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1.发明授权Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes 失效用作黑色素浓缩激素拮抗剂治疗肥胖和糖尿病的多环化合物公开(公告)号：US07229987B2
公开(公告)日：2007-06-12
申请号：US10512986
申请日：2003-05-06
申请人： Jochen Ammenn , James Ronald Gillig , Lawrence Joseph Heinz , Philip Arthur Hipskind , Michael Dean Kinnick , Yen-Shi Lai , John Michael Morin, Jr. , James Arthur Nixon , Carsten Ott , Kenneth Allen Savin , Theo Schotten , Lawrence John Slieker , Nancy June Snyder , Michael Alan Robertson
发明人： Jochen Ammenn , James Ronald Gillig , Lawrence Joseph Heinz , Philip Arthur Hipskind , Michael Dean Kinnick , Yen-Shi Lai , John Michael Morin, Jr. , James Arthur Nixon , Carsten Ott , Kenneth Allen Savin , Theo Schotten , Lawrence John Slieker , Nancy June Snyder , Michael Alan Robertson
IPC分类号： A61K31/5355 , A61K31/454 , C07D401/12 , C07D403/12 , C07D263/32
CPC分类号： C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/26 , C07D333/18 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to a melanin concentrating hormone antagonist compound of formula I: (I); or a pharmaceutically acceptable salt, solvate, enantiomer or prodrug thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.
摘要翻译： 本发明涉及式I的黑色素浓缩激素拮抗剂化合物：（I）; 或其药学上可接受的盐，溶剂化物，对映异构体或前药，用于治疗，预防或改善与肥胖症和相关疾病相关的症状。
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公开(公告)号：US06579871B2
公开(公告)日：2003-06-17
申请号：US10235005
申请日：2002-09-03
申请人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
发明人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
IPC分类号： A61K31425
CPC分类号： C07D263/57 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/14 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12
摘要： This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
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公开(公告)号：US06472387B1
公开(公告)日：2002-10-29
申请号：US10109133
申请日：2002-03-27
申请人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
发明人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
IPC分类号： A61K31425
CPC分类号： C07D263/57 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/14 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12
摘要： This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
摘要翻译： 本发明涉及可用作神经保护剂的新型苯基恶唑，噻唑，恶唑啉，恶二唑和苯并恶唑。
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公开(公告)号：US06448396B2
公开(公告)日：2002-09-10
申请号：US09159346
申请日：1998-09-23
申请人： Benjamin Alan Anderson , Lawrence Joseph Heinz , Jill Ann Panetta , Michael LeRoy Phillips , John Allan Rieck, III , John Robert Rizzo , John Kevin Shadle , David Lee Varie
发明人： Benjamin Alan Anderson , Lawrence Joseph Heinz , Jill Ann Panetta , Michael LeRoy Phillips , John Allan Rieck, III , John Robert Rizzo , John Kevin Shadle , David Lee Varie
IPC分类号： C07D41312
CPC分类号： C07D263/57 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/14 , C07D263/32 , C07D271/06 , C07D277/24 , C07D413/12
摘要： The present invention provides a process of preparing a compound of the formula IV wherein: R1 and R2 are each individually -(C1-C6)alkyl, -(C1-C6)alkoxy or phenyl, R3 is H or -(C1-C6)alkyl, R6 is —NR7R8, morpholin-1-yl, imidazol-1-yl, 4,5-dihydro-1H-imidazol-2-yl, thiomorpholin-1-yl, piperazin-1-yl or piperazin-1-yl substituted with -(C1-C4)alkyl or and R7 and R8 are each individually hydrogen, -(C1-C6)alkyl, —(CH2)pOH, —(CH2)p-piperidyl, —(CH2)pS(C1-C6)alkyl, —(CH2)pO(C1-C6)alkyl where R9 is (C1-C6)alkyl; P is an integer from 1-3 both inclusive; q is 0 or 1; and t is 1 to 6 both inclusive; or a pharmaceutically acceptable salt, hydrate or optical isomer thereof, which is useful as a neuroprotective agent.
