公开(公告)号：US07998239B1

公开(公告)日：2011-08-16

申请号：US12620633

申请日：2009-11-18

Applicant: Tina M. Nenoff ,  Dana A. Powers ,  Zhenyuan Zhang

Inventor： Tina M. Nenoff ,  Dana A. Powers ,  Zhenyuan Zhang

IPC: B22F9/24

CPC classification number: B22F9/24 ,  B22F1/0018 ,  B22F2999/00 ,  B82Y30/00 ,  B22F2202/11

Abstract: A method of forming stable nanoparticles comprising substantially uniform alloys of metals. A high dose of ionizing radiation is used to generate high concentrations of solvated electrons and optionally radical reducing species that rapidly reduce a mixture of metal ion source species to form alloy nanoparticles. The method can make uniform alloy nanoparticles from normally immiscible metals by overcoming the thermodynamic limitations that would preferentially produce core-shell nanoparticles.

Abstract translation: 形成稳定的纳米颗粒的方法，其包括基本上均匀的金属合金。 高剂量的电离辐射用于产生高浓度的溶剂化电子和任选的自由基还原物质，其迅速减少金属离子源物质的混合物形成合金纳米颗粒。 该方法可以通过克服优先产生核 - 壳纳米颗粒的热力学限制来制备来自正常不混溶金属的均匀合金纳米颗粒。

公开(公告)号：US08389958B2

公开(公告)日：2013-03-05

申请号：US12725108

申请日：2010-03-16

Applicant: Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian Nicholas Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Zak Fathi ,  Jennifer Ann Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

Inventor： Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian Nicholas Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Zak Fathi ,  Jennifer Ann Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

IPC: G01J1/58

CPC classification number: F21K2/00 ,  A61L2/08 ,  A61L2202/22 ,  A61N5/062 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/63 ,  G02B5/003 ,  G02F2/02 ,  Y10T428/25 ,  Y10T428/256

Abstract: A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λ1 of radiation, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1 and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength λ1 or the second wavelength λ2, or with both λ1 and λ2. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength λ2, generates the photostimulated reaction.

Abstract translation: 一种用于能量上转换和/或下转换的系统和用于在介质中产生光刺激反应的系统。 这些系统包括1）在暴露于辐射的第一波长λ1时配置的纳米颗粒，以产生具有比第一波长λ1更高的能量的辐射的第二波长λ2，和2）相对于纳米颗粒设置的金属结构。 金属结构的物理特性被设定为金属结构中的表面等离子体共振在以与第一波长λ1或第二波长λ2或与λ1和λ2两者提供光谱重叠的频率谐振的值。 用于在培养基中产生光刺激反应的系统包括设置在接近纳米颗粒的培养基中的受体，其在第二波长λ2激活时产生光刺激反应。

公开(公告)号：US09302116B2

公开(公告)日：2016-04-05

申请号：US12764184

申请日：2010-04-21

Applicant: Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian N. Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Harold Walder ,  Zak Fathi ,  Jennifer A. Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

Inventor： Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian N. Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Harold Walder ,  Zak Fathi ,  Jennifer A. Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

IPC: A61N5/06 ,  A61K49/00 ,  A61L2/08 ,  A61N1/40 ,  A61N5/02

CPC classification number: A61N5/062 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/481 ,  A61K41/0042 ,  A61K41/0052 ,  A61K41/0061 ,  A61K49/0039 ,  A61L2/0047 ,  A61L2/08 ,  A61L2202/21 ,  A61L2202/22 ,  A61M5/007 ,  A61N1/406 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/063 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2005/1098

Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Abstract translation: 用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病 或胞外结构。 所述方法可以以非侵入性方式在原位进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并向受试者施加引发能量，从而产生 直接或通过调制剂对目标结构的影响或改变。 纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激活剂活性剂的存在下进行，从而产生对其的作用或改变 目标结构。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

公开(公告)号：US20110021970A1

公开(公告)日：2011-01-27

申请号：US12764184

申请日：2010-04-21

Applicant: Tuan VO-DINH ,  Jonathan P. SCAFFIDI ,  Venkata Gopal Reddy CHADA ,  Benoit LAULY ,  Yan ZHANG ,  Molly K. GREGAS ,  Ian N. STANTON ,  Joshua T. STECHER ,  Michael J. THERIEN ,  Frederic A. BOURKE, JR. ,  Harold WALDER ,  Zak FATHI ,  Jennifer A. AYRES ,  Zhenyuan ZHANG ,  Joseph H. SIMMONS ,  Stephen John NORTON

