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    Polymeric nano-particles for siRNA delivery using charge interaction and covalent bonding
    1.
    发明授权
    Polymeric nano-particles for siRNA delivery using charge interaction and covalent bonding 有权
    用于使用电荷相互作用和共价键的siRNA递送的聚合物纳米颗粒

    公开(公告)号：US09061068B2

    公开(公告)日：2015-06-23

    申请号：US12905212

    申请日：2010-10-15

    申请人： Kwang Meyung Kim ,  Ick Chan Kwon ,  Kuiwon Choi ,  Myung Sook Huh ,  Seung Young Lee ,  So Jin Lee

    发明人： Kwang Meyung Kim ,  Ick Chan Kwon ,  Kuiwon Choi ,  Myung Sook Huh ,  Seung Young Lee ,  So Jin Lee

    IPC分类号： C07H21/02 ,  A61K47/48 ,  C12N15/11 ,  C12N15/87

    CPC分类号： A61K47/4823 ,  A61K47/61 ,  A61K47/6939 ,  C12N15/111 ,  C12N15/87 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/32

    摘要： Disclosed is a polymer-siRNA delivery carrier in which a siRNA is combined with a polymer and the use thereof. More specifically, there is disclosed a stable in vivo polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time and the use thereof.The polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time has a high siRNA deliver efficiency to a target portion in vivo. Hence, according to the polymer-siRNA binder, the siRNA for treatment can be effectively delivered to a target portion such as in vivo cancer tissue, and the like even with administration of a relatively low concentration, and thus widely used for the treatment of various kinds of diseases.

    摘要翻译： 公开了将siRNA与聚合物组合的聚合物-siRNA递送载体及其用途。 更具体地，公开了一种稳定的体内聚合物-siRNA递送载体，其中通过使用电荷相互作用和可生物降解的共价键在同一时间将聚合物和siRNA组合起来，以及其用途。 通过使用电荷相互作用和可生物降解的共价键合将聚合物和siRNA组合的聚合物-siRNA递送载体在体内对目标部分具有高的siRNA递送效率。 因此，根据聚合物-siRNA粘合剂，即使施用相对低的浓度，也可以将治疗用siRNA有效地输送到诸如体内癌组织等目标部位，广泛用于各种治疗 各种疾病

    Human serum albumin-siRNA nano-sized carrier system
    3.
    发明授权
    Human serum albumin-siRNA nano-sized carrier system 有权
    人血清白蛋白siRNA siRNA纳米载体体系

    公开(公告)号：US08513402B2

    公开(公告)日：2013-08-20

    申请号：US13245180

    申请日：2011-09-26

    申请人： Kwangmeyung Kim ,  Ick Chan Kwon ,  Kuiwon Choi ,  In Chan Youn ,  MyungSook Huh ,  Sojin Lee

    发明人： Kwangmeyung Kim ,  Ick Chan Kwon ,  Kuiwon Choi ,  In Chan Youn ,  MyungSook Huh ,  Sojin Lee

    IPC分类号： C07H21/04

    CPC分类号： C12N15/111 ,  A61K47/643 ,  C12N2320/32

    摘要： Disclosed are a human serum albumin-siRNA carrier system having siRNA bound to human serum albumin and a user thereof, and especially, human serum albumin-siRNA carrier system, which has a biodegradable covalent bond between human serum albumin polymer and siRNA and is stable in a living body, and a user thereof.The human serum albumin-siRNA carrier system having the biodegradable covalent bond between the human serum albumin and the siRNA exhibits high siRNA delivery efficiency to a target site in the living body. Therefore, the human serum albumin-siRNA carrier system may allow siRNA for therapy to be efficiently delivered to a target site such as cancer tissues in the living body even by being administrated in a relatively low concentration, which may result in a wide use for therapies of various diseases.

    摘要翻译： 公开了具有与人血清白蛋白结合的siRNA及其使用者的人血清白蛋白-siRNA载体体系，特别是人血清白蛋白-siRNA载体体系，其在人血清白蛋白聚合物和siRNA之间具有可生物降解的共价键，并且在 生物体及其使用者。 在人体血清白蛋白和siRNA之间具有可生物降解的共价键的人血清白蛋白-siRNA载体体系对生物体中的靶位点显示出高的siRNA递送效率。 因此，人体血清白蛋白-siRNA载体体系可以使siRNA用于治疗有效地递送到目标部位如生物体中的癌组织，甚至通过以相对低的浓度施用，这可能导致广泛用于治疗 的各种疾病。