摘要翻译： 本发明提供制备式IV化合物的方法，其中R 1和R 2各自为 - （C 1 -C 6）烷基， - （C 1 -C 6）烷氧基或苯基，R 3为H或 - （C 1 -C 6）烷基 ，R6是-NR7R8，吗啉-1-基，咪唑-1-基，4,5-二氢-1H-咪唑-2-基，硫代吗啉-1-基，哌嗪-1-基或哌嗪-1-基取代的 与（C 1 -C 4）烷基或R 7和R 8各自独立地为氢， - （C 1 -C 6）烷基， - （CH 2）p OH， - （CH 2） 烷基， - （CH 2）p O（C 1 -C 6）烷基，其中R 9为（C 1 -C 6）烷基; P为1-3的整数，其中q为0或1; andt是1至6，包括它们;或其药学上可接受的盐，水合物或旋光异构体，其可用作神经保护剂。
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公开(公告)号：US06380213B1
公开(公告)日：2002-04-30
申请号：US09715987
申请日：2000-11-17
申请人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
发明人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
IPC分类号： A61K31427
CPC分类号： C07D263/57 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/14 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12
摘要： This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
摘要翻译： 本发明涉及可用作神经保护剂的新型苯基恶唑，噻唑，恶唑啉，恶二唑和苯并恶唑。
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公开(公告)号：US06423709B1
公开(公告)日：2002-07-23
申请号：US09996005
申请日：2001-11-28
申请人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
发明人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
IPC分类号： A61K31425
CPC分类号： C07D263/57 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/14 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12
摘要： This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
摘要翻译： 本发明涉及可用作神经保护剂的新型苯基恶唑，噻唑，恶唑啉，恶二唑和苯并恶唑。
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公开(公告)号：US6156748A
公开(公告)日：2000-12-05
申请号：US944468
申请日：1997-10-06
申请人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
发明人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
IPC分类号： A61P25/00 , A61P25/28 , C07D233/64 , C07D233/68 , C07D263/14 , C07D263/32 , C07D263/56 , C07D263/57 , C07D271/06 , C07D277/22 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12 , C07D521/00 , A61K31/425 , A61K31/415 , A61K31/42 , C07D263/30 , C07D271/12 , C07D413/00
CPC分类号： C07D263/57 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/14 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12
摘要： This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
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8.发明授权Benzenesulfonic acid indol-5-yl esters as antagonists of the 5ht6 receptor 失效苯磺酸吲哚-5-基酯作为5ht6受体的拮抗剂公开(公告)号：US07230011B2
公开(公告)日：2007-06-12
申请号：US10466969
申请日：2002-01-17
申请人： Sandra Ann Filla , Michael Edward Flaugh , James Ronald Gillig , Lawrence Joseph Heinz , Joseph Herman Krushinski, Jr. , Bin Liu , Marta Maria Pineiro-Nunez , John Mehnert Schaus , John Stanley Ward
发明人： Sandra Ann Filla , Michael Edward Flaugh , James Ronald Gillig , Lawrence Joseph Heinz , Joseph Herman Krushinski, Jr. , Bin Liu , Marta Maria Pineiro-Nunez , John Mehnert Schaus , John Stanley Ward
IPC分类号： A61K31/454 , A61K31/4545 , C07D401/04 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14 , C07D487/04
摘要： The present invention relates to compounds of formula I: which are antagonists of 5-HT6 receptor.
摘要翻译： 本发明涉及式I化合物，它是5-HT 6受体的拮抗剂。
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公开(公告)号：US07132456B2
公开(公告)日：2006-11-07
申请号：US10536053
申请日：2003-12-03
申请人： James Ronald Gillig , Lawrence Joseph Heinz , Michael Dean Kinnick , Yen-Shi Lai , John Michael Morin , Nancy June Snyder
发明人： James Ronald Gillig , Lawrence Joseph Heinz , Michael Dean Kinnick , Yen-Shi Lai , John Michael Morin , Nancy June Snyder
IPC分类号： A61K31/165 , C07C55/06 , C07C323/42
CPC分类号： C07C323/60
摘要： The present invention relates to a melanin concentrating hormone antagonist compound of Formula I: (I) wherein Ar1, Ar2, Ar3, L1, L2 and Q areas defined, or a pharmaceutically acceptable salt, solvate, enantiomer or mixture of diastereomers thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and Related Diseases
摘要翻译： 本发明涉及式I的黑色素浓缩激素拮抗剂化合物：（I）其中Ar 1，Ar 2，Ar 3，L 限定的1个或2个Q区域，或其可用于治疗，预防或改善与肥胖有关的症状的非对映异构体的药学上可接受的盐，溶剂合物，对映异构体或混合物 和相关疾病
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公开(公告)号：US06166216A
公开(公告)日：2000-12-26
申请号：US368236
申请日：1999-08-04
申请人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
发明人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
IPC分类号： A61P25/00 , A61P25/28 , C07D233/64 , C07D233/68 , C07D263/14 , C07D263/32 , C07D263/56 , C07D263/57 , C07D271/06 , C07D277/22 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12 , C07D521/00
CPC分类号： C07D263/57 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/14 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12
摘要： This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
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