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    Computer aided design system and computer aided design program using a geometric surface model
    1.
    发明授权
    Computer aided design system and computer aided design program using a geometric surface model 有权
    计算机辅助设计系统和计算机辅助设计程序使用几何表面模型

    公开(公告)号：US07917342B2

    公开(公告)日：2011-03-29

    申请号：US10529645

    申请日：2003-10-06

    申请人： Masami Miura ,  Takayuki Kawano ,  Yuichi Sasaki ,  Takeshi Nakahama ,  Yasuhiko Yoshida

    发明人： Masami Miura ,  Takayuki Kawano ,  Yuichi Sasaki ,  Takeshi Nakahama ,  Yasuhiko Yoshida

    IPC分类号： G06F17/50 ,  G06F7/60 ,  G06T15/00 ,  G06T11/20

    CPC分类号： G06T17/20 ,  G06T17/30

    摘要： A computer aided design system and a computer aided design program which can greatly increase the utility of a computer aided design model, and can improve the efficiency of design and production processes, by adopting a curved surface theory which ensures the continuity of a free-form line or surface. A computer executes: a point sequence information extraction process for extracting a plurality of point sequences on a curved surface; a dividing process for generating a curved surface from the point sequences and dividing the curved surface into a predetermined number of mesh points; a first fundamental form computing process for computing coefficients of the first fundamental form; a second fundamental form computing process for computing coefficients of the second fundamental form; and a storage process for storing the point sequence information, the coefficients of the first fundamental form and the coefficients of the second fundamental form.

    摘要翻译： 计算机辅助设计系统和计算机辅助设计程序，可大大增加计算机辅助设计模型的实用性，并可以通过采用曲面理论来提高设计和生产过程的效率，从而确保自由形式的连续性 线或表面。 计算机执行：用于提取曲面上的多个点序列的点序列信息提取处理; 从所述点序列生成曲面并将所述曲面分割成预定数目的网格点的分割处理; 用于计算第一基本形式的系数的第一基本形式计算过程; 用于计算第二基本形式的系数的第二基本形式计算过程; 以及用于存储点序列信息，第一基本形式的系数和第二基本形式的系数的存储处理。

    Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby
    3.
    发明申请
    Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby 有权
    生产蛋白质的方法是由此产生的酸性糖链和糖蛋白的还原

    公开(公告)号：US20070202569A1

    公开(公告)日：2007-08-30

    申请号：US11707737

    申请日：2007-02-16

    申请人： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

    发明人： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

    IPC分类号： C12P21/06 ,  C12P19/04 ,  C12N15/74 ,  C12N1/21 ,  C12N1/18

    CPC分类号： C12N9/1205 ,  C12P21/005

    摘要： The present invention intends to find out a gene participating in addition of mannose phosphate to a sugar chain of a glycoprotein originating in a yeast belonging to the genus Pichia and provide a means of controlling the same. The present invention also intends to provide a process for producing a protein with reduction of an acidic sugar chain by using the thus controlled yeast strain belonging to the genus Pichia. Namely, the present invention includes a protein participating in the addition of mannose phosphate to a sugar chain of a glycoprotein; a gene coding this protein; a mutant of this gene; a vector carrying the mutant gene; a yeast strain belonging to the genus Pichia having been transformed by this vector; a process for producing a protein with reduction of an acidic sugar chain by using the transformed yeast strain; and a glycoprotein thus produced.

    摘要翻译： 本发明意图将参与加入甘露糖磷酸酯的基因找到源自属于毕赤酵母属的酵母的糖蛋白的糖链，并提供对其进行控制的方法。 本发明还提供通过使用由此控制的属于毕赤酵母属的酵母菌株来制备具有酸性糖链还原性蛋白质的方法。 即，本发明包括参与向糖蛋白的糖链添加甘露糖磷酸的蛋白质; 编码该蛋白的基因; 该基因的突变体; 携带突变基因的载体; 已经通过该载体转化了属于毕赤酵母属的酵母菌株; 通过使用转化的酵母菌株来生产具有降低酸性糖链的蛋白质的方法; 和由此产生的糖蛋白。

