公开(公告)号：US20110318824A1

公开(公告)日：2011-12-29

申请号：US13149195

申请日：2011-05-31

Applicant: Takeo Tanaami ,  Hisao Katakura ,  Nobuyuki Kakuryu

Inventor： Takeo Tanaami ,  Hisao Katakura ,  Nobuyuki Kakuryu

IPC: C12M1/02

CPC classification number: B01F11/0266 ,  B01L3/502715 ,  B01L7/52 ,  B01L2300/0816 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/1805 ,  B01L2400/0481

Abstract: An end portion of a head has a recess having an inner shape corresponding to a dome shape of a well when the well is in an expanded state. The radius of curvature of the recess is larger than the radius of curvature of the dome shape of the well. Moreover, the depth of the recess is smaller than the height of the dome shape of the well. Therefore, the head first contacts the apex of the well, and the contact area gradually expands toward the outer periphery. At this time, a gap is generated between the head and the cartridge around the well. Thus, the air between the head and the well is expelled from around the well as the head is pressed against the well.

Abstract translation: 头部的端部具有当井处于膨胀状态时具有与井的圆顶形状对应的内部形状的凹部。 凹槽的曲率半径大于孔的圆顶形状的曲率半径。 此外，凹部的深度小于孔的圆顶形状的高度。 因此，头部首先接触孔的顶点，并且接触区域朝向外周逐渐扩大。 此时，头部和墨盒周围产生间隙。 因此，当头部被压靠在井上时，头部和井之间的空气被排出孔周围。

公开(公告)号：US20110177979A1

公开(公告)日：2011-07-21

申请号：US13009264

申请日：2011-01-19

Applicant: Takeo Tanaami ,  Hisao Katakura ,  Katsumori Gyounouchi

Inventor： Takeo Tanaami ,  Hisao Katakura ,  Katsumori Gyounouchi

IPC: C40B60/00

CPC classification number: B01L3/5027 ,  B01J2219/00418 ,  B01J2219/00529 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01L3/508 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2400/0481 ,  B82Y30/00 ,  G01N2021/6439 ,  G01N2035/00158

Abstract: A cartridge for chemical processing carries out chemical processing while moving a content by deformation based on an externally applied force, and includes a microarray chip housed in the cartridge for chemical processing; a member having a surface that faces a surface of the microarray chip; a supporting unit for supporting the member such that a width of a gap between the member and the microarray chip is variable by the externally applied force; and a limiting unit for restricting a variable range of the gap by the supporting unit such that the width of the entire gap between the surface of the member and the surface of the microarray chip does not become smaller than a predetermined width.

Abstract translation: 用于化学处理的墨盒通过基于外部施加的力的变形来移动内容物进行化学处理，并且包括容纳在用于化学处理的墨盒中的微阵列芯片; 具有面向微阵列芯片的表面的表面的构件; 用于支撑所述构件的支撑单元，使得所述构件和所述微阵列芯片之间的间隙的宽度可通过外部施加的力而变化; 以及限制单元，用于通过支撑单元限制间隙的可变范围，使得构件的表面与微阵列芯片的表面之间的整个间隙的宽度不会变得小于预定宽度。

公开(公告)号：US07935316B2

公开(公告)日：2011-05-03

申请号：US12013019

申请日：2008-01-11

Applicant: Katsumori Gyonouchi ,  Nobuyuki Takeuchi ,  Takeo Tanaami ,  Hisao Katakura

Inventor： Katsumori Gyonouchi ,  Nobuyuki Takeuchi ,  Takeo Tanaami ,  Hisao Katakura

IPC: B01J7/02 ,  B01J19/00 ,  B01L3/00 ,  B01L99/00 ,  B01L9/00

CPC classification number: B01L3/502 ,  B01L2200/026 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0655

Abstract: Disclosed is a chemical reaction cartridge including an elastic body with which at least a portion of the chemical reaction cartridge is formed and a plurality of chambers and a flow path to connect the plurality of chambers, which contain solution inside, and the solution is moved or blocked in the chambers and the flow path by applying external force to the elastic body from outside, the elastic body is structured in at least two elastic body layers which are layered vertically and the plurality of chambers and the flow path are provided between an upper elastic body layer and a lower elastic body layer, and the elastic body is attached to a surface of a substrate made of hard material.

