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1.发明申请UP AND DOWN CONVERSION SYSTEMS FOR PRODUCTION OF EMITTED LIGHT FROM VARIOUS ENERGY SOURCES INCLUDING RADIO FREQUENCY, MICROWAVE ENERGY AND MAGNETIC INDUCTION SOURCES FOR UPCONVERSION 有权用于生产来自各种能量源的发射光的UP和DOWN转换系统，包括无线电频率，微波能量和用于上变换的磁感应源公开(公告)号：US20110117202A1
公开(公告)日：2011-05-19
申请号：US12943787
申请日：2010-11-10
Applicant: Frederic A. Bourke, JR. , Zakaryae Fathi , Ian Nicholas Stanton , Michael J. Therien , Paul Rath Stauffer , Paolo MacCarini , Katherine Sarah Hansen , Diane Renee Fels , Cory Robert Wyatt , Mark Wesley Dewhirst
Inventor： Frederic A. Bourke, JR. , Zakaryae Fathi , Ian Nicholas Stanton , Michael J. Therien , Paul Rath Stauffer , Paolo MacCarini , Katherine Sarah Hansen , Diane Renee Fels , Cory Robert Wyatt , Mark Wesley Dewhirst
IPC: A61N5/00 , H01J61/00 , H01J61/20 , B01J8/18 , B01J19/08 , A61K9/14 , A61K38/20 , A61K39/395 , A61K38/44 , A61K33/00 , A61K33/38 , A61K33/24 , A61K38/28 , A61K38/22 , A61K38/14 , A61K31/7052 , A61K31/7084 , A61K31/655 , A61K31/5415 , A61K31/525 , A61K31/473 , A61K31/47 , A61K31/40 , A61K31/405 , A61K31/352 , A61K31/122 , A61K31/015 , C08G77/00 , A61L2/10 , G21G5/00 , A61M37/00 , B01J19/12 , C23C14/28 , B32B37/00 , B29C65/14 , B82Y15/00 , B82Y25/00 , B82Y99/00
CPC classification number: H05B41/2806 , A61L2/10 , A61N1/40 , A61N1/44 , A61N2/00 , A61N5/10 , C02F1/32 , H01J65/042 , Y02B20/22 , Y02W10/37
Abstract: Methods and systems for producing a change in a medium. A first method and system (1) place in a vicinity of the medium at least one upconverter including a gas for plasma ignition, with the upconverter being configured, upon exposure to initiation energy, to generate light for emission into the medium, and (2) apply the initiation energy from an energy source including the first wavelength λ1 to the medium, wherein the emitted light directly or indirectly produces the change in the medium. A second method and system (1) place in a vicinity of the medium an agent receptive to microwave radiation or radiofrequency radiation, and (2) apply as an initiation energy the microwave radiation or radiofrequency radiation by which the agent directly or indirectly generates emitted light in the infrared, visible, or ultraviolet range to produce at least one of physical and biological changes in the medium.
Abstract translation: 用于产生介质变化的方法和系统。 第一种方法和系统（1）在介质附近放置至少一个包括用于等离子体点火的气体的上变频器，其中上变频器被配置为在暴露于引发能量时产生用于发射到介质中的光，和（2 ）将包括第一波长λ1的能量源的引发能量施加到介质，其中发射的光直接或间接地产生介质中的变化。 第二种方法和系统（1）在介质附近放置接收微波辐射或射频辐射的试剂，以及（2）作为引发能量施加微波辐射或射频辐射，其中所述试剂直接或间接产生发射光 在红外线，可见光或紫外线范围内产生介质中物理和生物变化中的至少一种。
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公开(公告)号：US07842758B2
公开(公告)日：2010-11-30
申请号：US12160265
申请日：2007-01-10
Applicant: Michael J. Therien , Kimihiro Susumu
Inventor： Michael J. Therien , Kimihiro Susumu
IPC: C08C19/20
CPC classification number: C08G61/123 , C07D519/00 , C08G61/10 , C08G61/122 , C08G61/124 , C08G61/126 , C08L2201/06 , H01L51/0055 , H01L51/0077 , H01L51/009 , Y02E10/549
Abstract: The invention concerns compounds, oligomers, and polymers that contain: (I), (II), (III), or (IV) groups; where “-” indicates points of attachment.
