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    Humanized immunoglobulin reacting specifically with Fas ligand or active fragments thereof and region inducing apoptosis originating in Fas ligand
    1.
    发明授权
    Humanized immunoglobulin reacting specifically with Fas ligand or active fragments thereof and region inducing apoptosis originating in Fas ligand 有权
    与Fas配体或其活性片段特异性反应的人源化免疫球蛋白和诱导Fas配体凋亡的区域

    公开(公告)号：US06777540B1

    公开(公告)日：2004-08-17

    申请号：US09254180

    申请日：1999-04-15

    申请人： Ko Okumura ,  Motomi Nakata ,  Hirofumi Higuchi ,  Yoshitaka Ushio ,  Hiroaki Maeda ,  Yasuyuki Eda

    发明人： Ko Okumura ,  Motomi Nakata ,  Hirofumi Higuchi ,  Yoshitaka Ushio ,  Hiroaki Maeda ,  Yasuyuki Eda

    IPC分类号： C07K1600

    CPC分类号： C07K16/2875 ,  C07K14/70575 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2319/00

    摘要： Novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are provided, and a site on Fas ligand which is important to inhibit apoptosis induced by the Fas-Fas ligand interaction against Fas-expressing cells is demonstrated. The novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are prepared from hybridomas which produce monoclonal antibodies specifically reactive to Fas ligand, via recombinant DNA techniques. The humanized immunoglobulins can inhibit the physiological reactions between Fas ligand and Fas such as apoptosis. Further, identification of the site which is on Fas ligand and responsible for apoptosis induction allows creation of recombinant proteins or peptides which are specifically reactive to the amino acids within the site so as to inhibit apoptosis, and to find new therapeutic or diagnostic agents.

    摘要翻译： 提供了与Fas配体特异性反应的新型人源化免疫球蛋白及其活性片段，证明了Fas配体上对Fas-Fas配体与Fas表达细胞相互作用诱导的细胞凋亡重要的位点。 通过重组DNA技术从与Fas配体特异性反应的单克隆抗体的杂交瘤制备与Fas配体特异性反应的新型人源化免疫球蛋白及其活性片段。 人源化免疫球蛋白可以抑制Fas配体和Fas之间的生理反应，如细胞凋亡。 此外，鉴定在Fas配体上并负责细胞凋亡诱导的位点允许产生对位点内的氨基酸具有特异性反应性的重组蛋白质或肽，以便抑制细胞凋亡，并找到新的治疗剂或诊断剂。

    ANALYZER OF PHOSPHORYLATION OF PEPTIDE OR PROTEIN, PHOSPHORYLATION DETERMINATION PROGRAM, AND RECORDING MEDIUM FOR THE PROGRAM
    2.
    发明申请
    ANALYZER OF PHOSPHORYLATION OF PEPTIDE OR PROTEIN, PHOSPHORYLATION DETERMINATION PROGRAM, AND RECORDING MEDIUM FOR THE PROGRAM 审中-公开
    肽或蛋白质磷酸化分析仪，磷化测定程序和程序记录介质

    公开(公告)号：US20110184660A1

    公开(公告)日：2011-07-28

    申请号：US13053030

    申请日：2011-03-21

    申请人： MOTOMI NAKATA ,  KUNIO AWAZU

    发明人： MOTOMI NAKATA ,  KUNIO AWAZU

    IPC分类号： G06F19/00

    CPC分类号： G01N21/35 ,  G01N21/3577

    摘要： To provide an analyzer configured to enable to determine whether or not phosphoric acid is bound to a peptide or protein in a short time according to a simple procedure, and to provide a program for use in the analyzer, and a recording medium for storing the program.A spectrum of a peptide or protein in the infrared region is determined so as to specify the type of a phosphorylated amino acid in the peptide or protein based on a peak position in a region of 1,000 to 1,100 [cm−1] of the spectrum.

    摘要翻译： 提供一种分析器，其被配置为能够根据简单的过程在短时间内确定磷酸是否与肽或蛋白质结合，并且提供用于分析仪的程序和用于存储程序的记录介质 。 确定红外区域中的肽或蛋白质的光谱，以便基于光谱的1000至1100 [cm -1]的区域中的峰位置来指定肽或蛋白质中的磷酸化氨基酸的类型。

    Composite structure and process for producing the same
    3.
    发明授权
    Composite structure and process for producing the same 有权
    复合结构及其制造方法

    公开(公告)号：US08506750B2

    公开(公告)日：2013-08-13

    申请号：US12401219

    申请日：2009-03-10

    申请人： Fumihiro Hayashi ,  Yasuhiro Okuda ,  Motomi Nakata

    发明人： Fumihiro Hayashi ,  Yasuhiro Okuda ,  Motomi Nakata

    IPC分类号： B32B37/00

    CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2002/072 ,  A61F2002/075

    摘要： A composite structure comprising two polytetrafluoroethylene porous layers and a framework structural member having a plurality of gaps or openings, the framework structural member being disposed between the two polytetrafluoroethylene porous layers, wherein the composite structure is structured such that the polytetrafluoroethylene porous layers are united together by being adhered with each other through the gaps or openings of the framework structural member and such that the respective polytetrafluoroethylene porous layers (A1) and (A2) are united with the framework structural member closely along the surfaces of the respective constituent elements of the framework structural member in such a manner as to wrap the respective elements. The method of manufacturing the composite structure is characterized in that it includes a step of applying pressure through a mass of fine particles.

