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1.发明申请公开(公告)号：US20180344990A1
公开(公告)日：2018-12-06
申请号：US15889933
申请日：2018-02-06
发明人： Matthew F. Ogle , Jason C. Isenburg
CPC分类号： A61M25/1002 , A61B17/12045 , A61B17/12109 , A61B17/12113 , A61B17/12136 , A61K31/05 , A61M25/0032 , A61M25/10 , A61M2025/0681 , A61M2025/1015 , A61M2025/1052
摘要： Devices for the isolation of a selected portion of a vessel are described. In some embodiments, the device comprises an introducer sheath and a sealing catheter that are movable relative to each other to create an isolated volume with adjustable size and location. The methods for the treatment of vascular aneurysms using the devices are described. The treatment is achieved through the delivery of an effective amount of stabilization agent to an isolated volume that encompass the aneurysm. The device optionally has an aspiration means to improve the effectiveness of the treatment.
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公开(公告)号：US20180344665A1
公开(公告)日：2018-12-06
申请号：US15952099
申请日：2018-04-12
发明人： Jason C. Isenburg , Matthew F. Ogle
IPC分类号： A61K31/11 , A61K31/13 , A61K36/185 , A61K36/484 , A61K36/63 , A61K36/82 , A61K36/886 , A61L27/50 , A61L27/54 , A61L31/16
CPC分类号： A61K31/11 , A61K31/13 , A61K36/185 , A61K36/484 , A61K36/63 , A61K36/82 , A61K36/886 , A61L27/507 , A61L27/54 , A61L31/16 , A61L2300/624 , A61K2300/00
摘要： Collagen crosslinking/stabilization composition optionally in combination with elastin crosslinking composition as treatment of vascular aneurysms, methods of using the compositions, especially with respect to in vivo procedures are described. The treatment is achieved through the delivery of an effective amount of crosslinking/stabilization composition to the site of the aneurysm. The crosslinking/stabilization agent may be embedded in a delivery composition and delivered to the site of aneurysm using a delivery device. The site of the aneurysm may be isolated for treatment using the delivery device. The elastin stabilization agent may be simultaneously or sequentially delivered with the collagen crosslinking/stabilization agent for the treatment of vascular aneurysms in the isolated section of blood vessel.
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公开(公告)号：US09889279B2
公开(公告)日：2018-02-13
申请号：US13871840
申请日：2013-04-26
发明人： Matthew F. Ogle , Jason C. Isenburg
CPC分类号： A61M25/1002 , A61B17/12045 , A61B17/12109 , A61B17/12113 , A61B17/12136 , A61K31/05 , A61M25/0032 , A61M25/10 , A61M2025/0681 , A61M2025/1015 , A61M2025/1052
摘要： Devices for the isolation of a selected portion of a vessel are described. In some embodiments, the device has an introducer sheath and a sealing catheter that are movable relative to each other to create an isolated volume with adjustable size and location. The methods for the treatment of vascular aneurysms using the devices are described. The treatment is achieved through the delivery of an effective amount of stabilization agent to an isolated volume that encompass the aneurysm. The device optionally has an aspiration device to improve the effectives of the treatment.
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公开(公告)号：US20180326071A1
公开(公告)日：2018-11-15
申请号：US15947399
申请日：2018-04-06
CPC分类号： A61K47/32 , A61K31/11 , A61K31/7024 , A61L29/06 , A61L29/085 , A61L29/145 , A61L29/16 , A61L2300/102 , A61M25/1011 , A61M25/104 , A61M2025/105 , A61M2025/1052 , A61M2025/1075 , A61M2025/1086 , A61M2025/1097 , F04C2270/0421 , A61K2300/00 , C08L75/04 , C08L29/04
摘要： A coated balloon device for stabilizing a section of a blood vessel in a living subject is disclosed. The coating layer of the coated balloon comprises a phenolic compound having a plurality of phenolic groups connected to form a hydrophobic core with peripheral phenolic hydroxyl groups. The coating layer of the coated balloon may contain a hydrophilic polymer to facilitate the release of the phenolic compound. The balloon in general is made of a compliant polymer for atraumatic contact with the blood vessel. In some embodiments, the coating of the coated balloon device further comprises a hydrophilic undercoat layer between the balloon and the coating layer. In some embodiments, the coated balloon device further comprises a sacrificial top coating that dissolves upon delivery into the section of the blood vessel and comprises a hydrophilic composition including sugar, sugar derivatives, or a combination thereof.
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公开(公告)号：US20180338766A1
公开(公告)日：2018-11-29
申请号：US15963312
申请日：2018-04-26
发明人： Matthew F. Ogle , Jason C. Isenburg
IPC分类号： A61B17/12 , A61M25/10 , A61K47/26 , A61K47/08 , A61K35/614 , A61K31/7004 , A61K31/353 , A61K31/352 , A61K31/192 , A61K47/42
摘要： Devices for the treatment of vascular aneurysms are described. The treatment is achieved through the delivery of an effective amount of elastin stabilization agent to an isolated volume at the aneurysm. The elastin stabilization agent maybe embedded in a delivery composition. The device optionally has an aspiration means to improve the effectiveness of the treatment.
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