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1.发明授权Methods of treating and preventing colitis involving IL-13 and NK-T cells 有权治疗和预防涉及IL-13和NK-T细胞的结肠炎的方法公开(公告)号：US08821866B2
公开(公告)日：2014-09-02
申请号：US13464323
申请日：2012-05-04
IPC分类号： A61K39/395
CPC分类号： C07K16/2833 , A61K2039/505 , C07K16/2809 , C07K2317/73 , C07K2317/76 , C07K2319/30 , G01N33/505 , G01N33/5088 , G01N2333/5437
摘要： Method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates IL-13 activity (FIG. 3). The invention also provides a method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates NK-T cell activity. The invention also provides for the screening of substances that treat or prevent the inflammatory response of colitis.
摘要翻译： 治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节IL-13活性的物质（图3）。 本发明还提供了治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节NK-T细胞活性的物质。 本发明还提供了治疗或预防结肠炎炎症反应的物质的筛选。
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2.发明申请公开(公告)号：US20130330715A1
公开(公告)日：2013-12-12
申请号：US13981388
申请日：2012-01-26
申请人： Richard S. Blumberg , Arthur Kaser
发明人： Richard S. Blumberg , Arthur Kaser
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6888 , C12Q1/04 , C12Q1/6806 , C12Q1/6883 , C12Q1/689 , G01N33/68 , G01N2800/26
摘要： Provided herein are MiIP-Seq assays and methods for detecting and/or identifying an immune-stimulating microbe in a patient sample. Also provided herein are methods for diagnosing an infectious disease or identifying a previously uncharacterized microbe in a patient sample. The methods and assays described herein are advantageous over existing methods in that they (i) do not require a culture step for microbe expansion, (ii) are not specific for a particular microbe and can be used to identify a previously uncharacterized microbe, and (iii) permits rapid processing due to the lack of a microbe culture step.
摘要翻译： 本文提供了MiIP-Seq测定法和用于在患者样品中检测和/或鉴定免疫刺激微生物的方法。 本文还提供了用于诊断感染性疾病或鉴定患者样品中先前未表征的微生物的方法。 本文所述的方法和测定对于现有方法是有利的，因为它们（i）不需要用于微生物扩增的培养步骤，（ii）不特定于特定微生物并且可用于鉴定先前未表征的微生物，和（ iii）由于缺乏微生物培养步骤，允许快速处理。
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公开(公告)号：US06852320B2
公开(公告)日：2005-02-08
申请号：US09884196
申请日：2001-06-19
申请人： Richard S. Blumberg
发明人： Richard S. Blumberg
IPC分类号： C12Q1/02 , A61K38/00 , A61K39/395 , A61K45/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C07K19/00 , C12P21/08 , A61K38/16
CPC分类号： C07K14/70596 , A61K2039/505 , C07K16/2803
摘要： The invention relates to compositions which bind T cell inhibitory receptor molecules and modulate T cell activity, and methods of using such compositions. Such compositions include biliary glycoprotein binding agents. Methods for modulating killer T cell activities, including cytotoxicity and proliferation also are provided.
摘要翻译： 本发明涉及结合T细胞抑制受体分子和调节T细胞活性的组合物，以及使用这些组合物的方法。 这样的组合物包括胆糖糖蛋白结合剂。 还提供了调节杀伤T细胞活性的方法，包括细胞毒性和增殖。
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公开(公告)号：US09689044B2
公开(公告)日：2017-06-27
申请号：US13981388
申请日：2012-01-26
申请人： Richard S. Blumberg , Arthur Kaser
发明人： Richard S. Blumberg , Arthur Kaser
CPC分类号： C12Q1/6888 , C12Q1/04 , C12Q1/6806 , C12Q1/6883 , C12Q1/689 , G01N33/68 , G01N2800/26
摘要： Provided herein are MiIP-Seq assays and methods for detecting and/or identifying an immune-stimulating microbe in a patient sample. Also provided herein are methods for diagnosing an infectious disease or identifying a previously uncharacterized microbe in a patient sample. The methods and assays described herein are advantageous over existing methods in that they (i) do not require a culture step for microbe expansion, (ii) are not specific for a particular microbe and can be used to identify a previously uncharacterized microbe, and (iii) permits rapid processing due to the lack of a microbe culture step.
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公开(公告)号：US20120107845A1
公开(公告)日：2012-05-03
申请号：US13322983
申请日：2010-05-28
IPC分类号： G01N33/566 , C12M1/34 , G01N30/96
CPC分类号： C07K14/76 , C07K14/70535 , G01N33/566 , G01N2500/02
摘要： Provided herein are, inter alia, methods for identifying a candidate compound for treating the toxic effects of compounds or molecules that bind to albumin in a subject. The methods include identifying test compounds that inhibit the binding between FcRn and albumin.
