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公开(公告)号：US07763112B2
公开(公告)日：2010-07-27
申请号：US11413353
申请日：2006-04-28
IPC分类号： C30B7/02
CPC分类号： B02C17/20 , B01F11/0005 , B01F13/005 , B01F13/0052 , B01J2219/00313 , B01J2219/00484 , B01J2219/00756 , B01L3/06 , B02C17/14 , B02C17/1815 , B02C2017/065 , C30B7/00 , C30B29/54
摘要： The present invention comprises methods and apparatuses for the production or formation of co-crystals. The methods and apparatuses can be used to grind two or more co-crystal components resulting in the formation of co-crystals. The resultant co-crystals can have several uses as disclosed herein.
摘要翻译： 本发明包括用于生产或形成共晶体的方法和装置。 该方法和装置可用于研磨两种或多种共晶体组分，从而形成共晶体。 所得的共晶体可以具有本文公开的多种用途。
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公开(公告)号：US07671093B2
公开(公告)日：2010-03-02
申请号：US11139245
申请日：2005-05-27
IPC分类号： A61K31/165
CPC分类号： A61K31/165 , A61K9/145 , A61K31/191 , C07C55/10 , C07C57/15 , C07C317/44 , A61K2300/00
摘要： A mixed co-crystal comprising an API, a first co-crystal former, and a second co-crystal former which is isomorphically substitutable with said first co-crystal former is described. A pharmaceutical composition comprising a mixed co-crystal, methods of making mixed co-crystals, and methods of using mixed co-crystals are also described.
摘要翻译： 描述了包含API，第一共晶体形成器和与所述第一共晶体形成体同构取代的第二共晶体形成器的混合共晶体。 还描述了包含混合共晶的药物组合物，制备混合共晶体的方法和使用混合共晶体的方法。
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公开(公告)号：US20090091740A1
公开(公告)日：2009-04-09
申请号：US10599804
申请日：2005-04-14
申请人： Nathan Kane , Michael MacPhee , Mark Oliveira
发明人： Nathan Kane , Michael MacPhee , Mark Oliveira
IPC分类号： G01N23/201 , G01N1/00 , G01J3/00
CPC分类号： G01N23/2005 , B01L9/06 , B01L2300/0838 , G01N1/08 , G01N21/65 , G01N2001/2873
摘要： Methods and systems for the analysis of solid materials are disclosed. The present invention comprises x-ray and Raman analytical techniques and systems which facilitate the rapid characterization of a plurality of solid samples.
摘要翻译： 公开了用于分析固体材料的方法和系统。 本发明包括有助于快速表征多个固体样品的x射线和拉曼分析技术和系统。
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公开(公告)号：US20060287392A1
公开(公告)日：2006-12-21
申请号：US11461830
申请日：2006-08-02
申请人： Matthew Peterson , Mark Oliveira
发明人： Matthew Peterson , Mark Oliveira
IPC分类号： A61K31/195 , C07C229/28 , C07C275/02
CPC分类号： C07C59/255 , C07C57/145
摘要： The present invention comprises an organic acid salt of gabapentin, wherein the organic acid is tartaric acid, ethanedisulfonic acid, or maleic acid. Methods for modulating the solubility and dose response of gabapentin are discussed. Methods of making organic acid salts of gabapentin are also discussed.
