公开(公告)号：US20180200245A1

公开(公告)日：2018-07-19

申请号：US15917421

申请日：2018-03-09

申请人： Celgene Corporation

发明人： G. Patrick Stahly ,  David Jonaitis ,  Ho-Wah Hui ,  Kevin J. Klopfer

IPC分类号： A61K31/454 ,  G01N23/2005 ,  A61K47/02 ,  A61K47/12 ,  C07D419/14

CPC分类号： A61K31/454 ,  A61K47/02 ,  A61K47/12 ,  C07B2200/13 ,  C07C55/08 ,  C07C65/03 ,  C07C65/21 ,  C07C69/88 ,  C07C305/04 ,  C07C307/02 ,  C07C2601/14 ,  C07D275/06 ,  C07D309/40 ,  C07D401/04 ,  C07D419/14 ,  C07H3/02 ,  G01N23/2005

摘要： Provided herein are solid forms comprising (a) 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione and (b) a coformer. Pharmaceutical compositions comprising the solid forms (e.g., cocrystals) and methods for treating, preventing and managing various disorders are also disclosed.

公开(公告)号：US09974780B2

公开(公告)日：2018-05-22

申请号：US15607163

申请日：2017-05-26

申请人： Celgene Corporation

发明人： G. Patrick Stahly ,  David Jonaitis ,  Ho-Wah Hui ,  Kevin J. Klopfer

IPC分类号： A61K31/454 ,  A61K47/12 ,  A61K47/02 ,  C07D419/14 ,  G01N23/20

CPC分类号： A61K31/454 ,  A61K47/02 ,  A61K47/12 ,  C07B2200/13 ,  C07C55/08 ,  C07C65/03 ,  C07C65/21 ,  C07C69/88 ,  C07C305/04 ,  C07C307/02 ,  C07C2601/14 ,  C07D275/06 ,  C07D309/40 ,  C07D401/04 ,  C07D419/14 ,  C07H3/02 ,  G01N23/2005

摘要： Provided herein are solid forms comprising (a) 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione and (b) a coformer. Pharmaceutical compositions comprising the solid forms (e.g., cocrystals) and methods for treating, preventing and managing various disorders are also disclosed.

公开(公告)号：US20160370306A1

公开(公告)日：2016-12-22

申请号：US15183149

申请日：2016-06-15

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人： Chelsie Conrad ,  Petra Fromme ,  Daniel James ,  Christopher Kupitz

IPC分类号： G01N23/20 ,  G01N23/207 ,  C30B29/58 ,  G01N33/483 ,  C30B7/14

CPC分类号： G01N23/2005 ,  C30B7/14 ,  C30B29/58 ,  G01N33/483

摘要： A system and method for preparing a crystal delivery medium comprising agarose for serial femtosecond crystallography and uses thereof.

摘要翻译： 一种用于制备包含用于连续飞秒晶体学的琼脂糖的晶体输送介质的系统和方法及其用途。

公开(公告)号：US20110046022A1

公开(公告)日：2011-02-24

申请号：US12747029

申请日：2008-12-11

申请人： Nickolay Chirgadze ,  Joseph Miller ,  Robert Lam ,  Kathy Johns

发明人： Nickolay Chirgadze ,  Joseph Miller ,  Robert Lam ,  Kathy Johns

IPC分类号： C40B60/12

CPC分类号： G01N23/2005 ,  C30B7/04 ,  C30B29/58 ,  C30B35/00 ,  G01N2223/612

摘要： A crystallization chip has a two-dimensional substrate surface with modified wetting properties convenient for the evaluation of the crystallization experiment results by optical microscope and by X-ray diffraction. A crystallization chip mount comprises a base and a support structure that is connected to the base. The support structure provides a first channel that receives a portion of the crystallization chip. A crystallization chip holder comprises a body defining at least one slot to slidably receive the crystallization chip described herein. The at least one slot extends from an upper surface to a lower surface of the body. The crystallization chip holder further includes at least one support surface for each slot. For a given slot the at least one support surface is disposed on an edge of at least two surfaces of portions of the body that define the given slot. During use, the at least one support surface supports the crystallization chip prior to, during or after the formation of crystals.

