公开(公告)号：US20230233209A1

公开(公告)日：2023-07-27

申请号：US18190692

申请日：2023-03-27

申请人： Nectero Medical, Inc.

发明人： Eric Wells ,  Kelvin Ning

IPC分类号： A61B17/12 ,  A61K31/7032 ,  A61K47/10 ,  A61K47/20 ,  A61L29/16 ,  A61M25/10 ,  C07H1/06 ,  C07H13/08

CPC分类号： A61B17/12113 ,  A61B17/12136 ,  A61K31/7032 ,  A61K47/10 ,  A61K47/20 ,  A61L29/16 ,  A61M25/1011 ,  C07H1/06 ,  C07H13/08 ,  A61L2300/232 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1086 ,  A61M2205/0238

摘要： Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.

公开(公告)号：US11331102B2

公开(公告)日：2022-05-17

申请号：US17158897

申请日：2021-01-26

申请人： Nectero Medical, Inc.

发明人： Eric Wells ,  Kelvin Ning

IPC分类号： C07H13/08 ,  C07H1/06 ,  A61B17/12 ,  A61L29/16 ,  A61M25/10 ,  A61K31/7032 ,  A61K47/10 ,  A61K47/20

摘要： Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.

公开(公告)号：US20210147462A1

公开(公告)日：2021-05-20

申请号：US17158897

申请日：2021-01-26

申请人： Nectero Medical, Inc.

发明人： Eric Wells ,  Kelvin Ning

IPC分类号： C07H13/08 ,  C07H1/06 ,  A61L29/16 ,  A61M25/10 ,  A61B17/12

摘要： Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.

公开(公告)号：US20210106339A1

公开(公告)日：2021-04-15

申请号：US17131447

申请日：2020-12-22

申请人： Nectero Medical, Inc.

发明人： Eric Wells ,  Kelvin Ning

IPC分类号： A61B17/12 ,  A61M25/10 ,  A61L29/16 ,  A61K31/7032 ,  A61K47/10 ,  A61K47/20

摘要： Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.