公开(公告)号：US08663915B2

公开(公告)日：2014-03-04

申请号：US12595824

申请日：2008-04-11

申请人： Lance D. Miller ,  Bing Lim ,  Jinqiu Zhang

发明人： Lance D. Miller ,  Bing Lim ,  Jinqiu Zhang

IPC分类号： C12Q1/68

CPC分类号： G01N33/57423 ,  A61K31/7088 ,  A61K38/1709 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57492 ,  G01N2500/04 ,  G01N2800/50

摘要： The present invention relates to methods of controlling tumorigenesis, including preventing, inhibiting, arresting or reversing tumorigenesis. The present invention also provides methods of treatment, prevention and diagnosis of neoblastoma, including cancer, such as metastatic cancer. In one method one or more cells having a predisposition to turn tumorigenic are identifyied. In the one or more cells an altered amount, an altered subcellular localisation or an altered activity of a Rab binding protein is detected. In a method of diagnosing the risk of developing a neoplasmt at least one of the expression level, the activity level and the subcellular localisation of a Rab binding protein is determined. In an in-vitro method of identifying a compound capable of forming a complex with a Rab binding protein the components that form the respective complex are contacted with each other. In a method of determining whether a neoplasm is sensitive to an alteration of intracellular calcium levels, at least one of the expression and the activity of a Rab binding protein is determined. An altered expression or an altered activity of the Rab binding protein is an indication that the neoplasm is sensitive to an alteration of intracellular calcium levels.

摘要翻译： 本发明涉及控制肿瘤发生的方法，包括预防，抑制，阻止或逆转肿瘤发生。 本发明还提供了治疗，预防和诊断包括癌症在内的新生血管瘤如转移性癌症的方法。 在一种方法中，鉴定出具有转变成致瘤性倾向的一种或多种细胞。 在一个或多个细胞中，检测到改变的量，改变的亚细胞定位或改变的Rab结合蛋白的活性。 在诊断发展赘生物的风险的方法中，确定Rab结合蛋白的表达水平，活性水平和亚细胞定位中的至少一个。 在鉴定能够与Rab结合蛋白形成复合物的化合物的体外方法中，形成相应复合物的组分彼此接触。 在确定肿瘤是否对细胞内钙水平的改变敏感的方法中，确定Rab结合蛋白的表达和活性中的至少一种。 Rab结合蛋白的改变的表达或改变的活性表明肿瘤对细胞内钙水平的改变敏感。

公开(公告)号：US08563146B1

公开(公告)日：2013-10-22

申请号：US13169710

申请日：2011-06-27

申请人： Jinqiu Zhang ,  Ying Hong ,  Hai Sun ,  Hongping Yuan ,  Guanghong Luo ,  Xiaoyu Yang ,  Hongmei Han ,  Lingyun Miao

发明人： Jinqiu Zhang ,  Ying Hong ,  Hai Sun ,  Hongping Yuan ,  Guanghong Luo ,  Xiaoyu Yang ,  Hongmei Han ,  Lingyun Miao

IPC分类号： G11B5/33

CPC分类号： G11B5/1278 ,  G11B5/3116 ,  G11B5/3163

摘要： A method for fabricating a magnetic transducer having an air-bearing surface (ABS). An underlayer having a first and second regions and a bevel connecting these regions is provided. The first region is thicker and closer to the ABS than the second region. An intermediate layer conformal with the underlayer is provided. A hard mask layer having a top surface perpendicular to the ABS is formed on the intermediate layer. Part of the hard mask and intermediate layers are removed to provide a trench. The trench has a bottom surface and sidewalls having a first angle between the bottom surface and the intermediate layer and a second angle corresponding to the hard mask layer. A pole is provided in the trench. The pole has a pole tip, a yoke distal, and a bottom bevel. At least the yoke includes sidewalls having sidewall angles corresponding to the first and second angles.

摘要翻译： 一种制造具有空气轴承表面（ABS）的磁换能器的方法。 提供具有第一和第二区域的底层以及连接这些区域的斜面。 第一区域比第二区域更厚且更接近ABS。 提供与底层共形的中间层。 在中间层上形成具有垂直于ABS的顶表面的硬掩模层。 除去硬掩模和中间层的一部分以提供沟槽。 沟槽具有底表面和在底表面和中间层之间具有第一角度的侧壁和对应于硬掩模层的第二角度。 在沟槽中设置一个极点。 杆具有极尖，轭远端和底斜面。 至少轭包括具有对应于第一和第二角度的侧壁角的侧壁。

