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公开(公告)号：US20240216914A1
公开(公告)日：2024-07-04
申请号：US18603030
申请日：2024-03-12
申请人： Alexandra Ros , Daihyun Kim , Jinghui Luo
发明人： Alexandra Ros , Daihyun Kim , Jinghui Luo
CPC分类号： B01L3/502715 , B01L3/502753 , B01L3/502761 , B03C5/005 , B03C5/026 , B03C5/028 , B01L3/50273 , B01L2200/0647 , B01L2200/0652 , B01L2300/0816 , B01L2400/0406 , B01L2400/0415 , B01L2400/0424 , B01L2400/086 , B03C2201/26 , G01N2001/4038 , G01N2015/0038
摘要： Sub-micrometer bioparticles are separated by size in a microfluidic channel utilizing a ratchet migration mechanism. A structure within the microfluidic channel includes an array of micro-posts arranged in laterally shifted rows. Reservoirs are disposed at each end of the microfluidic channel. A biased AC potential is applied across the channel via electrodes immersed into fluid in each of the reservoirs to induce a non-uniform electric field through the microfluidic channel. The applied potential comprises a first waveform with a first frequency that induces electro-kinetic flow of sub-micrometer bioparticles in the microfluidic channel, and an intermittent superimposed second waveform with a higher frequency. The second waveform selectively induces a dielectrophoretic trapping force to selectively impart ratchet migration based on particle size for separating the sub-micrometer bioparticles by size in the microfluidic channel.
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公开(公告)号：US11944967B2
公开(公告)日：2024-04-02
申请号：US17524976
申请日：2021-11-12
申请人： Alexandra Ros , Daihyun Kim , Jinghui Luo
发明人： Alexandra Ros , Daihyun Kim , Jinghui Luo
CPC分类号： B01L3/502715 , B01L3/502753 , B01L3/502761 , B03C5/005 , B03C5/026 , B03C5/028 , B01L3/50273 , B01L2200/0647 , B01L2200/0652 , B01L2300/0816 , B01L2400/0406 , B01L2400/0415 , B01L2400/0424 , B01L2400/086 , B03C2201/26 , G01N2001/4038 , G01N2015/0038
摘要： Sub-micrometer bioparticles are separated by size in a microfluidic channel utilizing a ratchet migration mechanism. A structure within the microfluidic channel includes an array of micro-posts arranged in laterally shifted rows. Reservoirs are disposed at each end of the microfluidic channel. A biased AC potential is applied across the channel via electrodes immersed into fluid in each of the reservoirs to induce a non-uniform electric field through the microfluidic channel. The applied potential comprises a first waveform with a first frequency that induces electro-kinetic flow of sub-micrometer bioparticles in the microfluidic channel, and an intermittent superimposed second waveform with a higher frequency. The second waveform selectively induces a dielectrophoretic trapping force to selectively impart ratchet migration based on particle size for separating the sub-micrometer bioparticles by size in the microfluidic channel.
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公开(公告)号：US20060220997A1
公开(公告)日：2006-10-05
申请号：US11391296
申请日：2006-03-29
申请人： Byeong Ahn , Seung Baek , Namjin Kim , Seonghak Moon , Joo Lee , Daihyun Kim
发明人： Byeong Ahn , Seung Baek , Namjin Kim , Seonghak Moon , Joo Lee , Daihyun Kim
IPC分类号： G09G3/28
CPC分类号： G09G3/291 , G09G3/2965 , G09G2310/0218 , G09G2310/0232 , G09G2310/04 , G09G2320/0238 , G09G2330/021 , G09G2340/0442
摘要： A plasma display apparatus and a method of driving the plasma display apparatus are provided. The plasma display apparatus sets a part of the entire image signal corresponding to a specific region of a plasma display panel to a gray level value 0.
