发明授权
US06777540B1 Humanized immunoglobulin reacting specifically with Fas ligand or active fragments thereof and region inducing apoptosis originating in Fas ligand
有权
与Fas配体或其活性片段特异性反应的人源化免疫球蛋白和诱导Fas配体凋亡的区域
- 专利标题： Humanized immunoglobulin reacting specifically with Fas ligand or active fragments thereof and region inducing apoptosis originating in Fas ligand
- 专利标题（中）： 与Fas配体或其活性片段特异性反应的人源化免疫球蛋白和诱导Fas配体凋亡的区域
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申请号： US09254180申请日： 1999-04-15
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公开(公告)号： US06777540B1公开(公告)日： 2004-08-17
- 发明人: Ko Okumura , Motomi Nakata , Hirofumi Higuchi , Yoshitaka Ushio , Hiroaki Maeda , Yasuyuki Eda
- 申请人： Ko Okumura , Motomi Nakata , Hirofumi Higuchi , Yoshitaka Ushio , Hiroaki Maeda , Yasuyuki Eda
- 优先权： JP8/231742 19960902; JP8/271546 19960920
- 主分类号： C07K1600
- IPC分类号： C07K1600
摘要：
Novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are provided, and a site on Fas ligand which is important to inhibit apoptosis induced by the Fas-Fas ligand interaction against Fas-expressing cells is demonstrated. The novel humanized immunoglobulins and active fragments thereof which are specifically reactive to Fas ligand are prepared from hybridomas which produce monoclonal antibodies specifically reactive to Fas ligand, via recombinant DNA techniques. The humanized immunoglobulins can inhibit the physiological reactions between Fas ligand and Fas such as apoptosis. Further, identification of the site which is on Fas ligand and responsible for apoptosis induction allows creation of recombinant proteins or peptides which are specifically reactive to the amino acids within the site so as to inhibit apoptosis, and to find new therapeutic or diagnostic agents.
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