Abstract translation: 公开了一种化学反应盒，其包括弹性体，至少部分化学反应盒形成有弹性体，多个室和用于连接多个室的流路，所述多个室包含溶液，溶液移动或 通过从外部向弹性体施加外力而在腔室和流路中阻塞，弹性体构造成至少两个垂直分层的弹性体层，并且多个室和流路设置在上弹性体 身体层和下部弹性体层，并且弹性体附着到由硬质材料制成的基底的表面。

公开(公告)号：US07858045B2

公开(公告)日：2010-12-28

申请号：US11528535

申请日：2006-09-28

Applicant: Takeo Tanaami ,  Saya Satou ,  Hisao Katakura

Inventor： Takeo Tanaami ,  Saya Satou ,  Hisao Katakura

IPC: B01L3/00

CPC classification number: B01L3/5027 ,  B01L7/525 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2400/0421 ,  B01L2400/0481 ,  G01N27/447 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

Abstract: A cartridge adaptable to various measurement forms is provided. A sample is injected into a well via an injection path. When a roller while kept pressed into contact with the cartridge is rotated rightward, the sample held in the well, and liquid solvent held in a well are caused to reach a well via flow paths, respectively, thereby mixing the sample with the liquid solvent. A mixed liquid is branched into flow paths, respectively, to thereby reach wells, respectively, and reagents pre-held in wells, respectively, are caused to flow into the wells, respectively. Next, temperatures in the wells, respectively, are controlled, thereby executing DNA amplification. Then, PCR by-products as amplified in the wells, respectively, are transferred as far as a position in the vicinity of an electrode via flow paths. Subsequently, a voltage is applied across the electrode as a negative electrode, and an electrode as a positive electrode via a drawing electrode and a drawing electrode, to thereby cause the PCR by-products to undergo electrophoresis.

Abstract translation: 提供适用于各种测量形式的盒式磁带。 样品通过注射路径注入孔中。 当保持按压与筒接触的辊子向右旋转时，将样品保持在井中，并且使保持在孔中的液体溶剂分别通过流动路径到达井，从而将样品与液体溶剂混合。 分别将混合液体分支成流路，从而分别到达井，分别将预先保存在井中的试剂流入孔中。 接下来，分别控制孔中的温度，从而进行DNA扩增。 然后，分别在孔中扩增的PCR副产物通过流路被转移到电极附近的位置。 随后，通过拉伸电极和拉伸电极将作为负极的电极和作为正极的电极施加电压，从而使PCR副产物进行电泳。

公开(公告)号：US20100226199A1

公开(公告)日：2010-09-09

申请号：US12783931

申请日：2010-05-20

Applicant: Takeyuki MOGI ,  Takeo TANAAMI

Inventor： Takeyuki MOGI ,  Takeo TANAAMI

IPC: B01F5/06

CPC classification number: B01F11/0045 ,  B01F15/0087 ,  B01F15/0203 ,  B01F15/0256 ,  B01L3/50273 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0655 ,  Y10T436/25

Abstract: Disclosed is a chemical reaction cartridge including an elastic body as a construction material and a flow path and two or more chambers connected by the flow path formed inside the cartridge, and the cartridge is structured so as to move or block a fluid substance in the flow path or the chambers by partially sealing the flow path, the chambers or both the flow path and the chambers by applying external force to the elastic body from outside, as the chambers, the cartridge has two or more mixing chambers each of which is to contain a mixture in a fluid state and the cartridge has two or more ingredient chambers provided for each of the mixing chambers by being connected with the flow path, in each of which an ingredient of the mixture divided in an amount according to a mixing ratio is to be contained.

