公开(公告)号：US5889038A

公开(公告)日：1999-03-30

申请号：US621169

申请日：1996-03-20

Applicant: Wayne I. Lencer ,  Carlo Brugnara ,  Seth Alper

Inventor： Wayne I. Lencer ,  Carlo Brugnara ,  Seth Alper

IPC: C07D233/56 ,  A61K31/00 ,  A61K31/03 ,  A61K31/05 ,  A61K31/055 ,  A61K31/065 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4174 ,  A61K39/395 ,  A61K45/06 ,  A61P1/00 ,  A61P1/12 ,  A61P31/00 ,  A61P31/12 ,  A61K31/47 ,  A61K31/34 ,  A61K31/38 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44

CPC classification number: A61K45/06 ,  A61K31/05 ,  A61K31/065 ,  A61K31/4174 ,  A61K39/39508 ,  Y10S514/867

Abstract: A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.

Abstract translation: 提供了治疗和预防腹泻和冲洗的方法和产品。 所述方法包括治疗患有腹泻或冲刷的患者，或者患有本发明的芳香族化合物引起腹泻或冲刷的风险。 本发明的产品是本发明的芳族化合物和抗冲刷剂的兽用制剂，本发明的芳族化合物和抗腹泻剂的药物制剂。

公开(公告)号：US20090118343A1

公开(公告)日：2009-05-07

申请号：US10572667

申请日：2004-09-20

Applicant: Paul Rufo ,  Wayne I. Lencer

Inventor： Paul Rufo ,  Wayne I. Lencer

IPC: A61K31/4164 ,  A61P29/00

CPC classification number: A61K31/4174

Abstract: This invention relates to methods and materials involved in the treatment of diseases with severe distal colitis component, and more specifically non-fungal and/or non-microbial induced mucositis of the distal intestinal tract. Kits and pharmaceutical compositions for medical treatments also are provided.

Abstract translation: 本发明涉及涉及治疗具有严重远端结肠炎组分的疾病的方法和材料，更具体地涉及远端肠道的非真菌和/或非微生物诱导的粘膜炎。 还提供用于医疗治疗的药盒和药物组合物。

公开(公告)号：US07067129B2

公开(公告)日：2006-06-27

申请号：US10215298

申请日：2002-08-08

Applicant: Richard S. Blumberg ,  Neil E. Simister ,  Wayne I. Lencer

Inventor： Richard S. Blumberg ,  Neil E. Simister ,  Wayne I. Lencer

IPC: A61K39/395

CPC classification number: A61K39/385 ,  A61K38/28 ,  A61K39/00 ,  A61K47/646 ,  A61K47/68 ,  A61K47/6811 ,  A61K2039/505 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/6056 ,  C07K2319/30 ,  Y02A50/472 ,  Y10S424/809 ,  Y10S424/81 ,  Y10S530/866 ,  Y10S530/868

Abstract: The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.

Abstract translation: 本发明一般涉及用于启动针对抗原的免疫应答的方法和产品，特别涉及抗原的跨上皮递送以引起耐受性和免疫性。 本发明还涉及治疗剂的跨上皮递送的方法和产品。 特别地，本发明涉及将与FcRn结合配偶体缀合的治疗剂递送至肠上皮，粘膜上皮和肺上皮的方法和组合物。 本发明还涉及作为或用于药物和疫苗的口服系统递送的药物组合物中的FcRn结合配偶体缀合物的合成，制备和用途。

公开(公告)号：US06291449B1

公开(公告)日：2001-09-18

申请号：US09159333

申请日：1998-09-23

Applicant: Wayne I. Lencer ,  Carlo Brugnara ,  Seth Alper

Inventor： Wayne I. Lencer ,  Carlo Brugnara ,  Seth Alper

IPC: A61K3155

CPC classification number: C07D223/20 ,  A61K31/55 ,  Y10S514/867

Abstract: A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.

Abstract translation: 提供了治疗和预防腹泻和冲洗的方法和产品。 所述方法包括治疗患有腹泻或冲刷的患者，或者患有本发明的芳香族化合物引起腹泻或冲刷的风险。 本发明的产品是本发明的芳族化合物和抗冲刷剂的兽用制剂，本发明的芳族化合物和抗腹泻剂的药物制剂。

公开(公告)号：US09457097B2

公开(公告)日：2016-10-04

申请号：US13062638

申请日：2009-09-04

Applicant: Wayne I. Lencer ,  Daniel J F Chinnapen ,  Randy Mrsny

Inventor： Wayne I. Lencer ,  Daniel J F Chinnapen ,  Randy Mrsny

IPC: C07K17/10 ,  C12N5/071 ,  A61K38/26 ,  A61K47/48

CPC classification number: A61K47/549 ,  A61K31/4164 ,  A61K38/26 ,  A61K39/15 ,  A61K47/543 ,  A61K47/544 ,  A61K47/61 ,  C12N7/00 ,  C12N2720/12322 ,  C12N2720/12334

Abstract: Described herein are compositions and methods useful for allowing for the absorption (passage) of agents of interest, such as therapeutic agents, across epithelial and mucosal barriers and/or into certain subcellular compartments of the cell, such as the recycling endosome (RE), Golgi, and the endoplasmic reticulum (ER).

