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公开(公告)号：US06974831B2
公开(公告)日：2005-12-13
申请号：US10450741
申请日：2001-12-06
申请人： Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , Edward C R Smith
发明人： Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , Edward C R Smith
IPC分类号： A61K31/403 , A61P1/00 , A61P1/18 , A61P11/02 , A61P11/06 , A61P11/08 , A61P17/02 , A61P19/02 , A61P29/00 , A61P31/04 , A61P43/00 , C07D209/60 , C07D209/70 , C07D409/10 , A61K31/404 , C07D209/56
CPC分类号： C07D209/70 , C07D209/60 , C07D409/10
摘要： A novel class of cycloalkyl fused indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译： 公开了一类新型的环烷基稠合吲哚化合物以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎症性疾病如败血性休克的用途。
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公开(公告)号：US06730694B1
公开(公告)日：2004-05-04
申请号：US10332480
申请日：2003-01-07
IPC分类号： A61K31407
CPC分类号： C07D495/04
摘要： A class of novel substituted pyrrole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译： 公开了一类新颖的取代吡咯以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎症性疾病如败血性休克的用途。
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3.发明授权
公开(公告)号：US06140327A
公开(公告)日：2000-10-31
申请号：US310563
申请日：1999-05-12
申请人： Jason Scott Sawyer , John Michael Morin, Jr. , Douglas Wade Beight , Daniel Jon Sall , John Andrew Buben
发明人： Jason Scott Sawyer , John Michael Morin, Jr. , Douglas Wade Beight , Daniel Jon Sall , John Andrew Buben
IPC分类号： A61K31/5377 , A61P1/18 , A61P3/06 , A61P5/12 , A61P7/04 , A61P7/06 , A61P11/00 , A61P11/16 , A61P17/02 , A61P19/02 , A61P25/00 , A61P29/00 , A61P31/04 , A61P31/06 , A61P31/10 , A61P31/12 , A61P37/08 , C07D209/18 , C07D209/24 , C07D413/02
CPC分类号： A61K31/5377 , C07D209/24
摘要： The compound, ((3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl)oxy)acetic acid morpholino-N-ethyl ester, is disclosed together with its use as a highly bioavailable indole compound for inhibiting sPLA.sub.2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译： 化合物（（3-（2-氨基-1,2-二氧代乙基）-2-乙基-1-（苯基甲基）-1H-吲哚-4-基）氧代）乙酸吗啉代-N-乙基酯是 公开了其用作高度生物可利用的吲哚化合物，用于抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。
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公开(公告)号：US06013674A
公开(公告)日：2000-01-11
申请号：US71684
申请日：1998-05-01
申请人： John Michael Morin, Jr. , Michael Dean Kinnick , Robert Theodore Vasileff , William Thomas Jackson
发明人： John Michael Morin, Jr. , Michael Dean Kinnick , Robert Theodore Vasileff , William Thomas Jackson
IPC分类号： A61K31/165 , A61K31/166 , A61P11/00 , A61P25/28 , A61P29/00 , A61P43/00 , C07C235/82
CPC分类号： A61K31/166 , C07C235/82 , C07C2102/08 , Y10S514/821 , Y10S514/825 , Y10S514/826 , Y10S514/863 , Y10S514/886 , Y10S514/908 , Y10S514/927
摘要： This invention provides novel indenone derivatives, their pharmaceutical formulations and their use for the inhibition of leukocyte adherence to cells.
摘要翻译： 本发明提供新的茚酮酮衍生物，其药物制剂及其用于抑制白细胞对细胞粘附的用途。
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5.发明授权N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection 失效N-芳基烷基-N-杂芳基脲和胍基化合物以及治疗HIV感染的方法
公开(公告)号：US5849769A
公开(公告)日：1998-12-15
申请号：US601030
申请日：1996-05-03
IPC分类号： A61K31/17 , A61K31/40 , A61K31/44 , A61K31/50 , C07D213/75 , C07D213/76 , C07D213/85 , C07D231/40 , C07D237/20 , C07D239/42 , C07D277/48 , C07D277/56 , C07D277/82 , C07D401/12 , A61K31/505 , C07D213/72 , C07D239/26
CPC分类号： C07D213/75 , A61K31/17 , A61K31/40 , A61K31/44 , A61K31/50 , C07D213/76 , C07D213/85 , C07D231/40 , C07D237/20 , C07D239/42 , C07D277/48 , C07D277/56 , C07D277/82 , C07D401/12
摘要： A method for treating HIV which comprises a compound of the formula ##STR1## wherein A is ##STR2## and Z.sub.i is O, Se, NR.sup.a or C(R.sup.a).sub.2, and Z.sub.ii is --O or (.dbd.O).sub.2 ; wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are as defined in the specification.