    Cad system and cad program
    4.
    发明申请
    Cad system and cad program 有权
    Cad系统和cad程序

    公开(公告)号：US20060129361A1

    公开(公告)日：2006-06-15

    申请号：US10529645

    申请日：2003-10-06

    申请人： Masami Miura ,  Takayuki Kawano ,  Yuichi Sasaki ,  Takeshi Nakahama ,  Yasuhiko Yoshida

    发明人： Masami Miura ,  Takayuki Kawano ,  Yuichi Sasaki ,  Takeshi Nakahama ,  Yasuhiko Yoshida

    IPC分类号： G06F17/10

    CPC分类号： G06T17/20 ,  G06T17/30

    摘要： There is provided a computer aided design system and a computer aided design program which can greatly increase the utility value of a computer aided design model, and can improve the efficiency of design and production processes, by adopting a curved surface theory which ensures the continuity of a free-form line/free-form surface. A computer executes: a point sequence information extraction process for extracting a plurality of point sequences on a curved surface; a dividing process for generating a curved surface from the point sequences using another computer graphics program, and dividing the curved surface into a predetermined number of meshes; a first fundamental form computing process for computing coefficients of the first fundamental form defined by a tangent vector which forms a tangent plane of the mesh; a second fundamental form computing process for computing coefficients of the second fundamental form defined by the tangent vector and a normal vector of the mesh; and a storage process for storing the point sequence information, the coefficients of the first fundamental form and the coefficients of the second fundamental form.

    摘要翻译： 提供了计算机辅助设计系统和计算机辅助设计程序，可以大大提高计算机辅助设计模型的效用值，并且可以通过采用曲面理论来提高设计和生产过程的效率，从而确保连续性 自由形式的线/自由曲面。 计算机执行：用于提取曲面上的多个点序列的点序列信息提取处理; 用于使用另一计算机图形程序从所述点序列生成曲面并将所述曲面分割成预定数目的网格的分割处理; 用于计算由形成网格的切平面的切线向量定义的第一基本形式的系数的第一基本形式计算过程; 用于计算由切线向量和网格的法向量定义的第二基本形式的系数的第二基本形式计算过程; 以及用于存储点序列信息，第一基本形式的系数和第二基本形式的系数的存储处理。

    Albumin gene-containing plasmid, transformant carrying same, production of such transformant and production of albumin
    6.
    发明授权
    Albumin gene-containing plasmid, transformant carrying same, production of such transformant and production of albumin 失效
    含有白蛋白基因的质粒，携带相同的转化体，生产这种转化体和产生白蛋白

    公开(公告)号：US5756313A

    公开(公告)日：1998-05-26

    申请号：US138384

    申请日：1993-10-20

    申请人： Ken Okabayashi ,  Hideyuki Oi ,  Kazumoto Hirabayashi ,  Masami Miura ,  Miho Shimizu ,  Haruhide Kawabe

    发明人： Ken Okabayashi ,  Hideyuki Oi ,  Kazumoto Hirabayashi ,  Masami Miura ,  Miho Shimizu ,  Haruhide Kawabe

    IPC分类号： C12N1/19 ,  C07K14/765 ,  C12N9/26 ,  C12N15/09 ,  C12N15/14 ,  C12N15/81 ,  C12N15/90 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865 ,  C12N15/00

    CPC分类号： C07K14/765 ,  C12N15/81 ,  C12N15/90 ,  C12N9/2408 ,  C07K2319/02

    摘要： A plasmid for a yeast host, the plasmid comprising in sequence: (1) a yeast derived promoter, (2) an albumin-encoding region placed under control of the yeast-derived promoter, (3) a transcription terminator and (4) a sequence homologous to a part of the yeast host chromosomal sequence such that the plasmid is capable of being integrated into the yeast host cell chromosome and wherein the plasmid is incapable of autonomous replication in yeast cells; a yeast host transformed with the above plasmid; a method of producing a yeast transformant which comprises transforming a yeast host by integrating at least two different plasmids each having a sequence homologous to a part of the host yeast chromosomal sequence one at a time into the chromosome of the yeast host cell; and a method of producing albumin which comprises cultivating the above transformant and recovering the thus-produced albumin.

