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公开(公告)号：US20190054112A1
公开(公告)日：2019-02-21
申请号：US15760659
申请日：2016-09-16
Applicant: Moderna Therapeutics, Inc.
Inventor： Francine M. GREGOIRE
IPC: A61K31/7115 , A61K38/17 , C12N15/62 , C12N15/113 , A61K47/14 , A61K47/24 , A61K47/28 , A61K9/127 , C12N15/85 , A61K47/18 , A61K47/10 , C12N15/88 , A61P13/12 , A61K48/00
Abstract: The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of renal polynucleotides.
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公开(公告)号：US09827332B2
公开(公告)日：2017-11-28
申请号：US14940512
申请日：2015-11-13
Applicant: Moderna Therapeutics, Inc.
Inventor： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Jeff Lynn Ellsworth , Kenechi Ejebe , Justin Guild , Matthias John , Paul Hatala , Atanu Roy , Jason P. Schrum , Susan Whoriskey , Kristy M. Wood
IPC: C12N15/85 , A61K47/48 , A61K48/00 , A61K31/7115 , A61K9/127 , C12N9/64 , C07K14/515 , C07K16/00 , C07K14/535 , C07K14/47 , A61K38/17 , A61K38/45 , C07K14/005 , C07K14/435 , C07K14/485 , C07K14/505 , C07K14/62 , C07K14/705 , C12N9/10 , C12N9/16 , C12N9/24 , C12N9/42 , C12N9/88 , C12N9/00 , C12N15/11 , C12N15/52 , C12N15/87 , C12P13/04 , C12P21/00 , A61K9/51 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/48 , C07K14/525 , C07K14/56 , A61K9/14 , A61K31/7088 , A61K38/00
CPC classification number: A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US20160348099A1
公开(公告)日：2016-12-01
申请号：US15240297
申请日：2016-08-18
Applicant: Moderna Therapeutics, Inc.
Inventor： Atanu ROY , Christopher R. CONLEE , Antonin DE FOUGEROLLES , Andrew W. FRALEY
CPC classification number: A61K48/0066 , A61K38/1816 , A61K38/193 , A61K48/00 , C07H19/10 , C07H21/00 , C12N15/11 , C12N2310/321 , C12N2310/322 , C12N2310/335 , C12N2310/336 , C12N2320/30 , C12P19/34 , C12P21/00 , C12P21/005
Abstract: The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
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公开(公告)号：US20160317647A1
公开(公告)日：2016-11-03
申请号：US15089050
申请日：2016-04-01
Applicant: Moderna Therapeutics, Inc.
Inventor： Giuseppe Ciaramella , Axel Bouchon , Eric Yi-Chun Huang
IPC: A61K39/155 , A61K9/00 , A61K39/39
CPC classification number: A61K39/145 , A61K9/0019 , A61K9/1271 , A61K9/5123 , A61K9/5146 , A61K31/7105 , A61K39/12 , A61K39/155 , A61K39/39 , A61K48/00 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16234
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
Abstract translation: 本发明涉及包含编码一种或多种抗原的多核苷酸分子的制备，制备和治疗用核糖核酸疫苗（NAV）的组合物和方法。
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公开(公告)号：US09464124B2
公开(公告)日：2016-10-11
申请号：US14533264
申请日：2014-11-05
Applicant: Moderna Therapeutics, Inc.
Inventor： Stephane Bancel , Jason P. Schrum , Alexander Aristarkhov
CPC classification number: A61K38/1729 , A61K38/465 , A61K45/06 , A61K48/0075 , C07K14/4723 , C12Y301/27
Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing.
