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公开(公告)号：US20110268749A1
公开(公告)日：2011-11-03
申请号：US12671652
申请日：2008-07-31
申请人： Warren Strober , Jay A. Berzofsky , Stefan Fichtner-Feigl , Atsushi Kitani , Ivan J. Fuss , Masaki Terabe , Peter Mannon
发明人： Warren Strober , Jay A. Berzofsky , Stefan Fichtner-Feigl , Atsushi Kitani , Ivan J. Fuss , Masaki Terabe , Peter Mannon
IPC分类号： A61K39/395 , A61K31/7088 , A61P35/00 , A61K38/17
CPC分类号： A61K31/00 , A61K38/1793 , A61K2039/505 , C07K16/241 , C12N15/1138 , C12N2310/13 , C12N2310/14
摘要： Disclosed herein are compositions and methods for treating or preventing cancer involving the use of a TNF-alpha antagonist, an IL-13Rα2 antagonist, and/or a AP-I antagonist.
摘要翻译： 本文公开了用于治疗或预防涉及TNF-α拮抗剂，IL-13Rα2拮抗剂和/或AP-1拮抗剂的使用的组合物和方法。
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2.发明申请METHODS OF TREATING AND PREVENTING COLITIS INVOLVING IL-13 AND NK-T CELLS 有权治疗和预防涉及IL-13和NK-T细胞的位点的方法公开(公告)号：US20100143339A1
公开(公告)日：2010-06-10
申请号：US12709029
申请日：2010-02-19
IPC分类号： A61K39/395
CPC分类号： C07K16/2833 , A61K2039/505 , C07K16/2809 , C07K2317/73 , C07K2317/76 , C07K2319/30 , G01N33/505 , G01N33/5088 , G01N2333/5437
摘要： Method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates IL-13 activity (FIG. 3). The invention also provides a method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates NK-T cell activity. The invention also provides for the screening of substances that treat or prevent the inflammatory response of colitis.
摘要翻译： 治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节IL-13活性的物质（图3）。 本发明还提供了治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节NK-T细胞活性的物质。 本发明还提供了治疗或预防结肠炎炎症反应的物质的筛选。
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3.发明授权Methods of treating and preventing colitis involving IL-13 and NK-T cells 有权治疗和预防涉及IL-13和NK-T细胞的结肠炎的方法公开(公告)号：US07666411B2
公开(公告)日：2010-02-23
申请号：US10517898
申请日：2002-06-14
IPC分类号： A61K39/395
CPC分类号： C07K16/2833 , A61K2039/505 , C07K16/2809 , C07K2317/73 , C07K2317/76 , C07K2319/30 , G01N33/505 , G01N33/5088 , G01N2333/5437
摘要： Method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates IL-13 activity (FIG. 3). The invention also provides a method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates NK-T cell activity. The invention also provides for the screening of substances that treat or prevent the inflammatory response of colitis.
摘要翻译： 治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节IL-13活性的物质（图3）。 本发明还提供了治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节NK-T细胞活性的物质。 本发明还提供了治疗或预防结肠炎炎症反应的物质的筛选。
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4.发明申请METHODS OF TREATING AND PREVENTING COLITIS INVOLVING IL-13 AND NK-T CELLS 有权治疗和预防涉及IL-13和NK-T细胞的位点的方法公开(公告)号：US20120276113A1
公开(公告)日：2012-11-01
申请号：US13464323
申请日：2012-05-04
IPC分类号： A61K39/395 , A61P1/04
CPC分类号： C07K16/2833 , A61K2039/505 , C07K16/2809 , C07K2317/73 , C07K2317/76 , C07K2319/30 , G01N33/505 , G01N33/5088 , G01N2333/5437
摘要： Method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates IL-13 activity (FIG. 3). The invention also provides a method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates NK-T cell activity. The invention also provides for the screening of substances that treat or prevent the inflammatory response of colitis.
摘要翻译： 治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节IL-13活性的物质（图3）。 本发明还提供了治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节NK-T细胞活性的物质。 本发明还提供了治疗或预防结肠炎炎症反应的物质的筛选。
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公开(公告)号：US08173123B2
公开(公告)日：2012-05-08
申请号：US12709029
申请日：2010-02-19
申请人： Warren Strober , Ivan J. Fuss , Frank Heller , Richard Blumberg
发明人： Warren Strober , Ivan J. Fuss , Frank Heller , Richard Blumberg
IPC分类号： A61K39/395
CPC分类号： C07K16/2833 , A61K2039/505 , C07K16/2809 , C07K2317/73 , C07K2317/76 , C07K2319/30 , G01N33/505 , G01N33/5088 , G01N2333/5437
摘要： Method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates IL-13 activity (FIG. 3). The invention also provides a method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates NK-T cell activity. The invention also provides for the screening of substances that treat or prevent the inflammatory response of colitis.