Inventor： Tuan VO-DINH ,  Jonathan P. SCAFFIDI ,  Venkata Gopal Reddy CHADA ,  Benoit LAULY ,  Yan ZHANG ,  Molly K. GREGAS ,  Ian N. STANTON ,  Joshua T. STECHER ,  Michael J. THERIEN ,  Frederic A. BOURKE, JR. ,  Harold WALDER ,  Zak FATHI ,  Jennifer A. AYRES ,  Zhenyuan ZHANG ,  Joseph H. SIMMONS ,  Stephen John NORTON

IPC: A61M37/00 ,  G02F1/01 ,  A61K35/12 ,  A61K39/00 ,  A61K9/16 ,  B82Y5/00

CPC classification number: A61N5/062 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/481 ,  A61K41/0042 ,  A61K41/0052 ,  A61K41/0061 ,  A61K49/0039 ,  A61L2/0047 ,  A61L2/08 ,  A61L2202/21 ,  A61L2202/22 ,  A61M5/007 ,  A61N1/406 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/063 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2005/1098

Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Abstract translation: 用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病 或胞外结构。 所述方法可以以非侵入性方式在原位进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并向受试者施加引发能量，从而产生 直接或通过调制剂对目标结构的影响或改变。 纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激活剂活性剂的存在下进行，从而产生对其的作用或改变 目标结构。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

公开(公告)号：US20100261263A1

公开(公告)日：2010-10-14

申请号：US12725108

申请日：2010-03-16

Applicant: Tuan VO-DINH ,  Jonathan P. SCAFFIDI ,  Venkata Gopal Reddy CHADA ,  Benoit LAULY ,  Yan ZHANG ,  Molly K. GREGAS ,  Ian N. STANTON ,  Joshua T. STECHER ,  Michael J. THERIEN ,  Frederic A. BOURKE, JR. ,  Zak FATHI ,  Jennifer A. AYRES ,  Zhenyuan ZHANG ,  Joseph H. SIMMONS ,  Stephen John Norton

Inventor： Tuan VO-DINH ,  Jonathan P. SCAFFIDI ,  Venkata Gopal Reddy CHADA ,  Benoit LAULY ,  Yan ZHANG ,  Molly K. GREGAS ,  Ian N. STANTON ,  Joshua T. STECHER ,  Michael J. THERIEN ,  Frederic A. BOURKE, JR. ,  Zak FATHI ,  Jennifer A. AYRES ,  Zhenyuan ZHANG ,  Joseph H. SIMMONS ,  Stephen John Norton

IPC: B32B5/16 ,  B01J19/08 ,  B01J19/12 ,  G01N30/96 ,  B01J19/00 ,  C12M1/34 ,  C08F2/46 ,  F21V9/16 ,  A61L2/08 ,  G21K1/00 ,  G01N21/63 ,  A61N5/06

CPC classification number: F21K2/00 ,  A61L2/08 ,  A61L2202/22 ,  A61N5/062 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/63 ,  G02B5/003 ,  G02F2/02 ,  Y10T428/25 ,  Y10T428/256

Abstract: A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λ1 of radiation, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1 and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength λ1 or the second wavelength λ2, or with both λ1 and λ2. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength λ2, generates the photostimulated reaction.

Abstract translation: 一种用于能量上转换和/或下转换的系统和用于在介质中产生光刺激反应的系统。 这些系统包括1）在暴露于辐射的第一波长λ1时配置的纳米颗粒，以产生具有比第一波长λ1更高的能量的辐射的第二波长λ2，和2）相对于纳米颗粒设置的金属结构。 金属结构的物理特性被设定为金属结构中的表面等离子体共振在以与第一波长λ1或第二波长λ2或与λ1和λ2两者提供光谱重叠的频率谐振的值。 用于在培养基中产生光刺激反应的系统包括设置在接近纳米颗粒的培养基中的受体，其在第二波长λ2激活时产生光刺激反应。