Abstract translation: 提供了将生物学部分如修饰的核酸递送到细胞中以杀死或减少微生物生长的组合物和方法。 这样的组合物和方法包括使用修饰的信使RNA，并且可用于治疗或预防微生物感染或改善受试者的健康或健康。
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Patent Agency Ranking
公开(公告)号：US09428535B2
公开(公告)日：2016-08-30
申请号：US13644072
申请日：2012-10-03
Applicant: modeRNA Therapeutics
Inventor： Antonin de Fougerolles , Atanu Roy , Jason P. Schrum , Suhaib Siddiqi , Paul Hatala , Stephane Bancel
CPC classification number: A61K48/0066 , A61K38/193 , C07H21/02 , C07K14/535 , C12N15/11 , C12N15/67
Abstract: The present disclosure provides methods of increasing the level of a polypeptide of interest in a mammalian subject by administering a polynucleotide having one or more chemical modifications and a Protein:Cytokine ratio of greater than 100.
Abstract translation: 本公开提供了通过施用具有一种或多种化学修饰和蛋白质：细胞因子比率大于100的多核苷酸来增加哺乳动物受试者中感兴趣的多肽的水平的方法。
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公开(公告)号：US20160237108A1
公开(公告)日：2016-08-18
申请号：US15026836
申请日：2014-10-02
Applicant: MODERNA THERAPEUTICS, INC.
Inventor： Andrew W. FRALEY , Atanu ROY , Matthew STANTON
IPC: C07H19/10 , C07K14/535 , C07K14/525 , C07K14/565 , C07H19/20 , C07H21/02
CPC classification number: C07H19/10 , C07H19/067 , C07H19/167 , C07H19/20 , C07H21/02 , C07K14/525 , C07K14/535 , C07K14/565
Abstract: The present disclosure provides alternative sugar moieties and polynucleotides comprising such sugar moieties, and methods of use thereof.
Abstract translation: 本公开提供了替代的糖部分和包含这种糖部分的多核苷酸及其使用方法。
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公开(公告)号：US20160194625A1
公开(公告)日：2016-07-07
申请号：US14915959
申请日：2014-09-03
Applicant: MODERNA THERAPEUTICS, INC.
Inventor： Stephen G. HOGE , Andrew W. FRALEY , Divakar RAMAKRISHNAN
CPC classification number: C12N15/102 , C12N15/11 , C12N15/67 , C12P19/34
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of chimeric polynucleotide molecules.
Abstract translation: 本发明涉及用于制备，制备和治疗性使用嵌合多核苷酸分子的组合物和方法。
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公开(公告)号：US09295689B2
公开(公告)日：2016-03-29
申请号：US13897375
申请日：2013-05-18
Applicant: Moderna Therapeutics, Inc.
Inventor： Antonin de Fougerolles , Kristy M. Wood , Pedro Valencia
IPC: A61K31/7115 , A61K48/00 , A61K9/58 , A61K31/7105 , A61K9/14 , A61K9/16 , A61K9/127 , A61K38/48 , C12N15/00 , A61K9/00 , C07K2/00 , A61K31/7088 , C12P21/00 , C12N15/117 , C12N15/88
CPC classification number: A61K38/193 , A61K9/0019 , A61K9/0024 , A61K9/0048 , A61K9/1271 , A61K9/1272 , A61K9/14 , A61K9/16 , A61K9/1647 , A61K31/7088 , A61K31/7105 , A61K38/4833 , A61K48/00 , A61K48/0033 , A61K48/0041 , A61K48/005 , A61K48/0066 , C07K2/00 , C07K14/535 , C12N15/00 , C12N15/117 , C12N15/88 , C12P21/00
Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
Abstract translation: 本公开尤其提供了包含修饰的核酸分子的制剂组合物，其可以编码蛋白质，蛋白质前体或部分或完全加工形式的蛋白质或蛋白质前体。 制剂组合物还可包含经修饰的核酸分子和递送剂。 本发明还提供了用于编码能够调节细胞功能和/或活性的多肽的核酸。
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公开(公告)号：US09283287B2
公开(公告)日：2016-03-15
申请号：US14694357
申请日：2015-04-23
Applicant: Moderna Therapeutics, Inc.
Inventor： Tirtha Chakraborty , Antonin de Fougerolles , Ron Weiss
CPC classification number: C07K14/535 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/5031 , A61K31/7088 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/54 , A61K47/542 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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