摘要翻译： 治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节IL-13活性的物质（图3）。 本发明还提供了治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节NK-T细胞活性的物质。 本发明还提供了治疗或预防结肠炎炎症反应的物质的筛选。
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公开(公告)号：US07531352B2
公开(公告)日：2009-05-12
申请号：US10258109
申请日：2001-04-20
CPC分类号： A01K67/027 , A01K2227/105 , A01K2267/035 , A61K48/00 , A61K48/005 , A61K48/0066 , C07K14/495 , C12N15/85 , C12N2830/002 , C12N2830/003 , C12N2830/15 , C12N2830/205
摘要： The present invention provides alternatives to traditional drug and surgical treatments for IBD. In particular, the present invention provides compositions and methods for the treatment of autoimmune diseases such as IBD in humans using TGF-β therapy. The compositions of the present invention provide vectors containing TGF-β under the control of an inducible promoter. In particularly preferred embodiments, the present invention provides regulated plasmid constructs capable of inducing TGF-β production. In preferred embodiments, the methods of the present invention utilize the vectors described for assaying the expression of a gene in a cell. In some preferred embodiments, the methods of the present invention utilize the administration of TGF-β containing vectors to treat IBD. In alternative preferred embodiments, the present invention provides methods and compositions for the induction of high-level interleukin (e.g., IL-10) production.
摘要翻译： 本发明提供了用于IBD的传统药物和外科治疗的替代方案。 特别地，本发明提供了使用TGF-β治疗在人体中治疗自身免疫疾病如IBD的组合物和方法。 本发明的组合物提供了在诱导型启动子控制下含有TGF-β的载体。 在特别优选的实施方案中，本发明提供能够诱导TGF-β产生的调控质粒构建体。 在优选的实施方案中，本发明的方法利用所述用于测定细胞中基因表达的载体。 在一些优选的实施方案中，本发明的方法利用施用含TGF-β的载体来治疗IBD。 在替代的优选实施方案中，本发明提供用于诱导高水平白细胞介素（例如IL-10）产生的方法和组合物。
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7.发明授权公开(公告)号：US07041296B1
公开(公告)日：2006-05-09
申请号：US10129907
申请日：2000-11-09
IPC分类号： A61K39/00
CPC分类号： A61K38/4886
摘要： The present invention provides a method of treating or preventing inflammation in a subject, comprising administering to the subject an effective amount of cholera toxin subunit B. The present invention also provides a method of decreasing the activity of interferon gamma in a subject, comprising administering to the subject an effective amount of cholera toxin subunit B. Further provided is a method of decreasing the activity of IL-12 in a subject, comprising administering to the subject an effective amount of cholera toxin subunit B. Additionally, the present invention provides a method of treating or preventing a Th1 T-cell mediated autoimmune disorder in a subject, comprising administering to the subject an effective amount of cholera toxin subunit B.
摘要翻译： 本发明提供了治疗或预防受试者炎症的方法，其包括对受试者施用有效量的霍乱毒素亚基B.本发明还提供降低受试者中干扰素γ活性的方法，包括给予 该受试者有效量的霍乱毒素亚基B.进一步提供了降低受试者中IL-12活性的方法，其包括向受试者施用有效量的霍乱毒素亚基B.此外，本发明提供了一种方法 治疗或预防受试者中Th1T细胞介导的自身免疫性疾病，其包括向受试者施用有效量的霍乱毒素亚基B.
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8.发明授权Methods of treating and preventing colitis involving IL-13 and NK-T cells 有权治疗和预防涉及IL-13和NK-T细胞的结肠炎的方法公开(公告)号：US08821866B2
公开(公告)日：2014-09-02
申请号：US13464323
申请日：2012-05-04
IPC分类号： A61K39/395
CPC分类号： C07K16/2833 , A61K2039/505 , C07K16/2809 , C07K2317/73 , C07K2317/76 , C07K2319/30 , G01N33/505 , G01N33/5088 , G01N2333/5437
摘要： Method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates IL-13 activity (FIG. 3). The invention also provides a method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates NK-T cell activity. The invention also provides for the screening of substances that treat or prevent the inflammatory response of colitis.
摘要翻译： 治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节IL-13活性的物质（图3）。 本发明还提供了治疗或预防受试者结肠炎炎症反应的方法，包括向受试者施用有效量的调节NK-T细胞活性的物质。 本发明还提供了治疗或预防结肠炎炎症反应的物质的筛选。
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