摘要翻译： 提供等离子体显示装置和驱动等离子体显示装置的方法。 等离子体显示装置将对应于等离子体显示面板的特定区域的整个图像信号的一部分设置为灰度值0。
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公开(公告)号：US20230243765A1
公开(公告)日：2023-08-03
申请号：US18295761
申请日：2023-04-04
申请人： Alexandra Ros , Daihyun Kim , Diandra Doppler , Jorvani Cruz Villarreal , Richard Kirian , Reza Nazari , Sahir Gandhi
发明人： Alexandra Ros , Daihyun Kim , Diandra Doppler , Jorvani Cruz Villarreal , Richard Kirian , Reza Nazari , Sahir Gandhi
IPC分类号： G01N23/20025 , G01N23/201 , B01L3/02 , G01N35/10 , B01L3/00
CPC分类号： G01N23/20025 , G01N23/201 , B01L3/0241 , G01N35/1016 , B01L3/502715 , G01N2223/30 , G01N2223/604 , G01N2223/612 , G01N2223/637 , G01N2223/1016 , G01N2223/203 , G01N2223/054 , G01N2035/1034 , B01L2300/0645
摘要： A single-piece hybrid droplet generator and nozzle component for serial crystallography. The single-piece hybrid droplet generator component including an internally-formed droplet-generation channel, an internally-formed sample channel, a nozzle, and a pair of electrode chambers. The droplet-generation channel extends from a first fluid inlet opening to the nozzle. The sample channel extends from a second fluid inlet opening to the droplet-generation channel and joins the droplet-generation channel at a junction. The nozzle is configured to eject a stream of segmented aqueous droplets in a carrier fluid from the droplet-generation channel through a nozzle opening of the single-piece component. The pair of electrode chambers are positioned adjacent to the droplet-generation channel near the junction between the droplet-generation channel and the sample channel. The timing of sample droplets in the stream of fluid ejected through the nozzle is controlled by applying a triggering signal to electrodes positioned in the electrode chambers of the single-piece component.
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公开(公告)号：US20190184395A1
公开(公告)日：2019-06-20
申请号：US16226165
申请日：2018-12-19
申请人： Alexandra Ros , Daihyun Kim , Jinghui Luo
发明人： Alexandra Ros , Daihyun Kim , Jinghui Luo
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2400/0406 , B01L2400/0424
摘要： Sub-micrometer bioparticles are separated by size in a microfluidic channel utilizing a ratchet migration mechanism. A structure within the microfluidic channel includes an array of micro-posts arranged in laterally shifted rows. Reservoirs are disposed at each end of the microfluidic channel. A biased AC potential is applied across the channel via electrodes immersed into fluid in each of the reservoirs to induce a non-uniform electric field through the microfluidic channel. The applied potential comprises a first waveform with a first frequency that induces electro-kinetic flow of sub-micrometer bioparticles in the microfluidic channel, and an intermittent superimposed second waveform with a higher frequency. The second waveform selectively induces a dielectrophoretic trapping force to selectively impart ratchet migration based on particle size for separating the sub-micrometer bioparticles by size in the microfluidic channel.
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公开(公告)号：US11318487B2
公开(公告)日：2022-05-03
申请号：US15930239
申请日：2020-05-12
申请人： Alexandra Ros , Daihyun Kim , Austin Echelmeier , Jorvani Cruz Villarreal , Diandra Doppler , Richard Kirian , Reza Nazari
发明人： Alexandra Ros , Daihyun Kim , Austin Echelmeier , Jorvani Cruz Villarreal , Diandra Doppler , Richard Kirian , Reza Nazari
IPC分类号： B05B7/04 , G01N23/20008
摘要： Systems and methods for performing serial crystallography by providing an aqueous suspension of a crystal sample to a T-junction at a first flow rate and providing an immiscible oil fluid to the T-junction at a second flow rate. The aqueous suspension and the oil are combined at the T-junction to produce a co-flow output fluid including a parallel co-flow of the aqueous suspension and the oil in the same output channel. The co-flow output fluid is ejected as a jet stream through a nozzle and the sample flow rate in the crystal sample in the jet stream is adjusted by adjusting the first flow rate of the aqueous suspension and the second flow rate of the oil. By combining the aqueous sample and the oil in this manner, the output of the jet stream can be regulated for compatibility with X-ray free electron laser serial crystallography.
