专利检索 ap:"Michael John Martinelli" 第 1 页

1.

发明授权
Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof 有权
标题翻译：（R）-2-（7-（4-环戊基-3-（三氟甲基）苄氧基）-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基）乙酸及其盐的制备方法

公开(公告)号：US08853419B2

公开(公告)日：2014-10-07

申请号：US13575458

申请日：2011-01-27

申请人： Antonio Garrido Montalban , Daniel J. Buzard , John A. DeMattei , Tawfik Gharbaoui , Stephen R. Johannsen , Ashwin M. Krishnan , Young Mi Khulman , You-An Ma , Michael John Martinelli , Suzanne Michiko Sato , Dipanjan Sengupta

发明人： Antonio Garrido Montalban , Daniel J. Buzard , John A. DeMattei , Tawfik Gharbaoui , Stephen R. Johannsen , Ashwin M. Krishnan , Young Mi Khulman , You-An Ma , Michael John Martinelli , Suzanne Michiko Sato , Dipanjan Sengupta

IPC分类号： C07D209/80 , A61K31/403 , C07D209/94

CPC分类号： C12P17/10 , C07B2200/13 , C07C17/278 , C07D209/80 , C07D209/88 , C07D209/94 , C07D295/155

摘要： The present invention relates to processes and intermediates useful in the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of Formula (Ia) and salts thereof, an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development and atherosclerosis).

摘要翻译： 本发明涉及可用于制备（R）-2-（7-（4-环戊基-3-（三氟甲基）苄氧基）-1,2,3,4-四氢环戊二烯并[b]吲哚-3 - 基）乙酸及其盐，可用于治疗S1P1受体相关疾病的S1P1受体调节剂，例如由淋巴细胞介导的疾病和病症，移植排斥反应，自身免疫性疾病和病症，炎性疾病和病症（例如急性和慢性炎性病症），癌症和特征在于血管完整性的潜在缺陷或与血管发生相关的病症，例如可能是病理性的（例如，可能发生在炎症，肿瘤发展和动脉粥样硬化）。

2.

发明授权
Melanocortin receptor agonists 失效
标题翻译：黑皮质素受体激动剂

公开(公告)号：US07314879B2

公开(公告)日：2008-01-01

申请号：US10500476

申请日：2003-01-21

申请人： Ryan Thomas Backer , Caño Ivan Collado , Oscar De Frutos-Garcia , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Chaoyu Xie

发明人： Ryan Thomas Backer , Caño Ivan Collado , Oscar De Frutos-Garcia , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Chaoyu Xie

IPC分类号： A61K31/496 , C07D401/12 , C07D405/12 , C07D407/12

CPC分类号： C07D217/26 , C07D209/44 , C07D211/26 , C07D211/96 , C07D295/033 , C07D309/04 , C07D335/02 , C07D401/12 , C07D405/12 , C07D409/12

摘要： The present invention relates to melanocortin receptor agonist of the formula (I): which is useful in the treatment for obesity, diabetes, and male and/or female sexual dysfunction

摘要翻译： 本发明涉及式（I）的黑皮质素受体激动剂：其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍

3.

发明授权
Piperazine- and piperidine-derivatives as melanocortin receptor agonists 失效
标题翻译：哌嗪和哌啶衍生物作为黑皮质素受体激动剂

公开(公告)号：US07186715B2

公开(公告)日：2007-03-06

申请号：US10466248

申请日：2002-01-23

申请人： Karin Briner , Christopher William Doecke , Vincent Mancuso , Michael John Martinelli , Timothy Ivo Richardson , Roger Ryan Rothhaar , Qing Shi , Chaoyu Xie

发明人： Karin Briner , Christopher William Doecke , Vincent Mancuso , Michael John Martinelli , Timothy Ivo Richardson , Roger Ryan Rothhaar , Qing Shi , Chaoyu Xie

IPC分类号： A61K31/496 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14

CPC分类号： A61K45/06 , C07D209/44 , C07D217/14 , C07D217/26 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12

摘要： The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction

摘要翻译： 本发明涉及式I的黑皮质素受体激动剂，其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍

4.

发明授权
Substituted piperidines/piperazines as melanocortin receptor agonists 失效
标题翻译：取代的哌啶/哌嗪作为黑皮质素受体激动剂

公开(公告)号：US07157463B2

公开(公告)日：2007-01-02

申请号：US10466249

申请日：2002-01-23

申请人： Ryan Thomas Backer , Karin Briner , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Chaoyu Xie

发明人： Ryan Thomas Backer , Karin Briner , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Chaoyu Xie

IPC分类号： A61K31/496 , C07D401/12 , C07D403/12 , C07D403/14

CPC分类号： C07D401/12 , C07D209/44 , C07D217/26 , C07D401/14

摘要： The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction

摘要翻译： 本发明涉及式I的黑皮质素受体激动剂，其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍

5.

发明授权
spla2 inhibitors 失效
标题翻译： spla2抑制剂

公开(公告)号：US06713505B2

公开(公告)日：2004-03-30

申请号：US10297282

申请日：2002-12-03

申请人： Michael Dean Kinnick , Ho-Shen Lin , Michael John Martinelli , John Michael Morin , Michael Enrico Richett

发明人： Michael Dean Kinnick , Ho-Shen Lin , Michael John Martinelli , John Michael Morin , Michael Enrico Richett

IPC分类号： A61K3138

CPC分类号： C07D333/62 , C07D333/60 , C07D333/64 , C07D333/66 , C07D333/70

摘要： A class of novel benzo(b)thiophene is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.