Abstract translation: 本发明涉及包含（I），（II），（III）或（IV）基团的化合物，低聚物和聚合物; 其中“ - ”表示附着点。
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3.发明授权Non-invasive energy upconversion methods and systems for in-situ photobiomodulation 有权用于原位光生物调节的非侵入性能量上转换方法和系统公开(公告)号：US09302116B2
公开(公告)日：2016-04-05
申请号：US12764184
申请日：2010-04-21
Applicant: Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian N. Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
Inventor： Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian N. Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
CPC classification number: A61N5/062 , A61B5/0059 , A61B5/0071 , A61B5/055 , A61B5/4848 , A61B6/481 , A61K41/0042 , A61K41/0052 , A61K41/0061 , A61K49/0039 , A61L2/0047 , A61L2/08 , A61L2202/21 , A61L2202/22 , A61M5/007 , A61N1/406 , A61N5/02 , A61N5/0601 , A61N5/0618 , A61N5/0622 , A61N5/0624 , A61N5/10 , A61N2005/063 , A61N2005/0656 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , A61N2005/1098
Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
Abstract translation: 用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病 或胞外结构。 所述方法可以以非侵入性方式在原位进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并向受试者施加引发能量，从而产生 直接或通过调制剂对目标结构的影响或改变。 纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激活剂活性剂的存在下进行，从而产生对其的作用或改变 目标结构。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。
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4.发明申请NON-INVASIVE ENERGY UPCONVERSION METHODS AND SYSTEMS FOR IN-SITU PHOTOBIOMODULATION 有权非入侵能源逆转方法和系统用于现场光电转换公开(公告)号：US20110021970A1
公开(公告)日：2011-01-27
申请号：US12764184
申请日：2010-04-21
Applicant: Tuan VO-DINH , Jonathan P. SCAFFIDI , Venkata Gopal Reddy CHADA , Benoit LAULY , Yan ZHANG , Molly K. GREGAS , Ian N. STANTON , Joshua T. STECHER , Michael J. THERIEN , Frederic A. BOURKE, JR. , Harold WALDER , Zak FATHI , Jennifer A. AYRES , Zhenyuan ZHANG , Joseph H. SIMMONS , Stephen John NORTON
Inventor： Tuan VO-DINH , Jonathan P. SCAFFIDI , Venkata Gopal Reddy CHADA , Benoit LAULY , Yan ZHANG , Molly K. GREGAS , Ian N. STANTON , Joshua T. STECHER , Michael J. THERIEN , Frederic A. BOURKE, JR. , Harold WALDER , Zak FATHI , Jennifer A. AYRES , Zhenyuan ZHANG , Joseph H. SIMMONS , Stephen John NORTON
CPC classification number: A61N5/062 , A61B5/0059 , A61B5/0071 , A61B5/055 , A61B5/4848 , A61B6/481 , A61K41/0042 , A61K41/0052 , A61K41/0061 , A61K49/0039 , A61L2/0047 , A61L2/08 , A61L2202/21 , A61L2202/22 , A61M5/007 , A61N1/406 , A61N5/02 , A61N5/0601 , A61N5/0618 , A61N5/0622 , A61N5/0624 , A61N5/10 , A61N2005/063 , A61N2005/0656 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , A61N2005/1098
Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
Abstract translation: 用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病 或胞外结构。 所述方法可以以非侵入性方式在原位进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并向受试者施加引发能量，从而产生 直接或通过调制剂对目标结构的影响或改变。 纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激活剂活性剂的存在下进行，从而产生对其的作用或改变 目标结构。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。
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5.发明申请UP AND DOWN CONVERSION SYSTEMS FOR PRODUCTION OF EMITTED LIGHT FROM VARIOUS ENERGY SOURCES 有权用于生产来自各种能源的发光的向上和向下转换系统公开(公告)号：US20100261263A1
公开(公告)日：2010-10-14
申请号：US12725108
申请日：2010-03-16
Applicant: Tuan VO-DINH , Jonathan P. SCAFFIDI , Venkata Gopal Reddy CHADA , Benoit LAULY , Yan ZHANG , Molly K. GREGAS , Ian N. STANTON , Joshua T. STECHER , Michael J. THERIEN , Frederic A. BOURKE, JR. , Zak FATHI , Jennifer A. AYRES , Zhenyuan ZHANG , Joseph H. SIMMONS , Stephen John Norton
Inventor： Tuan VO-DINH , Jonathan P. SCAFFIDI , Venkata Gopal Reddy CHADA , Benoit LAULY , Yan ZHANG , Molly K. GREGAS , Ian N. STANTON , Joshua T. STECHER , Michael J. THERIEN , Frederic A. BOURKE, JR. , Zak FATHI , Jennifer A. AYRES , Zhenyuan ZHANG , Joseph H. SIMMONS , Stephen John Norton
IPC: B32B5/16 , B01J19/08 , B01J19/12 , G01N30/96 , B01J19/00 , C12M1/34 , C08F2/46 , F21V9/16 , A61L2/08 , G21K1/00 , G01N21/63 , A61N5/06
CPC classification number: F21K2/00 , A61L2/08 , A61L2202/22 , A61N5/062 , B82Y20/00 , B82Y30/00 , G01N21/63 , G02B5/003 , G02F2/02 , Y10T428/25 , Y10T428/256
Abstract: A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λ1 of radiation, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1 and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength λ1 or the second wavelength λ2, or with both λ1 and λ2. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength λ2, generates the photostimulated reaction.
