PRODUCTION METHOD OF IMMUNE CELLS
    1.
    发明申请
    PRODUCTION METHOD OF IMMUNE CELLS 审中-公开
    免疫细胞生产方法

    公开(公告)号:US20110027881A1

    公开(公告)日:2011-02-03

    申请号:US12845178

    申请日:2010-07-28

    IPC分类号: C12N5/00

    摘要: A production method of T cells is disclosed which includes generating iPS cells from immune cells and differentiating the iPS cells into desired immune cells. In this method, 4 different genes Oct4, Sox2, Klf4 and c-Myc are introduced into immune cells for generation of iPS cells, and the iPS cells are then differentiated into immune cells by coculture with OP9 cells. Source immune cells are taken from a patient, and the produced desired immune cells are injected into the patient for medical treatment.

    摘要翻译: 公开了一种T细胞的制备方法,其包括从免疫细胞产生iPS细胞并将iPS细胞分化为所需的免疫细胞。 在该方法中,将4种不同的基因Oct4,Sox2,Klf4和c-Myc引入到免疫细胞中用于产生iPS细胞,然后通过与OP9细胞共培养将iPS细胞分化为免疫细胞。 从患者取出源免疫细胞,将产生的所需免疫细胞注射到患者中用于治疗。