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    Microchip, measurement system and method using the same, and test reagent to be used for microchip
    1.
    发明授权
    Microchip, measurement system and method using the same, and test reagent to be used for microchip 有权
    Microchip的测量系统和使用该仪器的方法以及用于微芯片的测试试剂

    公开(公告)号：US09274107B2

    公开(公告)日：2016-03-01

    申请号：US13474863

    申请日：2012-05-18

    Applicant: Shun Momose

    Inventor： Shun Momose

    IPC: G01N33/543 ,  G01N21/03 ,  G01N21/07

    CPC classification number: G01N33/54386 ,  G01N21/03 ,  G01N21/07 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2333/11

    Abstract: A microchip to be used for measuring a plurality of types of objects to be measured. The microchip includes at least a reagent retaining portion and a detecting portion. The test reagent retaining portion includes a plurality of types of test reagents corresponding respectively to the plurality of types of objects to be measured. A plurality of time courses for a change in detected value at the detecting portion caused by a reaction between the test reagents and the objects to be measured corresponding respectively thereto are all different from each other.

    Abstract translation: 一种微芯片，用于测量待测量的多种类型的物体。 微芯片至少包括试剂保持部和检测部。 测试试剂保持部分包括分别对应于待测量的多种类型的物体的多种试验试剂。 由测试试剂和与其分别对应的测量对象之间的反应引起的检测部分处的检测值的变化的多个时间过程彼此不同。

    Microchip
    2.
    发明申请
    Microchip 有权

    公开(公告)号：US20130266483A1

    公开(公告)日：2013-10-10

    申请号：US13993172

    申请日：2011-12-13

    Applicant: Shun Momose ,  Hiroki Takeuchi

    Inventor： Shun Momose ,  Hiroki Takeuchi

    IPC: G01N21/01

    CPC classification number: G01N21/01 ,  B01L3/502753 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2400/0409 ,  B01L2400/0457 ,  G01N33/487 ,  G01N2035/00158

    Abstract: A microchip including a fluid circuit therein and a specimen inlet for introducing a specimen containing a first component and a second component different in specific gravity from each other into the fluid circuit is provided, in which the fluid circuit includes a specimen measurement unit connected to the specimen inlet and having a prescribed volume for measuring the specimen introduced through the specimen inlet and a separation unit which is a site connected to the specimen measurement unit and having a capacity capable of storing the total amount of the measured specimen, for storing the total amount of the measured specimen and separating the first component and the second component in the stored specimen from each other.

    Abstract translation: 提供一种其中包括流体回路的微芯片和用于将含有彼此不同比例的第一组分和第二组分的样本引入流体回路的样本入口，其中流体回路包括与样品测量单元连接的样品测量单元 试样入口并具有用于测量通过试样入口引入的试样的规定体积，以及分离单元，该分离单元是与试样测量单元连接并具有能够存储测量样本总量的位置的存储总量 并将储存的样品中的第一组分和第二组分彼此分离。

    MICROCHIP
    5.
    发明申请
    MICROCHIP 有权

    公开(公告)号：US20090142232A1

    公开(公告)日：2009-06-04

    申请号：US12270942

    申请日：2008-11-14

    Applicant: Hidetaka Okada ,  Yasuhisa Kageyama ,  Shun Momose ,  Youichi Aoki

    Inventor： Hidetaka Okada ,  Yasuhisa Kageyama ,  Shun Momose ,  Youichi Aoki

    IPC: B01J19/00

    CPC classification number: G01N21/07 ,  B01L3/502753 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0409 ,  B01L2400/0622 ,  B01L2400/086 ,  Y10T436/2575

    Abstract: The present invention provides a microchip which is made by bonding a first substrate having a groove provided at the substrate surface and a second substrate together, and has a fluid circuit therein, the fluid circuit having a separation portion for separating a first component, and a groove which constitutes the separation portion including an approximately V-shaped region surrounded by prescribed flow channel walls. At a top of the separation portion, a flow rate limiting portion limiting a flow rate of a fluid is preferably provided.

    Abstract translation: 本发明提供一种微芯片，其通过将具有设置在基板表面上的凹槽的第一基板和第二基板结合在一起而形成，其中具有流体回路，该流体回路具有用于分离第一部件的分离部分， 构成分离部的槽包括由规定的流路壁包围的大致V字形的区域。 在分离部分的顶部，优选提供限制流体流速的流量限制部分。

    ANALYTE COLLECTION CHIP
    6.
    发明申请
    ANALYTE COLLECTION CHIP 审中-公开
    分析器收集芯片

    公开(公告)号：US20090105614A1

    公开(公告)日：2009-04-23

    申请号：US12063561

    申请日：2006-08-15

    Applicant: Shun Momose ,  Takaaki Shimasaki

    Inventor： Shun Momose ,  Takaaki Shimasaki

    IPC: A61B5/15 ,  A61M37/00 ,  A61M5/42

    CPC classification number: A61B5/15142 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150969 ,  A61B5/15105 ,  A61B5/15107 ,  A61B5/15117 ,  A61B10/0045 ,  A61B17/205 ,  A61B2010/0006 ,  A61B2010/0009 ,  G01N33/491 ,  G01N2035/00158