公开(公告)号：US08277669B1

公开(公告)日：2012-10-02

申请号：US12643954

申请日：2009-12-21

申请人： Tsung Yuan Chen ,  Yimin Guo ,  Jinqiu Zhang ,  Ut Tran

发明人： Tsung Yuan Chen ,  Yimin Guo ,  Jinqiu Zhang ,  Ut Tran

IPC分类号： B44C1/22

CPC分类号： G11B5/3116 ,  G11B5/315 ,  G11B5/3163 ,  Y10T29/49046

摘要： A method and system for providing a pole of magnetic transducer having an air-bearing surface (ABS) are described. Leading shield and planarization stop layers are provided. Portions of the planarization stop and shield layers distal from the ABS location are removed, providing a depression forming a bevel. The bevel has an angle greater than zero and less than ninety degrees. An intermediate layer having a top surface substantially perpendicular to the ABS location is provided. Part of the intermediate layer is removed, forming a trench having a bottom corresponding to the leading shield and a location and profile corresponding to the pole. A nonmagnetic layer is provided at least partially in the trench. The pole with a leading edge bevel corresponding to the bevel is provided in the trench. A capping layer covering the pole is provided, at least part of the intermediate layer removed, and a wrap-around shield provided.

摘要翻译： 描述了一种用于提供具有空气轴承表面（ABS）的磁换能器极的方法和系统。 提供了领先的屏蔽和平坦化停止层。 除去远离ABS位置的平坦化停止和屏蔽层的部分，提供形成斜面的凹陷。 斜面角度大于零，小于九十度。 提供具有基本上垂直于ABS位置的顶表面的中间层。 中间层的一部分被去除，形成具有对应于前屏蔽的底部的沟槽和对应于极的位置和轮廓。 至少部分地在沟槽中提供非磁性层。 在沟槽中设置有与斜面相对应的前缘斜面的极。 提供覆盖极的覆盖层，去除中间层的至少一部分和设置的环绕护罩。

公开(公告)号：US08104166B1

公开(公告)日：2012-01-31

申请号：US10741857

申请日：2003-12-19

申请人： Jinqiu Zhang ,  Ming Zhao ,  Mohamad T. Krounbi ,  Henry Yuan ,  Lien-Chang Wang

发明人： Jinqiu Zhang ,  Ming Zhao ,  Mohamad T. Krounbi ,  Henry Yuan ,  Lien-Chang Wang

IPC分类号： G11B5/127 ,  H04R31/00

CPC分类号： G11B5/3163 ,  B82Y25/00 ,  G01R33/093 ,  G11B5/398 ,  Y10T29/49043 ,  Y10T29/49044 ,  Y10T29/49046 ,  Y10T29/49048 ,  Y10T29/49052

摘要： A method is provided for fabricating a read element with leads that overlay a top surface of a sensor of the read element. The method includes forming a mask over a sensor layer, then using the mask to define the sensor from the sensor layer. The mask is then narrowed and a lead layer is formed that overlays both ends of the top surface of the sensor without covering a center portion of the top surface.

摘要翻译： 提供了一种制造读取元件的方法，该元件具有覆盖读取元件的传感器的顶表面的引线。 该方法包括在传感器层上形成掩模，然后使用掩模从传感器层定义传感器。 然后使掩模变窄，并且形成覆盖传感器顶表面两端的引线层，而不覆盖顶表面的中心部分。

公开(公告)号：US07639457B1

公开(公告)日：2009-12-29

申请号：US10788765

申请日：2004-02-27

申请人： Yingjian Chen ,  Wei Zhang ,  Jinqiu Zhang ,  Haifeng Wang ,  Satoru Araki ,  Mohamad T. Krounbi

发明人： Yingjian Chen ,  Wei Zhang ,  Jinqiu Zhang ,  Haifeng Wang ,  Satoru Araki ,  Mohamad T. Krounbi

IPC分类号： G11B5/39 ,  G11B5/127

CPC分类号： G11B5/3909 ,  B82Y10/00 ,  B82Y25/00 ,  G01R33/098 ,  G11B5/3163 ,  G11B5/3932 ,  G11B2005/3996 ,  H01F10/3272

摘要： A magnetic sensor is disclosed comprising an antiferromagnetic layer; a first ferromagnetic layer disposed over the antiferromagnetic layer, the first ferromagnetic layer having a magnetization that is pinned by the antiferromagnetic layer; a second ferromagnetic layer disposed over the first ferromagnetic layer, the second ferromagnetic layer having a magnetization that rotates due to an applied magnetic field; a third ferromagnetic layer disposed adjacent to an end of the second ferromagnetic layer, the third ferromagnetic layer having a primarily in-plane magnetization providing a magnetic field to stabilize the end of the second ferromagnetic layer; an amorphous, metallic, nonmagnetic underlayer disposed adjacent to the antiferromagnetic layer; and a crystalline seed layer disposed between the underlayer and the third ferromagnetic layer, the seed layer having a crystalline structure that promotes the in-plane magnetization of the third ferromagnetic layer.

