公开(公告)号：US08440220B2

公开(公告)日：2013-05-14

申请号：US10420428

申请日：2003-04-22

申请人： Robert M. Gale ,  Thomas M. Stein ,  Jay Audett ,  Jane Stepic ,  Joseph B. Phipps ,  Michel J. N. Cormier

发明人： Robert M. Gale ,  Thomas M. Stein ,  Jay Audett ,  Jane Stepic ,  Joseph B. Phipps ,  Michel J. N. Cormier

IPC分类号： A61K9/70

CPC分类号： A61K9/7092 ,  A61K9/7061 ,  A61K31/4468 ,  A61K31/4535 ,  A61K45/06 ,  A61K2300/00

摘要： A transdermal analgesic system having reduced potential for abuse, wherein the system provides for the controlled release of the antagonist at a rate sufficient to provide an abuse limiting release rate ratio of the antagonist to the analgesic when the dosage form is subject to abuse is disclosed.

摘要翻译： 一种具有降低的滥用可能性的透皮镇痛系统，其中所述系统以足以在剂型受到滥用时提供拮抗剂与镇痛剂的滥用限制释放速率比的速率提供拮抗剂的受控释放。

公开(公告)号：US07131960B2

公开(公告)日：2006-11-07

申请号：US09976798

申请日：2001-10-12

申请人： Joseph C. Trautman ,  Richard L. Keenan ,  Ahmad P. Samiee ,  WeiQi Lin ,  Michel J. N. Cormier ,  James A. Matriano ,  Peter E. Daddona

发明人： Joseph C. Trautman ,  Richard L. Keenan ,  Ahmad P. Samiee ,  WeiQi Lin ,  Michel J. N. Cormier ,  James A. Matriano ,  Peter E. Daddona

IPC分类号： A61B17/20

CPC分类号： A61M37/0015 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150824 ,  A61B5/150984 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15142 ,  A61B5/1519 ,  A61B17/205 ,  A61B2017/00747 ,  A61M2037/0023 ,  A61M2037/0046

摘要： A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.

摘要翻译： 描述了一种方法和装置，用于将包括多个微突出物（90）的微量挤压构件（44）施加到角质层上。 该方法和装置用于改善药剂在皮肤上的运输，用于药剂递送或取样。 施加器（10,60,80）导致微推进构件（44）以确定的一定量的冲击力冲击角质层，以有效地用微突起（90）刺穿皮肤。 优选的施用器（10,60,80）在微滴注构件（44）中以10毫秒或更小的速度冲击至少0.05焦耳/微米/ 2微米输注构件（44）的冲击角 减。

公开(公告)号：US07087035B2

公开(公告)日：2006-08-08

申请号：US09733506

申请日：2000-12-08

申请人： Joseph C. Trautman ,  Michel J. N. Cormier ,  Kellee Eng ,  Wei-Qi Lin ,  Hyunok L. Kim ,  Sara L. Sendelbeck ,  Armand P. Neukermans ,  Bruce P. Edwards ,  Wai-Loong Lim ,  Andrew I. Poutiatine ,  J. Richard Gyory

发明人： Joseph C. Trautman ,  Michel J. N. Cormier ,  Kellee Eng ,  Wei-Qi Lin ,  Hyunok L. Kim ,  Sara L. Sendelbeck ,  Armand P. Neukermans ,  Bruce P. Edwards ,  Wai-Loong Lim ,  Andrew I. Poutiatine ,  J. Richard Gyory

IPC分类号： A61B17/20 ,  A61B17/22

CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61M5/425 ,  A61M2037/0023 ,  A61M2037/0046

摘要： A device and method for enhancing skin piercing by microprotrusions involves pre-stretching the skin to enhance pathway formation when the microprotrusions are pressed into the skin. An expandable device includes skin engaging opposite ends that contact the skin surface so that when the device is expanded the skin is stretched. The skin is placed under a tension of about 0.01 to about 10 megapascals, preferably about 0.05 to 2 megapascals. The device has a plurality of microprotrusions which penetrate the skin while the skin is being stretched by the expanded device. Another stretching device employs suction for skin stretching.