Abstract translation: 本文描述的是用于允许感兴趣的试剂（例如治疗剂）穿过上皮和粘膜屏障和/或进入细胞的某些亚细胞区（例如再循环内体（RE））的吸收（通过）的组合物和方法， 高尔基体和内质网（ER）。

公开(公告)号：US20120252727A1

公开(公告)日：2012-10-04

申请号：US13062638

申请日：2009-09-04

Applicant: Wayne I. Lencer ,  Daniel JF Chinnapen ,  Randy Mrsny

Inventor： Wayne I. Lencer ,  Daniel JF Chinnapen ,  Randy Mrsny

IPC: C07K17/10 ,  C12N5/071 ,  A61K38/26

CPC classification number: A61K47/549 ,  A61K31/4164 ,  A61K38/26 ,  A61K39/15 ,  A61K47/543 ,  A61K47/544 ,  A61K47/61 ,  C12N7/00 ,  C12N2720/12322 ,  C12N2720/12334

Abstract: Described herein are compositions and methods useful for allowing for the absorption (passage) of agents of interest, such as therapeutic agents, across epithelial and mucosal barriers and/or into certain subcellular compartments of the cell, such as the recycling endosome (RE), Golgi, and the endoplasmic reticulum (ER).

Abstract translation: 本文描述的是用于允许感兴趣的试剂（例如治疗剂）穿过上皮和粘膜屏障和/或进入细胞的某些亚细胞区（例如再循环内体（RE））的吸收（通过）的组合物和方法， 高尔基体和内质网（ER）。

公开(公告)号：US07547436B2

公开(公告)日：2009-06-16

申请号：US11360849

申请日：2006-02-23

Applicant: Richard S. Blumberg ,  Wayne I. Lencer ,  Neil E. Simister

Inventor： Richard S. Blumberg ,  Wayne I. Lencer ,  Neil E. Simister

IPC: A61K39/395 ,  A61K38/21

CPC classification number: A61K39/385 ,  A61K38/28 ,  A61K39/00 ,  A61K47/646 ,  A61K47/68 ,  A61K47/6811 ,  A61K2039/505 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/6056 ,  C07K2319/30 ,  Y02A50/472 ,  Y10S424/809 ,  Y10S424/81 ,  Y10S530/866 ,  Y10S530/868

Abstract: The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.

公开(公告)号：US07060274B2

公开(公告)日：2006-06-13

申请号：US10215297

申请日：2002-08-08

Applicant: Richard S. Blumberg ,  Neil E. Simister ,  Wayne I. Lencer

Inventor： Richard S. Blumberg ,  Neil E. Simister ,  Wayne I. Lencer

IPC: A61K39/395

CPC classification number: A61K39/385 ,  A61K38/28 ,  A61K39/00 ,  A61K47/646 ,  A61K47/68 ,  A61K47/6811 ,  A61K2039/505 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/6056 ,  C07K2319/30 ,  Y02A50/472 ,  Y10S424/809 ,  Y10S424/81 ,  Y10S530/866 ,  Y10S530/868

Abstract: The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.

公开(公告)号：US6030613A

公开(公告)日：2000-02-29

申请号：US899856

申请日：1997-07-24

Applicant: Richard S. Blumberg ,  Neil E. Simister ,  Wayne I. Lencer

Inventor： Richard S. Blumberg ,  Neil E. Simister ,  Wayne I. Lencer

IPC: A61K38/28 ,  A61K39/00 ,  A61K39/385 ,  A61K39/395 ,  A61K45/00 ,  A61K47/48 ,  A61P37/02 ,  A61P37/04 ,  A61K39/44

CPC classification number: A61K47/48415 ,  A01K67/0276 ,  A61K39/00 ,  A61K39/385 ,  A61K47/4833 ,  A61K47/48369 ,  C07K14/70539 ,  C07K16/065 ,  C12N15/8509 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55522 ,  A61K2039/6056 ,  C07K2319/30

Abstract: The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.

公开(公告)号：US09072728B2

公开(公告)日：2015-07-07

申请号：US10572667

申请日：2004-09-20

Applicant: Paul Rufo ,  Wayne I. Lencer

Inventor： Paul Rufo ,  Wayne I. Lencer

IPC: A61K31/4174

CPC classification number: A61K31/4174

Abstract: This invention relates to methods and materials involved in the treatment of diseases with severe distal colitis component, and more specifically non-fungal and/or non-microbial induced mucositis of the distal intestinal tract. Kits and pharmaceutical compositions for medical treatments also are provided.

Abstract translation: 本发明涉及涉及治疗具有严重远端结肠炎组分的疾病的方法和材料，更具体地涉及远端肠道的非真菌和/或非微生物诱导的粘膜炎。 还提供用于医疗治疗的药盒和药物组合物。