公开(公告)号：US20230233209A1

公开(公告)日：2023-07-27

申请号：US18190692

申请日：2023-03-27

申请人： Nectero Medical, Inc.

发明人： Eric Wells ,  Kelvin Ning

IPC分类号： A61B17/12 ,  A61K31/7032 ,  A61K47/10 ,  A61K47/20 ,  A61L29/16 ,  A61M25/10 ,  C07H1/06 ,  C07H13/08

CPC分类号： A61B17/12113 ,  A61B17/12136 ,  A61K31/7032 ,  A61K47/10 ,  A61K47/20 ,  A61L29/16 ,  A61M25/1011 ,  C07H1/06 ,  C07H13/08 ,  A61L2300/232 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1086 ,  A61M2205/0238

摘要： Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.

公开(公告)号：US20180344990A1

公开(公告)日：2018-12-06

申请号：US15889933

申请日：2018-02-06

申请人： Nectero Medical, Inc.

发明人： Matthew F. Ogle ,  Jason C. Isenburg

IPC分类号： A61M25/10 ,  A61B17/12 ,  A61K31/05 ,  A61M25/06 ,  A61M25/00

CPC分类号： A61M25/1002 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12113 ,  A61B17/12136 ,  A61K31/05 ,  A61M25/0032 ,  A61M25/10 ,  A61M2025/0681 ,  A61M2025/1015 ,  A61M2025/1052

摘要： Devices for the isolation of a selected portion of a vessel are described. In some embodiments, the device comprises an introducer sheath and a sealing catheter that are movable relative to each other to create an isolated volume with adjustable size and location. The methods for the treatment of vascular aneurysms using the devices are described. The treatment is achieved through the delivery of an effective amount of stabilization agent to an isolated volume that encompass the aneurysm. The device optionally has an aspiration means to improve the effectiveness of the treatment.

公开(公告)号：US20180344665A1

公开(公告)日：2018-12-06

申请号：US15952099

申请日：2018-04-12

申请人： NECTERO MEDICAL, INC.

发明人： Jason C. Isenburg ,  Matthew F. Ogle

IPC分类号： A61K31/11 ,  A61K31/13 ,  A61K36/185 ,  A61K36/484 ,  A61K36/63 ,  A61K36/82 ,  A61K36/886 ,  A61L27/50 ,  A61L27/54 ,  A61L31/16

CPC分类号： A61K31/11 ,  A61K31/13 ,  A61K36/185 ,  A61K36/484 ,  A61K36/63 ,  A61K36/82 ,  A61K36/886 ,  A61L27/507 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/624 ,  A61K2300/00

摘要： Collagen crosslinking/stabilization composition optionally in combination with elastin crosslinking composition as treatment of vascular aneurysms, methods of using the compositions, especially with respect to in vivo procedures are described. The treatment is achieved through the delivery of an effective amount of crosslinking/stabilization composition to the site of the aneurysm. The crosslinking/stabilization agent may be embedded in a delivery composition and delivered to the site of aneurysm using a delivery device. The site of the aneurysm may be isolated for treatment using the delivery device. The elastin stabilization agent may be simultaneously or sequentially delivered with the collagen crosslinking/stabilization agent for the treatment of vascular aneurysms in the isolated section of blood vessel.

公开(公告)号：US09889279B2

公开(公告)日：2018-02-13

申请号：US13871840

申请日：2013-04-26

申请人： Nectero Medical, Inc.

发明人： Matthew F. Ogle ,  Jason C. Isenburg

IPC分类号： A61M25/10 ,  A61K31/05 ,  A61B17/12 ,  A61M25/00 ,  A61M25/06

CPC分类号： A61M25/1002 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12113 ,  A61B17/12136 ,  A61K31/05 ,  A61M25/0032 ,  A61M25/10 ,  A61M2025/0681 ,  A61M2025/1015 ,  A61M2025/1052

摘要： Devices for the isolation of a selected portion of a vessel are described. In some embodiments, the device has an introducer sheath and a sealing catheter that are movable relative to each other to create an isolated volume with adjustable size and location. The methods for the treatment of vascular aneurysms using the devices are described. The treatment is achieved through the delivery of an effective amount of stabilization agent to an isolated volume that encompass the aneurysm. The device optionally has an aspiration device to improve the effectives of the treatment.