公开(公告)号：US07011844B2

公开(公告)日：2006-03-14

申请号：US10302490

申请日：2002-11-22

申请人： Robert M. Gale ,  Melinda K. Nelson ,  Michel J. N. Cormier ,  Suneel K. Gupta ,  Patricia S. Campbell

发明人： Robert M. Gale ,  Melinda K. Nelson ,  Michel J. N. Cormier ,  Suneel K. Gupta ,  Patricia S. Campbell

IPC分类号： A61K9/70

CPC分类号： A61K9/7084 ,  A61K31/135 ,  A61K31/138 ,  A61K31/57 ,  A61K2300/00

摘要： Composition of matter for application to a body surface or membrane to administer fluoxetine by permeation through the body surface or membrane, the composition comprising fluoxetine to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. A preferred embodiment is directed to the transdermal administration of fluoxetine at reduced skin irritation levels wherein fluoxetine, preferably provided as fluoxetine acetate, is coadministered with a corticosteroid such as hydrocortisone. Also disclosed are drug delivery devices containing the fluoxetine or fluoxetine and enhancer composition and methods for the transdermal administration of the fluoxetine and fluoxetine/enhancer composition.

公开(公告)号：US06562014B2

公开(公告)日：2003-05-13

申请号：US09737882

申请日：2000-12-14

申请人： Wei-Qi Lin ,  Michel J. N. Cormier ,  Felix Theeuwes

发明人： Wei-Qi Lin ,  Michel J. N. Cormier ,  Felix Theeuwes

IPC分类号： A61M100

CPC分类号： A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150984 ,  A61B10/0045 ,  A61B17/205 ,  A61B2010/0009 ,  A61B2010/008 ,  A61M2037/0007

摘要： A transdermal agent sampling device is provided. The sampling device is comprised of a microblade array and a device for applying a partial vacuum. The microblade array comprises a sheet having a plurality of microblades for piercing the skin to a very shallow depth (i.e., 25 &mgr;m to 400 &mgr;m) to create microslits in the outermost stratum corneum layer of the skin. The partial vacuum applying device applies a partial vacuum in the range of about 0.1 to about 0.8 atm, and preferably about 0.3 to about 0.7 atm, for sampling a body analyte such as glucose in interstitial fluid. The partial vacuum is applied for a period of about 2 to about 30 seconds, and preferably about 5 to about 15 seconds. The interstial fluid is analyzed for body analyte (e.g., glucose) content or concentration.

公开(公告)号：US06537264B1

公开(公告)日：2003-03-25

申请号：US09466819

申请日：1999-12-16

申请人： Michel J. N. Cormier ,  Felix Theeuwes

发明人： Michel J. N. Cormier ,  Felix Theeuwes

IPC分类号： A61M3100

CPC分类号： A61M37/0015 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150282 ,  A61B5/150427 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15142 ,  A61B10/0045 ,  A61B17/205 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0038 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61N1/30 ,  A61N1/303

摘要： A minimally invasive transdermal agent sampling device (2, 10) comprises a sheet (6) having a plurality of openings (8) and a plurality of microblades (4) for piercing the skin (20). A suction device (10) applies a negative pressure through the openings (8) to the microslits in the skin (20) for enhanced efflux of interstitial fluid. The device (2, 10) can be used for transdermal sampling of body analytes such as glucose for measuring/estimating blood glucose concentration.

摘要翻译： 微创透皮剂取样装置（2,10）包括具有多个开口（8）的片材（6）和用于刺穿皮肤（20）的多个微刀片（4）。 抽吸装置（10）通过开口（8）将负压施加到皮肤（20）中的微孔，以增强组织液的排出。 装置（2,10）可用于体内分析物如葡萄糖的经皮采样，用于测量/估计血糖浓度。

公开(公告)号：US06324424B1

公开(公告)日：2001-11-27

申请号：US09105074

申请日：1998-06-26

申请人： Philip W. Ledger ,  Michel J. N. Cormier ,  Patricia S. Campbell

发明人： Philip W. Ledger ,  Michel J. N. Cormier ,  Patricia S. Campbell

IPC分类号： A61N130

CPC分类号： A61N1/0432 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/325

摘要： The invention is directed to a composition and product for use in an electrotransport device. The composition includes an ionized drug, an anti-inflammatory agent and a solvent. Preferably, the anti-inflammatory agent is hydrocortisone or esters thereof, and the solvent is water and a material such as an alcohol, a glycol, a glycerol, a cyclodextrin, a nonionic surfactant and/or mixtures thereof.

摘要翻译： 本发明涉及一种用于电输送装置的组合物和产品。 组合物包括电离药物，抗炎剂和溶剂。 优选地，抗炎剂是氢化可的松或其酯，并且溶剂是水和诸如醇，二醇，甘油，环糊精，非离子表面活性剂和/或其混合物的材料。

公开(公告)号：US06203817B1

公开(公告)日：2001-03-20

申请号：US09092606

申请日：1998-06-05

申请人： Michel J. N. Cormier ,  Peter E. Daddona ,  Juanita A. Johnson

发明人： Michel J. N. Cormier ,  Peter E. Daddona ,  Juanita A. Johnson

IPC分类号： A61F1302

CPC分类号： A61K9/7053 ,  A61K9/7084

摘要： Transdermal compositions, devices, and methods for the administration of a drug at reduced skin irritation levels are disclosed. More particularly, this invention relates to novel methods, compositions, and devices for the reduction or elimination of irritation or sensitization caused by an irritating or sensitizing drug when it is delivered transdermally. According to a preferred embodiment, transdermal administration of a drug salt of a non-zwitterionic drug is disclosed wherein the drug salt comprises a combination of surface activity and a low octanol-water partition coefficient. Such drug salts have been found to reduce irritation or sensitization to the drug being delivered while achieving therapeutically effective transdermal fluxes.

