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    Lansoprazole formulations and related processes and methods
    2.
    发明申请
    Lansoprazole formulations and related processes and methods 审中-公开
    兰索拉唑制剂及相关方法和方法

    公开(公告)号：US20060140985A1

    公开(公告)日：2006-06-29

    申请号：US10541703

    申请日：2004-01-08

    申请人： Zhong Zhang ,  Orn Almarsson ,  Hongming Chen

    发明人： Zhong Zhang ,  Orn Almarsson ,  Hongming Chen

    IPC分类号： A61K31/4439 ,  A61K9/00

    CPC分类号： A61K9/0019 ,  A61K31/4439

    摘要： The invention provides novel liquid lansoprazole formulations comprising lansoprazole and an excipient system, wherein: (a) the concentration of lansoprazole in the formulations ranges from about 0.3 mg/mL to about 50 mg/mL; (b) the excipient system comprises either a single excipient, or a combination of two to four compositionally distinct excipients; and (c) the formulations may be administered parenterally to a mammal to treat or prevent a gastrointestinal disorder.

    摘要翻译： 本发明提供了包含兰索拉唑和赋形剂体系的新型液体兰索拉唑制剂，其中：（a）制剂中兰索拉唑的浓度范围为约0.3mg / mL至约50mg / mL; （b）赋形剂体系包括单一赋形剂或两至四种组合不同赋形剂的组合; 和（c）制剂可以肠胃外给予哺乳动物以治疗或预防胃肠道疾病。

    Aqueous 2,6-diisopropylphenol pharmaceutical compositions
    5.
    发明授权
    Aqueous 2,6-diisopropylphenol pharmaceutical compositions 有权
    2,6-二异丙基苯酚水溶液药物组合物

    公开(公告)号：US07915317B2

    公开(公告)日：2011-03-29

    申请号：US10629308

    申请日：2003-07-29

    申请人： Zhong Zhang ,  Orn Almarsson ,  Hongming Chen

    发明人： Zhong Zhang ,  Orn Almarsson ,  Hongming Chen

    IPC分类号： A61K31/05 ,  A61K31/14

    CPC分类号： A61K47/28 ,  A61K9/0019 ,  A61K9/10 ,  A61K31/05 ,  A61K45/06 ,  A61K47/10 ,  A61K47/186 ,  A61K47/26 ,  A61K2300/00

    摘要： The present invention relates to aqueous pharmaceutical compositions comprising 2,6-diisopropylphenol (propofol). A composition of the present invention can comprise propofol and two or more excipients as an aqueous mixture. The propofol containing compositions are preferably sterile and are parenterally administered to any animal, including humans. The compositions are also chemically and physically stable over a wide range of environmental conditions.

    摘要翻译： 本发明涉及包含2,6-二异丙基苯酚（丙泊酚）的水性药物组合物。 本发明的组合物可以包含异丙酚和两种或更多种作为水性混合物的赋形剂。 含有异丙酚的组合物优选是无菌的，并且肠胃外给予任何动物，包括人。 组合物在宽范围的环境条件下也是化学和物理稳定的。

    COMPUTING METHODS FOR CONTROL OF HIGH-THROUGHPUT EXPERIMENTAL PROCESSING, DIGITAL ANALYSIS, AND RE-ARRAYING COMPARATIVE SAMPLES IN COMPUTER-DESIGNED ARRAYS
    7.
    发明申请
    COMPUTING METHODS FOR CONTROL OF HIGH-THROUGHPUT EXPERIMENTAL PROCESSING, DIGITAL ANALYSIS, AND RE-ARRAYING COMPARATIVE SAMPLES IN COMPUTER-DESIGNED ARRAYS 审中-公开
    用于控制高速实验处理，数字分析和计算机设计的阵列中的重新排列比较样本的计算方法

    公开(公告)号：US20070021929A1

    公开(公告)日：2007-01-25

    申请号：US11467096

    申请日：2006-08-24

    申请人： Anthony Lemmo ,  Javier Gonzalez-Zugasti ,  Michael Cima ,  Douglas Levinson ,  Alasdair Johnson ,  Orn Almarsson ,  Hongming Chen ,  Christopher McNulty

    发明人： Anthony Lemmo ,  Javier Gonzalez-Zugasti ,  Michael Cima ,  Douglas Levinson ,  Alasdair Johnson ,  Orn Almarsson ,  Hongming Chen ,  Christopher McNulty

    IPC分类号： G06F19/00

    CPC分类号： G01N35/0092 ,  G01N35/00613 ,  G01N35/00712 ,  G01N2015/1493

    摘要： Computer-controlled automated high-throughput systems can be used to design, prepare, process, screen, and analyze a large number of samples in removable sample vials each containing a compound of interest formulated with differing component combinations and varying concentrations. The computer-controlled methods of the present invention allow for a determination of the effects of additional or inactive components, such as excipients, carriers, enhancers, adhesives, additives, and the like, on the compound of interest, such as a pharmaceutical. The invention thus encompasses the computer systems, computer methods, and computer-program products for computer-controlled automated high-throughput testing of experimental formulations in order to identify experimental formulations that can be further processed. Identified experimental formulations from multiple arrays can be removed and re-arrayed together to form a new array for further processing.

