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    Vacuolar pyrophosphatases and uses in plants
    1.
    发明申请
    Vacuolar pyrophosphatases and uses in plants 有权
    真空焦磷酸酶及其在植物中的应用

    公开(公告)号：US20080104733A1

    公开(公告)日：2008-05-01

    申请号：US11890795

    申请日：2007-08-07

    Applicant: Roberto Gaxiola ,  Gerald Fink ,  Seth Alper

    Inventor： Roberto Gaxiola ,  Gerald Fink ,  Seth Alper

    IPC: C12N15/82 ,  A01H1/06 ,  C12N5/10 ,  A01H5/00

    CPC classification number: C12N15/8259 ,  C12N15/8261 ,  C12N15/8273 ,  Y02A40/146

    Abstract: The present invention relates to a transgenic plant which is tolerant to a salt, comprising one or more plant cells transformed with exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. The present invention also relates to a transgenic plant with increased Pi uptake, comprising one or more plant cells transformed with exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. Also encompassed by the present invention are transgenic progeny and seeds of the transgenic plants described herein. Progeny transgenic plant grown from seed are also described. Plant cells (e.g., root cells, stem cell, leaf cells, flower cells, fruit cells and seed cells) comprising exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant cell are also the subject of the present invention. Also encompassed by the present invention are methods of making a transgenic plant described herein. Transgenic plants produced by the methods of making a transgenic plant as described herein are also a subject of the present invention. The present invention also relates to a method of bioremediating soil, a method of increasing the yield of a plant, a method of making a plant which is larger than its corresponding wild type plant, a method of producing a transgenic plant which grows in salt water, and a method of producing a transgenic plant with increased Pi uptake. The transgenic plants of the present invention can also be used to produce double transgenic plants which are tolerant to a salt, or have increased Pi uptake.

    Abstract translation: 本发明涉及对盐具有耐受性的转基因植物，其包含用外源核酸转化的一种或多种植物细胞，其改变植物中液泡焦磷酸酶的表达。 本发明还涉及具有增加的Pi摄取的转基因植物，其包含用外源核酸转化的一种或多种植物细胞，其改变植物中液泡焦磷酸酶的表达。 本发明还包括本文所述的转基因植物的转基因后代和种子。 还描述了从种子生长的后代转基因植物。 包含改变植物细胞中液泡焦磷酸酶表达的外源核酸的植物细胞（例如根细胞，干细胞，叶细胞，花细胞，果实细胞和种子细胞）也是本发明的主题。 本发明还包括制备本文所述的转基因植物的方法。 通过制备如本文所述的转基因植物的方法产生的转基因植物也是本发明的主题。 本发明还涉及一种生物中和土壤的方法，提高植物产量的方法，制造大于其相应野生型植物的植物的方法，生产在盐水中生长的转基因植物的方法 ，以及生产具有增加的Pi摄取的转基因植物的方法。 本发明的转基因植物也可以用于产生耐受盐或具有增加的Pi吸收的双转基因植物。

    Triaryl methane compounds and their use in the treatment of diarrhea and scours
    2.
    发明授权
    Triaryl methane compounds and their use in the treatment of diarrhea and scours 有权
    三芳基甲烷化合物及其在治疗腹泻和冲洗中的应用

    公开(公告)号：US06495567B1

    公开(公告)日：2002-12-17

    申请号：US09159399

    申请日：1998-09-23

    Applicant: Wayne I. Lencer ,  Carlo Brugnara ,  Seth Alper

    Inventor： Wayne I. Lencer ,  Carlo Brugnara ,  Seth Alper

    IPC: A61K314429

    CPC classification number: A61K45/06 ,  A61K31/05 ,  A61K31/065 ,  A61K31/4174 ,  A61K39/39508 ,  Y10S514/867 ,  A61K2300/00

    Abstract: A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.