    Abstract: To provide a chip for collecting analyte from a living body. Specifically, the chip includes a thin plate-shaped main body, an analyte inlet portion, and a thin portion. Analyte is introduced into the analyte inlet portion, which is formed within the main body. The thin portion partitions the space forming the analyte inlet portion from the external space. According to the chip of the present invention, it is possible to eliminate the time for collecting analyte from a living body using a hypodermic syringe or the like, and placing the collected analyte into the chip. Also, the chip according to the present invention does not leave analyte remaining at the position from which the analyte was extracted, so after the test the position where the analyte was extracted from the living body is clean.

    Abstract translation: 提供用于从活体收集分析物的芯片。 具体地，芯片包括薄板状主体，​​分析物入口部分和薄部分。 将分析物引入到在主体内形成的分析物入口部分。 薄部分从外部空间分隔形成分析物入口部分的空间。 根据本发明的芯片，可以消除使用皮下注射器等从活体收集分析物的时间，并将收集的分析物放入芯片中。 此外，根据本发明的芯片不会将分析物残留在分析物被提取的位置，因此在测试之后，从生物体中提取分析物的位置是干净的。

    Microchip and method of using the same
    9.
    发明授权
    Microchip and method of using the same 有权
    Microchip及其使用方法

    公开(公告)号：US08367424B2

    公开(公告)日：2013-02-05

    申请号：US12250592

    申请日：2008-10-14

    Applicant: Shun Momose ,  Akinori Yokogawa ,  Toshihiro Mori

    Inventor： Shun Momose ,  Akinori Yokogawa ,  Toshihiro Mori

    IPC: G01N21/41 ,  G01N21/01

    CPC classification number: B01L3/50273 ,  B01L3/5025 ,  B01L3/5027 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2300/168 ,  G01N21/07 ,  G01N33/5002 ,  G01N2021/0325

    Abstract: A microchip includes fluid circuits therein, formed by uniting together at least a first substrate that is a transparent substrate and a second substrate having grooves provided at the substrate surface and/or through holes penetrating in a thickness direction. The fluid circuits include a liquid reagent receptacle unit to store a liquid reagent, a quantification unit to quantify the liquid reagent or specimen, and an overflow liquid storage unit connected to the quantification unit to store the liquid reagent or specimen overflowing from the quantification unit during quantification. There is also provided a method of using the microchip.

    Abstract translation: 微芯片包括其中的流体回路，至少通过将至少第一基板作为透明基板和具有设置在基板表面处的凹槽和/或穿过厚度方向的通孔的第二基板结合在一起。 流体回路包括：液体试剂容纳单元，用于存储液体试剂;定量单元，用于量化液体试剂或试样;以及溢流液储存单元，连接到定量单元，以存储从定量单元溢出的液体试剂或试样 量化。 还提供了使用微芯片的方法。

    Microchip and method of manufacturing microchip
    10.
    发明授权
    Microchip and method of manufacturing microchip 有权
    Microchip和微芯片制造方法

    公开(公告)号：US08143077B2

    公开(公告)日：2012-03-27

    申请号：US12129869

    申请日：2008-05-30

    Applicant: Shun Momose

    Inventor： Shun Momose

    IPC: H01L21/66

    CPC classification number: B29C66/53461 ,  B01L3/502707 ,  B01L2300/161 ,  B01L2400/0409 ,  B29C65/00 ,  B29C65/02 ,  B29C65/48 ,  B29C66/02 ,  B29C66/02245 ,  B29C66/026 ,  B29C66/112 ,  B29C66/71 ,  B29C66/712 ,  B29C66/73161 ,  B29L2031/756 ,  B29K2023/12 ,  B29K2023/38 ,  B29K2025/06 ,  B29K2027/06 ,  B29K2033/12 ,  B29K2067/003 ,  B29K2069/00

    Abstract: A microchip formed by joining a first substrate having at least one recess on its surface and a second substrate, wherein small projections of 0.5 to 30 μm in height are formed on at least a part of the surface having the recess of the first substrate, and a coating formed of a surface processing agent is provided on at least a part of the surface having the small projections formed thereon, as well as a method of manufacturing the microchip, are provided. A microchip allowing easy inspection of the state of application or state of adhesion of liquid material such as a surface processing agent, and allowing accurate optical measurement without causing disturbance such as fluorescence, can be provided.

    Abstract translation: 通过将其表面上具有至少一个凹部的第一基板与第二基板接合而形成的微芯片，其中，在具有第一基板的凹部的表面的至少一部分上形成有高度为0.5〜30μm的小突起， 在其上形成有小突起的表面的至少一部分上提供由表面处理剂形成的涂层以及制造微芯片的方法。 可以提供容易检查诸如表面处理剂的液体材料的施用状态或粘附状态的微芯片，并且可以提供精确的光学测量而不引起诸如荧光的干扰。

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