公开(公告)号：US07550287B2

公开(公告)日：2009-06-23

申请号：US10509447

申请日：2003-04-09

Applicant: Hiroki Hibino ,  Shin Katayama ,  Hiroyuki Irie ,  Hikaru Inoue ,  Hitoshi Mizuno ,  Yasuharu Hakamatsuka ,  Yoshiharu Saito ,  Hideki Koyanagi

Inventor： Hiroki Hibino ,  Shin Katayama ,  Hiroyuki Irie ,  Hikaru Inoue ,  Hitoshi Mizuno ,  Yasuharu Hakamatsuka ,  Yoshiharu Saito ,  Hideki Koyanagi

IPC: C12M3/00 ,  C12M1/36 ,  C12M1/38

CPC classification number: G06Q10/08 ,  G06Q10/06

Abstract: The present invention discloses a cell culturing system that cultures predetermined cells collected from a patient and supplies cultured cells to the original patient, which together with enabling correlations between the cultured cells and the supplier of the cells to be managed accurately and easily at all times, allows cultured cells and patients to be collated rapidly.

Abstract translation: 本发明公开了一种细胞培养系统，其对从患者收集的预定细胞进行培养，并向原始患者提供培养的细胞，同时能够随时准确，容易地管理培养细胞和细胞供应者之间的相关性， 允许培养细胞和患者快速整理。

公开(公告)号：US06350462B1

公开(公告)日：2002-02-26

申请号：US08044549

申请日：1993-04-07

Applicant: Yasuharu Hakamatsuka ,  Hiroyuki Irie ,  Gen Horie

Inventor： Yasuharu Hakamatsuka ,  Hiroyuki Irie ,  Gen Horie

IPC: A61K952

CPC classification number: A61K9/0024 ,  A61K9/2009

Abstract: An improved porous ceramic body to be embedded in a patient for sustained release of a medicament, and a method of making the ceramic body is provided. To control the release of the medicament, the pores of the ceramic body decrease in diameter from the inner surface to the outer surface of the body whereby the pore diameter is substantially proportional to the distance from the outer surface of the carrier. First, raw ceramic slurry is made from the blend of &bgr;-TCP, deflocculating agent, and water. Next, using a syringe the ceramic slurry is supplied to the internal region of a solvent-absorbable mold from an aperture along the inner wall surface. Then, the ceramic slurry is quickly dehydrated before thinly adhering itself onto the inner wall surface of the mold. Therefore, a preformed body having a hollow is obtained. Next, after fully being dried, the dried preformed body is fired at 1,050° C. for an hour before eventually yielding a spherical carrier for use in sustained release preparation. Substantially, the carrier is composed of a porous ceramic body which having the hollow for retaining the medicament and permits permeation of the medicament. The pore diameter corresponding to the peak value of the distribution thereof decreases toward to the outer periphery of the preformed body and yet, width of the distribution of the pore diameter becomes narrower.

Abstract translation: 一种改进的多孔陶瓷体，其被埋设在患者体内，用于药物的持续释放，并且提供了制造该陶瓷体的方法。 为了控制药物的释放，陶瓷体的孔直径从主体的内表面到外表面减小，因此孔径基本上与离开载体的外表面的距离成比例。首先，生陶瓷 浆料由β-TCP，抗絮凝剂和水的混合物制成。 接下来，使用注射器，陶瓷浆料从沿着内壁表面的孔口供应到吸收溶剂的模具的内部区域。 然后，在将其自身轻轻地粘附到模具的内壁表面之前，陶瓷浆料快速脱水。 因此，获得具有中空部的预制体。 接下来，完全干燥后，将干燥的预成型体在1050℃下烧制1小时，最后得到用于缓释制剂的球形载体。 基本上，载体由具有用于保持药物的中空部并允许药物渗透的多孔陶瓷体组成。 对应于其分布的峰值的孔径朝向预成形体的外周减小，而孔径分布的宽度变窄。

公开(公告)号：US5491082A

公开(公告)日：1996-02-13

申请号：US246940

申请日：1994-05-20

Applicant: Takahiro Suzuki ,  Sukezo Kawamura ,  Motohiro Toriyama ,  Yoshiyuki Yokokawa ,  Yukari Kawamoto ,  Yasuharu Hakamatsuka ,  Hiroyuki Irie

Inventor： Takahiro Suzuki ,  Sukezo Kawamura ,  Motohiro Toriyama ,  Yoshiyuki Yokokawa ,  Yukari Kawamoto ,  Yasuharu Hakamatsuka ,  Hiroyuki Irie

