公开(公告)号：US20060004037A1

公开(公告)日：2006-01-05

申请号：US11088469

申请日：2005-03-24

Applicant: Sherry Morissette ,  Michael Read

Inventor： Sherry Morissette ,  Michael Read

IPC: A61K31/4745 ,  C07D491/02

CPC classification number: C07D498/04

Abstract: The invention provides novel lipid soluble forms of tricyclic antineoplastic compounds. These forms include salts, co-crystals, and solvates of the tricyclic antineoplastic compounds. The invention also provides novel pharmaceutical compositions comprising these novel lipid soluble forms and related methods of treatment. Compositions and methods of the invention are useful in the treatment of neoplasms, including MRP-1-related resistant neoplasms.

Abstract translation: 本发明提供三环抗肿瘤化合物的新型脂溶性形式。 这些形式包括三环抗肿瘤化合物的盐，共晶和溶剂合物。 本发明还提供包含这些新型脂溶性形式和相关治疗方法的新型药物组合物。 本发明的组合物和方法可用于治疗包括MRP-1相关抗性肿瘤在内的肿瘤。

公开(公告)号：US20050070551A1

公开(公告)日：2005-03-31

申请号：US10926842

申请日：2004-08-26

Applicant: Julius Remenar ,  Michael MacPhee ,  Matthew Peterson ,  Sherry Morissette ,  Orn Almarsson

Inventor： Julius Remenar ,  Michael MacPhee ,  Matthew Peterson ,  Sherry Morissette ,  Orn Almarsson

IPC: A61K31/496 ,  C07D45/14

CPC classification number: A61K9/145 ,  A61K9/0004 ,  A61K9/0014 ,  A61K9/1617 ,  A61K9/1652 ,  A61K9/2077 ,  A61K9/209 ,  A61K47/10 ,  A61K47/32 ,  C07D405/14

Abstract: The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.

Abstract translation: 本发明提供了可用作药物的盐，共晶和相关溶剂合物的新型可溶性唑型结晶形式（例如伊曲康唑，泊沙康唑和沙伯康唑）。 本发明还提供药物组合物，其包含和制备这些唑型结晶形式。 还提供了使用这些组合物来治疗或预防全身和局部真菌，酵母和皮肤癣菌感染的方法。

公开(公告)号：US20050095696A9

公开(公告)日：2005-05-05

申请号：US10235553

申请日：2002-09-06

Applicant: Anthony Lemmo ,  Sherry Morissette ,  Orn Almarsson ,  Michael Cima ,  Alasdair Johnson ,  Javier Gonzalez-Zugasti ,  Christopher McNulty

Inventor： Anthony Lemmo ,  Sherry Morissette ,  Orn Almarsson ,  Michael Cima ,  Alasdair Johnson ,  Javier Gonzalez-Zugasti ,  Christopher McNulty

IPC: B01J19/00 ,  B01L3/14 ,  B01L7/00 ,  C30B7/00 ,  C40B60/14 ,  C40B70/00 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  C12Q1/00 ,  G01N33/53 ,  C12M1/34

CPC classification number: G01N35/028 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/0031 ,  B01J2219/00335 ,  B01J2219/00344 ,  B01J2219/00495 ,  B01J2219/00547 ,  B01J2219/00587 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00756 ,  B01L3/5082 ,  B01L7/52 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/1805 ,  C30B7/00 ,  C30B29/58 ,  C40B60/14 ,  C40B70/00 ,  G01N21/3577 ,  G01N35/0099 ,  G01N2035/041 ,  G01N2035/042 ,  G01N2035/0425

Abstract: Systems and methods are described that allow the high-throughput preparation, processing, and study of arrays of samples, each of which comprises at least one compound. Particular embodiments of the invention allow a large number of experiments to be performed in parallel on samples that comprised of one or more compounds on the milligram or microgram quantities of compounds. Other embodiments of the invention encompass methods and devices for the rapid screening of the results of such experiments, as well as methods and devices for rapidly determining whether or not similarities exist among groups of samples in an array. Particular embodiments of the invention encompass methods and devices for the high-throughput preparation of different forms of compounds (e.g., different crystalline forms), for the discovery of new forms of old compounds, and for the discovery of new methods of producing such forms. Embodiments of the invention also allow for the high-throughput determination of how specific compounds or forms of compounds behave when exposed to other chemicals or environmental conditions.

