros ,  Bahige G. Abdallah

    IPC分类号： C30B7/08 ,  B01L3/00 ,  G01N1/38

    摘要： A microfluidic apparatus, systems and methods for microfluidic crystallization based on gradient mixing. In one embodiment, the apparatus includes (a) a first layer, (b) a plurality of first channels and a plurality of vacuum chambers both arranged in the first layer, where the plurality of vacuum chambers are each coupled to at least one of the first channels, (c) a membrane having first and second surfaces, where the first surface of the membrane is coupled to the first layer, (d) a second layer coupled to the second surface of the membrane, (e) a plurality of wells and a plurality of second channels both arranged in the second layer, where the wells are each coupled to at least one of the plurality of second channels and (f) a plurality of barrier walls each disposed in the plurality of second channels and arranged opposite to one of the plurality of vacuum chambers.

    Methods, systems and apparatus for size-based particle separation
    5.
    发明授权
    Methods, systems and apparatus for size-based particle separation 有权
    用于基于尺寸的颗粒分离的方法，系统和装置

    公开(公告)号：US09192944B2

    公开(公告)日：2015-11-24

    申请号：US14041712

    申请日：2013-09-30

    申请人： Alexandra Ros ,  Bahige G. Abdallah ,  Tzu-Chiao Chao

    发明人： Alexandra Ros ,  Bahige G. Abdallah ,  Tzu-Chiao Chao

    IPC分类号： B03C7/02 ,  B03C5/00 ,  B03C5/02 ,  B01L3/00

    CPC分类号： B03C7/02 ,  B01L3/502753 ,  B01L2200/0652 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2400/086 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/26

    摘要： A microfluidic device for size-based particle separation and methods for its use, where the microfluidic device comprises: (a) an inlet reservoir, where the inlet reservoir is configured for communication with an inlet electrode, (b) an insulator constriction coupled to the inlet reservoir via a microchannel, where the insulator constriction comprises an insulating material, and (c) a plurality of outlet channels each defining a first end and a second end, where the first end of each of the plurality of outlet channels is coupled to the insulator constriction, where the second end of each of the plurality of outlet channels is coupled to one of a plurality of outlet reservoirs, and where the plurality of outlet reservoirs are configured for communication with one or more outlet electrodes.

    摘要翻译： 一种用于基于尺寸的颗粒分离的微流体装置及其使用方法，其中所述微流体装置包括：（a）入口储存器，其中所述入口储存器被配置为与入口电极连通，（b）绝缘体收缩部， 入口储存器，其中所述绝缘体收缩部包括绝缘材料，以及（c）多个出口通道，每个出口通道限定第一端和第二端，其中所述多个出口通道中的每一个的第一端连接到所述入口储存器， 绝缘体收缩，其中多个出口通道中的每一个的第二端联接到多个出口储存器中的一个，并且其中多个出口储存器被配置为与一个或多个出口电极连通。