IPC: A61K38/00 ,  C12N9/72 ,  C12N11/14 ,  A61K38/48

CPC classification number: C12N9/6456 ,  C12N11/14 ,  A61K38/00

Abstract: A plasminogen activator such as urokinase or tissue plasminogen activator is covalently bonded to a porous body composed of calcium phosphate to form a plasminogen activator-porous body complex. The tricalcium phosphate can be .alpha.-tricalcium phosphate, .beta.-tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, octacalcium phosphate and mixtures thereof. In a preferred embodiment, .beta.-tricalcium phosphate which has excellent biocompatibility with the body or a mixture of .beta.-tricalcium phosphate and hydroxyapatite is used. Preferably, synthetic calcium phosphate is used is to avoid impurities contained by natural calcium phosphate. Covalent bonding is by crosslinking with glutaraldehyde, bismaleimides, dihalogenic aryls or diisocyanates, or by using cyanogen bromide, diazotization or periodic acid. The complex can be filled into a column to form a bioreactor. A granular complex can be intravascularly injected into the blood of a patient to provide thrombotic activity for a long period of time. In another embodiment, a complex of a predetermined shape can be implanted to provide thrombotic activity.

Abstract translation: 纤维蛋白溶酶原激活剂如尿激酶或组织纤溶酶原激活剂共价键合到由磷酸钙组成的多孔体上以形成纤溶酶原激活剂多孔体复合体。 磷酸三钙可以是α-磷酸三钙，β-磷酸三钙，羟基磷灰石，磷酸四钙，磷酸八钙及其混合物。 在优选的实施方案中，使用与身体具有优异生物相容性的β-磷酸三钙或磷酸β-磷酸钙和羟基磷灰石的混合物。 优选地，合成磷酸钙是为了避免天然磷酸钙含有的杂质。 共价键是通过与戊二醛，双马来酰亚胺，二卤代芳基或二异氰酸酯交联，或通过使用溴化氰，重氮化或高碘酸进行交联。 复合物可以填充到柱中以形成生物反应器。 颗粒状复合物可以血管内注射到患者的血液中以长时间提供血栓形成活性。 在另一个实施方案中，可以植入预定形状的复合物以提供血栓形成活性。

公开(公告)号：US5152791A

公开(公告)日：1992-10-06

申请号：US839060

申请日：1992-02-18

Applicant: Yasuharu Hakamatsuka ,  Hiroyuki Irie

Inventor： Yasuharu Hakamatsuka ,  Hiroyuki Irie

IPC: A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61F2/30 ,  A61L27/12

CPC classification number: A61L27/12 ,  A61F2/28 ,  A61F2/30756 ,  A61F2002/2839 ,  A61F2002/30011 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30971 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2240/001 ,  A61F2250/0023 ,  A61F2310/00293

Abstract: A prosthetic artificial bone having a double-layered structure obtained by forming a high porosity portion having a porosity of from 40 to 90% and a lower porosity portion having a porosity of 50% or less, into an integral body, and wherein the high porosity portion and the lower porosity portion each comprise a ceramics containing calcium and phosphorus.

Abstract translation: 将具有孔隙率为40〜90％的高孔隙率部分和孔隙率为50％以下的孔隙率低的孔隙率部分形成为具有双层结构的假体人造骨制成整体，其中高孔隙率 部分和较低孔隙率部分各自包含含有钙和磷的陶瓷。

公开(公告)号：US5135394A

公开(公告)日：1992-08-04

申请号：US754358

申请日：1991-08-29

Applicant: Yasuharu Hakamatsuka ,  Hiroyuki Irie ,  Hiroshi Fukuda

Inventor： Yasuharu Hakamatsuka ,  Hiroyuki Irie ,  Hiroshi Fukuda

IPC: A61C8/00 ,  A61F2/00 ,  A61L27/12 ,  A61L27/56

CPC classification number: A61C8/00 ,  A61K6/0008 ,  A61K6/0085 ,  A61K6/0643 ,  A61L27/12 ,  A61L27/56 ,  A61F2310/00293

Abstract: A ceramic member for a living body includes a first end portion formed of a material having affinity with a living body and consisting of a dense material, and a second end portion formed of a material having affinity with a living body and consisting of a porous material. A method of manufacturing a ceramic member for a living body, includes the steps of mixing a ceramic powder having affinity with a living body, water, and a binder to prepare a dense material slurry, mixing a ceramic powder having affinity with a living body, water, a binder, and a foaming agent to prepare a porous material slurry, injecting, in order to form a two-layered base material consisting of the dense material slurry and the porous material slurry, the dense material slurry and the porous material slurry obtained in the two steps in a mold such that the dense and porous material slurries are not mixed with each other, and drying the base material, and after the drying step, heating the base material at a predetermined rate, and sintering the base material at a predetermined temperature.