摘要翻译： 公开了一种磁传感器，其包括反铁磁层; 设置在所述反铁磁层上的第一铁磁层，所述第一铁磁层具有由所述反铁磁层固定的磁化; 设置在所述第一铁磁层上的第二铁磁层，所述第二铁磁层具有由施加的磁场旋转的磁化; 与所述第二铁磁层的端部相邻设置的第三铁磁层，所述第三铁磁层具有主要的面内磁化，提供磁场以稳定所述第二铁磁层的端部; 邻近反铁磁层设置的无定形金属非磁性底层; 以及设置在所述底层和所述第三铁磁层之间的结晶种子层，所述种子层具有促进所述第三铁磁层的平面内磁化的晶体结构。

公开(公告)号：US09346672B1

公开(公告)日：2016-05-24

申请号：US12535645

申请日：2009-08-04

申请人： Jinqiu Zhang

发明人： Jinqiu Zhang

IPC分类号： G11B5/127 ,  H04R31/00 ,  B82Y10/00 ,  B82Y25/00 ,  G11B5/31

CPC分类号： B82Y10/00 ,  B82Y25/00 ,  G11B5/1278 ,  G11B5/3116 ,  G11B5/3163 ,  Y10T29/49032 ,  Y10T29/49044

摘要： A method for forming a write pole comprises the steps of providing a structure comprising a substrate layer, a ruthenium layer over the substrate layer, and a tantalum layer over the ruthenium layer, providing an opening in the tantalum layer over a portion of the ruthenium layer, performing a first reactive ion etching step on the portion of the ruthenium layer under the opening in the tantalum layer to provide an opening in the ruthenium layer over a portion of the substrate layer, performing a second reactive ion etching step on the portion of the substrate layer under the opening in the ruthenium layer to form a damascene trench therein, and filling the damascene trench with a magnetic material to form the write pole.

摘要翻译： 一种用于形成写极的方法包括以下步骤：提供包括基底层，基底层上的钌层和钌层之上的钽层的结构，在碲层的一部分上提供钽层中的开口 在钽层的开口下方的钌层的部分上进行第一反应离子蚀刻工序，以在基板层的一部分上设置钌层的开口部，在该部分上进行第二反应离子蚀刻工序 在钌层的开口下方形成基底层，以在其中形成镶嵌沟槽，并用磁性材料填充镶嵌沟槽以形成写入极。

公开(公告)号：US08793866B1

公开(公告)日：2014-08-05

申请号：US11960596

申请日：2007-12-19

申请人： Jinqiu Zhang ,  Liubo Hong ,  Yong Shen ,  Yizhong Wang ,  Hai Sun ,  Li He

发明人： Jinqiu Zhang ,  Liubo Hong ,  Yong Shen ,  Yizhong Wang ,  Hai Sun ,  Li He

IPC分类号： G11B5/187 ,  C23C14/22

CPC分类号： G11B5/3163 ,  G11B5/1278 ,  G11B5/3116

摘要： A method provides a PMR transducer. In one aspect, the method includes forming a trench in an intermediate layer using reactive ion etch(es). The trench top is wider than its bottom. In this aspect, the method also includes providing a seed layer using atomic layer deposition and providing a PMR pole on the seed layer. Portion(s) of the seed layer and PMR pole reside in the trench. In another aspect, the method includes providing a mask including a trench having a top wider than its bottom. In this aspect, the method includes providing mask material in the trench, providing an intermediate layer on the mask material and removing the mask material to provide another trench in the intermediate layer. In this aspect, the method also includes providing a PMR pole in the additional trench.

摘要翻译： 一种方法提供PMR换能器。 一方面，该方法包括使用反应离子蚀刻在中间层中形成沟槽。 沟槽顶部比底部宽。 在这方面，该方法还包括使用原子层沉积提供种子层并在种子层上提供PMR极点。 种子层和PMR极的部分位于沟槽中。 在另一方面，该方法包括提供一种掩模，该掩模包括具有比其底部更宽的顶部的沟槽。 在这方面，该方法包括在沟槽中提供掩模材料，在掩模材料上提供中间层并去除掩模材料以在中间层中提供另一个沟槽。 在这方面，该方法还包括在附加沟槽中提供PMR极点。

公开(公告)号：US08649123B1

公开(公告)日：2014-02-11

申请号：US12324519

申请日：2008-11-26

申请人： Jinqiu Zhang ,  Hai Sun ,  Hongping Yuan ,  Tsung Yuan Chen

发明人： Jinqiu Zhang ,  Hai Sun ,  Hongping Yuan ,  Tsung Yuan Chen

IPC分类号： G11B5/31

CPC分类号： G11B5/3116 ,  G11B5/1278 ,  G11B5/3163

摘要： A method for providing a perpendicular magnetic recording (PMR) head is disclosed. The method comprises: providing an insulating layer; covering the insulating layer with a hard mask material; forming a pre-defined shape in the hard mask material; forming a pole trench and a yoke area in the insulating layer by a first reactive ion etching (RIE) process in which the yoke area includes a loading prevention pattern; performing a wet etching process to remove the hard mask material from the pole trench and the yoke area; performing a second RIE process to remove the loading prevention pattern of the yoke area, wherein the pole trench and the remainder of the yoke area are not removed and remain having similar side wall angles; and providing a PMR pole in which at least a portion of the PMR pole resides in the pole trench.