摘要翻译： 本发明包括加巴喷丁的有机酸盐，其中有机酸是酒石酸，乙二磺酸或马来酸。 讨论了调节加巴喷丁的溶解度和剂量反应的方法。 还讨论了加巴喷丁的有机酸盐的制备方法。
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公开(公告)号：US20060246009A1
公开(公告)日：2006-11-02
申请号：US11381079
申请日：2006-05-01
申请人： Sherry Morissette , Mark Tawa , Mark Oliveira
发明人： Sherry Morissette , Mark Tawa , Mark Oliveira
IPC分类号： A61K31/4745 , C07D491/08 , A61K9/14
CPC分类号： C07D451/10
摘要： The invention relates to new crystalline forms of tiotropium bromide, processes for preparing them and their use for preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
摘要翻译： 本发明涉及噻托溴铵的新结晶形式，其制备方法及其用于制备用于治疗呼吸道疾病，特别是用于治疗COPD（慢性阻塞性肺疾病）和哮喘的药物组合物的用途。
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公开(公告)号：US20060052432A1
公开(公告)日：2006-03-09
申请号：US10528244
申请日：2003-09-16
申请人： Julius Remenar , Matthew Peterson , Orn Almarsson , Hector Guzman , Hongming Chen , Mark Tawa , Mark Oliveira
发明人： Julius Remenar , Matthew Peterson , Orn Almarsson , Hector Guzman , Hongming Chen , Mark Tawa , Mark Oliveira
IPC分类号： A61K9/00 , A61K31/18 , A61K31/415 , A61K31/365
CPC分类号： A61K9/0019 , A61K9/145 , A61K9/146 , A61K31/18 , A61K31/365 , A61K31/415 , A61K31/635 , A61K47/10
摘要： The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.
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公开(公告)号：US20050267209A1
公开(公告)日：2005-12-01
申请号：US11139245
申请日：2005-05-27
IPC分类号： A01N37/18 , A61K9/00 , A61K9/20 , A61K9/26 , A61K31/165 , A61K31/191 , A61K31/205
CPC分类号： A61K31/165 , A61K9/145 , A61K31/191 , C07C55/10 , C07C57/15 , C07C317/44 , A61K2300/00
摘要： A mixed co-crystal comprising an API, a first co-crystal former, and a second co-crystal former which is isomorphically substitutable with said first co-crystal former is described. A pharmaceutical composition comprising a mixed co-crystal, methods of making mixed co-crystals, and methods of using mixed co-crystals are also described.
摘要翻译： 描述了包含API，第一共晶体形成器和与所述第一共晶体形成器同构取代的第二共晶体形成器的混合共晶体。 还描述了包含混合共晶的药物组合物，制备混合共晶体的方法和使用混合共晶体的方法。
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公开(公告)号：US08362062B2
公开(公告)日：2013-01-29
申请号：US10541216
申请日：2003-12-24
申请人： Mark Tawa , Julius Remenar , Matthew L. Peterson , Örn Almarsson , Hector Guzman , Hongming Chen , Mark Oliveira
发明人： Mark Tawa , Julius Remenar , Matthew L. Peterson , Örn Almarsson , Hector Guzman , Hongming Chen , Mark Oliveira
CPC分类号： A61K9/1652 , A61K9/145 , A61K9/146 , A61K31/18 , A61K31/365 , A61K31/415 , A61K31/635 , A61K47/10 , A61K47/32 , C07D231/12
摘要： The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.
摘要翻译： 本发明涉及筛选含有药物化合物和赋形剂的混合物的方法，以鉴定延缓固态成核的药物化合物/赋形剂组合的性质。 本发明还涉及通过将药物与降凝剂和任选的增强剂组合来增加在胃液条件下具有低溶解度的药物的溶解度，溶解度和生物利用度。
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公开(公告)号：US08338646B2
公开(公告)日：2012-12-25
申请号：US12708998
申请日：2010-02-19
IPC分类号： C07C233/65
CPC分类号： C07C317/50 , A61K31/165 , C07C317/44
摘要： Polymorphs and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and discussed. In addition, said forms are described as useful for the treatment of many conditions including, but not limited to, narcolepsy.
摘要翻译： 形成和讨论了外消旋，对映异构体纯和对映体混合的莫达非尼的多晶型物和溶剂合物。 此外，所述形式被描述为可用于治疗许多病症，包括但不限于发作性睡病。
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公开(公告)号：US20090018202A1
公开(公告)日：2009-01-15
申请号：US10587086
申请日：2005-02-01
IPC分类号： A61K31/165 , C07C231/00 , A61P25/00
CPC分类号： C07C317/50 , A61K31/165 , C07C317/44
摘要： Polymorphs and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and discussed. In addition, said forms are described as useful for the treatment of many conditions including, but not limited to, narcolepsy.
摘要翻译： 形成和讨论了外消旋，对映异构体纯和对映体混合的莫达非尼的多晶型物和溶剂合物。 此外，所述形式被描述为可用于治疗许多病症，包括但不限于发作性睡病。
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