公开(公告)号：US08349554B2

公开(公告)日：2013-01-08

申请号：US12674146

申请日：2008-08-14

申请人： S. Bahram Bahrami ,  Mandana Veiseh ,  James Olson

发明人： S. Bahram Bahrami ,  Mandana Veiseh ,  James Olson

IPC分类号： C12Q1/00

CPC分类号： A61M5/3298 ,  A61B6/508 ,  A61M5/1452 ,  A61M5/14526 ,  A61M5/16827 ,  A61M5/20 ,  A61M5/3287 ,  A61M5/3291 ,  A61M5/3294 ,  A61M2205/50 ,  A61M2205/52

摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

公开(公告)号：US20120296206A1

公开(公告)日：2012-11-22

申请号：US13489324

申请日：2012-06-05

申请人： S. Bahram Bahrami ,  Mandana Veiseh ,  James Olson

发明人： S. Bahram Bahrami ,  Mandana Veiseh ,  James Olson

IPC分类号： A61B6/00 ,  A61B10/02 ,  A61M5/00

CPC分类号： A61M5/3298 ,  A61B6/508 ,  A61M5/1452 ,  A61M5/14526 ,  A61M5/16827 ,  A61M5/20 ,  A61M5/3287 ,  A61M5/3291 ,  A61M5/3294 ,  A61M2205/50 ,  A61M2205/52

摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of liquid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

摘要翻译： 流体递送装置包括针阵列，每个针与相应的储存器流体连通。 相应的致动器被联接以便可操作以通过针端口驱动来自储存器的流体。 每个针可以具有多个端口，并且端口可以布置成沿着其长度在任何给定位置处输送基本上相等量的流体。 驱动器联接到致动器以选择性地控制通过针的液体的流速，体积和方向。 该装置可以同时在体内在固体组织中沿相应的轴递送多个流体试剂。 如果之后切除，则可以将组织切片以评估每种药剂对组织的影响，并且基于评估，选择或取消选择用于临床试验或治疗的候选药剂，以及选择或取消选择用于临床试验或治疗性治疗的受试者。

公开(公告)号：US20120087866A1

公开(公告)日：2012-04-12

申请号：US13330106

申请日：2011-12-19

申请人： S. Bahram BAHRAMI ,  Mandana Veiseh ,  James Olson

发明人： S. Bahram BAHRAMI ,  Mandana Veiseh ,  James Olson

IPC分类号： A61K49/00 ,  C12Q1/02 ,  C40B30/06

CPC分类号： A61M5/3298 ,  A61B6/508 ,  A61M5/1452 ,  A61M5/14526 ,  A61M5/16827 ,  A61M5/20 ,  A61M5/3287 ,  A61M5/3291 ,  A61M5/3294 ,  A61M2205/50 ,  A61M2205/52

摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

公开(公告)号：US20100041566A1

公开(公告)日：2010-02-18

申请号：US12496730

申请日：2009-07-02

申请人： Miqin Zhang ,  Mandana Veiseh

发明人： Miqin Zhang ,  Mandana Veiseh

IPC分类号： C40B30/04 ,  C40B40/02 ,  C40B50/06

CPC分类号： G01N33/5008 ,  C40B20/02 ,  C40B40/02 ,  C40B60/04 ,  G01N33/5005 ,  H01L21/02164

摘要： Guided cell patterning arrays for single cell patterning, methods for making the arrays, and methods for using the arrays.

摘要翻译： 用于单细胞图案的引导细胞图案阵列，用于制备阵列的方法以及使用阵列的方法。

公开(公告)号：US20080279780A1

公开(公告)日：2008-11-13

申请号：US11897721

申请日：2007-08-31

申请人： Miqin Zhang ,  Richard G. Ellenbogen ,  Raymond W. Sze ,  Omid Veiseh ,  James M. Olson ,  Mandana Veiseh ,  Patrick Gabikian ,  S-Bahram Bahrami

发明人： Miqin Zhang ,  Richard G. Ellenbogen ,  Raymond W. Sze ,  Omid Veiseh ,  James M. Olson ,  Mandana Veiseh ,  Patrick Gabikian ,  S-Bahram Bahrami

IPC分类号： A61K49/00

CPC分类号： A61B17/22 ,  A61K38/16 ,  A61K47/6415 ,  A61K49/0017 ,  A61K49/0032 ,  A61K49/0041 ,  A61K49/005 ,  A61K49/0056 ,  A61K51/08 ,  C07K14/43522 ,  G01N33/57492

摘要： A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate.