摘要翻译： 本文提供了用于鉴定用于治疗受试者中结合白蛋白的化合物或分子的毒性作用的候选化合物的方法。 所述方法包括鉴定抑制FcRn和白蛋白结合的测试化合物。
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6.发明申请METHODS OF TREATING AND PREVENTING COLITIS INVOLVING IL-13 AND NK-T CELLS 有权治疗和预防涉及IL-13和NK-T细胞的位点的方法公开(公告)号：US20100143339A1
公开(公告)日：2010-06-10
申请号：US12709029
申请日：2010-02-19
IPC分类号： A61K39/395
CPC分类号： C07K16/2833 , A61K2039/505 , C07K16/2809 , C07K2317/73 , C07K2317/76 , C07K2319/30 , G01N33/505 , G01N33/5088 , G01N2333/5437
摘要： Method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates IL-13 activity (FIG. 3). The invention also provides a method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates NK-T cell activity. The invention also provides for the screening of substances that treat or prevent the inflammatory response of colitis.
摘要翻译： 治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节IL-13活性的物质（图3）。 本发明还提供了治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节NK-T细胞活性的物质。 本发明还提供了治疗或预防结肠炎炎症反应的物质的筛选。
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7.发明授权Methods of treating and preventing colitis involving IL-13 and NK-T cells 有权治疗和预防涉及IL-13和NK-T细胞的结肠炎的方法公开(公告)号：US07666411B2
公开(公告)日：2010-02-23
申请号：US10517898
申请日：2002-06-14
IPC分类号： A61K39/395
CPC分类号： C07K16/2833 , A61K2039/505 , C07K16/2809 , C07K2317/73 , C07K2317/76 , C07K2319/30 , G01N33/505 , G01N33/5088 , G01N2333/5437
摘要： Method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates IL-13 activity (FIG. 3). The invention also provides a method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates NK-T cell activity. The invention also provides for the screening of substances that treat or prevent the inflammatory response of colitis.
摘要翻译： 治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节IL-13活性的物质（图3）。 本发明还提供了治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节NK-T细胞活性的物质。 本发明还提供了治疗或预防结肠炎炎症反应的物质的筛选。
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公开(公告)号：US06485726B1
公开(公告)日：2002-11-26
申请号：US09122144
申请日：1998-07-24
IPC分类号： A61K3900
CPC分类号： A61K39/385 , A61K38/28 , A61K39/00 , A61K47/646 , A61K47/68 , A61K47/6811 , A61K2039/505 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55516 , A61K2039/55544 , A61K2039/6056 , C07K2319/30 , Y02A50/472 , Y10S424/809 , Y10S424/81 , Y10S530/866 , Y10S530/868
摘要： The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.
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公开(公告)号：US6086875A
公开(公告)日：2000-07-11
申请号：US374159
申请日：1995-01-17
IPC分类号： A61K39/385 , A61K47/48 , A61P37/02 , C07K16/00 , A61K39/44
CPC分类号： C07K16/00 , A61K39/385 , A61K47/4833 , A61K47/48369 , A61K2039/541 , A61K2039/543 , A61K2039/55516 , A61K2039/55522 , A61K2039/6056 , C07K2317/50 , C07K2319/30
摘要： Methods and products for modulating an immune response are provided. Pharmaceutical preparations contain a conjugate of an antigen and a FcRn binding partner. The conjugates are administered to mammals in effective amounts to modulate the immune system by stimulating the immune response against the antigen or tolerizing the immune system to the antigen. The antigen may be characteristic of a pathogen, of an autoimmune disease or of an allergen.
摘要翻译： 提供了调节免疫应答的方法和产品。 药物制剂含有抗原和FcRn结合配偶体的缀合物。 将缀合物以有效的量施用于哺乳动物，以通过刺激针对抗原的免疫应答或耐受抗原的免疫系统来调节免疫系统。 抗原可能是病原体，自身免疫性疾病或过敏原的特征。
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公开(公告)号：US08232067B2
公开(公告)日：2012-07-31
申请号：US13322983
申请日：2010-05-28
CPC分类号： C07K14/76 , C07K14/70535 , G01N33/566 , G01N2500/02
摘要： Provided herein are, inter alia, methods for identifying a candidate compound for treating the toxic effects of compounds or molecules that bind to albumin in a subject. The methods include identifying test compounds that inhibit the binding between FcRn and albumin.
摘要翻译： 本文提供了用于鉴定用于治疗受试者中结合白蛋白的化合物或分子的毒性作用的候选化合物的方法。 所述方法包括鉴定抑制FcRn和白蛋白结合的测试化合物。
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