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1.发明授权公开(公告)号：US08044090B2
公开(公告)日：2011-10-25
申请号：US12504242
申请日：2009-07-16
申请人： Zhaogen Chen , Michael Philip Cohen , Matthew Joseph Fisher , Bruno Giethlen , James Ronald Gillig , Jefferson Ray McCowan , Shawn Christopher Miller , John Mehnert Schaus
发明人： Zhaogen Chen , Michael Philip Cohen , Matthew Joseph Fisher , Bruno Giethlen , James Ronald Gillig , Jefferson Ray McCowan , Shawn Christopher Miller , John Mehnert Schaus
IPC分类号： A61K31/4045 , A61K31/137 , C07D209/14
CPC分类号： C07D213/64 , C07C211/52 , C07C211/56 , C07C217/58 , C07C217/60 , C07C225/16 , C07C311/37 , C07C317/34 , C07C323/32 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/86 , C07D213/38 , C07D213/65 , C07D213/68 , C07D213/74 , C07D233/24 , C07D239/34 , C07D277/34 , C07D307/91 , C07D333/20 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/12 , C07D471/04 , C07F7/0812
摘要： The present invention provides compounds of formula (I), which are antagonists of the 5-HT6 receptor.
摘要翻译： 本发明提供作为5-HT 6受体拮抗剂的式（I）化合物。
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2.发明授权公开(公告)号：US07157488B2
公开(公告)日：2007-01-02
申请号：US10472741
申请日：2002-03-15
申请人： Zhaogen Chen , Michael Philip Cohen , Matthew Joseph Fisher , Bruno Giethlen , James Ronald Gillig , Jefferson Ray McCowan , Shawn Christopher Miller , John Mehnert Schaus
发明人： Zhaogen Chen , Michael Philip Cohen , Matthew Joseph Fisher , Bruno Giethlen , James Ronald Gillig , Jefferson Ray McCowan , Shawn Christopher Miller , John Mehnert Schaus
IPC分类号： A61K31/4045 , A61K31/137 , C07D209/14 , C07C211/00
CPC分类号： C07D213/64 , C07C211/52 , C07C211/56 , C07C217/58 , C07C217/60 , C07C225/16 , C07C311/37 , C07C317/34 , C07C323/32 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/86 , C07D213/38 , C07D213/65 , C07D213/68 , C07D213/74 , C07D233/24 , C07D239/34 , C07D277/34 , C07D307/91 , C07D333/20 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/12 , C07D471/04 , C07F7/0812
摘要： The present invention provides compounds of formula I pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are antagonists of the 5-HT6 receptor. The present invention further provides a method of treating disorders associated with 5-HT6 receptors, including schizophrenia, anxiety, Alzheimer's disease, and cognitive disorders selected from the group consisting of age-related cognitive decline, mild cognitive impairment, and dementia, comprising: administering to a patient in need thereof an effective amount of a compound of formula I.
摘要翻译： 本发明提供式I化合物其药学上可接受的盐及其药物组合物，它们是5-HT 6受体的拮抗剂。 本发明还提供了一种治疗与5-HT 6受体相关的疾病的方法，包括精神分裂症，焦虑症，阿尔茨海默氏病和认知障碍，其选自年龄相关的认知衰退，轻度认知 损伤和痴呆，包括：向有需要的患者施用有效量的式I化合物。
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3.发明授权Benzenesulfonic acid indol-5-yl esters as antagonists of the 5ht6 receptor 失效苯磺酸吲哚-5-基酯作为5ht6受体的拮抗剂公开(公告)号：US07230011B2
公开(公告)日：2007-06-12
申请号：US10466969
申请日：2002-01-17
申请人： Sandra Ann Filla , Michael Edward Flaugh , James Ronald Gillig , Lawrence Joseph Heinz , Joseph Herman Krushinski, Jr. , Bin Liu , Marta Maria Pineiro-Nunez , John Mehnert Schaus , John Stanley Ward
发明人： Sandra Ann Filla , Michael Edward Flaugh , James Ronald Gillig , Lawrence Joseph Heinz , Joseph Herman Krushinski, Jr. , Bin Liu , Marta Maria Pineiro-Nunez , John Mehnert Schaus , John Stanley Ward
IPC分类号： A61K31/454 , A61K31/4545 , C07D401/04 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14 , C07D487/04
摘要： The present invention relates to compounds of formula I: which are antagonists of 5-HT6 receptor.