    摘要翻译： 包括两个聚四氟乙烯多孔层的复合结构和具有多个间隙或开口的框架结构构件，所述框架结构构件设置在所述两个聚四氟乙烯多孔层之间，其中所述复合结构被构造成使得所述聚四氟乙烯多孔层通过 通过框架结构构件的间隙或开口彼此粘合，并且使得相应的聚四氟乙烯多孔层（A1）和（A2）与框架结构构件紧密地沿着框架结构的各个构成元件的表面结合 构件以包裹各个元件的方式。 制造复合结构体的方法的特征在于，其包括通过大量微粒施加压力的步骤。

    Composite structure and process for producing the same
    4.
    发明申请
    Composite structure and process for producing the same 审中-公开
    复合结构及其制造方法

    公开(公告)号：US20070173917A1

    公开(公告)日：2007-07-26

    申请号：US10590739

    申请日：2004-02-27

    申请人： Fumihiro Hayashi ,  Yasuhiro Okuda ,  Motomi Nakata

    发明人： Fumihiro Hayashi ,  Yasuhiro Okuda ,  Motomi Nakata

    IPC分类号： A61F2/06

    CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2002/072 ,  A61F2002/075

    摘要： A composite structure comprising two polytetrafluoroethylene porous layers and a framework structural member having a plurality of gaps or openings, the framework structural member being disposed between the two polytetrafluoroethylene porous layers, wherein the composite structure is structured such that the polytetrafluoroethylene porous layers are united together by being adhered with each other through the gaps or openings of the framework structural member and such that the respective polytetrafluoroethylene porous layers (A1) and (A2) are united with the framework structural member closely along the surfaces of the respective constituent elements of the framework structural member in such a manner as to wrap the respective elements. The method of manufacturing the composite structure is characterized in that it includes a step of applying pressure through a mass of fine particles.

    摘要翻译： 包括两个聚四氟乙烯多孔层的复合结构和具有多个间隙或开口的框架结构构件，所述框架结构构件设置在所述两个聚四氟乙烯多孔层之间，其中所述复合结构被构造成使得所述聚四氟乙烯多孔层通过 通过框架结构构件的间隙或开口彼此粘合，并且使得相应的聚四氟乙烯多孔层（A 1）和（A 2）与框架结构构件紧密地沿着相应的构成元件的表面 框架结构构件以包裹各个元件的方式。 制造复合结构体的方法的特征在于，其包括通过大量微粒施加压力的步骤。

    Polynucleotides for detecting leishmanias and method of detection of leishmanial protozoan
    7.
    发明授权
    Polynucleotides for detecting leishmanias and method of detection of leishmanial protozoan 失效
    用于检测利什曼原虫的多核苷酸和检测利什曼原虫的方法

    公开(公告)号：US6022690A

    公开(公告)日：2000-02-08

    申请号：US930797

    申请日：1998-01-07

    申请人： Hideyuki Saya ,  Tatsuyuki Mimori ,  Jiichiro Sasaki ,  Motomi Nakata

    发明人： Hideyuki Saya ,  Tatsuyuki Mimori ,  Jiichiro Sasaki ,  Motomi Nakata

    IPC分类号： G01N33/566 ,  C07H21/04 ,  C12N15/00 ,  C12Q1/04 ,  C12Q1/68 ,  G01N33/569 ,  C12P19/34

    CPC分类号： C12Q1/6893

    摘要： The present invention enables detection, and isolation of DNP, specific to leishmanias, and identification of the sequence thereof.Accordingly, a leishmania protozoan can be precisely detected. The present invention can be applied to a diagnosis reagent, diagnosis kit, and the like for diagnosing infection with a leishmania protozoan. Furthermore, brazil type leishmanias and mexico type leishmania can be differentiated, whereby the present invention can be applied to development of a remedy after the diagnosis of the leishmania infection. The present invention can be applied also to development of a reagent, a diagnosis kit, and the like for large-group examination for examining quickly and simply a large number of samples at a time in leishmaniasis propagating area.