    摘要翻译： 计算机控制的自动化高通量系统可用于设计，制备，处理，筛选和分析大量可拆卸样品瓶中的样品，每个样品瓶均含有不同成分组合和不同浓度配制的感兴趣的化合物。 本发明的计算机控制的方法允许确定附加或非活性组分如赋形剂，载体，增强剂，粘合剂，添加剂等对目的化合物如药物的作用。 本发明因此包括计算机系统，计算机方法和计算机程序产品，用于实验制剂的计算机控制的自动高通量测试，以便鉴定可进一步处理的实验制剂。 来自多个阵列的识别的实验制剂可以被去除并重新排列在一起以形成用于进一步处理的新阵列。

    Transdermal assay with magnetic clamp
    9.
    发明授权
    Transdermal assay with magnetic clamp 失效
    用磁夹进行透皮测定

    公开(公告)号：US06852526B2

    公开(公告)日：2005-02-08

    申请号：US10282505

    申请日：2002-10-28

    申请人： Michael J. Cima ,  Hongming Chen ,  J. Richard Gyory

    发明人： Michael J. Cima ,  Hongming Chen ,  J. Richard Gyory

    IPC分类号： B01L3/00 ,  C12M1/34 ,  C12M3/00 ,  G01N13/00 ,  G01N33/15 ,  G01N33/50

    CPC分类号： G01N33/5088 ,  B01L3/50255 ,  G01N13/00 ,  G01N33/5008 ,  G01N33/5044 ,  G01N2500/00

    摘要： The transdermal assay apparatus includes first, second, and third members. The first member has one or more sample surfaces, each of which is configured to receive a sample thereon. The second member defines one or more reservoirs, each of which has an opening on a surface of the second member. Each sample surface is substantially the same size as each opening. The transdermal assay apparatus also includes a magnetic clamp configured to clamp a tissue specimen between the sample surface and the opening. The magnetic clamp preferably includes a magnet having a strength that is selected based on the clamping force required between the first member and the second member. The invention also provides a method for using a transdermal assay apparatus.

    摘要翻译： 透皮测定装置包括第一，第二和第三构件。 第一构件具有一个或多个样品表面，每个样品表面被配置为在其上接收样品。 第二构件限定一个或多个储存器，每个储存器在第二构件的表面上具有开口。 每个样品表面的大小与每个开口大致相同。 透皮测定装置还包括构造成在样品表面和开口之间夹持组织样本的磁性夹具。 磁夹具优选地包括具有基于第一构件和第二构件之间所需的夹紧力选择的强度的磁体。 本发明还提供了一种使用透皮测定装置的方法。

    Targeted polymerized liposomes for improved drug delivery
    10.
    发明授权
    Targeted polymerized liposomes for improved drug delivery 失效
    用于改善药物递送的靶向聚合脂质体

    公开(公告)号：US6004534A

    公开(公告)日：1999-12-21

    申请号：US844137

    申请日：1997-04-18

    申请人： Robert S. Langer ,  Hongming Chen

    发明人： Robert S. Langer ,  Hongming Chen

    IPC分类号： A61K9/127 ,  A61K39/00 ,  A61K49/00

    CPC分类号： A61K9/1273 ,  Y10S424/812 ,  Y10T428/2984

    摘要： The present invention relates to targeted polymerized liposomes for oral and/or mucosal delivery of vaccines, allergens and therapeutics. In particular, the present invention relates to polymerized liposomes which have been modified on their surface to contain a molecule or ligand which targets the polymerized liposome to a specific site or cell type in order to optimize the immune response to the encapsulated antigen or the efficacy of the encapsulated drug.

    摘要翻译： 本发明涉及用于口服和/或粘膜递送疫苗，变应原和治疗剂的目标聚合脂质体。 特别地，本发明涉及在其表面上已被修饰以包含将聚合的脂质体靶向特定部位或细胞类型的分子或配体的聚合脂质体，以便优化对包封的抗原的免疫应答或其功效 胶囊化药物。