Abstract translation: 一种用于能量上转换和/或下转换的系统和用于在介质中产生光刺激反应的系统。 这些系统包括1）在暴露于辐射的第一波长λ1时配置的纳米颗粒，以产生具有比第一波长λ1更高的能量的辐射的第二波长λ2，和2）相对于纳米颗粒设置的金属结构。 金属结构的物理特性被设定为金属结构中的表面等离子体共振在以与第一波长λ1或第二波长λ2或与λ1和λ2两者提供光谱重叠的频率谐振的值。 用于在培养基中产生光刺激反应的系统包括设置在接近纳米颗粒的培养基中的受体，其在第二波长λ2激活时产生光刺激反应。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20100098773A1
公开(公告)日：2010-04-22
申请号：US12548801
申请日：2009-08-27
Applicant: Daniel A. Hammer , Ivan Julian Dmochowski , Gregory Patrick Robbins , Masaya S. Jimbo , Michael J. Therien , Neha P. Kamat
Inventor： Daniel A. Hammer , Ivan Julian Dmochowski , Gregory Patrick Robbins , Masaya S. Jimbo , Michael J. Therien , Neha P. Kamat
IPC: A61K9/14
CPC classification number: A61K9/0009 , A61K9/1075 , A61K9/1273
Abstract: Provided are polymer vesicles comprising polymersomes, a radiofrequency absorbing moiety, a protein or a polysaccharide associated with the inner leaflet of the membrane and a therapeutic or diagnostic cargo. The invention also concerns the use of these polymer vesicles for selective electromagnetic energy-induced delivery of therapeutic or diagnostic agents.
Abstract translation: 提供了包含聚合物囊泡，聚合物囊泡，射频吸收部分，蛋白质或与膜的内部小叶相关联的多糖以及治疗或诊断性货物。 本发明还涉及这些聚合物囊泡用于治疗或诊断剂的选择性电磁能量诱导递送的用途。
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7.发明申请SYNTHESIS OF POLY-(P-ARYLENEETHYNYLENE)S IN NEAT WATER UNDER AEROBIC CONDIT 审中-公开聚氨酯（P-ARYLENEETHYNYLENE）S在微波介质中的合成公开(公告)号：US20090326150A1
公开(公告)日：2009-12-31
申请号：US12394146
申请日：2009-02-27
Applicant: Youn K. Kang , Pravas Deria , Michael J. Therien
Inventor： Youn K. Kang , Pravas Deria , Michael J. Therien
CPC classification number: C08G61/02 , C08G61/124 , C08G2261/1424 , C08G2261/1452 , C08G2261/314 , C08G2261/3328 , C08G2261/411
Abstract: Provided are ethyne synthons comprising boron and related methods. Also provided are related water-soluble arylethynylene polymers capable of being synthesized in neat water under aerobic conditions.