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公开(公告)号：US20220072542A1
公开(公告)日：2022-03-10
申请号：US17524976
申请日：2021-11-12
申请人： Alexandra Ros , Daihyun Kim , Jinghui Luo
发明人： Alexandra Ros , Daihyun Kim , Jinghui Luo
摘要： Sub-micrometer bioparticles are separated by size in a microfluidic channel utilizing a ratchet migration mechanism. A structure within the microfluidic channel includes an array of micro-posts arranged in laterally shifted rows. Reservoirs are disposed at each end of the microfluidic channel. A biased AC potential is applied across the channel via electrodes immersed into fluid in each of the reservoirs to induce a non-uniform electric field through the microfluidic channel. The applied potential comprises a first waveform with a first frequency that induces electro-kinetic flow of sub-micrometer bioparticles in the microfluidic channel, and an intermittent superimposed second waveform with a higher frequency. The second waveform selectively induces a dielectrophoretic trapping force to selectively impart ratchet migration based on particle size for separating the sub-micrometer bioparticles by size in the microfluidic channel.
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公开(公告)号：US11173487B2
公开(公告)日：2021-11-16
申请号：US16226165
申请日：2018-12-19
申请人： Alexandra Ros , Daihyun Kim , Jinghui Luo
发明人： Alexandra Ros , Daihyun Kim , Jinghui Luo
摘要： Sub-micrometer bioparticles are separated by size in a microfluidic channel utilizing a ratchet migration mechanism. A structure within the microfluidic channel includes an array of micro-posts arranged in laterally shifted rows. Reservoirs are disposed at each end of the microfluidic channel. A biased AC potential is applied across the channel via electrodes immersed into fluid in each of the reservoirs to induce a non-uniform electric field through the microfluidic channel. The applied potential comprises a first waveform with a first frequency that induces electro-kinetic flow of sub-micrometer bioparticles in the microfluidic channel, and an intermittent superimposed second waveform with a higher frequency. The second waveform selectively induces a dielectrophoretic trapping force to selectively impart ratchet migration based on particle size for separating the sub-micrometer bioparticles by size in the microfluidic channel.
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公开(公告)号：US11624718B2
公开(公告)日：2023-04-11
申请号：US15930313
申请日：2020-05-12
申请人： Alexandra Ros , Daihyun Kim , Diandra Doppler , Jorvani Cruz Villarreal , Richard Kirian , Reza Nazari , Sahir Gandhi
发明人： Alexandra Ros , Daihyun Kim , Diandra Doppler , Jorvani Cruz Villarreal , Richard Kirian , Reza Nazari , Sahir Gandhi
IPC分类号： B01L3/00 , G01N23/20025 , G01N23/201 , B01L3/02 , G01N35/10 , G01N23/20
摘要： A single-piece hybrid droplet generator and nozzle component for serial crystallography. The single-piece hybrid droplet generator component including an internally-formed droplet-generation channel, an internally-formed sample channel, a nozzle, and a pair of electrode chambers. The droplet-generation channel extends from a first fluid inlet opening to the nozzle. The sample channel extends from a second fluid inlet opening to the droplet-generation channel and joins the droplet-generation channel at a junction. The nozzle is configured to eject a stream of segmented aqueous droplets in a carrier fluid from the droplet-generation channel through a nozzle opening of the single-piece component. The pair of electrode chambers are positioned adjacent to the droplet-generation channel near the junction between the droplet-generation channel and the sample channel. The timing of sample droplets in the stream of fluid ejected through the nozzle is controlled by applying a triggering signal to electrodes positioned in the electrode chambers of the single-piece component.
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公开(公告)号：US20190224689A1
公开(公告)日：2019-07-25
申请号：US16317481
申请日：2017-07-12
申请人： Alexandra Ros , Daihyun Kim , Jinghui Luo , Mian Yang
发明人： Alexandra Ros , Daihyun Kim , Jinghui Luo , Mian Yang
IPC分类号： B03C5/00 , G01N27/447 , B03C5/02
摘要： Methods and systems are described for tuning an electrical field gradient for insulator-based di electrophoresis (iDEP). A fluidic layer defines a fluidic channel adjacent to a substrate. A deformable membrane is positioned adjacent to the fluidic channel. An actuator controllably causes the deformable membrane to deflect into the fluidic channel restricting a fluidic flow in the fluidic channel. A control system is configured to tune an electrical field gradient by operating the actuator to adjust a magnitude of the deflection of the deformable membrane into the fluidic channel.
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