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    POLYURETHANE NANOMETER POWDER OF WHICH SURFACE IS MODIFIED WITH PHOSPHORIC ACID AND ITS PREPARATION METHOD
    3.
    发明申请
    POLYURETHANE NANOMETER POWDER OF WHICH SURFACE IS MODIFIED WITH PHOSPHORIC ACID AND ITS PREPARATION METHOD 审中-公开
    表面改性磷酸铵的聚氨酯纳米粒子粉末及其制备方法

    公开(公告)号：US20110003155A1

    公开(公告)日：2011-01-06

    申请号：US12819297

    申请日：2010-06-21

    申请人： Jian Shen ,  Xiaohua Huang ,  Hongke Liu ,  Dan Zhu ,  Jianchun Bao ,  Chun Mao

    发明人： Jian Shen ,  Xiaohua Huang ,  Hongke Liu ,  Dan Zhu ,  Jianchun Bao ,  Chun Mao

    IPC分类号： B32B5/16 ,  B05D7/02 ,  B06B1/20

    CPC分类号： C08J3/12 ,  C08G18/0823 ,  C08G18/12 ,  C08G18/4854 ,  C08G18/6692 ,  C08G18/7671 ,  C08G18/836 ,  C08J3/16 ,  C08J2375/04 ,  Y10T428/2998 ,  C08G18/2825

    摘要： The present invention relates to a surface chemically modified organic high polymer nanometer powder and its preparation method. The phosphoric acid modified nanometer powdery material of the present invention is polyether polyurethane or polyester polyurethane nanometer powder. The surface of the powder has self-assembled phosphate groups. It is prepared by the following method: phosphate groups are introduced into polyether polyurethane or polyester polyurethane nanometer powder in a phosphoric acid buffer solution by means of physical adsorption. This method can improve the stability and dispersibility of the powder and change its physical, chemical and biological properties and hopefully will realize intensive and extensive application in biomedical field. The surface modified nanometer powder of the present invention is in a controllable size of 50 nm˜500 nm and its surface Zeta potential in physiological environment is negative. The present invention is characterized by simple process route, small energy consumption and no pollution. It provides a new thought for the surface modification of organic high polymer nanometer powder and also widens the road of the development and utilization of high polymer nanometer medical material.

    摘要翻译： 本发明涉及表面化学改性有机高分子纳米粉体及其制备方法。 本发明的磷酸改性纳米粉末材料是聚醚聚氨酯或聚酯聚氨酯纳米粉末。 粉末的表面具有自组装磷酸盐基团。 通过以下方法制备：通过物理吸附将磷酸基团引入磷酸缓冲溶液中的聚醚聚氨酯或聚酯聚氨酯纳米粉末中。 该方法可以提高粉末的稳定性和分散性，改变其物理，化学和生物学性质，有望在生物医学领域得到广泛应用。 本发明的表面改性纳米粉末的可控尺寸为50nm〜500nm，其生理环境中的表面ζ电位为负。 本发明的特点是工艺路线简单，能耗小，无污染。 为有机高分子纳米粉末的表面改性提供了新的思路，也拓宽了高分子纳米医药材料开发利用的道路。

    Capillary device
    5.
    发明授权
    Capillary device 失效
    毛细管装置

    公开(公告)号：US5298134A

    公开(公告)日：1994-03-29

    申请号：US64849

    申请日：1993-05-20

    申请人： Richard N. Zare ,  Xiaohua Huang ,  Stephen L. Pentoney, Jr.

    发明人： Richard N. Zare ,  Xiaohua Huang ,  Stephen L. Pentoney, Jr.