Abstract translation: 提供包含硼的乙炔合成子和相关方法。 还提供了能够在有氧条件下在纯净水中合成的相关的水溶性芳族亚乙烯基聚合物。
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8.发明授权Electron-deficient porphyrins and processes and intermediates for preparing same 有权电子缺陷卟啉及其制备方法和中间体
公开(公告)号：US6100392A
公开(公告)日：2000-08-08
申请号：US129620
申请日：1998-08-05
Applicant: Michael J. Therien , Stephen DiMagno
Inventor： Michael J. Therien , Stephen DiMagno
IPC: A61K41/00 , C07D487/22 , C07D519/00 , C08G73/06 , C08G79/00 , C09B47/00 , C09B69/10 , G01N27/12 , G03G5/06 , G03G5/07
CPC classification number: C07D487/22 , A61K47/48069 , C07D519/00 , C08G73/0611 , C08G79/00 , C09B47/00 , C09B69/10 , C09B69/108 , G01N27/126 , G03G5/0696 , G03G5/076
Abstract: Electron-deficient porphyrins are provided, as well as processes and intermediates for their preparation. In preferred embodiments, the electron-deficient porphyrins are prepared by condensing pyrrole derivatives and removing water thus formed from the resulting reaction mixture.
Abstract translation: 提供了电子缺陷卟啉，以及其制备方法和中间体。 在优选的实施方案中，电子缺陷卟啉通过将吡咯衍生物缩合并从所得反应混合物除去由此形成的水来制备。
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公开(公告)号：US5493017A
公开(公告)日：1996-02-20
申请号：US64468
申请日：1993-05-20
Applicant: Michael J. Therien , Stephen G. DiMagno
Inventor： Michael J. Therien , Stephen G. DiMagno
IPC: A61K31/409 , A61K31/555 , A61K41/00 , A61K47/48 , A61K49/00 , A61K51/04 , A61L2/08 , A61L2/18 , A61P31/04 , B01J31/02 , B01J31/16 , B01J31/18 , B01J31/22 , B01J31/24 , C07C29/50 , C07D207/32 , C07D207/33 , C07D207/333 , C07D487/22 , C07D513/22 , C07D519/00 , C07F3/00 , C07F7/08 , C07F7/10 , C07H23/00 , C08F8/42 , C08F30/04 , C08F38/00 , C08G61/12 , C08G73/06 , C08G79/00 , C08G83/00 , C09B47/00 , C09B47/08 , C09B69/10 , G01N27/12 , G01N27/40 , G03G5/06 , G03G5/07
CPC classification number: A61K31/555 , A61K41/0071 , A61K47/48023 , A61K47/48069 , A61K51/0485 , B01J31/0244 , B01J31/1658 , B01J31/1805 , B01J31/1815 , B01J31/2409 , C07C29/50 , C07D207/33 , C07D207/333 , C07D487/22 , C07F7/082 , C07F7/0832 , C08F30/04 , C08G73/0611 , C08G79/00 , C09B47/00 , C09B69/10 , C09B69/108 , G01N27/126 , G03G5/0696 , G03G5/076 , B01J2231/42 , B01J2531/025 , B01J2531/16 , B01J2531/20 , B01J2531/22 , B01J2531/23 , B01J2531/26 , B01J2531/27 , B01J2531/42 , B01J2531/48 , B01J2531/824
Abstract: Reaction products comprising ring-metalated porphyrins are provided that are useful in the synthesis of porphyrin polymers and porphyrins substituted with, for example, vinyl and acetylene groups.
Abstract translation: 提供了包含环金属化卟啉的反应产物，其可用于合成卟啉聚合物和用例如乙烯基和乙炔基团取代的卟啉。
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公开(公告)号：US09907976B2
公开(公告)日：2018-03-06
申请号：US14131564
申请日：2012-07-09
Applicant: Frederic A. Bourke, Jr. , Harold Walder , Zakaryae Fathi , Michael J. Therien , Mark W. Dewhirst , Ian N. Stanton , Jennifer Ann Ayres , Diane Renee Fels , Joseph A. Herbert
Inventor： Frederic A. Bourke, Jr. , Harold Walder , Zakaryae Fathi , Michael J. Therien , Mark W. Dewhirst , Ian N. Stanton , Jennifer Ann Ayres , Diane Renee Fels , Joseph A. Herbert
CPC classification number: A61N5/062 , A61K41/0085 , A61N5/0622 , A61N5/1077 , A61N2005/0661 , A61N2005/1091 , A61N2005/1098
Abstract: A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with at least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.
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