    NOVEL PHOTOSENSITIZER BASED ON POLYMER DERIVATIVES-PHOTOSENSITIZER CONJUGATES FOR PHOTODYNAMIC THERAPY
    6.
    发明申请
    NOVEL PHOTOSENSITIZER BASED ON POLYMER DERIVATIVES-PHOTOSENSITIZER CONJUGATES FOR PHOTODYNAMIC THERAPY 有权
    基于聚合物衍生物的新型光敏剂 - 光致变色治疗光敏剂

    公开(公告)号：US20100222538A1

    公开(公告)日：2010-09-02

    申请号：US12595103

    申请日：2008-04-23

    申请人： Ick-Chan Kwon ,  Kui-Won Choi ,  Kwang-Meyung Kim ,  In-Chan Youn ,  Jong-Ho Kim ,  Kyeong-Soon Park

    发明人： Ick-Chan Kwon ,  Kui-Won Choi ,  Kwang-Meyung Kim ,  In-Chan Youn ,  Jong-Ho Kim ,  Kyeong-Soon Park

    IPC分类号： C08F251/00

    CPC分类号： A61K41/0071 ,  A61K47/61 ,  A61K47/6929

    摘要： Disclosed is a novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy capable of being selectively accumulated in cancerous tissues and producing singlet oxygen or free radical by laser irradiation. The polymer derivatives-photosensitizer conjugates for photodynamic therapy are prepared as nano-sized particles, and have excellent selection and accumulation ratio for cancerous tissues. The photosensitizer conjugates can produce singlet oxygen or free radical by a specific laser wavelength. Owing to the excellent selection and accumulation ratio for cancerous tissues, the conjugates minimizes photo-cytotoxicity of the conventional photosensitizer having a low molecular amount. Accordingly, the conjugates are very useful as a photosensitizes for photodynamic therapy with reduced side effects and excellent therapeutic effectiveness.

    摘要翻译： 公开了一种基于用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物的新型光敏剂，其能够选择性地积累在癌组织中并通过激光照射产生单线态氧或自由基。 用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物制备为纳米尺寸颗粒，并且对于癌组织具有优异的选择和积累比。 光敏剂共轭物可以通过特定的激光波长产生单线态氧或自由基。 由于癌组织的优异的选择和积累比，共轭物使具有低分子量的常规光敏剂的光细胞毒性最小化。 因此，缀合物对于具有降低的副作用和优异治疗有效性的光动力疗法的光敏剂是非常有用的。

    Photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy
    8.
    发明授权
    Photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy 有权
    基于聚合物衍生物的光敏剂 - 用于光动力疗法的光敏剂共轭物

    公开(公告)号：US08614285B2

    公开(公告)日：2013-12-24

    申请号：US12595103

    申请日：2008-04-23

    申请人： Ick-Chan Kwon ,  Kui-Won Choi ,  Kwang-Meyung Kim ,  In-Chan Youn ,  Jong-Ho Kim ,  Kyeong-Soon Park

    发明人： Ick-Chan Kwon ,  Kui-Won Choi ,  Kwang-Meyung Kim ,  In-Chan Youn ,  Jong-Ho Kim ,  Kyeong-Soon Park

    IPC分类号： C08F251/00 ,  A61K31/555

    CPC分类号： A61K41/0071 ,  A61K47/61 ,  A61K47/6929

    摘要： Disclosed is a novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy capable of being selectively accumulated in cancerous tissues and producing singlet oxygen or free radical by laser irradiation. The polymer derivatives-photosensitizer conjugates for photodynamic therapy are prepared as nano-sized particles, and have excellent selection and accumulation ratio for cancerous tissues. The photosensitizer conjugates can produce singlet oxygen or free radical by a specific laser wavelength. Owing to the excellent selection and accumulation ratio for cancerous tissues, the conjugates minimizes photo-cytotoxicity of the conventional photosensitizer having a low molecular amount. Accordingly, the conjugates are very useful as a photosensitizes for photodynamic therapy with reduced side effects and excellent therapeutic effectiveness.

    摘要翻译： 公开了一种基于用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物的新型光敏剂，其能够选择性地积累在癌组织中并通过激光照射产生单线态氧或自由基。 用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物制备为纳米尺寸颗粒，并且对于癌组织具有优异的选择和积累比。 光敏剂共轭物可以通过特定的激光波长产生单线态氧或自由基。 由于癌组织的优异的选择和积累比，共轭物使具有低分子量的常规光敏剂的光细胞毒性最小化。 因此，缀合物对于具有降低的副作用和优异治疗有效性的光动力疗法的光敏剂是非常有用的。

    FUSION PROTEIN COMPRISING SMALL HEAT SHOCK PROTEIN, CAGE PROTEIN FORMED THEREBY, AND NOVEL USE THEREOF
    9.
    发明申请
    FUSION PROTEIN COMPRISING SMALL HEAT SHOCK PROTEIN, CAGE PROTEIN FORMED THEREBY, AND NOVEL USE THEREOF 有权
    包含小热蛋白的蛋白质蛋白，形成的蛋白质蛋白及其新用途

