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公开(公告)号：US20150031855A1
公开(公告)日：2015-01-29
申请号：US13615072
申请日：2012-09-13
Applicant: PATRICK S. DAUGHERTY , Jeffrey Rice
Inventor： PATRICK S. DAUGHERTY , Jeffrey Rice
IPC: C07K14/245 , C12N15/10
CPC classification number: C12N15/1037 , C07K14/195 , C07K14/245 , C07K2319/00 , C12N15/00
Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
Abstract translation: 公开了使用循环置换的OmpX（CPX）变体制备和使用细菌展示多肽文库的方法。 本发明还涉及通过优化接头并在CPX的位置165和166处并入突变来增强细菌表面上的蛋白质和肽的显示的方法。
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公开(公告)号：US07256038B2
公开(公告)日：2007-08-14
申请号：US10920244
申请日：2004-08-18
Applicant: Patrick S. Daugherty , Paul H. Bessette , Jeffrey Rice
Inventor： Patrick S. Daugherty , Paul H. Bessette , Jeffrey Rice
CPC classification number: C12N15/1037 , C07K14/245 , C12N15/1044 , C40B30/04 , C40B40/10 , G01N33/554
Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
Abstract translation: 本文公开了在生物实体的外表面上显示乘客多肽的表达载体。 如本文所公开的，显示的乘客多肽能够与给定的配体相互作用或结合。 还公开了制备和使用表达载体的方法。 还公开了N / C末端融合表达载体及其制备和使用方法。
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公开(公告)号：US09062107B2
公开(公告)日：2015-06-23
申请号：US13615072
申请日：2012-09-13
Applicant: Patrick S. Daugherty , Jeffrey Rice
Inventor： Patrick S. Daugherty , Jeffrey Rice
IPC: C07K14/195 , C12N15/00 , C07K14/245 , C12N15/10
CPC classification number: C12N15/1037 , C07K14/195 , C07K14/245 , C07K2319/00 , C12N15/00
Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
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公开(公告)号：US08361933B2
公开(公告)日：2013-01-29
申请号：US12563897
申请日：2009-09-21
Applicant: Patrick S. Daugherty , Paul H. Bessette , Jeffrey Rice
Inventor： Patrick S. Daugherty , Paul H. Bessette , Jeffrey Rice
IPC: C40B40/02
CPC classification number: C12N15/1037 , C07K14/245 , C12N15/1044 , C40B30/04 , C40B40/10 , G01N33/554
Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
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Patent Agency Ranking
公开(公告)号：US20090035317A1
公开(公告)日：2009-02-05
申请号：US12008828
申请日：2008-01-14
Applicant: Patrick S. Daugherty , Sophia Kenrick
Inventor： Patrick S. Daugherty , Sophia Kenrick
IPC: C07K14/475 , C07K14/00 , C07K7/06 , A61K39/395 , C40B30/04 , A61P35/00 , G01N33/53 , A61K38/02 , C07K7/08
CPC classification number: C07K14/52 , A61K38/00 , C07K7/08 , C07K14/001 , G01N33/74 , G01N2333/49 , G01N2500/04
Abstract: The invention relates to peptides that bind to vascular endothelial growth factor (VEGF). The invention further relates to methods of screening for VEGF-binding peptides, methods of using VEGF-binding peptides to detect the presence of VEGF in a biological sample, and methods of using VEGF-binding peptides to modulate VEGF activity and angiogenesis, and as components in a therapeutic or prophylactic composition.
Abstract translation: 本发明涉及结合血管内皮生长因子（VEGF）的肽。 本发明还涉及筛选VEGF结合肽的方法，使用VEGF结合肽检测生物样品中VEGF的存在的方法，以及使用VEGF结合肽调节VEGF活性和血管发生的方法，以及作为组分 在治疗或预防组合物中。
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公开(公告)号：US20090062142A1
公开(公告)日：2009-03-05
申请号：US12220448
申请日：2008-07-24
Applicant: Patrick S. Daugherty , Jeffrey Rice
Inventor： Patrick S. Daugherty , Jeffrey Rice
IPC: C40B30/04 , C07K14/00 , C12N15/31 , C12N15/74 , C12N1/21 , C40B30/06 , C40B40/10 , C40B50/08 , C12Q1/02
CPC classification number: C12N15/1037 , C07K14/195 , C07K14/245 , C07K2319/00 , C12N15/00
Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
Abstract translation: 公开了使用循环置换的OmpX（CPX）变体制备和使用细菌展示多肽文库的方法。 本发明还涉及通过优化接头并在CPX的位置165和166处并入突变来增强细菌表面上的蛋白质和肽的显示的方法。
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公开(公告)号：US08293685B2
公开(公告)日：2012-10-23
申请号：US12220448
申请日：2008-07-24
Applicant: Patrick S. Daugherty , Jeffrey Rice
Inventor： Patrick S. Daugherty , Jeffrey Rice
IPC: C40B20/00 , C40B30/04 , C40B40/02 , C40B50/06 , C12Q1/68 , G01N33/53 , C12P21/06 , C12P21/04 , C07K17/00 , C07K1/00 , C07H21/04
CPC classification number: C12N15/1037 , C07K14/195 , C07K14/245 , C07K2319/00 , C12N15/00
Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
Abstract translation: 公开了使用循环置换的OmpX（CPX）变体制备和使用细菌展示多肽文库的方法。 本发明还涉及通过优化接头并在CPX的位置165和166处并入突变来增强细菌表面上的蛋白质和肽的显示的方法。
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公开(公告)号：US20100113303A1
公开(公告)日：2010-05-06
申请号：US12563897
申请日：2009-09-21
Applicant: Patrick S. Daugherty , Paul H. Bessette , Jeffrey Rice
Inventor： Patrick S. Daugherty , Paul H. Bessette , Jeffrey Rice
IPC: C40B40/02
CPC classification number: C12N15/1037 , C07K14/245 , C12N15/1044 , C40B30/04 , C40B40/10 , G01N33/554
Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
Abstract translation: 本文公开了在生物实体的外表面上显示乘客多肽的表达载体。 如本文所公开的，显示的乘客多肽能够与给定的配体相互作用或结合。 还公开了制备和使用表达载体的方法。 还公开了N / C末端融合表达载体及其制备和使用方法。
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公开(公告)号：US07612019B2
公开(公告)日：2009-11-03
申请号：US11612757
申请日：2006-12-19
Applicant: Patrick S. Daugherty , Paul H. Bessette , Jeffrey Rice
Inventor： Patrick S. Daugherty , Paul H. Bessette , Jeffrey Rice
CPC classification number: C12N15/1037 , C07K14/245 , C12N15/1044 , C40B30/04 , C40B40/10 , G01N33/554
Abstract: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression vectors and methods of making and using are also disclosed.
Abstract translation: 本文公开了在生物实体的外表面上显示乘客多肽的表达载体。 如本文所公开的，显示的乘客多肽能够与给定的配体相互作用或结合。 还公开了制备和使用表达载体的方法。 还公开了N / C末端融合表达载体及其制备和使用方法。
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