摘要翻译： 公开了一类新的苯并（b）噻吩以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎性疾病如败血性休克的用途。

6.

发明申请
PROCESSES FOR THE PREPARATION OF (R)-2-(7-(4-CYCLOPENTYL-3-(TRIFLUOROMETHYL)BENZYLOXY)-1,2,3,4-TETRAHYDROCYCLOPENTA[B]INDOL-3-YL)ACETIC ACID AND SALTS THEREOF 有权
标题翻译：（R）-2-（7-（4-环丙基-3-（三氟甲基）苯甲酰基）-1,2,3,4-四氢环戊二烯并[B]吲哚-3-基）乙酸及其盐的制备方法

公开(公告)号：US20120295947A1

公开(公告)日：2012-11-22

申请号：US13575458

申请日：2011-01-27

申请人： Antonio Garrido Montalban , Daniel J. Buzard , John A. DeMattei , Tawfik Gharbaoui , Stephen R. Johannsen , Ashwin M. Krishnan , Young Mi Khulman , You-An Ma , Michael John Martinelli , Suzanne Michiko Sato , Dipanjan Sengupta

发明人： Antonio Garrido Montalban , Daniel J. Buzard , John A. DeMattei , Tawfik Gharbaoui , Stephen R. Johannsen , Ashwin M. Krishnan , Young Mi Khulman , You-An Ma , Michael John Martinelli , Suzanne Michiko Sato , Dipanjan Sengupta

IPC分类号： C12P17/10 , A61K31/403 , A61P25/00 , A61P37/06 , A61P9/12 , A61P17/10 , A61P29/00 , A61P17/06 , C07D209/70 , A61P3/10

CPC分类号： C12P17/10 , C07B2200/13 , C07C17/278 , C07D209/80 , C07D209/88 , C07D209/94 , C07D295/155

摘要： The present invention relates to processes and intermediates useful in the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of Formula (Ia) and salts thereof, an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development and atherosclerosis).

摘要翻译： 本发明涉及可用于制备（R）-2-（7-（4-环戊基-3-（三氟甲基）苄氧基）-1,2,3,4-四氢环戊二烯并[b]吲哚-3 - 基）乙酸及其盐，可用于治疗S1P1受体相关疾病的S1P1受体调节剂，例如由淋巴细胞介导的疾病和病症，移植排斥反应，自身免疫性疾病和病症，炎性疾病和病症（例如急性和慢性炎性病症），癌症和特征在于血管完整性的潜在缺陷或与血管发生相关的病症，例如可能是病理性的（例如，可能发生在炎症，肿瘤发展和动脉粥样硬化）。

7.

发明授权
Glycoprotein IIb/IIIa antagonists 失效
标题翻译：糖蛋白IIb / IIIa拮抗剂

公开(公告)号：US06448269B1

公开(公告)日：2002-09-10

申请号：US09883639

申请日：2001-06-18

申请人： Matthew J. Fisher , Anne Marie Happ , Joseph A. Jakubowski , Michael Dean Kinnick , Allen D. Kline , Michael John Martinelli , John Michael Morin, Jr. , Michael Paal , Gerd Rühter , Kenneth James Ruterbories , Daniel J. Sall , Theo Schotten , Marshall A. Skelton , Wolfgang Stenzel , Robert Theodore Vasileff

发明人： Matthew J. Fisher , Anne Marie Happ , Joseph A. Jakubowski , Michael Dean Kinnick , Allen D. Kline , Michael John Martinelli , John Michael Morin, Jr. , Michael Paal , Gerd Rühter , Kenneth James Ruterbories , Daniel J. Sall , Theo Schotten , Marshall A. Skelton , Wolfgang Stenzel , Robert Theodore Vasileff

IPC分类号： C07D40112

CPC分类号： C07D311/22 , C07C257/18 , C07C271/64 , C07C2602/10 , C07D211/22 , C07D211/34 , C07D213/82 , C07D217/04 , C07D217/06 , C07D217/24 , C07D311/58 , C07D333/38 , C07D401/12 , C07D405/06 , C07D405/12

摘要： This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.

摘要翻译： 本发明涉及具有由两个稠合的六元环形成的核的某些二环化合物，例如苯并吡喃，异喹啉，异喹诺酮，四氢萘，二氢萘或四氢萘酮，其被碱性和酸性官能团所取代，其可用于抑制血小板聚集。

8.

发明申请
METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF 审中-公开
标题翻译：合成CINACALCET及其盐的方法

公开(公告)号：US20090137837A1

公开(公告)日：2009-05-28

申请号：US12142450

申请日：2008-06-19

申请人： Oliver Thiel , Charles Bernard , Robert Larsen , Michael John Martinelli , Masooma Tamim Raza

发明人： Oliver Thiel , Charles Bernard , Robert Larsen , Michael John Martinelli , Masooma Tamim Raza

IPC分类号： C07C271/06 , C07C211/27 , C07C233/02

CPC分类号： C07C209/70 , C07C209/22 , C07C211/30

摘要： Methods of preparing cinacalcet, cinacalcet derivatives, and salts thereof is disclosed herein. Also disclosed herein are polymorphs of cinacalcet, compositions of cinacalcet, and methods of treating a subject by administering cinacalcet, wherein cinacalcet is prepared by the disclosed methods.

摘要翻译： 本文公开了西那卡塞，西那卡塞衍生物及其盐的制备方法。还公开了西那卡塞的多晶型物，西那卡塞的组合物，以及通过施用西那卡塞治疗受试者的方法，其中依撒卡塞通过所公开的方法制备。