    公开(公告)号：US20130230562A1

    公开(公告)日：2013-09-05

    申请号：US13702752

    申请日：2011-06-07

    申请人： Hyung-Jun Ahn ,  Ick-Chan Kwon ,  Kul-Won Choi

    发明人： Hyung-Jun Ahn ,  Ick-Chan Kwon ,  Kul-Won Choi

    IPC分类号： A61K47/42 ,  C12Q1/37 ,  C07K14/435

    CPC分类号： A61K47/42 ,  C07K14/435 ,  C07K14/47 ,  C07K2319/21 ,  C12Q1/37 ,  G01N33/542 ,  G01N2333/96466 ,  G01N2333/96494 ,  G01N2510/00

    摘要： The present invention relates to a fusion protein comprising small heat shock protein, a cage protein formed thereby, and novel use thereof, more particularly, a fusion protein comprising a small heat shock protein, a recognition site of a protease, and a histidine polymer, wherein the recognition site and the histidine polymer are sequentially linked to a carboxyl terminal of the small heat shock protein, a cage protein formed thereby, and novel use thereof. The fusion protein of the present invention, and a cage protein formed by the self-assembly properties of the fusion protein are not cytotoxic, and emits a fluorescence signal of about 20 to about 50 times higher comparing to a single peptide for the conventional molecular imaging, per unit protein. Additionally, cell permeability is very excellent, thereby to be effectively used as a biosensor or a bioactive material carrier.

    摘要翻译： 本发明涉及包含小型热休克蛋白的融合蛋白，由此形成的笼状蛋白及其新用途，更具体地，涉及包含小热休克蛋白，蛋白酶的识别位点和组氨酸聚合物的融合蛋白， 其中识别位点和组氨酸聚合物依次连接到小热休克蛋白的羧基末端，由此形成的笼状蛋白质及其新用途。 本发明的融合蛋白和通过融合蛋白的自组装性质形成的笼状蛋白不是细胞毒性的，并且与用于常规分子成像的单一肽相比，发射约20至约50倍的荧光信号 ，单位蛋白。 此外，细胞渗透性非常优异，从而有效地用作生物传感器或生物活性物质载体。

    POLYMERIC NANO-PARTICLES FOR siRNA DELIVERY USING CHARGE INTERACTION AND COVALENT BONDING
    10.
    发明申请
    POLYMERIC NANO-PARTICLES FOR siRNA DELIVERY USING CHARGE INTERACTION AND COVALENT BONDING 有权
    使用电荷交互和共价键合的siRNA交付的聚合纳米颗粒

    公开(公告)号：US20120065242A1

    公开(公告)日：2012-03-15

    申请号：US12905212

    申请日：2010-10-15

    申请人： Kwang Meyung KIM ,  Ick Chan KWON ,  Kuiwon CHOI ,  Myung Sook HUH ,  Seung Young LEE ,  So Jin LEE

    发明人： Kwang Meyung KIM ,  Ick Chan KWON ,  Kuiwon CHOI ,  Myung Sook HUH ,  Seung Young LEE ,  So Jin LEE

    IPC分类号： A61K31/713 ,  A61P35/00 ,  C07H21/04 ,  B82Y5/00

    CPC分类号： A61K47/4823 ,  A61K47/61 ,  A61K47/6939 ,  C12N15/111 ,  C12N15/87 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/32

    摘要： Disclosed is a polymer-siRNA delivery carrier in which a siRNA is combined with a polymer and the use thereof. More specifically, there is disclosed a stable in vivo polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time and the use thereof.The polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time has a high siRNA deliver efficiency to a target portion in vivo. Hence, according to the polymer-siRNA binder, the siRNA for treatment can be effectively delivered to a target portion such as in vivo cancer tissue, and the like even with administration of a relatively low concentration, and thus widely used for the treatment of various kinds of diseases.

    摘要翻译： 公开了将siRNA与聚合物组合的聚合物-siRNA递送载体及其用途。 更具体地，公开了一种稳定的体内聚合物-siRNA递送载体，其中通过使用电荷相互作用和可生物降解的共价键在同一时间将聚合物和siRNA组合起来，以及其用途。 通过使用电荷相互作用和可生物降解的共价键合将聚合物和siRNA组合的聚合物-siRNA递送载体在体内对目标部分具有高的siRNA递送效率。 因此，根据聚合物-siRNA粘合剂，即使施用相对低的浓度，也可以将治疗用siRNA有效地输送到诸如体内癌组织等目标部位，广泛用于各种治疗 各种疾病