    摘要翻译： 一种用于酵母宿主的质粒，所述质粒按顺序包含：（1）酵母衍生的启动子，（2）置于酵母衍生的启动子控制下的白蛋白编码区，（3）转录终止子和（4） 序列与酵母宿主染色体序列的一部分同源，使得质粒能够整合到酵母宿主细胞染色体中，并且其中质粒不能在酵母细胞中自主复制; 用上述质粒转化的酵母宿主; 生产酵母转化体的方法，其包括通过将至少两种与宿主酵母染色体部分的序列同源的不同质粒整合到酵母宿主细胞的染色体中来转化酵母宿主; 以及生产白蛋白的方法，其包括培养上述转化体并回收由此产生的白蛋白。

    Full-wave rectifier using an operational amplifier
    7.
    发明授权
    Full-wave rectifier using an operational amplifier 失效
    全波整流器采用运算放大器

    公开(公告)号：US4564814A

    公开(公告)日：1986-01-14

    申请号：US435173

    申请日：1982-10-19

    申请人： Masami Miura ,  Takeshi Kuwajima

    发明人： Masami Miura ,  Takeshi Kuwajima

    IPC分类号： H02M7/21 ,  G06G7/25 ,  H02M7/12 ,  H03K5/00

    CPC分类号： G06G7/25

    摘要： A full-wave rectifier having a limited number of circuit elements comprises an amplifier, such as an operational amplifier, having an inverting input held at a reference potential, a non-inverting input receiving an input signal through a first resistor and an output, a transistor having its base connected to the output of the amplifier and its collector connected to the non-inverting input of the amplifier through a second resistor and optionally an output circuit for producing an output signal from the connection point between the collector of the transistor and the second resistor.

    摘要翻译： 具有有限数量的电路元件的全波整流器包括具有保持在参考电位的反相输入的放大器，例如运算放大器，通过第一电阻和输出接收输入信号的非反相输入， 晶体管的基极连接到放大器的输出端，其集电极通过第二电阻器连接到放大器的非反相输入端，并且可选地是输出电路，用于从晶体管的集电极与晶体管的集电极之间的连接点产生输出信号 第二电阻。

    Demodulator of angle modulated signal operable by low power voltage
    8.
    发明授权
    Demodulator of angle modulated signal operable by low power voltage 失效
    角度调制信号的解调器可由低功率电压工作

    公开(公告)号：US4339726A

    公开(公告)日：1982-07-13

    申请号：US181930

    申请日：1980-08-27

    申请人： Masami Miura

    发明人： Masami Miura

    IPC分类号： H03D3/20 ,  H03D13/00 ,  H03D3/22

    CPC分类号： H03D3/20 ,  H03B2200/0082 ,  H03D13/004 ,  H03D2200/0009 ,  H03D2200/0082

    摘要： A demodulator for an angle modulated signal consists of circuitry particularly adaptable to integrated circuit construction. The various circuit functional groups are adapted to be connected in parallel, rather than serially, across the power source, thereby enabling good performance in systems having low voltage power sources. The angle modulated signal is converted into first and second signals of opposite phase. Also, the angle modulated signal is phase shifted an amount dependent upon the frequency deviation from a center frequency, the first and phase shifted signals are applied to a first OR circuit which provides the largest input signal as its output. The second and phase shifted signals are applied to a second OR circuit which provides the largest input signal as its output. The two OR circuit outputs are low-pass filtered and subtracted to provide the demodulated output.

    摘要翻译： 用于角度调制信号的解调器由特别适用于集成电路结构的电路组成。 各种电路功能组适于在电源上并联连接而不是串联连接，从而在具有低电压电源的系统中实现良好的性能。 角度调制信号被转换成相位相位的第一和第二信号。 此外，角度调制信号相对于与中心频率的频率偏差相关的量，第一和相移信号被施加到提供最大输入信号作为其输出的第一OR电路。 第二和相移信号被施加到提供最大输入信号作为其输出的第二OR电路。 两个OR电路输出被低通滤波并减法以提供解调输出。