    Abstract translation: 提供了治疗和预防腹泻和冲洗的方法和产品。 所述方法包括治疗患有腹泻或冲刷的患者，或者患有本发明的芳香族化合物引起腹泻或冲刷的风险。 本发明的产品是本发明的芳族化合物和抗冲刷剂的兽用制剂，本发明的芳族化合物和抗腹泻剂的药物制剂。

    Use of 11-phenyl-dibenzazepine compounds to treat diarrhea or scours
    3.
    发明授权
    Use of 11-phenyl-dibenzazepine compounds to treat diarrhea or scours 失效
    使用11-phenyl-dibenzazepine化合物治疗腹泻或冲刷

    公开(公告)号：US06291449B1

    公开(公告)日：2001-09-18

    申请号：US09159333

    申请日：1998-09-23

    Applicant: Wayne I. Lencer ,  Carlo Brugnara ,  Seth Alper

    Inventor： Wayne I. Lencer ,  Carlo Brugnara ,  Seth Alper

    IPC: A61K3155

    CPC classification number: C07D223/20 ,  A61K31/55 ,  Y10S514/867

    Abstract: A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.

    Abstract translation: 提供了治疗和预防腹泻和冲洗的方法和产品。 所述方法包括治疗患有腹泻或冲刷的患者，或者患有本发明的芳香族化合物引起腹泻或冲刷的风险。 本发明的产品是本发明的芳族化合物和抗冲刷剂的兽用制剂，本发明的芳族化合物和抗腹泻剂的药物制剂。

    Proton transporters and uses in plants
    5.
    发明申请
    Proton transporters and uses in plants 有权
    质子运输商和植物用途

    公开(公告)号：US20050262598A1

    公开(公告)日：2005-11-24

    申请号：US11119683

    申请日：2005-05-02

    Applicant: Roberto Gaxiola ,  Gerald Fink ,  Seth Alper

    Inventor： Roberto Gaxiola ,  Gerald Fink ,  Seth Alper

    IPC: A01H1/00 ,  C07K14/415 ,  C12N15/82

    CPC classification number: C12N15/8273 ,  C07K14/415 ,  C12N15/8242 ,  C12N15/8261 ,  Y02A40/146

    Abstract: The present invention relates to a transgenic plant which is tolerant to a salt, comprising one or more plant cells transformed with exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. Also encompassed by the present invention are transgenic progeny and seeds of the transgenic plants described herein. Progeny transgenic plant grown from seed are also described. The present invention also relates to a construct comprising an AVP1 gene operably linked to a chimeric promoter designed to overexpress AVP1 or designed to down regulate endogenous pyrophosphatase. Plant cells (e.g., root cells, stem cell, leaf cells) comprising exogenous nucleic acid which alters expression of vacuolar pyrophosphatase in the plant cell are also the subject of the present invention. Also encompassed by the present invention are methods of making a transgenic plant described herein. Transgenic plants produced by the methods of making a transgenic plant as described herein are also a subject of the present invention. The present invention also relates to a method of bioremediating soil, a method of increasing the yield of a plant, a method of making a plant which is larger than its corresponding wild type plant, and a method of producing a transgenic plant which grows in salt water comprising introducing into one or more cells of a plant nucleic acid which alters expression of vacuolar pyrophosphatase in the plant. The transgenic plants of the present invention can also be used to produce double transgenic plants which are tolerant to a salt.

    Abstract translation: 本发明涉及对盐具有耐受性的转基因植物，其包含用外源核酸转化的一种或多种植物细胞，其改变植物中液泡焦磷酸酶的表达。 本发明还包括本文所述的转基因植物的转基因后代和种子。 还描述了从种子生长的后代转基因植物。 本发明还涉及包含与设计为过表达AVP1或设计用于下调内源焦磷酸酶的嵌合启动子可操作地连接的AVP1基因的构建体。 包含改变植物细胞中液泡焦磷酸酶表达的外源核酸的植物细胞（例如根细胞，干细胞，叶细胞）也是本发明的主题。 本发明还包括制备本文所述的转基因植物的方法。 通过制备如本文所述的转基因植物的方法产生的转基因植物也是本发明的主题。 本发明还涉及一种生物介导土壤的方法，提高植物产量的方法，制备大于其相应野生型植物的植物的方法，以及生产盐的转基因植物的方法 水包括将改变植物中空泡焦磷酸酶表达的植物核酸的一个或多个细胞引入。 本发明的转基因植物也可用于产生耐受盐的双转基因植物。

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