Abstract translation: 用于生物体的陶瓷构件包括由与活体亲和并由致密材料组成的材料形成的第一端部和由与活体亲和力并由多孔材料组成的材料形成的第二端部 。 一种制造生物体用陶瓷构件的方法包括以下步骤：将具有亲和力的陶瓷粉末与生物体，水和粘合剂混合以制备致密材料浆料，将与活体具有亲和力的陶瓷粉末混合， 水，粘合剂和发泡剂以制备多孔材料浆料，注入以形成由致密材料浆料和多孔材料浆料组成的两层基材，得到致密材料浆料和多孔材料浆料 在模具中的两个步骤中，使致密多孔材料浆料彼此不混合，并干燥基材，并且在干燥步骤之后，以预定速率加热基材，并将基材以 预定温度。

公开(公告)号：US4542322A

公开(公告)日：1985-09-17

申请号：US602086

申请日：1984-04-19

Applicant: Hiroyuki Irie ,  Susumu Ide ,  Kinzo Nonomura ,  Masanori Watanabe ,  Yoshinobu Takesako

Inventor： Hiroyuki Irie ,  Susumu Ide ,  Kinzo Nonomura ,  Masanori Watanabe ,  Yoshinobu Takesako

IPC: H01J31/12 ,  H04N3/12 ,  H01J29/70 ,  H01J29/72

CPC classification number: H04N3/122 ,  H01J31/126

Abstract: A picture image display apparatus has a flat type vacuum enclosure having a transparent face panel. A row of parallelly disposed linear thermionic cathodes are provided with an electron beam extractor electrode which produces a predetermined number of two dimensionally disposed electron beams out of the electron emission from the linear thermionic cathodes. A row of control electrodes is disposed parallelly in a direction perpendicular to those of the linear thermionic cathodes. A row of vertical deflection electrodes and a row of horizontal deflection electrodes are provided. A phosphor screen formed on the inner force of the face panel has an anode of thin metal film formed on its surface. A horizontal deflection signal generator issues a horizontal deflection signal having, in 1 cycle, a first scanning period wherein voltage increases and a second scanning period of the same length wherein voltage decreases. In both of the first and second scanning periods control signals are applied to the control electrodes to produce image spots in both scanning periods.

Abstract translation: 图像显示装置具有具有透明面板的平面型真空外壳。 一排平行布置的线性热离子阴极设置有电子束提取器电极，其从线性热阴极阴极产生电子发射的预定数量的二维设置的电子束。 一排控制电极与垂直于线性热阴极阴极的方向平行设置。 提供一排垂直偏转电极和一排水平偏转电极。 在面板的内力上形成的荧光屏在其表面上形成有金属薄膜的阳极。 水平偏转信号发生器发出水平偏转信号，该水平偏转信号在1个周期内具有电压增加的第一扫描周期和电压降低的相同长度的第二扫描周期。 在第一和第二扫描周期中，控制信号被施加到控制电极以在两个扫描周期中产生图像点。

公开(公告)号：US4525727A

公开(公告)日：1985-06-25

申请号：US467355

申请日：1983-02-16

Applicant: Tadao Kohashi ,  Hiroyuki Irie ,  Susumu Ide ,  Hiroshi Esaki

Inventor： Tadao Kohashi ,  Hiroyuki Irie ,  Susumu Ide ,  Hiroshi Esaki

IPC: B41J2/04 ,  G01D15/18

CPC classification number: B41J2/04

Abstract: An electroosmotic ink printer comprising a head having an array of recording electrodes successively arranged to define a print line along one edge of the head. A common electrode is provided in spaced overlying relation with the recording electrodes. Between the electrode array and the common electrode is a means for electroosmotically moving ink in a direction toward the print line and in an opposite direction depending on an electrical potential applied to the recording electrodes with respect to the common electrode. A memory stores a video input signal in a plurality of storage locations corresponding to the recording electrodes for delivery in parallel form to a modulator for generating individual recording signals corresponding to the recording electrodes. Control means activates first and second groups of the recording electrodes by successively applying the individual recording signals thereto to cause the ink to move to the print line and deactivates the remainder of the recording electrodes by successively applying a deactivating potential to the electrodes of the group other than those to which the recording signals are applied.

