-
公开(公告)号:US20110027881A1
公开(公告)日:2011-02-03
申请号:US12845178
申请日:2010-07-28
申请人: Ken-ichiro SEINO , Haruka WADA
发明人: Ken-ichiro SEINO , Haruka WADA
IPC分类号: C12N5/00
CPC分类号: C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/11 , C12N2510/00
摘要: A production method of T cells is disclosed which includes generating iPS cells from immune cells and differentiating the iPS cells into desired immune cells. In this method, 4 different genes Oct4, Sox2, Klf4 and c-Myc are introduced into immune cells for generation of iPS cells, and the iPS cells are then differentiated into immune cells by coculture with OP9 cells. Source immune cells are taken from a patient, and the produced desired immune cells are injected into the patient for medical treatment.
摘要翻译: 公开了一种T细胞的制备方法,其包括从免疫细胞产生iPS细胞并将iPS细胞分化为所需的免疫细胞。 在该方法中,将4种不同的基因Oct4,Sox2,Klf4和c-Myc引入到免疫细胞中用于产生iPS细胞,然后通过与OP9细胞共培养将iPS细胞分化为免疫细胞。 从患者取出源免疫细胞,将产生的所需免疫细胞注射到患者中用于治疗。
-
公开(公告)号:US6068841A
公开(公告)日:2000-05-30
申请号:US65059
申请日:1998-04-27
申请人: Ken-ichiro Seino , Nobuhiko Kayagaki , Hideo Yagita , Ko Okumura , Motomi Nakata
发明人: Ken-ichiro Seino , Nobuhiko Kayagaki , Hideo Yagita , Ko Okumura , Motomi Nakata
IPC分类号: A61K39/395 , A61K38/00 , A61P1/16 , A61P31/12 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12P21/08
CPC分类号: C07K16/2875 , A61K38/00
摘要: The invention provides therapeutic agents for hepatitis, comprising an antibody against a human Fas ligand, or an active fragment thereof as an active ingredient. The therapeutic agents for hepatitis according to the invention are particularly effective for the treatment of hepatitis caused by the death of hepatocytes due to apoptosis among many kinds of hepatitis.
摘要翻译: PCT No.PCT / JP96 / 03089 Sec。 371日期:1998年4月27日 102(e)日期1998年4月27日PCT 1996年10月24日PCT公布。 公开号WO97 / 15326 日期:1997年5月1日本发明提供了包含针对人Fas配体的抗体或其活性片段作为活性成分的肝炎治疗剂。 根据本发明的肝炎治疗剂对于治疗肝细胞死亡引起的肝炎特别有效,因为许多种肝炎引起的细胞凋亡。
-
公开(公告)号:US20090214596A1
公开(公告)日:2009-08-27
申请号:US11910311
申请日:2006-03-30
申请人: Ken-ichiro Seino , Masaru Taniguchi , Takuya Tashiro , Ken-ichi Fuhshuku , Kenji Mori , Hideki Hasegawa
发明人: Ken-ichiro Seino , Masaru Taniguchi , Takuya Tashiro , Ken-ichi Fuhshuku , Kenji Mori , Hideki Hasegawa
CPC分类号: A61K39/39 , A61K9/0043 , A61K31/7052 , A61K31/7056 , A61K2039/543 , A61K2039/55511
摘要: The present invention provides a nasal vaccine capable of intranasally inducing an effective immunity reaction. Specifically, the invention provides a nasal vaccine containing a compound having an NKT cell-activating action, particularly a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a compound represented by the formula (II): wherein each symbol is as defined in the specification, and an immunogen in an amount effective for stimulating an immune response.
摘要翻译: 本发明提供能够鼻内诱导有效免疫反应的鼻腔疫苗。 具体地说,本发明提供含有具有NKT细胞活化作用的化合物,特别是由式(I)表示的化合物的鼻腔疫苗:其中每个符号如说明书中所定义,或由式(II)表示的化合物, :其中每个符号如说明书中所定义,并且具有有效刺激免疫应答量的免疫原。
-
公开(公告)号:US08173608B2
公开(公告)日:2012-05-08
申请号:US11817616
申请日:2006-03-03
CPC分类号: C07D207/12 , C07D205/04 , C07D405/12 , C07F7/1804 , C07H15/26
摘要: The present invention relates to a compound represented by the following formula (1′) wherein R is an aldopyranose residue, R2 is a C2-18 hydrocarbon group optionally having substituent(s), R3 is an acyl group, X is an oxygen atom, a sulfur atom or —NH—, and p is an integer of 0-4, or a salt thereof. The compound of the present invention has a specific immunoregulatory ability, and is useful for the prophylaxis or treatment of autoimmune diseases and the like.
摘要翻译: 本发明涉及由下式(1')表示的化合物,其中R为吡喃葡萄糖残基,R2为任选具有取代基的C2-18烃基,R3为酰基,X为氧原子, 硫原子或-NH-,p为0-4的整数,或其盐。 本发明的化合物具有特异的免疫调节能力,可用于预防或治疗自身免疫性疾病等。
-
公开(公告)号:US20090215707A1
公开(公告)日:2009-08-27
申请号:US11817616
申请日:2006-03-03
IPC分类号: A61K31/7056 , C07H15/26 , A61K31/7052 , A61P19/02 , A61P17/06 , A61P3/10 , A61P37/06 , A61P37/00
CPC分类号: C07D207/12 , C07D205/04 , C07D405/12 , C07F7/1804 , C07H15/26
摘要: The present invention relates to a compound represented by the following formula (1′) wherein R is an aldopyranose residue, R2 is a C2-18 hydrocarbon group optionally having substituent(s), R3 is an acyl group, X is an oxygen atom, a sulfur atom or —NH—, and p is an integer of 0-4, or a salt thereof.The compound of the present invention has a specific immunoregulatory ability, and is useful for the prophylaxis or treatment of autoimmune diseases and the like.
摘要翻译: 本发明涉及由下式(1')表示的化合物,其中R为吡喃葡萄糖残基,R2为任选具有取代基的C2-18烃基,R3为酰基,X为氧原子, 硫原子或-NH-,p为0-4的整数,或其盐。 本发明的化合物具有特异的免疫调节能力,可用于预防或治疗自身免疫性疾病等。
-
-
-
-