Abstract translation: 描述了允许高通量制备，处理和研究样品阵列的系统和方法，每个样品包含至少一种化合物。 本发明的具体实施方案允许在由毫克或微克数量的化合物上的一种或多种化合物组成的样品上并行进行大量实验。 本发明的其它实施例包括用于快速筛选这些实验的结果的方法和装置，以及用于快速确定阵列中的样品组之间是否存在相似性的方法和装置。 本发明的具体实施方案包括用于高通量制备不同形式的化合物（例如不同结晶形式）的方法和装置，用于发现新形式的旧化合物，以及发现生产此类形式的新方法。 本发明的实施方案还允许高通量测定当化合物或形式的化合物在暴露于其它化学物质或环境条件时的表现。

公开(公告)号：US07446107B2

公开(公告)日：2008-11-04

申请号：US10926842

申请日：2004-08-26

Applicant: Julius Remenar ,  Michael MacPhee ,  Matthew Peterson ,  Sherry Morissette ,  Orn Almarsson

Inventor： Julius Remenar ,  Michael MacPhee ,  Matthew Peterson ,  Sherry Morissette ,  Orn Almarsson

IPC: A61K31/497 ,  C07D241/06

CPC classification number: A61K9/145 ,  A61K9/0004 ,  A61K9/0014 ,  A61K9/1617 ,  A61K9/1652 ,  A61K9/2077 ,  A61K9/209 ,  A61K47/10 ,  A61K47/32 ,  C07D405/14

Abstract: The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.

Abstract translation: 本发明提供了可用作药物的盐，共晶和相关溶剂合物的新型可溶性唑型结晶形式（例如伊曲康唑，泊沙康唑和沙伯康唑）。 本发明还提供药物组合物，其包含和制备这些唑型结晶形式。 还提供了使用这些组合物来治疗或预防全身和局部真菌，酵母和皮肤癣菌感染的方法。

公开(公告)号：US20060246009A1

公开(公告)日：2006-11-02

申请号：US11381079

申请日：2006-05-01

Applicant: Sherry Morissette ,  Mark Tawa ,  Mark Oliveira

Inventor： Sherry Morissette ,  Mark Tawa ,  Mark Oliveira

IPC: A61K31/4745 ,  C07D491/08 ,  A61K9/14

CPC classification number: C07D451/10

Abstract: The invention relates to new crystalline forms of tiotropium bromide, processes for preparing them and their use for preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.

Abstract translation: 本发明涉及噻托溴铵的新结晶形式，其制备方法及其用于制备用于治疗呼吸道疾病，特别是用于治疗COPD（慢性阻塞性肺疾病）和哮喘的药物组合物的用途。

公开(公告)号：US20090088443A1

公开(公告)日：2009-04-02

申请号：US12234420

申请日：2008-09-19

Applicant: Julius Remenar ,  Michael MacPhee ,  Matthew Peterson ,  Sherry Morissette ,  Orn Almarsson

Inventor： Julius Remenar ,  Michael MacPhee ,  Matthew Peterson ,  Sherry Morissette ,  Orn Almarsson

IPC: A61K31/496 ,  A61P31/10

CPC classification number: A61K9/145 ,  A61K9/0004 ,  A61K9/1617 ,  A61K9/2077 ,  A61K9/209

Abstract: The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.

Abstract translation: 本发明提供了可用作药物的盐，共晶和相关溶剂合物的新型可溶性唑型结晶形式（例如伊曲康唑，泊沙康唑和沙伯康唑）。 本发明还提供药物组合物，其包含和制备这些唑型结晶形式。 还提供了使用这些组合物来治疗或预防全身和局部真菌，酵母和皮肤癣菌感染的方法。