摘要翻译： 公开了一种用于提供垂直磁记录（PMR）头的方法。 该方法包括：提供绝缘层; 用硬掩模材料覆盖绝缘层; 在硬掩模材料中形成预定形状; 通过第一反应离子蚀刻（RIE）工艺在绝缘层中形成极沟和轭区，其中轭区包括负载防止图案; 执行湿蚀刻工艺以从磁极沟槽和磁轭区域去除硬掩模材料; 执行第二RIE处理以去除轭区域的负载防止图案，其中极沟槽和轭区域的其余部分不被去除并保持具有相似的侧壁角度; 以及提供PMR极，其中PMR极的至少一部分位于极沟中。

公开(公告)号：US08520337B1

公开(公告)日：2013-08-27

申请号：US13436712

申请日：2012-03-30

申请人： Feng Liu ,  Zhigang Bai ,  Yugang Wang ,  Jinqiu Zhang ,  Ying Hong ,  Tao Pan

发明人： Feng Liu ,  Zhigang Bai ,  Yugang Wang ,  Jinqiu Zhang ,  Ying Hong ,  Tao Pan

IPC分类号： G11B5/127

CPC分类号： G11B5/1278 ,  G11B5/3116 ,  G11B5/315

摘要： A perpendicular magnetic recording transducer with leading and trailing bevel side wall angles at air bearing surface for use in a data storage device is provided. The transducer includes a magnetic writer pole having a pole tip facing an air bearing surface (ABS). The pole tip includes a pole tip face having a leading edge, a trailing edge, a first side wall, and a second side wall. The first side wall includes a first side wall section adjoining the leading edge and a second side wall section adjoining the trailing edge. The first side wall section is at a first angle measured from a perpendicular center line dividing the trailing edge. The second side wall section is at a second angle measured from a perpendicular center line dividing the trailing edge. The second angle is greater than three degrees. The first angle is greater than the second angle.

摘要翻译： 提供了一种用于数据存储装置的在空气轴承表面具有前后倾斜侧壁角度的垂直磁记录传感器。 换能器包括具有面向空气轴承表面（ABS）的极尖的磁性写入极。 极尖包括具有前缘，后缘，第一侧壁和第二侧壁的极尖端面。 第一侧壁包括邻接前缘的第一侧壁部分和与后缘相邻的第二侧壁部分。 第一侧壁部分是从分割后缘的垂直中心线测量的第一角度。 第二侧壁部分是从分割后缘的垂直中心线测量的第二角度。 第二个角度大于三度。 第一角度大于第二角度。

公开(公告)号：US08334093B2

公开(公告)日：2012-12-18

申请号：US12262572

申请日：2008-10-31

申请人： Jinqiu Zhang ,  Hai Sun ,  Hongping Yuan ,  Tsung Yuan Chen ,  Guanxiong Li

发明人： Jinqiu Zhang ,  Hai Sun ,  Hongping Yuan ,  Tsung Yuan Chen ,  Guanxiong Li

IPC分类号： H04R31/00

CPC分类号： G11B5/3163 ,  G11B5/1278 ,  G11B5/3116 ,  Y10T29/49041

摘要： A method and system for providing a PMR pole in a magnetic recording transducer including an intermediate layer are disclosed. The method and system include providing a mask on the intermediate layer. The mask includes a line having at least one side. A hard mask layer is provided on the mask. At least a portion of the hard mask layer resides on the side(s) of the line. At least part of the hard mask layer on the side(s) of the line is removed. Thus, at least a portion of the line is exposed. The line is then removed, providing an aperture in the hard mask corresponding to the line. The method also includes forming a trench in the intermediate layer under the aperture. The trench top is wider than its bottom. The method further includes providing a PMR pole, at least a portion of which resides in the trench.

摘要翻译： 公开了一种用于在包括中间层的磁记录换能器中提供PMR极的方法和系统。 该方法和系统包括在中间层上提供掩模。 掩模包括具有至少一个侧面的线。 在掩模上设置硬掩模层。 硬掩模层的至少一部分位于线的一侧。 除去线的侧面上的硬掩模层的至少一部分。 因此，线的至少一部分被暴露。 然后去除线，在对应于线的硬掩模中提供孔。 该方法还包括在孔下方的中间层中形成沟槽。 沟槽顶部比底部宽。 该方法还包括提供PMR极，其至少一部分位于沟槽中。