摘要翻译： 公开了用于在皮肤刺激水平降低的药物给药的透皮组合物，装置和方法。 更具体地说，本发明涉及当通过皮肤递送时由刺激性或致敏性药物引起的刺激或致敏的减少或消除的新方法，组合物和装置。 根据优选的实施方案，公开了非两性离子药物的药物盐的透皮给药，其中所述药物盐包含表面活性和低辛醇 - 水分配系数的组合。 已经发现，这些药物盐可以减少对所递送药物的刺激或致敏，同时实现治疗有效的经皮通气。

公开(公告)号：US5624415A

公开(公告)日：1997-04-29

申请号：US427336

申请日：1995-04-24

申请人： Michel J. N. Cormier ,  Philip W. Ledger ,  Juanita Johnson ,  Joseph B. Phipps ,  Stella Chao

发明人： Michel J. N. Cormier ,  Philip W. Ledger ,  Juanita Johnson ,  Joseph B. Phipps ,  Stella Chao

IPC分类号： A61N1/30

CPC分类号： A61N1/0432 ,  A61N1/0448 ,  A61N1/0436

摘要： An electrotransport delivery device utilizing reservoir buffering at a select pH ranges in order to reduce skin irritation and skin resistance is provided. Cathodic reservoirs are buffered to a pH of less than about 4, preferably to a pH in the range of about 2 to 4, while anodic reservoirs are buffered to a pH above about 4, preferably to a pH in the range of about 4 to 10. Another electrotransport delivery device utilizes a potassium sensor to monitor potassium efflux from the skin. Potassium efflux above a certain predetermined level has been found to be a precursor to skin irritation/erythema. Operation of the device is modified (eg, terminated) when the predetermined potassium efflux level is sensed.

摘要翻译： 提供了一种在选择的pH范围内利用储存器缓冲以便减少皮肤刺激和皮肤抵抗的电输送输送装置。 阴极储存器缓冲至小于约4的pH，优选至约2至4范围内的pH，而阳极储存器缓冲至高于约4，优选至约4至10范围内的pH 另一种电输送装置利用钾传感器来监测来自皮肤的钾流出。 已经发现高于某一预定水平的钾流出物是皮肤刺激/红斑的前体。 当检测到预定的钾流出水平时，装置的操作被修改（例如，终止）。

公开(公告)号：US5130139A

公开(公告)日：1992-07-14

申请号：US549584

申请日：1990-07-06

申请人： Michel J-N Cormier ,  Philip W. Ledger ,  Alfred Amkraut

发明人： Michel J-N Cormier ,  Philip W. Ledger ,  Alfred Amkraut

IPC分类号： A61K31/00 ,  A61K47/00 ,  A61K47/02 ,  A61K47/18

CPC分类号： A61K31/70 ,  A61K47/02 ,  A61K47/18 ,  A61K9/0014

摘要： The present invention provides a method of reducing or preventing skin irritation of a weak base drug by inhibiting the accumulation of the drug in the lysosomes. The drug is irritating to humans, i.e., the drug is susceptible to inducing skin or mucosa irritation in a human when the drug is transdermally administered to the human at a therapeutically effective rate. Irritation reduction or prevention is induced by coadministering to the skin or mucosa of the human:(a) a therapeutically effective amount of a weak base drug which is irritating to humans, at a therapeutically effective rate over a predetermined period of time; and(b) an effective amount of an agent capable of inhibiting the lysosomal uptake of the drug to reduce or prevent irritation to the skin or mucosa.

摘要翻译： 本发明提供了通过抑制药物在溶酶体中的积累来减少或预防弱碱性药物的皮肤刺激的方法。 该药物对人类有刺激性，即当药物以治疗有效率透皮给药时，该药物易于引起人体皮肤或粘膜刺激。 通过向人的皮肤或粘膜共同诱导刺激减少或预防：（a）在预定时间段内以治疗有效速率治疗有效量的对人类有刺激性的弱碱性药物; 和（b）有效量的能够抑制药物的溶酶体摄取以减少或防止对皮肤或粘膜的刺激​​的药剂。