摘要翻译： 通过荧光成像可检测的氯毒素缀合物，其允许癌组织的术中可视化，包括氯毒素缀合物的组合物，以及使用氯毒素缀合物的方法。

公开(公告)号：US20210229095A1

公开(公告)日：2021-07-29

申请号：US17183010

申请日：2021-02-23

申请人： Mandana Veiseh ,  Seyed Bahram Bahrami ,  Michial Duff Howell ,  James Ferguson

发明人： Mandana Veiseh ,  Seyed Bahram Bahrami ,  Michial Duff Howell ,  James Ferguson

IPC分类号： B01L3/00 ,  G01N15/10 ,  G01N15/14

摘要： A hybrid biosensing-imaging system that can operate inside an incubator, structures and methods are directed to placing modular and removable biosensors and biocompatible interfaces in 3D transparent test wells that contain biological samples. The technology enables continuous monitoring of multiple simultaneous parameters and functions of a living cell or cell clusters such as alterations of cellular ligands, physicochemical biomarkers, phenotypes, and/or extracellular compositions upon interactions with analytes or during progressions. Methods of capturing and analyzing direct orthogonal information from biological samples in 2D and 3D.

公开(公告)号：US08672887B2

公开(公告)日：2014-03-18

申请号：US13330106

申请日：2011-12-19

申请人： S. Bahram Bahrami ,  Mandana Veiseh ,  James Olson

发明人： S. Bahram Bahrami ,  Mandana Veiseh ,  James Olson

IPC分类号： A61M37/00

CPC分类号： A61M5/3298 ,  A61B6/508 ,  A61M5/1452 ,  A61M5/14526 ,  A61M5/16827 ,  A61M5/20 ,  A61M5/3287 ,  A61M5/3291 ,  A61M5/3294 ,  A61M2205/50 ,  A61M2205/52

摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

公开(公告)号：US08778310B2

公开(公告)日：2014-07-15

申请号：US11897721

申请日：2007-08-31

申请人： Miqin Zhang ,  Richard G. Ellenbogen ,  Raymond W. Sze ,  Omid Veiseh ,  James M. Olson ,  Mandana Veiseh ,  Patrik Gabikian ,  S-Bahram Bahrami

发明人： Miqin Zhang ,  Richard G. Ellenbogen ,  Raymond W. Sze ,  Omid Veiseh ,  James M. Olson ,  Mandana Veiseh ,  Patrik Gabikian ,  S-Bahram Bahrami

IPC分类号： A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  A61K49/00 ,  A61K38/16 ,  A61K51/08

CPC分类号： A61B17/22 ,  A61K38/16 ,  A61K47/6415 ,  A61K49/0017 ,  A61K49/0032 ,  A61K49/0041 ,  A61K49/005 ,  A61K49/0056 ,  A61K51/08 ,  C07K14/43522 ,  G01N33/57492

摘要： A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate.

摘要翻译： 通过荧光成像可检测的氯毒素缀合物，其允许癌组织的术中可视化，包括氯毒素缀合物的组合物，以及使用氯毒素缀合物的方法。

公开(公告)号：US20120109104A1

公开(公告)日：2012-05-03

申请号：US13330124

申请日：2011-12-19

申请人： S. Bahram Bahrami ,  Mandana Veiseh ,  James Olson

发明人： S. Bahram Bahrami ,  Mandana Veiseh ,  James Olson

IPC分类号： A61M5/00

CPC分类号： A61M5/3298 ,  A61B6/508 ,  A61M5/1452 ,  A61M5/14526 ,  A61M5/16827 ,  A61M5/20 ,  A61M5/3287 ,  A61M5/3291 ,  A61M5/3294 ,  A61M2205/50 ,  A61M2205/52

摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

公开(公告)号：US20120089095A1

公开(公告)日：2012-04-12

申请号：US13330022

申请日：2011-12-19

申请人： S. Bahram Bahrami ,  Mandana Veiseh ,  James Olson

发明人： S. Bahram Bahrami ,  Mandana Veiseh ,  James Olson

IPC分类号： A61M5/00

CPC分类号： A61M5/3298 ,  A61B6/508 ,  A61M5/1452 ,  A61M5/14526 ,  A61M5/16827 ,  A61M5/20 ,  A61M5/3287 ,  A61M5/3291 ,  A61M5/3294 ,  A61M2205/50 ,  A61M2205/52

摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.