    IPC分类号： G01N27/447 ,  G01N30/02 ,  G01N30/16 ,  G01N30/28 ,  G01N30/60 ,  G01N30/84 ,  G01N27/26

    CPC分类号： G01N30/6039 ,  G01N27/44717 ,  G01N27/44773 ,  G01N30/16 ,  G01N2030/027 ,  G01N2030/162 ,  G01N2030/285 ,  G01N2030/8435 ,  G01N30/02

    摘要： A cross or T-shaped device is disclosed for use in capillary electrophoresis or capillary chromatography. The device includes a first capillary tube and a second capillary tube connected to the first tube at a point between the two ends of the first tube so that the contents flowing in the second tube will mix with a fluid flowing in the first tube. The two tubes enclose spaces with cross-sectional dimensions less than about 200 microns. The two tubes are connected so that there is substantially no dead space at the connection. The device is made by boring a hole at a selected location in the first tube, introducing an elongated guide member into the hole, threading the member into the second tube until the second tube contacts the first tube. The second tube is then permanently connected to the first tube and the guide member is then removed to form a T-shaped device. To form the cross-shaped device, a second hole is drilled at a location opposite to the first hole and a guide member is introduced into the second hole as well. A third tube is threaded onto the guide member on the opposite side of the second tube until it contacts the first tube. The third tube is also permanently connected to the first tube and the guide member is removed to yield a device with a cross-shaped configuration.

    摘要翻译： 公开了用于毛细管电泳或毛细管色谱中的十字或T形装置。 该装置包括第一毛细管和第二毛细管，第二毛细管在第一管的两端之间的点处连接到第一管，使得在第二管中流动的内容物将与在第一管中流动的流体混合。 两个管围绕截面尺寸小于约200微米的空间。 连接两个管，使得连接处基本上没有死空间。 该装置通过在第一管中的选定位置钻孔，将细长引导构件引入孔中，将构件穿入第二管直到第二管接触第一管而制成。 然后将第二管永久连接到第一管，然后移除引导构件以形成T形装置。 为了形成十字形装置，在与第一孔相对的位置处钻出第二孔，并且引导构件也被引入到第二孔中。 第三管在第二管的相反侧被拧到导向件上，直到它接触第一管。 第三管也永久连接到第一管并且引导构件被移除以产生具有十字形构造的装置。

    Mostly natural DNA sequencing by synthesis
    6.
    发明授权
    Mostly natural DNA sequencing by synthesis 有权
    大部分通过合成进行天然DNA测序

    公开(公告)号：US08772473B2

    公开(公告)日：2014-07-08

    申请号：US13262369

    申请日：2010-03-30

    申请人： Xiaohua Huang ,  Eric Roller

    发明人： Xiaohua Huang ,  Eric Roller

    IPC分类号： C07H21/00

    CPC分类号： C12Q1/6869 ,  C12Q2535/119 ,  C12Q2525/301 ,  C12Q2527/137 ,  C12Q2535/113

    摘要： The invention provides a new method for DNA sequencing called “natural sequencing by synthesis” (nSBS). According to the method, DNA that includes a desired sequence is synthesized using a dNTP mix with a small percentage of fluorescently-labeled nucleotides. The fluorescent label is cleavable. In contrast to previous methods that utilize 100% labeled nucleic acids, use of a small percentage of labeled nucleic acids minimizes the distortion of the natural structure of the extending DNA strand and the DNA polymerase. Using the disclosed methods with less than 10,000 copies of template DNA and 10% of the nucleotides labeled, long homopolymer stretches up to 20 bases can be sequenced with high accuracy and Q20 (with 99% accuracy) read lengths of up to 1,000 bases can be achieved. A Q20 read length of greater than 100 bases can potentially be achieved, even if the sequencing is performed with 1,000 copies of a template and 10% of the nucleotides labeled.

    摘要翻译： 本发明提供了一种称为“合成天然测序”（nSBS）的DNA测序的新方法。 根据该方法，使用具有小百分比的荧光标记核苷酸的dNTP混合物合成包含所需序列的DNA。 荧光标记是可切割的。 与使用100％标记的核酸的先前方法相比，使用小百分比的标记的核酸使延伸的DNA链和DNA聚合酶的天然结构的变形最小化。 使用所公开的方法，使用少于10,000拷贝的模板DNA和10％标记的核苷酸，长均聚物延伸多达20个碱基可以高精度测序，Q20（具有99％的准确度）读取长度可达1,000个碱基可以 实现了 即使用1000份拷贝的模板和10％的标记的核苷酸进行测序，潜在地可以实现大于100个碱基的Q20读取长度。