摘要翻译： 结晶芯片具有改性润湿性能的二维基材表面，便于通过光学显微镜和X射线衍射评价结晶实验结果。 结晶芯片安装架包括底座和连接到基座的支撑结构。 支撑结构提供接收结晶芯片的一部分的第一通道。 结晶芯片保持器包括限定至少一个狭槽的主体以可滑动地容纳本文所述的结晶芯片。 至少一个狭槽从主体的上表面延伸到下表面。 结晶芯片保持架还包括用于每个槽的至少一个支撑表面。 对于给定的槽，至少一个支撑表面设置在限定给定槽的主体部分的至少两个表面的边缘上。 在使用期间，至少一个支撑表面在形成晶体之前，之中或之后支撑结晶芯片。

公开(公告)号：US11821857B2

公开(公告)日：2023-11-21

申请号：US17495396

申请日：2021-10-06

申请人： Robert Krumm ,  Ryan Antle ,  Haifeng Jiang

发明人： Robert Krumm ,  Ryan Antle ,  Haifeng Jiang

IPC分类号： G01N23/20 ,  G01N23/2055 ,  G01N23/223 ,  G01N33/24 ,  G01N23/207 ,  G01N23/222 ,  G01N1/28 ,  G01N1/34 ,  E21B49/06 ,  E21B49/00 ,  G01N23/2005 ,  G01V5/04 ,  G01V5/08 ,  G01V5/12

CPC分类号： G01N23/223 ,  E21B49/005 ,  E21B49/06 ,  G01N1/286 ,  G01N1/34 ,  G01N23/20 ,  G01N23/2005 ,  G01N23/207 ,  G01N23/2055 ,  G01N23/222 ,  G01N33/24 ,  G01V5/04 ,  G01V5/045 ,  G01V5/08 ,  G01V5/12 ,  G01V5/125 ,  G01N2001/2866 ,  G01N2223/056 ,  G01N2223/076 ,  G01N2223/106 ,  G01N2223/616

摘要： Methods for determining mineral compositions of materials are described. The methods include obtaining elemental data associated with a geologic sample, calculating a measurement correlation matrix of the geologic sample from the elemental data, calculating an artificial correlation matrix, comparing the measurement correlation matrix and the artificial correlation matrix to determine an error value, minimizing the error value by updating the artificial correlation matrix and comparing the measurement correlation matrix to the updated artificial correlation matrix, and determining a mineral composition of the geologic sample based on the minimized measurement correlation matrix.

公开(公告)号：US09695146B2

公开(公告)日：2017-07-04

申请号：US14780289

申请日：2014-03-25

申请人： CELGENE CORPORATION

发明人： G. Patrick Stahly ,  David Jonaitis ,  Ho-Wah Hui ,  Kevin J. Klopfer

IPC分类号： C07D401/04 ,  A61K31/454 ,  C07C55/08 ,  C07C65/03 ,  C07C65/21 ,  C07C69/88 ,  C07C305/04 ,  C07C307/02 ,  C07D275/06 ,  C07D309/40 ,  C07H3/02

CPC分类号： A61K31/454 ,  A61K47/02 ,  A61K47/12 ,  C07B2200/13 ,  C07C55/08 ,  C07C65/03 ,  C07C65/21 ,  C07C69/88 ,  C07C305/04 ,  C07C307/02 ,  C07C2601/14 ,  C07D275/06 ,  C07D309/40 ,  C07D401/04 ,  C07D419/14 ,  C07H3/02 ,  G01N23/2005

摘要： Provided herein are solid forms comprising (a) 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione and (b) a coformer. Pharmaceutical compositions comprising the solid forms (e.g., cocrystals) and methods for treating, preventing and managing various disorders are also disclosed.

公开(公告)号：US20100025482A1

公开(公告)日：2010-02-04

申请号：US12559652

申请日：2009-09-15

申请人： JOHN A. MOON ,  MARTIN A. PUTNAM ,  ALAN D. KERSEY ,  PAUL SZCZEPANEK

发明人： JOHN A. MOON ,  MARTIN A. PUTNAM ,  ALAN D. KERSEY ,  PAUL SZCZEPANEK

IPC分类号： G06K19/06

CPC分类号： G03H5/00 ,  G01N23/2005 ,  G03H2001/0016 ,  G07D7/003

摘要： A composition including an item and an optical identification element that is physically associated with the item. The optical identification element includes a binder material and one or more materials embedded in the binder material. The one or more materials provides a composite X-ray diffraction pattern when illuminated by an X-ray beam. The composite X-ray diffraction pattern being indicative of a code. The code relating to information about the item.

