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公开(公告)号：US09827332B2
公开(公告)日：2017-11-28
申请号：US14940512
申请日：2015-11-13
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Jeff Lynn Ellsworth , Kenechi Ejebe , Justin Guild , Matthias John , Paul Hatala , Atanu Roy , Jason P. Schrum , Susan Whoriskey , Kristy M. Wood
IPC分类号： C12N15/85 , A61K47/48 , A61K48/00 , A61K31/7115 , A61K9/127 , C12N9/64 , C07K14/515 , C07K16/00 , C07K14/535 , C07K14/47 , A61K38/17 , A61K38/45 , C07K14/005 , C07K14/435 , C07K14/485 , C07K14/505 , C07K14/62 , C07K14/705 , C12N9/10 , C12N9/16 , C12N9/24 , C12N9/42 , C12N9/88 , C12N9/00 , C12N15/11 , C12N15/52 , C12N15/87 , C12P13/04 , C12P21/00 , A61K9/51 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/48 , C07K14/525 , C07K14/56 , A61K9/14 , A61K31/7088 , A61K38/00
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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公开(公告)号：US20150246139A1
公开(公告)日：2015-09-03
申请号：US14694357
申请日：2015-04-23
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC分类号： A61K48/00 , A61K38/48 , A61K38/18 , A61K38/19 , A61K39/395
CPC分类号： C07K14/535 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/5031 , A61K31/7088 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/54 , A61K47/542 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及多核苷酸，初级转录物和mmRNA分子的制备，制备和治疗用途的组合物和方法。
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3.发明申请MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS 有权用于生产CYPOPLASMIC和CYTOSKELETET蛋白质的改性多核苷酸公开(公告)号：US20150086614A1
公开(公告)日：2015-03-26
申请号：US14390098
申请日：2013-03-09
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC分类号： C07K14/535 , C07K14/505 , C07K14/475 , A61K47/34
CPC分类号： C07K14/535 , A61K47/34 , A61K48/005 , C07K14/475 , C07K14/505 , C12N15/67 , C12N15/85 , C12N2840/85
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及多核苷酸，初级转录物和mmRNA分子的制备，制备和治疗用途的组合物和方法。
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4.发明授权Modified polynucleotides for the production of oncology-related proteins and peptides 有权用于产生肿瘤学相关蛋白和肽的修饰多核苷酸公开(公告)号：US09587003B2
公开(公告)日：2017-03-07
申请号：US15015684
申请日：2016-02-04
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC分类号： C07K14/535 , C07K14/505
CPC分类号： C07K14/535 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/5031 , A61K31/7088 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/54 , A61K47/542 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
摘要翻译： 本发明涉及用于制备，制造和治疗使用肿瘤学相关多核苷酸，肿瘤学相关的初级转录物和肿瘤相关的mmRNA分子的组合物和方法。
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5.发明授权Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins 有权用于产生细胞质和细胞骨架蛋白的修饰多核苷酸公开(公告)号：US09572897B2
公开(公告)日：2017-02-21
申请号：US15042173
申请日：2016-02-12
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC分类号： A61K48/00 , A61K31/7115 , A61K9/127 , C12N9/64 , C07K14/515 , C07K16/00 , C07K14/535 , C07K14/47 , A61K38/17 , A61K38/45 , C07K14/005 , C07K14/435 , C07K14/485 , C07K14/505 , C07K14/62 , C07K14/705 , C12N9/10 , C12N9/16 , C12N9/24 , C12N9/42 , C12N9/88 , C12N9/00 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , A61K9/51 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/48 , A61K47/48 , C07K14/525 , C07K14/56 , A61K9/14 , A61K38/00
CPC分类号： A61K48/0066 , A61K9/0019 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/48046 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及多核苷酸，初级转录物和mmRNA分子的制备，制备和治疗用途的组合物和方法。
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公开(公告)号：US09504734B2
公开(公告)日：2016-11-29
申请号：US14975141
申请日：2015-12-18
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild , Ron Weiss
IPC分类号： C12N15/85 , A61K38/48 , A61K48/00 , C12N15/88 , A61K9/127 , A61K9/50 , A61K31/7088 , A61K47/48 , C07K19/00 , A61K38/18 , A61K38/19 , C07K14/47 , A61K9/00
CPC分类号： C07K14/535 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/5031 , A61K31/7088 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/54 , A61K47/542 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及用于制备，制造和治疗性使用多核苷酸，初级转录物和mmRNA分子的组合物和方法。
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公开(公告)号：US09254311B2
公开(公告)日：2016-02-09
申请号：US14390100
申请日：2013-03-09
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC分类号： C07K14/47 , A61K38/17 , A61K31/7115 , A61K9/127 , A61K48/00 , C12N9/64 , C07K14/515 , C07K16/00 , C07K14/535 , A61K38/45 , C07K14/005 , C07K14/435 , C07K14/485 , C07K14/505 , C07K14/62 , C07K14/705 , C12N9/10 , C12N9/16 , C12N9/24 , C12N9/42 , C12N9/88 , C12N9/00 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , A61K38/00
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及多核苷酸，初级转录物和mmRNA分子的制备，制备和治疗用途的组合物和方法。
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公开(公告)号：US09221891B2
公开(公告)日：2015-12-29
申请号：US14390106
申请日：2013-03-15
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC分类号： C12N15/85 , C07K14/47 , A61K31/7115 , A61K9/127 , A61K48/00 , C12N9/64 , C07K14/515 , C07K16/00 , C07K14/535 , A61K38/00
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07K14/005 , C07K14/435 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/485 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/56 , C07K14/62 , C07K14/705 , C07K16/00 , C12N9/1051 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/644 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y304/21022 , C12Y603/02019
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及多核苷酸，初级转录物和mmRNA分子的制备，制备和治疗用途的组合物和方法。
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公开(公告)号：US20150017211A1
公开(公告)日：2015-01-15
申请号：US14337513
申请日：2014-07-22
CPC分类号： A61K47/18 , A61K31/7088 , A61K31/7115 , A61K38/193 , A61K38/4846 , A61K47/22 , A61K47/28 , A61K48/00 , C07K14/535 , C12N9/644 , C12N15/67 , C12N15/87 , C12N2310/335
摘要： Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.
摘要翻译： 提供了将生物学部分如修饰的核酸递送到细胞中以调节蛋白质表达的制剂，组合物和方法。 这样的组合物和方法包括递送生物部分，并且可用于生产蛋白质。
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公开(公告)号：US09782462B2
公开(公告)日：2017-10-10
申请号：US15060707
申请日：2016-03-04
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
IPC分类号： A61K48/00 , A61K38/48 , C12N15/88 , A61K9/127 , A61K9/50 , A61K31/7088 , A61K47/48 , C07K19/00 , C12N15/85 , A61K38/18 , A61K38/19 , C07K14/47 , A61K9/00
CPC分类号： C07K14/535 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K9/1277 , A61K9/14 , A61K9/5031 , A61K31/7088 , A61K38/1767 , A61K38/1816 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/36 , A61K38/363 , A61K38/44 , A61K38/4833 , A61K38/4846 , A61K39/3955 , A61K47/10 , A61K47/54 , A61K47/542 , A61K48/00 , A61K48/0033 , A61K48/0066 , A61K48/0075 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/525 , C07K14/56 , C07K14/565 , C07K14/745 , C07K14/75 , C07K16/2887 , C07K16/32 , C07K19/00 , C12N9/0069 , C12N9/644 , C12N15/85 , C12N15/88 , C12N2840/00 , C12Y113/12007 , C12Y304/21005 , C12Y304/21022
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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