    摘要翻译： PCT No.PCT / JP96 / 00893 Sec。 371日期：1998年1月7日 102（e）1998年1月7日PCT PCT 1996年4月2日PCT公布。 公开号WO96 / 31623 日期1996年10月10日本发明能够检测和分离特定于利什曼原虫的DNP，以及其序列的鉴别。 因此，可以精确地检测利什曼原虫。 本发明可以应用于用于诊断利什曼原虫感染的诊断试剂，诊断试剂盒等。 此外，可以区分巴西式利什曼原虫和墨西哥型利什曼原虫，由此本发明可以应用于利什曼原虫感染诊断后的补救发展。 本发明也可以应用于大规模检查用的试剂，诊断试剂盒等的开发，以便在利什曼病传播区域中一次快速简单地检查大量的样品。

    Process for production of expanded polytetrafluoroetylene products
    9.
    发明授权
    Process for production of expanded polytetrafluoroetylene products 有权
    生产膨胀聚四氟乙烯产品的方法

    公开(公告)号：US07691299B2

    公开(公告)日：2010-04-06

    申请号：US10513150

    申请日：2003-05-01

    申请人： Fumihiro Hayashi ,  Yasuhiro Okuda ,  Motomi Nakata ,  Koichiro Natori

    发明人： Fumihiro Hayashi ,  Yasuhiro Okuda ,  Motomi Nakata ,  Koichiro Natori

    IPC分类号： B27J5/00 ,  D01D5/24 ,  A61F2/06

    CPC分类号： B29C47/54 ,  B29C47/0004 ,  B29C47/0014 ,  B29C47/0023 ,  B29C55/005 ,  B29C55/22 ,  B29K2027/18 ,  B29L2031/7534 ,  B29L2031/7542

    摘要： Disclosed are expanded polytetrafluoroethylene products, such as porous polytetrafluoroethylene tubes, having high axial tear strength and a process for their production. Each expanded polytetrafluoroethylene product has a microstructure, which comprises fibrils and nodes interconnected with each other by the fibrils, and has an axial tear strength of not lower than 6,000 gf/mm as calculated in accordance with the following formula: L/[T×(V/100)] where L (gf) is an axial tear load, T (mm) is a wall thickness, and V (%) is a volume ratio of resin. The process for the production of the expanded polytetrafluoroethylene product includes a high-speed extrusion step.

    摘要翻译： 公开了具有高轴向撕裂强度的膨胀聚四氟乙烯产品，例如多孔聚四氟乙烯管，以及它们的生产方法。 每个膨胀的聚四氟乙烯产品具有显微组织，其包括通过原纤维相互连接的原纤维和节点，并且具有根据下式计算的不低于6,000gf / mm的轴向撕裂强度：L / [T×（ V / 100）]其中L（gf）是轴向撕裂载荷，T（mm）是壁厚，V（％）是树脂的体积比。 膨胀聚四氟乙烯制品的生产方法包括高速挤出步骤。

    COMPOSITE STRUCTURE AND PROCESS FOR PRODUCING THE SAME
    10.
    发明申请
    COMPOSITE STRUCTURE AND PROCESS FOR PRODUCING THE SAME 有权
    复合结构及其制造方法

    公开(公告)号：US20090173439A1

    公开(公告)日：2009-07-09

    申请号：US12401219

    申请日：2009-03-10

    申请人： Fumihiro HAYASHI ,  Yasuhiro Okuda ,  Motomi Nakata

    发明人： Fumihiro HAYASHI ,  Yasuhiro Okuda ,  Motomi Nakata

    IPC分类号： B32B37/02

    CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2002/072 ,  A61F2002/075

    摘要： A composite structure comprising two polytetrafluoroethylene porous layers and a framework structural member having a plurality of gaps or openings, the framework structural member being disposed between the two polytetrafluoroethylene porous layers, wherein the composite structure is structured such that the polytetrafluoroethylene porous layers are united together by being adhered with each other through the gaps or openings of the framework structural member and such that the respective polytetrafluoroethylene porous layers (A1) and (A2) are united with the framework structural member closely along the surfaces of the respective constituent elements of the framework structural member in such a manner as to wrap the respective elements. The method of manufacturing the composite structure is characterized in that it includes a step of applying pressure through a mass of fine particles.

    摘要翻译： 包括两个聚四氟乙烯多孔层的复合结构和具有多个间隙或开口的框架结构构件，所述框架结构构件设置在所述两个聚四氟乙烯多孔层之间，其中所述复合结构被构造成使得所述聚四氟乙烯多孔层通过 通过框架结构构件的间隙或开口彼此粘合，并且使得相应的聚四氟乙烯多孔层（A1）和（A2）与框架结构构件紧密地沿着框架结构的各个构成元件的表面结合 构件以包裹各个元件的方式。 制造复合结构体的方法的特征在于，其包括通过大量微粒施加压力的步骤。