Abstract translation: 一种电渗墨水打印机，包括具有连续布置成沿着头部的一个边缘限定打印线的记录电极阵列的头部。 公共电极以与记录电极间隔开的关系提供。 在电极阵列和公共电极之间是根据施加到记录电极相对于公共电极的电位使油墨沿着打印线的方向和相反方向电动移动的装置。 存储器将视频输入信号存储在对应于记录电极的多个存储位置中，用于以并行形式传送到用于产生对应于记录电极的各个记录信号的调制器。 控制装置通过连续施加各个记录信号来激活第一组记录电极和第二组记录信号，使墨水移动到打印行，并且通过对该组的其他电极依次施加去激活电位而使剩余的记录电极停用 比应用记录信号的那些。

公开(公告)号：US4319237A

公开(公告)日：1982-03-09

申请号：US120000

申请日：1980-02-08

Applicant: Tamotsu Matsuo ,  Susumu Ide ,  Hiroyuki Irie

Inventor： Tamotsu Matsuo ,  Susumu Ide ,  Hiroyuki Irie

IPC: G09G3/36

CPC classification number: G09G3/36 ,  G09G3/3655 ,  G09G2320/028 ,  G09G2320/041

Abstract: A drive circuit drives a liquid crystal display device of the type in which liquid crystal fills a space between an X-Y matrix substrate having a number of picture elements each including a switching element, and a common electrode plate. The drive circuit provides an optimum picture displayed to an observer in accordance with ambient conditions such as light and temperature. To this end, a DC bias voltage to determine the operating point of the liquid crystal display device is applied to the common electrode. The brightness of the displayed picture may be controlled by adjusting the DC bias voltage. The DC bias is changed in accordance with a change in an amount of ambient light or ambient temperature. Furthermore, in accordance with the fall of the ambient temperature the DC voltage applied to the common electrode is made to oscillate at a frequency to which the liquid crystal is insensitive, with respect to the bias point. At this time, the amplitude of the oscillation is made large.

Abstract translation: 驱动电路驱动液晶显示装置，其中液晶填充具有各自包括开关元件的多个像素的X-Y矩阵基板和公共电极板之间的空间。 驱动电路根据诸如光和温度的环境条件向观察者提供最佳图像。 为此，将用于确定液晶显示装置的工作点的DC偏置电压施加到公共电极。 显示图像的亮度可以通过调整直流偏置电压来控制。 DC偏置根据环境光或环境温度的变化而改变。 此外，根据环境温度的下降，施加到公共电极的直流电压相对于偏压点以液晶不敏感的频率振荡。 此时振荡的振幅变大。

公开(公告)号：US07872111B2

公开(公告)日：2011-01-18

申请号：US12184334

申请日：2008-08-01

Applicant: Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

Inventor： Masami Miura ,  Masaaki Hirose ,  Taeko Miwa ,  Hiroyuki Irie ,  Shinobu Kuwae ,  Kenmi Miyano ,  Wataru Otani ,  Hideyuki Ohi

IPC: C07H21/04 ,  C12N1/00 ,  C12N14/39 ,  C12N9/10

CPC classification number: C12N9/1205 ,  C12P21/005

Abstract: A protein participating in the addition of mannose phosphate to a sugar chain of a glycoprotein originating in a yeast belonging to the genus Pichia; a gene coding this protein; a mutant of this gene; a vector carrying the mutant gene; a yeast strain belonging to the genus Pichia having been transformed by this vector; a process for producing a protein with reduction of an acidic sugar chain by using the transformed yeast strain; and a glycoprotein thus produced, are described.

Abstract translation: 参与将磷酸甘露糖添加到源自毕赤酵母属的酵母的糖链的糖链上的蛋白质; 编码该蛋白的基因; 该基因的突变体; 携带突变基因的载体; 已经通过该载体转化了属于毕赤酵母属的酵母菌株; 通过使用转化的酵母菌株来生产具有降低酸性糖链的蛋白质的方法; 和如此制备的糖蛋白。

公开(公告)号：US20090198278A1

公开(公告)日：2009-08-06

申请号：US12303345

申请日：2007-06-05

Applicant: Koichi Shibata ,  Hiroyuki Irie ,  Mitsuya Urata ,  Satoshi Ojima

Inventor： Koichi Shibata ,  Hiroyuki Irie ,  Mitsuya Urata ,  Satoshi Ojima

IPC: A61B17/70

CPC classification number: A61B17/7071

Abstract: To provide a spinous process spacer that can be stably inserted and fixed between split faces of a split spinous process in a gapless manner, without made-to-order production for each patient. There is provided a spinous process spacer (1) for insertion between split halves of a spinous process resulting from longitudinal splitting of the spinous process, wherein the spinous process spacer is formed in an approximately cylindrical shape and the opposite end faces (2, 3) thereof are constituted by planes which mutually form a fixed angle.

Abstract translation: 提供可以无间隙地稳定地插入和固定在分裂棘突的分裂面之间的棘突间隔物，而不需要每个患者的按需生产。 提供了一种用于插入由棘突的纵向分裂产生的棘突的分割半部之间的棘突间隔件（1），其中棘突间隔件形成为大致圆柱形，并且相对的端面（2,3） 由相互形成固定角度的平面构成。