摘要翻译： 本发明涉及式I化合物，它是5-HT 6受体的拮抗剂。
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公开(公告)号：US07132456B2
公开(公告)日：2006-11-07
申请号：US10536053
申请日：2003-12-03
申请人： James Ronald Gillig , Lawrence Joseph Heinz , Michael Dean Kinnick , Yen-Shi Lai , John Michael Morin , Nancy June Snyder
发明人： James Ronald Gillig , Lawrence Joseph Heinz , Michael Dean Kinnick , Yen-Shi Lai , John Michael Morin , Nancy June Snyder
IPC分类号： A61K31/165 , C07C55/06 , C07C323/42
CPC分类号： C07C323/60
摘要： The present invention relates to a melanin concentrating hormone antagonist compound of Formula I: (I) wherein Ar1, Ar2, Ar3, L1, L2 and Q areas defined, or a pharmaceutically acceptable salt, solvate, enantiomer or mixture of diastereomers thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and Related Diseases
摘要翻译： 本发明涉及式I的黑色素浓缩激素拮抗剂化合物：（I）其中Ar 1，Ar 2，Ar 3，L 限定的1个或2个Q区域，或其可用于治疗，预防或改善与肥胖有关的症状的非对映异构体的药学上可接受的盐，溶剂合物，对映异构体或混合物 和相关疾病
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5.发明申请公开(公告)号：US20090306110A1
公开(公告)日：2009-12-10
申请号：US12504242
申请日：2009-07-16
申请人： Zhaogen Chen , Michael Philip Cohen , Matthew Joseph Fisher , Bruno Giethlen , James Ronald Gillig , Jefferson Ray McCowan , Shawn Christopher Miller , John Mehnert Schaus
发明人： Zhaogen Chen , Michael Philip Cohen , Matthew Joseph Fisher , Bruno Giethlen , James Ronald Gillig , Jefferson Ray McCowan , Shawn Christopher Miller , John Mehnert Schaus
IPC分类号： A61K31/404 , A61K31/506 , A61K31/435 , A61K31/445 , A61P25/28
CPC分类号： C07D213/64 , C07C211/52 , C07C211/56 , C07C217/58 , C07C217/60 , C07C225/16 , C07C311/37 , C07C317/34 , C07C323/32 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/86 , C07D213/38 , C07D213/65 , C07D213/68 , C07D213/74 , C07D233/24 , C07D239/34 , C07D277/34 , C07D307/91 , C07D333/20 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/12 , C07D471/04 , C07F7/0812
摘要： The present invention provides compounds of formula (I), which are antagonists of the 5-HT6 receptor.
摘要翻译： 本发明提供作为5-HT 6受体拮抗剂的式（I）化合物。
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6.发明授权Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes 失效用作黑色素浓缩激素拮抗剂治疗肥胖和糖尿病的多环化合物公开(公告)号：US07229987B2
公开(公告)日：2007-06-12
申请号：US10512986
申请日：2003-05-06
申请人： Jochen Ammenn , James Ronald Gillig , Lawrence Joseph Heinz , Philip Arthur Hipskind , Michael Dean Kinnick , Yen-Shi Lai , John Michael Morin, Jr. , James Arthur Nixon , Carsten Ott , Kenneth Allen Savin , Theo Schotten , Lawrence John Slieker , Nancy June Snyder , Michael Alan Robertson
发明人： Jochen Ammenn , James Ronald Gillig , Lawrence Joseph Heinz , Philip Arthur Hipskind , Michael Dean Kinnick , Yen-Shi Lai , John Michael Morin, Jr. , James Arthur Nixon , Carsten Ott , Kenneth Allen Savin , Theo Schotten , Lawrence John Slieker , Nancy June Snyder , Michael Alan Robertson
IPC分类号： A61K31/5355 , A61K31/454 , C07D401/12 , C07D403/12 , C07D263/32
CPC分类号： C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/26 , C07D333/18 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to a melanin concentrating hormone antagonist compound of formula I: (I); or a pharmaceutically acceptable salt, solvate, enantiomer or prodrug thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.
摘要翻译： 本发明涉及式I的黑色素浓缩激素拮抗剂化合物：（I）; 或其药学上可接受的盐，溶剂化物，对映异构体或前药，用于治疗，预防或改善与肥胖症和相关疾病相关的症状。
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