Abstract translation: 公开了一种化学反应盒，其包括作为构造材料的弹性体和流路以及通过形成在筒内部的流路连接的两个或更多个室，并且盒被构造成在流动中移动或阻挡流体物质 路径或腔室，通过从外部向弹性体施加外力，通过部分地密封流动路径，腔室或两者的流动路径和腔室，作为腔室，盒具有两个或更多个混合室，每个混合室各自包含 流体状态的混合物，并且筒具有通过与流路连接而设置用于每个混合室的两个或更多个成分室，其中每个混合物中的成分按照混合比分配为 被包含

公开(公告)号：US20090270762A1

公开(公告)日：2009-10-29

申请号：US12365489

申请日：2009-02-04

Applicant: Takeo Tanaami ,  Atsushi Ito

Inventor： Takeo Tanaami ,  Atsushi Ito

IPC: A61B5/157

CPC classification number: A61B5/153 ,  A61B5/15003 ,  A61B5/150389 ,  A61B5/150473 ,  A61B5/150526 ,  A61B5/150732 ,  A61B5/150755

Abstract: A medical adapter ensuring a safety and a chemical reaction cartridge adapted to the medical adapter are provided. Both ends of an injection needle are covered with a cover member. When the blood collection tube is inserted in the interior of the cover member via one opening section, one end of the injection needle smashes into a plug to be inserted in the blood collection tube, and the tip end of the injection needle reaches blood inside the blood collection tube. Further, when an insertion section of the cartridge is inserted in the interior of the cover member via the other opening section, the other end of the injection needle in inserted in the interior of the cartridge.

Abstract translation: 提供了确保安全的医疗适配器和适用于医疗适配器的化学反应盒。 注射针的两端用盖构件覆盖。 当采血管经由一个开口部分插入到盖构件的内部时，注射针的一端砸入插入到采血管中的塞子中，并且注射针的末端到达内部的血液 采血管。 此外，当盒的插入部分经由另一个开口部分插入盖构件的内部时，注射针的另一端插入盒的内部。

公开(公告)号：US20090201506A1

公开(公告)日：2009-08-13

申请号：US12365280

申请日：2009-02-04

Applicant: Takeo TANAAMI ,  Hidetoshi AOKI ,  Saya SATOU ,  Yumiko SUGIYAMA

Inventor： Takeo TANAAMI ,  Hidetoshi AOKI ,  Saya SATOU ,  Yumiko SUGIYAMA

IPC: G01N21/17

CPC classification number: G01N21/6458

Abstract: There is provided a molecularity measurement instrument capable of working out the number of molecules in a sample by comparing a measured value of a light quantity with a theoretical light quantity per a single molecule, and a molecularity measurement method using the same. The molecularity of the sample is quantitatively estimated on the basis of a light quantity having correlation with the molecularity. The molecularity measurement method comprises the step of working out a theoretical light quantity per a single molecule, the step of measuring a light quantity of the sample by use of an image detector, and the step of working out the molecularity of the sample on the basis of a ratio of the light quantity of the sample to the theoretical light quantity as worked out.

Abstract translation: 提供一种能够通过将光量的测定值与单一分子的理论光量进行比较来求出样品中的分子数的分子量测定仪和使用其的分子量测定方法。 基于与分子相关的光量定量地估计样品的分子量。 分子量测定方法包括：通过使用图像检测器测定单个分子的理论光量的步骤，测定样品的光量的步骤，以及基于样品的分子量的步骤 测定样品的光量与理论光量的比率。

公开(公告)号：US07508516B2

公开(公告)日：2009-03-24

申请号：US11527565

申请日：2006-09-27

Applicant: Yumiko Sugiyama ,  Takeo Tanaami

Inventor： Yumiko Sugiyama ,  Takeo Tanaami

IPC: G01N21/64 ,  G01N21/55

CPC classification number: G01N21/6428 ,  G01N21/6456 ,  G01N21/66

Abstract: A site position can be detected using transmitted light or reflected light which does not include an excitation wavelength according to a configuration of a biochip 60. When reflected light is used, a light source 21 is actuated. Light from the light source 21 passes through a barrier filter 22 and is bent by a dichroic mirror 23 and passes through a dichroic mirror 3 and illuminates the biochip 60. The reflected light in the biochip 60 enters a CCD camera 13. An output signal of the CCD camera 13 is sent to a computation part 51 and a position of a site on the biochip 60 is detected in the computation part 51.