摘要翻译： PCT No.PCT / US94 / 09406 Sec。 371日期：1996年5月3日 102（e）日期1996年5月3日PCT 1994年8月24日PCT公布。 公开号WO95 / 06034 日期1995年3月2日一种治疗HIV的方法，其包含下式的化合物，其中A为O，Se，NRa或C（Ra）2，Zii为-O或（= O ）2; 其中R1，R2，R3和R4如说明书中所定义。
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6.发明授权Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes 失效用作黑色素浓缩激素拮抗剂治疗肥胖和糖尿病的多环化合物公开(公告)号：US07229987B2
公开(公告)日：2007-06-12
申请号：US10512986
申请日：2003-05-06
申请人： Jochen Ammenn , James Ronald Gillig , Lawrence Joseph Heinz , Philip Arthur Hipskind , Michael Dean Kinnick , Yen-Shi Lai , John Michael Morin, Jr. , James Arthur Nixon , Carsten Ott , Kenneth Allen Savin , Theo Schotten , Lawrence John Slieker , Nancy June Snyder , Michael Alan Robertson
发明人： Jochen Ammenn , James Ronald Gillig , Lawrence Joseph Heinz , Philip Arthur Hipskind , Michael Dean Kinnick , Yen-Shi Lai , John Michael Morin, Jr. , James Arthur Nixon , Carsten Ott , Kenneth Allen Savin , Theo Schotten , Lawrence John Slieker , Nancy June Snyder , Michael Alan Robertson
IPC分类号： A61K31/5355 , A61K31/454 , C07D401/12 , C07D403/12 , C07D263/32
CPC分类号： C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/26 , C07D333/18 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to a melanin concentrating hormone antagonist compound of formula I: (I); or a pharmaceutically acceptable salt, solvate, enantiomer or prodrug thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.
摘要翻译： 本发明涉及式I的黑色素浓缩激素拮抗剂化合物：（I）; 或其药学上可接受的盐，溶剂化物，对映异构体或前药，用于治疗，预防或改善与肥胖症和相关疾病相关的症状。
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公开(公告)号：US06992100B2
公开(公告)日：2006-01-31
申请号：US10450745
申请日：2001-12-06
申请人： Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , John David Jandzinski
发明人： Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , John David Jandzinski
IPC分类号： A61K31/403 , C07D209/56
CPC分类号： A61K31/403 , A61K31/407 , A61K31/4745
摘要： A novel class of tetracyclic compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译： 公开了一类新的四环化合物以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎性疾病如脓毒性休克的用途。
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公开(公告)号：US06448269B1
公开(公告)日：2002-09-10
申请号：US09883639
申请日：2001-06-18
申请人： Matthew J. Fisher , Anne Marie Happ , Joseph A. Jakubowski , Michael Dean Kinnick , Allen D. Kline , Michael John Martinelli , John Michael Morin, Jr. , Michael Paal , Gerd Rühter , Kenneth James Ruterbories , Daniel J. Sall , Theo Schotten , Marshall A. Skelton , Wolfgang Stenzel , Robert Theodore Vasileff
发明人： Matthew J. Fisher , Anne Marie Happ , Joseph A. Jakubowski , Michael Dean Kinnick , Allen D. Kline , Michael John Martinelli , John Michael Morin, Jr. , Michael Paal , Gerd Rühter , Kenneth James Ruterbories , Daniel J. Sall , Theo Schotten , Marshall A. Skelton , Wolfgang Stenzel , Robert Theodore Vasileff
IPC分类号： C07D40112
CPC分类号： C07D311/22 , C07C257/18 , C07C271/64 , C07C2602/10 , C07D211/22 , C07D211/34 , C07D213/82 , C07D217/04 , C07D217/06 , C07D217/24 , C07D311/58 , C07D333/38 , C07D401/12 , C07D405/06 , C07D405/12
摘要： This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
摘要翻译： 本发明涉及具有由两个稠合的六元环形成的核的某些二环化合物，例如苯并吡喃，异喹啉，异喹诺酮，四氢萘，二氢萘或四氢萘酮，其被碱性和酸性官能团所取代，其可用于抑制血小板聚集 。
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公开(公告)号：US06872743B2
公开(公告)日：2005-03-29
申请号：US10450633
申请日：2001-12-06
申请人： Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer
发明人： Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer
IPC分类号： A61K31/403 , A61P1/00 , A61P1/18 , A61P7/00 , A61P11/00 , A61P11/06 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/80 , C07D209/94 , C07D209/56
CPC分类号： C07D209/80 , C07D209/94
摘要： A novel class of tetracyclic compounds represented by the formula I wherein R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, and n are as defined is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译： 由式I代表的新一类四环化合物，其中R1，R2，R3，R4，R5，R6，R7，A，B，C，D，E和n定义同上， 抑制sPLA2介导的脂肪酸释放治疗炎症性疾病如脓毒性休克。
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公开(公告)号：US06713645B1
公开(公告)日：2004-03-30
申请号：US09688106
申请日：2000-10-13
申请人： Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
发明人： Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
IPC分类号： C07C6976
CPC分类号： C07D409/04 , C07D209/88 , C07F9/5728
摘要： A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译： 公开了一类新型三环类药物，以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。
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