公开(公告)号：US11331102B2

公开(公告)日：2022-05-17

申请号：US17158897

申请日：2021-01-26

申请人： Nectero Medical, Inc.

发明人： Eric Wells ,  Kelvin Ning

IPC分类号： C07H13/08 ,  C07H1/06 ,  A61B17/12 ,  A61L29/16 ,  A61M25/10 ,  A61K31/7032 ,  A61K47/10 ,  A61K47/20

摘要： Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.

公开(公告)号：US20210147462A1

公开(公告)日：2021-05-20

申请号：US17158897

申请日：2021-01-26

申请人： Nectero Medical, Inc.

发明人： Eric Wells ,  Kelvin Ning

IPC分类号： C07H13/08 ,  C07H1/06 ,  A61L29/16 ,  A61M25/10 ,  A61B17/12

摘要： Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.

公开(公告)号：US20180326071A1

公开(公告)日：2018-11-15

申请号：US15947399

申请日：2018-04-06

申请人： NECTERO MEDICAL, INC.

发明人： Matthew F. Ogle ,  Wenda C. Carlyle ,  Edward J. Anderson ,  Kishore Udipi

IPC分类号： A61K47/32 ,  A61L29/16 ,  A61L29/14 ,  A61L29/08 ,  A61L29/06

CPC分类号： A61K47/32 ,  A61K31/11 ,  A61K31/7024 ,  A61L29/06 ,  A61L29/085 ,  A61L29/145 ,  A61L29/16 ,  A61L2300/102 ,  A61M25/1011 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1075 ,  A61M2025/1086 ,  A61M2025/1097 ,  F04C2270/0421 ,  A61K2300/00 ,  C08L75/04 ,  C08L29/04

摘要： A coated balloon device for stabilizing a section of a blood vessel in a living subject is disclosed. The coating layer of the coated balloon comprises a phenolic compound having a plurality of phenolic groups connected to form a hydrophobic core with peripheral phenolic hydroxyl groups. The coating layer of the coated balloon may contain a hydrophilic polymer to facilitate the release of the phenolic compound. The balloon in general is made of a compliant polymer for atraumatic contact with the blood vessel. In some embodiments, the coating of the coated balloon device further comprises a hydrophilic undercoat layer between the balloon and the coating layer. In some embodiments, the coated balloon device further comprises a sacrificial top coating that dissolves upon delivery into the section of the blood vessel and comprises a hydrophilic composition including sugar, sugar derivatives, or a combination thereof.

公开(公告)号：US20230310475A1

公开(公告)日：2023-10-05

申请号：US18177019

申请日：2023-03-01

申请人： Nectero Medical, Inc.

发明人： Kelvin Ning

IPC分类号： A61K31/7034 ,  A61K9/06 ,  A61K47/10

CPC分类号： A61K31/7034 ,  A61K9/06 ,  A61K47/10

摘要： Methods and compositions for treating post-surgery laxity of tendons or tendon repair are provided that utilize 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof or LeGoo®. Also provided is a device to deliver 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof or LeGoo® to the tissue to be treated.

公开(公告)号：US20220000897A1

公开(公告)日：2022-01-06

申请号：US17448450

申请日：2021-09-22

申请人： Nectero Medical, Inc.

发明人： Kelvin Ning

IPC分类号： A61K31/7034 ,  A61K9/06 ,  A61K47/10

摘要： Methods and compositions for treating post-surgery laxity of tendons or tendon repair are provided that utilize 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof or LeGoo®. Also provided is a device to deliver 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof or LeGoo® to the tissue to be treated.

公开(公告)号：US20220000896A1

公开(公告)日：2022-01-06

申请号：US17448318

申请日：2021-09-21

申请人： Nectero Medical, Inc.

发明人： Kelvin Ning

IPC分类号： A61K31/7034 ,  A61M25/10 ,  A61L31/06 ,  A61L31/16

摘要： Methods and compositions for treatments associated with endovascular grafts, dissections, peripheral aneurysms, and neuro aneurysms are provided that deliver 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof and/or LeGoo®. Also provided is a device to deliver 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof or LeGoo® to the tissue to be treated.