摘要翻译： 一种组合物，其包括与所述物品物理相关联的物品和光学识别元件。 光学识别元件包括粘合剂材料和嵌入粘合剂材料中的一种或多种材料。 一种或多种材料在由X射线束照射时提供复合X射线衍射图案。 复合X射线衍射图表示代码。 有关该项目信息的代码。

公开(公告)号：US07623624B2

公开(公告)日：2009-11-24

申请号：US11601584

申请日：2006-11-16

申请人： John A. Moon ,  Martin A. Putnam ,  Alan D. Kersey ,  Paul Szczepanek

发明人： John A. Moon ,  Martin A. Putnam ,  Alan D. Kersey ,  Paul Szczepanek

IPC分类号： G01N23/20

CPC分类号： G03H5/00 ,  G01N23/2005 ,  G03H2001/0016 ,  G07D7/003

摘要： An optical identification element for identifying an item. The optical identification element includes a binder material and one or more materials embedded in the binder material. The one or more materials provides an encoded composite X-ray diffraction pattern when illuminated by an X-ray beam. The encoded composite X-ray diffraction pattern is indicative of the item.

摘要翻译： 一种用于识别物品的光学识别元件。 光学识别元件包括粘合剂材料和嵌入粘合剂材料中的一种或多种材料。 一种或多种材料在由X射线束照射时提供编码的复合X射线衍射图案。 编码的复合X射线衍射图表示该项目。

公开(公告)号：US11879884B1

公开(公告)日：2024-01-23

申请号：US18363686

申请日：2023-08-01

申请人： Chengdu University of Technology

发明人： Yiquan Ma ,  Xiaofeng Liu ,  Yangbo Lu ,  Yongchao Lu ,  Chen Zhang ,  Xuebin Du ,  Zhanhong Liu ,  Wei Wei ,  Yi Shu ,  Jingyu Zhang ,  Ke Zhao ,  Qinyu Cui ,  Hao Wang ,  Xiaojie Fan ,  Caiguang Zhi ,  Mengtian Gao ,  Lingna Shi

IPC分类号： G01N33/24 ,  G01N23/2005 ,  G01N1/28 ,  G06F18/2431 ,  G06F18/243 ,  G01N1/38

CPC分类号： G01N33/24 ,  G01N1/2813 ,  G01N1/38 ,  G01N23/2005 ,  G06F18/2431 ,  G06F18/24317 ,  G01N2033/243

摘要： The present disclosure discloses a classification method and system for fine-grained mixed sedimentary rocks, a medium and a terminal. Core description and thin section observation are used to accurately identify the sedimentary structure types and their vertical distribution characteristics from the macroscopic and microscopic perspectives, and indicates the mixed sedimentation characteristics of combination of different lamina or laminar couplets. The micro-drilling sampling technique is used to sample the samples with different types of sedimentary structures while avoiding diagenetic minerals. X-ray diffraction mineral content analysis and a high-precision carbon-sulfur analyzer are used to obtain the contents of different types of minerals and the total organic carbon contents in each sample, respectively, the basic rock type of each sample was determined using a triangular classification diagram. The name of sedimentary structure and the total organic carbon content are added in order before the name of the basic rock type.

公开(公告)号：US20180017510A1

公开(公告)日：2018-01-18

申请号：US15642533

申请日：2017-07-06

申请人： United States Gypsum Company

发明人： James W. Barber ,  Feng Peng

IPC分类号： G01N23/22 ,  G01N1/40 ,  G01N23/20 ,  G01N23/225

CPC分类号： G01N23/2206 ,  G01N1/4005 ,  G01N15/0625 ,  G01N15/1456 ,  G01N15/1468 ,  G01N23/2005 ,  G01N23/20091 ,  G01N23/2251 ,  G01N2015/0061 ,  G01N2015/1497

摘要： Provided is a method for detecting respirable participles in a bulk material comprising particles. The method comprises: analyzing morphology of the particles; analyzing chemical composition of the particles; creating a profile of the particles, wherein each particle in the profile is characterized by its shape, size and chemical composition; selecting particles from the profile which match the size and chemical composition of a respirable particle; and calculating a percentage of the respirable particles in the bulk material.