Abstract translation: 可以使用根据生物芯片60的结构的不包括激发波长的透射光或反射光检测位置位置。当使用反射光时，光源21被致动。 来自光源21的光通过阻挡滤光器22，并通过分色镜23弯曲并通过分色镜3并照射生物芯片60.生物芯片60中的反射光进入CCD照相机13.输出信号 CCD摄像机13被发送到计算部51，并且在计算部51中检测生物芯片60上的位置的位置。

公开(公告)号：US20090032736A1

公开(公告)日：2009-02-05

申请号：US12232704

申请日：2008-09-23

Applicant: Takeo Tanaami

Inventor： Takeo Tanaami

IPC: G01N21/64

CPC classification number: G02B21/0076 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/6478 ,  G01N2021/6491 ,  G02B21/0044 ,  G02B21/16

Abstract: The present invention provides a biochip reader for reading the image information of samples using a photodetector device, by irradiating a corresponding beam of excitation light at each site of a biochip on which a plurality of the samples are arranged at equal pitches, the biochip reader comprising: a microlens substrate provided with a plurality of microlenses to transform excitation light to be irradiated at the biochip into a multibeam; and a zoom lens located between the microlens substrate and the biochip and capable of projecting the multibeam while adjusting the pitch between sites of the biochip to the pitch of the multibeam. The present invention further provides a fluorometric imaging apparatus for detecting the image of a specimen by irradiating excitation light at samples on the specimen arranged in a two-dimensional manner and measuring fluorescent light produced from a fluorescent substance attached to the specimen, the fluorometric imaging apparatus comprising: a two-dimensional photodetector device for detecting excitation light passing through the specimen or reflecting off the surface thereof; and movement means for repositioning the specimen according to images observed on the photoreceptor device.

Abstract translation: 本发明提供一种生物芯片阅读器，用于通过在生物芯片的每个位置以相等的间距照射生物芯片的每一个位置处照射相应的激发光束，以使用光电检测器装置读取样本的图像信息，生物芯片读取器包括 ：具有多个微透镜的微透镜基板，用于将要在生物芯片上照射的激发光转换成多光束; 以及位于微透镜基板和生物芯片之间的变焦透镜，并且能够在将生物芯片的位置之间的间距调节到多光束的间距的同时投影多波束。 本发明还提供了一种荧光成像装置，用于通过以二维方式照射在样本上的样品照射激发光并测量由附着到样本的荧光物质产生的荧光来检测样本的图像，该荧光成像装置 包括：二维光电检测器装置，用于检测通过样本的激发光或者从其表面反射; 以及用于根据感光器件上观察到的图像重新定位样本的移动装置。

公开(公告)号：US07466408B2

公开(公告)日：2008-12-16

申请号：US10287658

申请日：2002-11-05

Applicant: Takeo Tanaami

Inventor： Takeo Tanaami

IPC: G01J3/30 ,  G01J1/58 ,  G01N21/85 ,  F21V9/16 ,  G01T1/10 ,  G21H3/02 ,  G21K5/00 ,  H01J65/06 ,  H01J65/08 ,  H01J3/14 ,  H01J5/16 ,  H01J40/14

CPC classification number: G01N21/6452 ,  G01N2021/6482

Abstract: A measurement system that optically measures in turn a plurality of samples arranged in an array via an objective lens and an imaging lens is disclosed, which is characterized by comprising an actuator means that moves the above described objective lens corresponding to each position of the above mentioned samples, and a photo-detecting part that detects a sample image via the above objective lens and imaging lens.

Abstract translation: 公开了一种测量系统，其通过物镜和成像透镜来依次光学地测量以阵列布置的多个样本，其特征在于包括致动器装置，该致动器装置将上述物镜移动到与上述 样品和经由上述物镜和成像透镜检测样本图像的光检测部分。